Category Archives: Nano medicine

By Srinivas Iyengar

One of the most awaited technologies on the verge of moving out of laboratories and set to enter commercial production is nanotechnology. There is so much buzz about nanotechnology that industries, from cosmetics, healthcare, and automobile to aerospace, expect big disruptions due to nanotech. In the race for nano supremacy, I see healthcare as the most exciting space with a variety of use cases that can have a profound impact on humankind. In fact, nanotechnology is the most radical and wide-reaching emerging technology, and healthcare is its most urgent application.

Before we delve deeper into the application of nanotechnology in healthcare, let us take a closer look at nanotechnology, its use cases, and its market share. This will give us a clearer perspective and some critical insights into this emerging technology.

Lets understand what a nanometer is all about. To give you a better perspective, A virus, on average, is 40- 100 nanometers in size! Isnt it amazing that we are now dealing with things 1/100th the size of a virus? And these subatomic particles are making big waves today! We are building nanorobots, nanotubes, nanodots, nanowires, and nanosheets that could be used for innovative and pathbreaking medical applications from diagnosis of disease and drug delivery to the disease-affected areas of the human body with great precision, something that hasnt been actively pursued until now.

The space where nanotechnology meets healthcare is called nanomedicine. Industry experts estimate the nanomedicine market share to grow up to $260Bn in 2025 from $141Bn in 2020.

While nanostructures occur naturally in soil, dust, oceans, plants, and animals, scientists today are building nano materials with newly manipulated attributes or engineered properties. This holds massive potential and opens new doors in drug delivery systems, body scans, gene therapy, identifying cancer cells, and health monitoring.

The lexicon of Nanotechnology Before outlining the possible use cases of nanotechnology in healthcare, it would serve us well to be acquainted with the basic verbiage of nanotechnology

Nanometer (m): A nanometer is a unit of measurement which is 1 billionth of a meter. The smallest things around us are measured in nanometers. To illustrate, a DNA molecule is about 2.5 m wide compared to a red blood cell which is about 7 m.

Nanoparticles (Nanodots/Quantum dots): These are small particles that range anywhere between 1 to 100 Nm. We all know well that the smaller the material, the surface area to volume ratio increases. This ensures that nanoparticles have distinct optical, physical, and chemical properties and produce quantum effects.

Nanotubes: These are tubes with atom-thick walls and a tube-like structure mainly made of carbon materials. Nanotubes are a few nanometers wide, and their length can be up to a few millimeters. What makes them more attractive in the healthcare arena is that they are non-toxic and, therefore, safe to use.

Nanorobotics: Nanorobotics is the process of building robots at the nanoscale and such robots are called nanobots. They are typically nanoelectromechanical systems that can be programmed to carry out specific tasks.

The most promising use-cases of Nanotechnology in HealthcareIndustry experts believe that nanotechnology will play a pivotal role in shaping the future of healthcare. Lets take a look at some of its most compelling use cases that are already show promising results

Targeted Drug Delivery System: In todays conventional drug delivery mechanism, did you know that when you take a medicine for a headache, it possibly goes through your entire body, including the head, to give you relief? This also means that the drug delivery mechanism is inefficient, slow, requires more drug consumption than needed, and may impact non-targeted organs. Nanotechnology can carry drugs to specific cells and release them when it reaches the targeted organ or area. This can be highly instrumental, for instance, in curtailing the side effects of chemotherapy.

Diagnosis: A biomarker, in general, is a measurement, substance, or chemical in the body which indicates a disease or a condition. It is seen that nanotechnology can bridge the gap between measurable biomarkers representing the physiology of a biological process and clinical outcomes. Nanoparticles injected into humans can detect these biomarkers with extremely high efficacy as compared to scanning the human body from the outside, thereby reducing the chances of drug failure/rejection.

Medical Imaging: Nanoparticles/Quantum dots are so small that their surface area to volume ratio is relatively high, thus producing excellent contrast and fluoresce. In generic terms, a nanoparticle is more like a glow-in-the-dark thing, and its ability to reflect light will help us in biological labeling at the molecular level. Nanoparticles in medical devices and drug therapy can give us much better diagnosis results and treatments with a higher success rate.

Wound Treatment: One of the major pain points of wound healing is contamination with microorganisms. Silver nanoparticles have antibacterial and anti-inflammatory properties that provide better wound healing efficacy with less bacterial resistance. They can be used as scaffolds for skin regeneration. Nanofibrous materials can also be used as delivery systems for drugs, proteins, growth factors, and other molecules. This will help us in targeted drug delivery with minimal and effective drug usage.

Needless to say, there exists great scope for advancements in nanotechnology that hold the potential to revolutionize and reinvent healthcare systems despite existing hurdles. Nanomedicine, nano pharmacology, nanoimaging, and targeted drug delivery systems will make the diagnosis and prevention of diseases, and care delivery more efficient and patient-centric.

By Srinivas Iyengar, VP & Head of Healthcare & Life Sciences, Happiest Minds Technologies.

(DISCLAIMER: The views expressed are solely of the author and ETHealthworld does not necessarily subscribe to it. ETHealthworld.com shall not be responsible for any damage caused to any person / organisation directly or indirectly)

Originally posted here:
Nanotechnology is poised to shape the future of Healthcare - ETHealthWorld

Being diagnosed with any illness is unnerving, but imagine you are one of only 30 people in the world to suffer from the illness or at least a particular form of it. Now, imagine that that disease is 100% fatal. Thats the reality faced by the Amyotrophic lateral sclerosis (ALS) patients being treated as part of a new initiative between Columbia University and non-profit biotech company n-Lorem Foundation.

These diseases or disease mutations have been dubbed nano-rare by San Diego-based n-Lorem, whose mission is to find effective treatments for these uniquely afflicted individuals and others like them.

There are few commercial incentives for pharmaceutical or biotech organizations to pursue the discovery and development of individualized treatments, n-Lorem Chief Development Officer Sarah Glass, Ph.D. told BioSpace. The 2021 FDA guidance documents for individualized antisense oligonucleotides have enabled this non-commercial route for n-Lorems non-profit model, which is driven entirely by the desire to help patients by embedding the same level of quality that is required for standard commercial drugs."

In recent years, researchers have come to the consensus that ALS is a heterogeneous disease. This is evidenced by patient subsets that have responded favorably to drugs like Radicava, which was approved in 2017 and BrainStorm Cell Therapeutics NurOwn, which is still fighting an uphill battle for approval.

Glass said that providing a blanket definition of ALS almost does [patients] a disservice given the many unique individuals within this patient group. Individuals with ALS that carry a nano-rare mutation are often one of only a few - or perhaps the only one - that are known to have this mutation worldwide."

Lisa Stockman Mauriellofaced a similar situation. Suffering from a particularly lethal A5V mutation within SOD1-ALS, Stockman Mauriello captured the nations attention and reinvigorated the ALS community in its fight for expanded access to investigational therapies.

Stockman Mauriello was fighting for access to the experimental therapy tofersen, which was being developed by Biogen and Ionis Pharmaceuticals. Tofersen is an antisense oligonucleotide (ASO) that targets a mutation in the superoxide dismutase 1 (SOD1) gene believed to be responsible for the genetic driver in SOD1-ALS, the second most common form of inherited, or familial ALS. This category is rare itself, accounting for just 2% of all ALS cases. Ultimately, tofersen failed to achieve its endpoint in Phase III, and although Stockman Mauriello eventually did receive access to the drug, she succumbed to her disease in August 2021.

The n-Lorem-Columbia project, Silence ALS, is funded by medical nonprofit Target ALS and focuses on developing personalized experimental ASO medicines for nano-rare ALS patients. Currently, eight patients have been accepted into the program. These patients are afflicted with nano-rare mutations in either TDP-43 or CHCHD10.

In the first case, the TDP-43 protein is incorrectly ejected from the cells nucleus, preventing it from performing essential functions such as ensuring that mRNA is produced correctly, which can produce chaotic effects in affected nerve cells. Mutations in the CHCHD10 gene were identified as a genetic cause of ALS in 2014. While the process is not yet well understood, some studies suggest the mutations lead to impaired functioning of mitochondria, the cellular structures that provide the energy necessary for survival. Then, there are separate mutations within both.

These are genes that are well known in the ALS community. They are very well characterized and have been extensively studied by the research community. Unique mutations may occur in any gene and n-Lorem is learning more and more about the types of mutations and genes that ASOs can target, Glass said. The Silence ALS partnership will enable iterative learning to help the broader population over time.

She explained how ASOs can address these mutations.

These are short segments of single-stranded genetic material that bind in a sequence-specific manner to RNA to alter the behavior and performance of that target RNA. ASOs can target a specific mutation as well as different variants that uniquely differentiate that patient from others. Glass added that for some patients, it may be necessary to differentiate the disease-causing allele from the normal allele.

ALS is a progressive, neurodegenerative disease. From the time of diagnosis, a patient can expect to live between 2-5 years. During that time, they will become increasingly paralyzed, losing the ability to walk, talk, eat, swallow and finally, breathe. Glass shared that this is a big part of the reason n-Lorem teamed up with Neil Shneider at Columbia on this initiative.

The clock is ticking. One of the biggest goals of the partnership is really to introduce efficiencies such as proactive sequencing, acquiring patient cells and other elements that are required to be able to accelerate our ability to develop an individualized therapy, she said.

One of these efficiencies is ensuring that patients are characterized at an early stage in their disease prognosis. Then, the ultimate end goal would be to eventually get to the place where we can try to preempt, almost pre-symptomatically be able to develop these ASOs when the natural history of a particular mutation is known.

Glass shared that there are thousands and thousands of nano-rare diseases and patients with nano-rare mutations. Besides ALS, n-Lorem is primarily focused on helping patients with other neurodegenerative diseases as well as those with severe neurodevelopmental, ophthalmologic and kidney diseases. The foundations neurological concentration owes to it being where patients are mostly diagnosed from a genetics perspective, she explained.

Genetic testing and genome sequencing has become much more common in the rare neurological disease space and many neurologists are becoming increasingly aware of the potential of individualized therapies. This is reflected in the fact that many patients for whom n-Lorem is discovering an ASO are affected primarily by neurological manifestations. Glass said. She clarified that n-Lorem is also already developing ASOs for patients with diseases in other organ systems as well and will continue to expand the breadth of the patients it can help.

Its been understood for a while now that personalized medicine is the way of the therapeutic future, and initiatives like this one reflect that sentiment.

As genetic sequencing becomes more common, it has become apparent that more and more pathogenic mutations are nano-rare and will require individualized treatments that are out of scope for commercial organizations, she said.

Glass suggested that partnering is key to leveraging platform approaches and collective abilities to find commonalities [and therefore therapeutic efficiencies] across some of these nano-rare diseases. How can we learn and try to think across different genes, different mutations that have a number of similarities and commonalities? This could ultimately lead to the nano-rare becoming a little less rare.

Glass, who did her Ph.D. in a rare form of cancer, shared that she has always had a passion for genetics and rare diseases. Then in 2020, her own son was diagnosed with a rare disease. Being immersed in drug discovery and development and now having a child with an N-of-1 mutation as well, she wondered how one could go about successfully developing a therapy for individual patients.

At the time, I reached out to Dr. Stan Crooke [founder and CEO of n-Lorem], the pioneer of RNA-targeted drugs, she said. I immediately learned a lot and was drawn to the mission. My joining n-Lorem was an organic evolution of my career and represented the true intersection of my personal and professional passions. Since joining Crooke, Glass has been working feverishly to stand up an infrastructure to enable many more patients to be helped.

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New Silence ALS Initiative is Giving Hope to Nano-Rare Patients - BioSpace

DUBLIN, May 09, 2022--(BUSINESS WIRE)--The "Nanotechnology in Medical Applications: The Global Market" report has been added to ResearchAndMarkets.com's offering.

Nano-enabled medical products began emerging on the market over a decade ago, and some have evolved as the best-sellers in their therapeutic categories. The leading areas in which nanomedical products have made an impact are CNS diseases, cancer, cardiovascular disease, and infection control.

Moreover, the availability of technologically advanced products and significant investments in nanotechnology-based research in drug discovery studies and cancer therapeutics will also drive the North American market during the forecast period. The Asia-Pacific region's high growth rate will be due to the drive to address unmet healthcare needs, high prevalence of cancer, high investments in nanotechnology-based research, and growing R&D funding for cancer drug discovery and personalized medicine opportunities.

The report examines the current and forecast market potential for nanomedicine. It offers a detailed analysis of the market background, technological advancements, competitive environment, drivers and restraints, and market growth trends.

The report includes market projections through 2026, detailing the market share for nanomedicine based on therapeutic areas and geography. By therapeutic area, the nanomedicine market is segmented into anticancer, CNS products, anti-infectives, anti-inflammatories, cardiovascular, and others. By geography, the nanomedicine market has been segmented into Europe, North America, Asia-Pacific (APAC), and the Rest of the Word (ROW).

The Report Includes

An overview of the global markets for nanotechnology used in medical applications

Estimation of the market size, and analyses of the global market trends with data from 2019, 2020, 2021, with projection of CAGR through 2026

A review of technologies involved, in-depth analysis of applications in practice, and evaluation of future or potential applications

Information on significant products in which the nano dimension has made a significant contribution to product effectiveness

A look at the regulatory environment, healthcare policies, demographics, and other factors that directly affect nanotechnology used in medicine

Identification of key market dynamics, trends, opportunities, and factors influencing the global market and highlights of the market potential for nanotechnology used in medical applications based on type, application, and region

Market share analysis of the key companies of the industry and coverage of events like mergers & acquisitions, joint ventures, collaborations or partnerships, and other key market strategies

Company profiles of major players in the market, including Abbott, Abraxis Bioscience, Elan, Orthovita Inc., EyePoint Pharmaceuticals Inc. and Farfield Scientific Ltd

Story continues

Key Topics Covered:

Chapter 1 Introduction

Chapter 2 Summary and Highlights

Chapter 3 Market Overview

Applications

Drug Delivery

Drugs and Therapy

in Vivo Imaging

in Vitro Diagnostics

Biomaterials

Active Implants

Overview

Medical Nanotechnology: Nanomedicine

Nanotechnology

Nanotechnology Uses

Medical Applications

Environmental Applications

Military Applications

Cosmetics

Nanotechnology Tools

Risks of Nanotechnology

Nanotechnology in the Marketplace

Development of Nanomedical Technologies

Liposomes

Dendrimers

Nanocrystals

Micelles

Fullerenes

Polymeric Nanoparticles

Nanoparticle-Drug Conjugates

Ligand-Targeted Nanoparticles

Ceramic Nanoparticles

Virosome Nanoparticles

Therapeutic Uses of Nanomedicine

Cancer Diagnostics and Therapy

Drug Delivery

Future Trends and Research Possibilities

Non-Invasive Nanodevices

Extracellular Devices

Intracellular Devices

Nanomachines to Control Tissue Healing

Eliminating Viruses

Correcting Chemistry

New Organs and Limbs

Fundamental Nanotechnology Research

Chapter 4 Impact of Covid-19 Pandemic

Chapter 5 Markets for Nanomedicine

Market Drivers

Market Estimates and Forecasts

Global Nanomedicine Market

Main Product Categories

Market Analysis by Clinical Application

Chapter 6 Global Nanomedicine Market Breakdown by Region

Chapter 7 Competitive Landscape

Chapter 8 Company Profiles

Abbott

Abraxis Bioscience

Aphios Corp.

Bioforce Nanosciences Holdings Inc.

C Sixty Inc.

Elan (Alkermes)

Eyepoint Pharmaceuticals Inc.

Farfield Scientific

Kleindiek Nanotechnik GmbH

Liplasome Pharma Aps

Magforce Nanotechnologies

Microfluidics Corp.

Nanobio Corp.

Nanobiotix Sa

Nanocarrier Co. Ltd.

Nanocopoeia, LLC.

Nanologix Inc.

Nanomix Inc.

Nanospectra Biosciences Inc.

Nanostructures Inc.

Orthovita Inc.

Pfizer Inc.

Sanofi S.A.

Starpharma

Tecangroup Ltd.

Transgenex Nanobiotech Inc.

For more information about this report visit https://www.researchandmarkets.com/r/dao9n5

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Nanotechnology in the Global Medical Applications Market 2022, Featuring Profiles of Abbott, Abraxis Bioscience, Elan, Orthovita, EyePoint...

In 2019, Ikea announced it had developed curtains that it claimed could break down common indoor air pollutants. The secret, it said, was the fabrics special coating. What if we could use textiles to clean the air? asked Ikeas product developer, Mauricio Affonso, in a promotional video for the Gunrid curtains.

After explaining that the coating was a photocatalyst (similar to photosynthesis, found in nature), Affonso is shown gazing up at the gauzy curtains while uplifting music plays. Its amazing to work on something that can give people the opportunity to live a healthier life at home.

Puzzled by these claims how could a mineral coating clean the air? Avicenn, a French environmental nonprofit organisation, investigated. Independent laboratory tests of the Gunrid textile reported that samples contained tiny particles of titanium dioxide (TiO2) a substance not normally toxic but which can be possibly carcinogenic if inhaled, and potentially in other forms which supposedly gives self-cleaning properties to things such as paint and windows when exposed to sunlight.

These tiny particles, or nanoparticles, are at the forefront of materials science. Nanoparticles come in all shapes spheres, cubes, fibres or sheets but the crucial thing is their size: they are smaller than 100 nanometres (a human hair is approximately 80,000nm thick).

Many nanoparticles exist in nature. Nano-hairs make a geckos feet sticky, and nano-proteins make a spiders silk strong. But they can be manufactured, and because they are so small, they have special properties that make them attractive across a range of endeavours not just to companies such as Ikea. In medicine, they can transport cancer drugs directly into tumour cells, and nanosilver is used to coat medical breathing tubes and bandages. Nanos could direct pesticides to parts of a plant, or release nutrients from fertilisers in a more controlled manner.

They also have more mundane uses. Synthetic nanos are added to cosmetics and food. Nanosilver is used in textiles, where it is claimed to give antibacterial properties to plasters, gym leggings, yoga mats and period pants.

But scientists such as those at Avicenn are concerned that when these household items get washed, recycled or thrown away, synthetic nanos are released into the environment making their way into the soil and sea in ways that are still not understood. Some scientists believe nanoparticles could pose an even greater threat than microplastics.

Synthetic nano particles of plastic have been found in the ocean and in ice on both poles. Nanoparticles from socks and sunscreen have been found to pollute water, and certain nanos have been shown to negatively affect marine wildlife including fish and crustaceans. As with antibiotics, resistance to antimicrobial nanosilver can develop silver-tolerant soil bacteria have now been found.

Little is known even about where nanoparticles are, let alone their effects on the environment. As they are so tiny, most experiments are conducted in labs, and it can be hard to pin down where they are applied.

The main problem with these substances is that we cannot measure them we know they are there but theyre so tiny theyre difficult to detect, which is why you dont hear as much about them, says Nick Voulvoulis, professor of environmental technology at Imperial College London.

He worries about the uncontrolled use of nanos in consumer products. If nanos are used properly in applications that are useful or beneficial, thats justified, but if they are used anywhere and everywhere because they have certain properties, thats crazy.

Synthetic nanoparticles are not inherently harmful. Like their natural cousins, many are metal-based, but they can be made of any substance. Crucially, unlike chemical compounds, they cannot be dissolved. Their tiny size gives them, paradoxically, an enormous surface area, which makes them behave differently to non-nano versions of the same material. It can make them more mobile, more reactive and potentially more toxic, depending on shape, size, type, how a substance is released into the environment and its concentration.

And released into the environment they are, on a massive scale. According to Avicenn, the release of nanos is most likely during manufacture or disposal, but it can also happen when items are washed which is known to occur with fabrics containing nanosilver. Sewage systems cannot trap them and they end up in the ocean: the OECD says even advanced wastewater-treatment plants cannot deal with nanoparticles.

From a health perspective, inhalation is the most harmful route of exposure to nanos such as TiO2 for factory workers and consumers. Avicenns tests concluded that the average particle size was 4.9nm, and all 300 particles analysed were below the official nano threshold of 100nm.

Ikea insisted its own tests showed the TiO2 particles were properly bound to the fabric and pose no risk to customers, and said it took workers safety extremely seriously. The firm has not referred to them as nanoparticles, and said that once integrated into textile surfaces there was no good standard method to measure the particle size distribution of a material, acknowledging that EU definitions of nanomaterials were under review.

We recognise that the tests and measurements of nano-particles are complex, especially for materials containing particles that tend to form agglomerates, it said.

As for Ikeas curtains shedding TiO2 nanoparticles when washed or discarded, Ikea said it was confident that the treatment is properly bound to the fabric, and therefore we do not see a risk of inhaling the treatment, but acknowledged that as with any textile, parts of the textile can come off during use or washing.

Many nanos do not persist for long in the environment. However, because they are consistently being discharged, levels remain fairly constant. Nanos are pseudo-persistent because they degrade quite quickly but they keep entering the environment, Voulvoulis says.

His main concern is whether nanos become carriers for other compounds, a subject of scientific debate. In 2009, Spanish scientists suggested nanos could bind to and transport toxic pollutants, and possibly be toxic themselves by generating reactive free radicals. If other toxic pollutants latch on to nanos surfaces, they argued, marine plants and animals could absorb them more easily.

Other scientists suggest the opposite: that organic matter in sewage coat nanoparticles, rendering them less active. And others fear nanos could trigger toxic cocktail effects making them more harmful in combination than individual substances would be separately.

So far, synthetic nanomaterials are relatively dispersed in the sea, and unlikely to significantly affect marine animals, says Dr Tobias Lammel of Gothenburg University, who has studied copper nanos. But he warns: Its possible that the concentration of some manufactured nanomaterials in the marine environment will increase It is important to keep an eye on this.

Given the huge question marks, Avicenn wants more stringent regulations on nanos, and more caution in product design. Companies are eager to sell innovative and fancy products, but they must thoroughly assess their benefits-risks balance at each step of the life-cycle of the products, says Mathilde Detcheverry, Avicenns policy manager.

From August, the EU will ban use of TiO2 nanos in food (where it is called E171) and the European Commission recently announced that 12 nanomaterials would soon be prohibited in cosmetics.

Detcheverry says: As scientific knowledge about the environmental and health impacts of engineered nanos such as silver and titanium dioxide advances, we need to make sure nanos are only allowed for specific and essential uses in order to minimise any adverse effects at the source and [ensure they are] not released uncontrollably.

Two years after the release of Ikeas Gunrid curtains, Avicenn tried to buy more for further tests, but they had been withdrawn from sale.

Ikea told the Guardian that Gunrid remained safe to use as a traditional curtain but it was withdrawn because the functionality was not as effective as expected. If thats true for example, that despite TiO2 having proven photocatalytic properties and being used in self-cleaning and air-purifying products, its efficacy on curtains could be localised and not powerful then at the very least Ikeas experience suggests nanoparticles benefits may not outweigh the potential and frequently unknown risks, Detcheverry says.

Nanoparticles are often promoted as silver bullets against pollution or bacteria, she says, but we must make sure that the cure is not worse than the disease.

Gunrid was just one product of many thousands that use nanoparticles. As Ikeas Affonso says in the video: Whats so great about Gunrid is that this technology could be applied to any textile.

This article was amended on 26 April 2022 to correct the spelling of Gothenburg.

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Nano state: tiny and now everywhere, how big a problem are nanoparticles? - The Guardian

Nanomedicine Market Overview

The nanomedicine market has been predicted to grow at a noticeable pace in the forthcoming years. The growth opportunities in the global market are attributed to the emerging innovative technologies for the delivery of the drug. In addition to this, advantages related to nanomedicine in different healthcare applications along with growth in the requirement for cost-effective and safe therapies. Thus, based on these factors, the global market has been predicted to drive growth opportunities in the global market during the forecast period.

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Nanomedicine is a branch of medicine that commonly applies the knowledge of nanotechnology to prevent and treat diseases. Further, nanomedicine involves the use of nanoscale materials, for instance, nanorobots and biocompatible nanoparticles to diagnose, deliver, sense, or for actuation purposes in the living organism.

Nanomedicine Market Key Drivers

Rising R & D activities related to nanorobots and noteworthy investments in the clinical trials by private as well as government sectors are projected to contribute to the growth impetuses in the nanomedicine market in the near future.

Nanomaterials generally possess novel physicochemical properties that vary from the traditional bulk chemical equivalents because of their smaller size. Further, these properties increase the set of opportunities in the development of drugs. These properties of nanoformulation can lead to alteration of pharmacokinetics, for instance, metabolism, elimination, distribution, and absorption. These properties have the potential to cross biological barriers and toxic properties. They are persistent in the human body and environment. Thus, on the basis of these advanced features, the nanomedicine market has been estimated to expand at a noteworthy speed in the following years.

On the flip side, the risk associated with nanomedicines, especially environmental impact and long approval process is estimated to restrict the growth prospects in the global market. Growth of the healthcare facilities and increasing out-licensing of the nano drugs are estimated to provide novel growth avenues in the global market in the following years.

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Nanomedicine Market Recent Developments and Key Players

The nanomedicine market is fragmented in nature. The market is further characterized by the presence of certain regional and international players. In addition to this, the market players are focusing on various strategies for the achievement of their desired profits, the development of brand awareness, and penetration in the developing markets. Furthermore, these market players concentrate on the enhancement of their services in order to gain a large consumer base. Novel product launches, agreements or partnerships, expansion of company networks, and mergers and acquisitions are certain factors that are estimated to drive the growth opportunities in the global market during the forecast period.

Some of the key players in the nanomedicine market are:

Nanomedicine Market Regional Assessment

The nanomedicine market has been divided into four major regional areas that include North America, Europe, Asia Pacific, and LAMEA. North America is predicted to hold a noteworthy share in the global market because of the increasing number of lethal diseases. In addition to this, availability of the advanced healthcare facilities and surging demand for nanomedicines are also estimated to create sales avenues in the regional market in the near future. In addition to this, the availability of trained healthcare professionals, the presence of larger market players, increased investments that are made by government bodies in the healthcare system, and the growing number of R & D activities are some other pivotal factors that are likely to stimulate the expansion opportunities in the nanomedicine market in the following years.

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Nanomedicine Market to 2030 Insights and Forecast with Impact of COVID-19 | Abbott Laboratories, DiaSorin S.p.A, Invitae Corporation, Mallinckrodt...

The NCI Cancer Nanotechnology Plan is a strategic document used by the NCI to guide the nanotechnology and onocoolgy fields in the future. The 2015 version is downloadable from this page.

Credit: National Cancer Institute

Currently, scientists are limited in their ability to turn promising molecular discoveries into cancer patient benefits. Nanotechnology the science and engineering of controlling matter, at the molecular scale, to create devices with novel chemical, physical and/or biological properties can provide technical control and tools to enable the development of new diagnostics, therapeutics, and preventions that keep pace with todays explosion in knowledge.

Nanotechnology has the potential to radically change how we diagnose and treat cancer. Although scientists and engineers have only recently (ca. 1980's) developed the ability to industrialize technologies at this scale, there has been good progress in translating nano-based cancer therapies and diagnostics into the clinic and many more are in development.

Nanotechnology is the application of materials, functionalized structures, devices, or systems at the atomic, molecular, or macromolecular scales. At these length scales, approximately the 1-100 nanometer range as defined by the U.S. National Nanotechnology Initiative (NNI) , unique and specific physical properties of matter exist, which can be readily manipulated for a desired application or effect. Furthermore, nanoscale structure can be used as individual entities or integrated into larger material components, systems, and architectures.

Nanoscale devices are one hundred to ten thousand times smaller than human cells. The depiction displays this scale in size.

Credit: National Cancer Institute

This emerging field involves scientists from many different disciplines, including physicists, chemists, engineers, information technologists, and material scientists, as well as biologists. Nanotechnology is being applied to almost every field imaginable, including electronics, magnetics, optics, information technology, materials development and biomedicine. Nanotechnology-based structures and devices are already enabling a large number of novel applications in various fields including medicine.

Nanotechnology offers many possible benefits to cancer therapy, detection and diagnosis. The benefits begin by way of the fundamental properties of nanotechnology and the biological challenges of which it can help to overcome.

In cancer, half the battle is won by its earlier detection and enhanced diagnosis. Furthmore, tools to enable precise monitoring of patient response to therapy can optimize therapy and improve patient outcomes. Find out how nanotechnology is and will continue to offer powerful solutions to these areas.

Nanotechnology offers the means to target therapies directly and selectively to cancerous cells and neoplasms. With these tools, clinicians can safely and effectively deliver chemotherapy, radiotherapy, and the next generation of immuno- and gene therapies to the tumor. Futhermore, surgical resection of tumors can be guided and enhanced by way of nanotechnology tools. Find out how nanotechnology will offer the next generation of our therapeutic arsenal to the patient.

As far back as 1995, nanotechnology has offered clinicians novel tools to treat patients. Find a list of the currently approved nano-enabled therapeutics here.

Nanotechnology continues to progress into the clinic with more advanced tools than before and for more clinical indications or tumor types. Find a list of current clinical trials actively recruiting patients for these novel solutions.

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Cancer and Nanotechnology - National Cancer Institute

The latest and updated research report on the GlobalNanobots/NanorobotsMarket covers a comprehensive overview of theNanobots/Nanorobotsmarket, future economic condition, competitive landscape mapping, supply and demand trends, and production and consumption analysis. The report also covers the influence of the COVID-19 pandemic on theNanobots/Nanorobotsmarket. The pandemic has dynamically affected all aspects of life on a global scale along with drastic changes in the economy and market conditions. The report covers the currently fluctuating market scenario along with present and future assessment of the COVID-19 impact. The report encompasses the historical data, company overview, financial standing, and necessary information about the new and key players of the market.

Magnetically guidedNanobots/Nanorobotssegment revenue is expected to register a significantly rapid rate during the forecast period. This can be attributed to increasing demand for delicate applications as magnetically guided nanorobots provide high degree of maneuverability in complex procedures.Nanobots/Nanorobotsis employed to carry and deliver live cells to targeted areas in the body, which further expected to advance, and this is expected to continue to drive revenue growth of this segment over the forecast period.

Rising investment in urgent care and increasing global geriatric population are key factors driving revenue growt of the global Nanobots/Nanorobots market

Nanobots/Nanorobots Market Size USD 6.12 Billion in 2020, Market Growth at a CAGR of 10.9%, Market Trends Advancements in technology

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Nanobots/Nanorobots are being used to perform complex tasks and procedures and help to reduce human error in various procedures and test in the healthcare industry. Latest studies in DNA nanotechnology support large-scale utility of nanorobots in the healthcare industry. Long-term returns derived from nanobots is encouraging market players to enter into long-term partnerships and to invest majorly in further research and development in nanotechnology. Upsurge in demand for miniaturized devices along with rapid rate of automation across various sectors are other factors fueling market revenue growth. Advancements in features ofNanobots/Nanorobotswill further drive market growth. However, increase in complexities with miniaturization is a key factor hampering revenue growth of the market currently.

Major players in the market include Bruker, Oxford Instruments, Toronto Nano Instrumentation, JEOL Ltd., Imina Technologies, Klocke Nanotechnik, Thermo-Fisher Scientific Inc., Ginkgo Bioworks, Agilent Technologies, and Park Systems.

The report offers a comprehensive overview of the competitive landscape and covers company profiles, production and manufacturing capacity, product portfolio, expansion strategies, and business initiatives such as mergers and acquisitions, joint ventures, collaborations, partnerships, and product launches and brand promotions among others.

Nanomedicine segment accounted for largest revenue share in 2020 due to its commercialization in the healthcare industry on large scale for drug delivery, in vitro diagnostics, in vivo imaging, biomaterial, drug therapy, and active implants.

In March 2021, Bionaut Labs, which is a company that is developing nanorobots to deliver drugs for treatment of brain diseases, announced that it had received a funding of USD 20 million led by Khosla Ventures and Upfront Ventures. The funds will be used to guide Bionaut Labs through clinical and preclinical development of its nanorobot technology.

North America accounted for largest revenue share in 2020 due to high spending on healthcare and increased investment in research development of nanotechnology. Another contributing factor is increased demand forNanobots/Nanorobotsfrom the National Science Foundation (NSF) and the Defense Advanced Research Projects Agency (DARPA). Various clinical trials and pipeline projects in the U.S. for development ofNanobots/Nanorobotsin various areas are also fueling market revenue growth.

Nanobots/Nanorobotsis the technology which creates robots or machines at a very small scale. The field ofNanobots/Nanorobotsbrings together various disciplines, including nanofabrication processes used for producing nanoactuators, nanomotors, and nanosensors, among others. Rising focus on regenerative medicine coupled with technological advancements is boosting market revenue growth. Furthermore, increasing adoption of medical equipment and more advanced technologies such as Machine Learning (ML) and Artificial Intelligence (AI) is driving growth of the globalNanobots/Nanorobotsmarket, and the trend is expected to continue going ahead.

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For the purpose of this report, Emergen Research has segmented the globalNanobots/Nanorobotsmarket based on type, application, and region:

Nanomanipulator

Electron Microscope (EM)

Scanning Electron Microscope (SEM)

Transmission Electron Microscope (TEM)

Scanning Probe Microscope (SPM)

Atomic Force Microscopes (AFM)

Scanning Tunneling Microscope (STM)

Type Outlook (Revenue, USD Billion; 20182028)

Bio-Nanobots/Nanorobots

Magnetically Guided

Bacteria-Based

Application Outlook (Revenue, USD Billion; 20182028)

Nanomedicine

Biomedical

Mechanical

Others (Space and Oil Gas)

Elucidating the competitive landscape of theGlobalNanobots/NanorobotsMarket:

The globalNanobots/Nanorobotsmarket report offers viable insights into the competitive spectrum of theNanobots/Nanorobotsbusiness sphere.

The report systematically profiles the company information of each market player.

It identifies the estimated industry share, production facilities, development prospects, and geographies served by each market player.

The study showcases the extensive product portfolios of the prominent market contenders.

It offers critical data information about the product application scope and the end-user landscape.

The study provides salient information about the pricing models of the products offered by these companies. Moreover, it determines the gross profits and losses experienced by them throughout their market tenures.

Market Taxonomy:

Chapter 1: Methodology & Scope

Definition and forecast parameters

Methodology and forecast parameters

Data Sources

Chapter 2:

Executive Summary

Business trends

Regional trends

Product trends

End-use trends

Chapter 3:

Industry Insights

Industry segmentation

Industry landscape

Vendor matrix

Technological and innovation landscape

Chapter 4:

Regional Landscape

Chapter 5:

Company Profile

Business Overview

Financial Data

Product Landscape

Strategic Outlook

Key geographical areas:

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

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The post Nanobots/Nanorobots Market Overview, Merger and Acquisitions , Drivers, Restraints and Industry Forecast By 2028 appeared first on Market O Graphics.

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Nanobots/Nanorobots Market Overview, Merger and Acquisitions , Drivers, Restraints and Industry Forecast By 2028 - Digital Journal

VICKSBURG, Miss. Researchers at the U.S. Army Engineer Research and Development Center (ERDC) are analyzing the need for increased resilience in nanotechnology supply chains.

Manufacturing and distribution of products requires a complex network of suppliers and distributors that constitute supply chains. In todays world, most people are aware of supply chains and have probably been affected by supply chain disruptions caused by the COVID-19 pandemic.

Supply chains are pivotal in the production of both military and civilian products and technologies, said Dr. Igor Linkov, senior scientific technical manager for ERDCs Environmental Laboratory (EL). Our team looked at two questions: a) how do you assess the impacts of supply chain disruptions on the manufacturing bottom line and product availability to consumers, and b) how do you mitigate supply chain disruption and increase their ability to recover, particularly when the various secondary or tertiary contributors to a supply chain are poorly characterized?

In the past, supply chains were optimized to be efficient and lean. Companies like suppliers with low labor costs and predictable and inexpensive material availabilities; suppliers having mature capabilities to ship basic or composite materials to manufacturing centers and consumers alike are also popular. However, when there is a crisis and supply chains are disrupted, efficiency may not equal the ability to recover from the disruption.

For example, it is efficient to have one supplier that covers all the material requirements for a given product, but it is not resilient because if that supplier is disrupted then the whole supply chain is impacted. On the other hand, having multiple suppliers for each component may not be efficient because of the extra costs required to maintain multiple suppliers with variable product lines, but if one supplier is disrupted, other suppliers are available, and the supply chain is less disrupted and far more capable of expeditious recovery.

The biggest thing is to understand how to balance efficiency and resilience in supply chains, Linkov said. Understanding this, organizations can work to create a more resilient supply chain for the products and services they provide.

In addition to analyzing supply chains in general, the ERDC research team also looked at supply chains as they relate to the nanotechnology industry and specifically to COVID vaccine production. Their results are published in recent paper in the journal Vaccine (https://www.sciencedirect.com/science/article/pii/S0264410X22001724?via%3Dihub), as well as in Current Opinion in Chemical Engineering (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549437/).

This research, as well as other ERDC work related to climate response and recovery, is led by Dr. Benjamin Trump, a research social scientist in ELs executive office.

Nanotechnology is an emerging technology that is the manipulation of matter on an almost atomic scale to produce new structures, materials and devices. Nanotechnology is helping to improve many technology and industry sectors, including medicine, transportation and environmental science.

One thing we looked at was the nanotechnology supply chain as it applied to vaccines, said Trump. Nano-enabled components are quickly becoming vital to vaccine production. COVID-19 vaccine candidates, for instance, used nano-enabled components to improve vaccine efficacy and delivery in vivo.

Nanotechnology allows properties of materials to be changed in a controlled way to address specific needs. In military applications, nanomaterials are used to make warfighters clothing waterproof and self-cleaning. Nanomaterials can also be used to heal wounds nanomaterials can make a shirt automatically act as an antiseptic if the warfighter is wounded.

We have tried to attract attention to the problem that in manufacturing nano-enabled products, supply chain operations are foundational logistical challenges that require careful governance, Trump said. We tried to look at how supply chain works for nano-enabled products and use this as a way to illustrate the importance of resilience and efficiency in supply chains.

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ERDC researchers analyze resilience in nanotechnology supply chains - erdc.usace.army.mil

Nanotechnology today is growing very rapidly and has infinite applications in almost everything we do. The medicine we take, food we eat, chemicals we use, car we drive and much much more.mknano offers large variety of nano products in various forms as mentioned below. We offer many nano powders at very affordable prices.

Material Formats Atomic & Molecular Clusters, Buckyballs & Fullerenes, Bulk Nanostructured Metals, Magnetic Nanoparticles / Magnetic Nanostructures, Nanobelts, Nanolubricant Powders, Nanocrystals & Nanopowders, NanoFillers / NanoAdditives, Nanoparticles / Nanopowders, Nanoparticle Dispersions, Nanorods, Nanosponge Abrasives, Nano Tubes, Nanowires, Quantum Dots / Nano Dots, Reactive Electro Exploded Nano Powders.

Carbon Nanotubes Single wall (SWNT), Double wall (DWNT), Multiwall (MWNT), (alligned/tangled/dispersable), OH, COOH Functionalized SWNT/MWNT, Industrial Grade SWCNTs, MWCNTs, Conducting (Metallic) and Semiconducting SWCNTs, MWCNT Nonwoven Papers, CNT Foam, Special application CNTs.

Other Nanotubes (Metals, Compounds, and Oxides/Hyroxides)

Quantum Dots Cadmium Mercury Telluride (CdHgTe), Cadmium Selenide (CdSe), Cadmium Selenide/Zinc Sulfide (CdSe/ZnS), Cadmium Sulfide (CdS), Cadmium Telluride (CdTe), Cadmium Telluride/Cadmium Sulfide (CdTe/CdS), Lead Selenide (PbSe), Lead Sulfide (PbS)

Nano Dry Lubricant Powders Tungsten Disulfide (WS2), Molybdenum Disulfide (MoS2), Hex-Boron Nitride (hBN), Graphite

Specially formulated Nano Lubricant Additive Powders to improve lubricity and save energy.

Originally posted here:
Nano Products Online Store | Nanoproducts, Nanoparticles ...

SAN DIEGO--(BUSINESS WIRE)--n-Lorem, a nonprofit foundation, is the recipient of a $300,000 grant from The Conrad Prebys Foundation that will support n-Lorems discovery and development efforts to provide personalized experimental antisense oligonucleotide (ASO) medicines for nano-rare patients (1 to 30 patients worldwide) for free, for life.

We are grateful to be a part of the San Diego community and to be working with the Foundation whose support may have a profound impact on the lives of several of our nano-rare patients. Nano-rare patients have a genetic mutation that is unique to them, and therefore they have few, if any therapeutic options. Today ASO technology and n-Lorem represent the only option for the treatment for many of these nano-rare patients, who are desperate and isolated, said Stanley T. Crooke, M.D., Ph.D., Founder, CEO and Chairman of n-Lorem Foundation. We have more than 40 nano-rare patients at n-Lorem, eight of whom are located in San Diego county. Out of this work, we hope to advance several programs from discovery into development. This work will lead us one step closer to providing a personalized ASO medicine for each nano-rare patient.

The funding will support n-Lorems efforts to discover optimal ASO candidates for several nano-rare patients. Once identified, n-Lorem will conduct preclinical studies necessary to support clinical development for each optimized ASO.

Through significant investments in medical research during his lifetime, Conrad Prebys helped pave the way for private philanthropy to play a meaningful role in the advancement of the field. The Conrad Prebys Foundation is proud to continue this legacy by supporting n-Lorem Foundations unique and vitally important work in rare genetic disease treatment, said Erin Decker, Director of Grantmaking at The Conrad Prebys Foundation. Beyond the significant communities of rare disease patients, n-Lorems research has the potential to accelerate important breakthroughs in the biomedical understanding of diseases in general for the benefit of all.

Learn more about n-Lorems mission at http://www.nlorem.org, and please consider giving to n-Lorem to bring hope, possibility and treatment options to these needy patients and families.

The Conrad Prebys Foundation

The Conrad Prebys Foundation was established by real estate entrepreneur Conrad Prebys to perpetuate his commitment to philanthropic endeavors. The Conrad Prebys Foundation inspires transformational change by funding projects in alignment with Conrad Prebys legacy interests and continuing his efforts that spark meaningful advancement in our communities. For more information, visit http://www.ConradPrebysFoundation.org.

About n-Lorem

n-Lorem Foundation is a non-profit organization established to apply the efficiency, versatility and specificity of antisense technology to charitably provide experimental antisense oligonucleotide (ASO) medicines to treat nano-rare patients diagnosed with diseases that are the result of a single genetic defect unique to only one or very few individuals. Nano-rare patients describe a very small group of patients (1-30 worldwide) who, because of their small numbers, have few if any treatment options. n-Lorem Foundation was created to provide hope to these nano-rare patients by developing individualized ASO medicines, which are short strands of modified DNA that can specifically target the transcripts of a defective gene to correct the abnormality. The advantage of experimental ASO medicines is that they can be developed rapidly, inexpensively and are highly specific. To date, n-Lorem has assisted in the development and treatment of 14 nano-rare patients and received over 130 applications for treatment with more than 50 nano-rare patients approved. n-Lorem was founded by Stanley T. Crooke, M.D., Ph.D., former chairman and CEO of Ionis Pharmaceuticals, who founded Ionis Pharmaceuticals in 1989 and, through his vision and leadership, established the company as the leader in RNA-targeted therapeutics. Follow us on Twitter, Facebook, LinkedIn, YouTube and Instagram.

Read more here:
The Conrad Prebys Foundation to Support the Discovery and Development of Personalized ASO Medicines for Nano-rare Patients - Business Wire