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Category Archives: New Jersey Stem Cells

Non-Surgical – The New Jersey Orthopaedic Institute

Posted: November 27, 2016 at 8:44 pm

From strains to sprains and more, the vast majority of sports related injuries respond well with non-surgical care.

That is why it is always the first approach at NJOI. The NJOI orthopaedists, and in particular its primary care physicians specializing in sports medicine, offer a variety of non-surgical services for musculoskeletal care. NJOIs vast experience with athletes of all ages and levels emphasizes both injury care and prevention with these services.

Nonsteroidal anti-inflammatory drugs (NSAIDs) include aspirin, ibuprofen (e.g., Advil), naproxen (e.g., Aleve) and nabumetone (e.g., Relafen). These medications address an injury by helping reduce pain and inflammation. However, they can have negative effects if used improperly and it is important than the experts at NJOI assess and recommend these medications for each individual so that they can be taken safely and effectively.

NJOI also offers various injections, including cortisone. These injections are designed to help with chronic, painful inflammation. Delivering cortisone by injection provides very high concentrations of the medication directly to the affected area, while minimizing potential side effects. These injections usually work within a few days, and the effects can last up to several weeks and sometimes even permanently.

Its extensive sports medicine experience means NJOI can provide all of its patients with the best advice for an athletic or active lifestyle. This includes such important areas as strength training and conditioning, flexibility exercises, sports nutrition, and concussion management.

While taping and bracing should not be used in place of personalized medical care when indicated (such as for ongoing pain or serious injury), nor as a substitute for important rehabilitation exercises, these methods can provide extra support for joint instability or for rehabilitating injuries. Both taping and bracing are a common feature of all sports participation. The experts at NJOI understand the concepts and techniques of these methods, and are particularly experienced due to their numerous positions as youth, collegiate and professional sports team physicians.

Platelet-rich plasma (PRP) has become a treatment option for a wide variety of athletes, from recreational to avid amateurs to professionals. This procedure is particularly useful for persistent partial tendon problems, such as tennis elbow, plantar fasciitis, quadriceps and patellar tendon tears; partial muscle tears and ligament tears as well as utilized in conjunction with surgical procedures to increase the chances of healing. While its success rate may vary, PRP holds out hope as a non-invasive potential solution to healing.

In addition to its plasma component, blood also contains red and white cells, as well as platelets. Besides their role in clotting blood, platelets also contain healing properties due to their growth factors (which are the proteins in the blood). For PRP, blood is drawn from the patients. The platelets are separated in a centrifuge process, increasing their concentration from 5 to 10 times greater than normal. They are then combined with the remaining blood and injected into injured tissues in order to facilitate more rapid healing. PRP is a non-surgical treatment, and the risks of PRP are minimal.

Among the ranks of those who have been treated with PRP are professional athletes, like Tiger Woods, Kobe Bryant and Rafael Nadal, as well as two injured NFL players before winning a Super Bowl. Countless weekend warriors have also found relief through this treatment.

While much publicity surrounds use of PRP for athletes, the procedure actually began in the 1990s in connection with plastic surgery. At NJOI, we use PRP for a variety of conditions. A number of studies have demonstrated that PRP injections have lessened pain and improved function in joints, including the elbow, wrist, shoulder, hip, knee, and ankle.

In separate trials done in 2011, PRP lowered blood loss in 81 patients with knee replacements, and lessened pain for 21 with tennis elbow.* *http://www.bloomberg.com/news/2012-08-24/blood-therapy-used-by-tiger-woods-lures-everyday-athletes.html

Over a million U.S. patients have been treated with stem cells in the past decade and a half. Currently, there are over 70 proven therapies using adult stem cells. Stem cell therapy at NJOI, done via ultrasound guidance, has the potential to help accelerate healing in tendon/ligament injuries, and to augment the sub-optimal healing from other techniques or surgeries.

The process of receiving stem cell therapy starts with harvesting your own stem cells from the bone marrow. Stem cells are harvested from the iliac crest (hip bone) using AN anesthetic and a special small biopsy needle. These stem cells- called Mesenchymal Stem Cells (MSC)- areautologous, meaning they are the patients own stem cells.

Harvesting MSCs for injection therapy is done in our office and only takes a short amount of time.The skin and hip bone are numbed. A special needle is then passed through the cortex of the bone into the marrow cavity. This is apainlessprocedure in most cases.The liquid marrow is then very slowly drawn into a syringe.

Then your bone marrow gets spun in a centrifuge for 15 minutes allowing the undifferentiated mesenchymal stem cells to separate from the platelets and blood. Our experienced surgeon will then inject your own stem cells into the joint or damaged tissue.

These mesenchymal stem cells have the ability to turn into cartilage, ligament, tendon, bone, nerve tissue, blood vessels, or muscle tissue. These cells find the area of damage, connect to your DNA and determine the code that tells them into what to reproduce. Stem cells can only grow the same tissue you would have had before the damage.

This procedure is particularly useful for persistent partial tendon tears, such as tennis elbow, plantar fasciitis, quadriceps and patellar tendon tears; partial muscle tears; meniscus tears in the knee and chondromalacia patella (patellofemoral syndrome).

Arthritis afflicts about 50 million people of all ages throughout the country. Osteoarthritis is the most common form of this disease, characterized by deteriorated cartilage surrounding the joints. Healthy cartilage serves to cushion and protect the bones in joints preventing friction and allowing for fluid movement.

Viscosupplementation is a minimally invasive, therapeutic treatment for those who have not seen improvements through medication or other traditional treatments. Hyaluronic acid, a naturally occurring gel-like substance found in the synovial fluid of the joints, is injected into the affected joint and acts as a lubricant. Individuals with osteoarthritis typically have less of this naturally occurring acid, so the treatment works to supplement for the lack of fluid. Viscosupplementation at NJOI is primarily used on the knee, but can also be done on the hip or shoulder.

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Non-Surgical - The New Jersey Orthopaedic Institute

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Stem Cell – New Jersey Catholic Conference – Trenton, NJ

Posted: November 23, 2016 at 7:44 pm

Position of the Catholic Bishops of New Jersey on Stem Cell Research

October 2007

The Catholic Church has been committed to the care and healing of the sick from its very beginning. When Jesus commissioned the Apostles to Go into the whole world and proclaim the gospel to every creature (Mark 16:15) he also told them that those who believed in his name should be healers, They will lay hands on the sick, and they will recover" (Mark 16:18). In America, Catholic Hospitals and Catholic Charities have continued that apostolic mission and are at the leading edge of care for the ill, those who are poor and especially those who are uninsured or underinsured.

Following this tradition to be healers, the Catholic Church strongly supports adult or non-embryonic stem cell research and treatment. In New Jersey, our Catholic hospitals are a major source for the collection of cord blood, placentas and amniotic fluid all of which are rich in non-embryonic stem cells. Adult stem cells have already helped thousands of patients with life threatening diseases and debilitating conditions. Over 70 clinical uses of adult stem cells have produced successful treatments for conditions such as diabetes, lupus, multiple sclerosis, corneal regeneration, Crohns disease and immune deficiencies.

In contrast, embryonic stem cell research has yet to provide a single successful clinical treatment. Moreover, harvesting embryonic stem cells requires the destruction of human embryos. The Catholic Church teaches human life begins at conception and must be absolutely protected from that moment of conception. The Catholic Church can never approve support for embryonic stem cell research which requires the destruction of innocent human life.

Adult stem cell research has a proven track record and we support adult stem cell research and therapy. We speak out against embryonic stem cell research and the allocation of monies for research which, in our judgment, fails to respect the sacredness of human life at its beginning. We call upon all people to respect life especially the lives of the most vulnerable among us the child in a mothers womb.

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Stem Cell - New Jersey Catholic Conference - Trenton, NJ

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Basic Science FAQs – Stem Cell Institute of New Jersey

Posted: October 29, 2016 at 6:45 am

What are stem cells?

Stem cells have the unique capacity to develop into many different cell types in the body, producing muscles, nerves, blood cells, or other tissues. They also exhibit the remarkable ability to self-renew.

GSBS website

Stem cells are precursors to an entire family of cells (referred to as a lineage). Embryonic stem cells have the potential to change into any type of stem cell (omnipotent). This process is known as differentiation. Stem cells can also replicate to form identical versions of themselves. This process is known as self-renewal. The figure depicts an embryonic stem cell undergoing self-renewal as well as the differentiation process. The two daughter cells are also stem cells; however, they are referred to as pluripotent stem cells since they are now committed to a particular lineage such as neuronal stem cells, muscle stem cells, vascular endothelial stem cells, or hematopoietic stem cells. As an example, hematopoietic stem cells (pluripotent) cannot create muscle cells derived from the muscle stem cells, but form all the variations of cells found in your blood.

Stem cells are the basic building blocks for all the specialized tissues that make up the body. They are primarily responsible for building, repairing and maintaining tissues and organs.

Stem cells are found throughout the body at all stages of life. Adult stem cells are found in bone marrow, the umbilical cord, the adult brain and spinal cord, skin, blood, intestines and other tissues. Embryonic stem cells are derived from blastocysts, 4- to 5-day old microscopic balls of cells fertilized in the laboratory.

Stem cells offer the possibility of replacing damaged or diseased cells inside the body with healthy ones. They could make it possible to strengthen failing heart muscle, regenerate severed spinal cord nerves, replace damaged brain cells and cure many other currently incurable disorders such as diabetes, Alzheimers and Parkinsons disease, or arthritis.

Adult stem cells are multipotent. This means they can become all the cells in a closely related family of cells. For example, bone marrow stem cells can become red blood cells, white blood cells and platelets. Recent research suggests that some adult stem cells may have greater potential to form different cell types than was previously thought. Embryonic stem cells are pluripotent. This means they can develop into any of the bodys cell types except those needed to produce a fetus. These cells are extremely versatile and are relatively easy to grow in culture.

Research on both adult and embryonic stem cells provides important insights into how cells develop in normal tissues and what interventions might stop or reverse the course of disease. Adult stem cells, studied for more than 40 years, have proven successful in several treatments, including bone-marrow transplants for leukemia and other cancers. The more versatile embryonic stems cells were first isolated in 1998, and their potential for therapies is only beginning to be explored. Because stem cell research offers such enormous promise for curing disease and revolutionizing medical practice, scientists need to pursue all likely lines of inquiry.

By better understanding the basic biology of stem cells, scientists hope to learn how to control the transformation of stem cells into the specialized cells a patient needs. They will also need to find ways to integrate the new cells seamlessly into the patients tissues and organs. In addition, scientists will have to counter possible tissue rejection by the patients immune system. Research, although very promising, is still at a preliminary stage. What are the proposed ethical considerations for stem cell research?

The New Jersey Stem Cell Institute prohibits human reproductive cloning and will establish a committee to monitor practices and policies related to research conducted under the auspices of the Institute.

Some useful Web sites with extensive information on the science of stem cells include:

Initially, scientists will focus on neurological disorders and spinal cord injury. They will also engage in fundamental research to better understand how stem cells produce and repair the wide variety of tissues found in the body.

Institute scientists will study both adult and embryonic stem cells. Much of this research will be conducted on non-human stem cells derived from mice. How will the institute ensure compliance with ethical guidelines?

The institute is committed to conducting responsible research. Institute researchers will follow the extensive policies and procedures outlined by national science associations, the federal government and the state of New Jersey to ensure that their research meets the highest ethical standards. For more information, see section on Science and Society.

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Basic Science FAQs - Stem Cell Institute of New Jersey

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New results on stem cells ageing – CODIF Recherche et …

Posted: August 1, 2016 at 7:56 am

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NJMS Stem Cells – Rutgers New Jersey Medical School

Posted: August 1, 2016 at 7:56 am

Welcome to the Stem Cell and Regenerative Medicine Web Site.

This web portal was developed by Dr. Pranela Rameshwar, Department of Medicine, Division of Hematology-Oncology. The site is intended to provide educational materials on stem cell biology and the application to regenerative medicine/tissue repair. The students who have taken the graduate courses in stem cell biology as well as those who were involved in stem cell research participated in the development of the contents.

The course material is useful for clinical application for stem cell and for those in training such as residents and fellows. A comprehensive collection of FAQ's serves as a great resource and starting point for those seeking general information. Much of the information provided within the FAQ's is directly referenced, enabling interested parties to locate the associated primary literature for greater detail. Further, the Recommended Articles section contains a list of relevant articles sorted by category. Due to space limit it is impossible to list all of the articles and any omission is not deliberate. The reader is recommended to access other databases for further information on stem cell biology.

The Resources section is a great `jump-off' point for nearly all visitors seeking additional information. This section includes News Resources, various Reports and much more.

The Current News section provides the latest news stories surrounding stem cell research and regenerative medicine. For additional news, please visit the News Resources section.

Research professionals are encouraged to visit the Seminar Series and Information for Researchers sections.

Please direct any questions regarding content or the seminar series to Dr. Pranela Rameshwar, course director of the stem cell course and Professor of Medicine, New Jersey Medical School.

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New York and New Jersey – Stem Cell Therapy & Platelet …

Posted: August 1, 2016 at 7:56 am

Select a Problem Area

If you have pain, we're here to help. Regenexx Procedures are patented stem cell and blood platelet procedures that are used to treat a wide range of joint and spine conditions.

Click a problem area to discover what Regenexx can do for you.

The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from shoulder pain due to arthritis, rotator cuff and shoulder labrum tears, overuse injuries, and other degenerative conditions. Regenexx is also a viable alternative for those considering shoulder replacement surgery.

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Regenexx Procedures are advanced stem cell and blood platelet procedures for foot and ankle conditions. Before you consider ankle surgery, fusion or replacement, consider the worlds leading stem cell and prp injection treatments.

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The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from pain or reduced range of motion due to basal joint / cmc arthritis, hand arthritis, or other injuries & conditions in the hand. View Details About Hand & Wrist Treatments Commonly Treated Conditions:

The Regenexx family of non-surgical stem cell and blood platelet procedures offer next-generation injection treatments for those who are suffering from knee pain or may be facing knee surgery or knee replacement due to common injuries, arthritis, overuse and other conditions.

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The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from pain, inflammation or reduced range of motion due tocommon elbow injuries, arthritis and overuse conditions.

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The Regenexx family of hip surgery alternatives are breakthrough, non-surgical stem-cell treatments for people suffering from hip pain due to common injuries, hip arthritis & other degenerative problems related to the hip joint.

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Regenexx has many non-surgical platelet and stem cell based procedures developed to help patients avoid spine surgery and high dose epidural steroid side effects. These procedures utilize the patients own natural growth factors or stem cells to treat bulging or herniated discs, degenerative conditions in the spine, and other back and neck conditions that cause pain.

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Regenexx has many non-surgical platelet and stem cell based procedures developed to help patients avoid spine surgery and high dose epidural steroid side effects. These procedures utilize the patients own natural growth factors or stem cells to treat bulging or herniated discs, degenerative conditions in the spine, and other back and neck conditions that cause pain.

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Research Overview | Rutgers Cancer Institute of New Jersey

Posted: October 19, 2015 at 5:49 pm

The research efforts in the Sabaawy laboratory is focused on studying normal stem cell development and cancer stem cells utilizing patient-derived cells, genome sequencing, tumor initiation models, 3D stem cell organoid cultures and zebrafish and humanized mouse xenografts for drug discovery. These studies aim to dissect normal stem cell developmental pathways, and how cancer stem cells divert from these regulatory pathways. One major pathway for research focus in the laboratory is the regulation of stem cell self-renewal by the polycomb gene BMI1 and cyclin dependent kinase inhibitors p15 and p16 regulating the cell cycle and senescence. Utilizing novel organoid cultures, CRISPR- and recombinase-mediated genome editing and drug modifiers together with transgenic and xenograft approaches; the laboratory is generating models for precision therapy of several cancers such as prostate and renal cancers, glioblastomas and leukemias.

The laboratory houses the Rutgers Cancer Institute of New Jersey zebrafish facility and is collaborating with several investigators at Rutgers, nationwide and globally to utilize our zebrafish stem cell reporters and Cre-Lox transgenics for cancer modeling and drug discovery strategies. With these approaches, we uncovered novel stem cell targets, and are developing small molecule inhibitors for targeting stem cell self-renewal for more effective regenerative and cancer therapies.

A parallel research effort in the Sabaawy laboratory is to study human adherent bone marrow-derived cells (ABMCs)-based therapy and transplantation in regenerative medicine. Cell therapy using stem cells for regeneration of a failing organ or injury repair is a promising approach. We are utilizing 3D organogenesis and animal models to study the mechanisms and dynamics of stem cell-mediated regeneration. These studies support ongoing collaborations in international clinical trials for utilizing ABMCs cell therapy for injury repair.

Hatem E. Sabaawy, MD, PhDis an assistant professor of medicine at Rutgers Robert Wood Johnson Medical School, an assistant professor of cellular and molecular pharmacology at the Rutgers Graduate School of Biomedical Sciences, director of the Cell and Gene Therapy Good Manufacturing Practice Facility at RWJMS, a member of the executive committee of the Stem Cell Institute of New Jersey, and a principal investigator at Rutgers Cancer Institute of New Jersey Molecular and Regenerative Medicine program.

He had his medical residency and graduate training at Cairo University Hospitals in Cairo, Egypt, and New York Medical College in Valhalla, NY in clinical Hematology with PhD in Genetic Pharmacology from the Gene Therapy program at New York Medical College. Dr. Sabaawy went on to complete a fellowship at the Transplantation and Immunology Branch of the Center for Cancer Research at the National Institutes of Health (NIH) and the National Cancer Institute (NCI) in Bethesda, MD.

His work at the Cancer Institute of New Jersey focuses on translational research studies of normal hematopoietic stem cells and tumor stem cell development utilizing mouse and zebrafish models. The studies received national funding from the National Institutes of Health and the Department of Defense. These studies aim to identify stem cell targets, genetic modifiers and small molecule inhibitors that would ultimately improve cancer patients' survival.

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The New Jersey Cord Blood Bank (NJCBB)

Posted: October 19, 2015 at 5:49 pm

Our state-designated public bank allows you to donate your baby's umbilical cord blood at participating hospitals in New Jersey so his or her stem cells can be used by a child or adult suffering from cancer or another life-threatening disease anywhere in the world.

Stem cell transplants are being used in the treatment of leukemia, lymphoma, Hodgkin's disease, sickle cell anemia, cerebral palsy, aplastic anemia and various other cancers, blood diseases, hereditary conditions and immune system disorders. In the future, stem cells may be used to fight heart disease, breast cancer, diabetes, Parkinsons disease, Alzheimers disease, multiple sclerosis, diabetes, Parkinsons disease, AIDS, and a score of other genetic diseases.

What are Stem Cells?

Stem cells are found concentrated in bone marrow and umbilical cord blood. Stem cells make the three types of blood cells that we need to survive: red cells to carry oxygen throughout our bodies, platelets to prevent bleeding and white cells to form our immune systems and guard us against infection. When stem cells are damaged or destroyed during aggressive treatment for cancer or other diseases, they can be replaced through bone marrow or cord blood transplants.

How Are Stem Cells Collected and Stored?

Why are More Ethnically and Racially Diverse Donors Needed?

Tissue types are inherited, so patients are more likely to match someone who shares their racial or ethnic heritage. As the need for transplants in diverse communities continues to grow, more ethnically and racially diverse donors are also needed from African American and Black, Hispanic, Latino, Asian and Native American communities to increase the chances of finding lifesaving matches for patients in need in those communities. A key goal of the NJCBB is to increase education and recruitment efforts within the State of New Jerseys diverse communities in an effort to save more lives.

What is the NJCBB?

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The New Jersey Cord Blood Bank (NJCBB)

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Research at Rutgers | Rutgers University

Posted: October 19, 2015 at 5:49 pm

Rutgers, The State University of New Jersey, is entrenched in a culture of research, innovation, and invention that is a hallmark of the American academic experience.

Of the thousands of institutions of higher learning in North America, only 62 are members of the Association of American Universities (AAU).This selective group ofleading research universities is recognized for the quality and scope of its research and educational programs.Rutgers is the only public New Jersey university in the AAU (fellow Garden State school Princeton is also a member).

On July 1, 2013, Rutgers University became a member of the Committee on Institutional Cooperation (CIC), a consortium of first-tier research universities, such as the University of Chicago, University of WisconsinMadison, and University of Michigan, that shares knowledge and best practices and pools resources and buying power to strengthen higher education and support research endeavors. CIC universities conduct $8.4 billion in funded research each year.

Rutgers is one of the nations 75 land-grant institutions, in the company of other land-grants such as Cornell, MIT, Ohio State, and Penn State. The Morrill Act of 1862 designated these institutions to serve the states and their citizens by disseminating practical knowledge developed at key institutions of higher learning. From an early emphasis on agriculture and the mechanical arts, the land-grant mission of Rutgers, like that of fellow institutions, has expanded to include a broad range of teaching, research, and service activities.

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Orthopedic Stem Cell Solutions at the Spine & Pain Center …

Posted: May 8, 2015 at 10:49 pm

At Orthopedic Stem Cell Solutions at the Spine and Pain Center, we carefully evaluate each patient by taking a detailed medical history and reviewing all of your previous therapies. We arrive at an accurate diagnosis in a timely fashion. We then develop a treatment plan for your specific needs using the most advanced Interventional Techniques and most effective Regenerative Orthopedic Therapies.

At Orthopedic Stem Cell Solutions we do not routinely prescribe narcotic medications, which can simply mask the pain. We believe in the responsible and judicious use of narcotic pain medicine. We design an individualized treatment plan for you, which targets and treats the cause of your pain at the source with a Minimally Invasive Procedure or Orthopedic Intervention to help you avoid major surgery. A great majority of our patients have already seen other Physicians and Surgeons without success. We specialize in the more difficult cases.

REGENEXX PROCEDURES Offering the most advanced regenerative stem cell & blood platelet procedures available.

MEET DR. AMOROSO Board certified by the American Board of Anesthesiology and the American Board of Pain Medicine.

FREQUENT QUESTIONS Have questions? Check here and if your dont find what you need, please contact us.

DOWNLOAD PATIENT FORMS Get a head start by downloading patient forms before your next appointment.

Phone 732.531.7246 or Email Us:

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