Category Archives: Human Genetics

Technology has evolved over the years in many fascinating ways

We live in a world where agricultural practices are very advanced. However, we started with collecting wild grains more than 10,50,00 years ago and then planting them around 11,500 years ago. A lot went between when nascent farmers began gathering seeds and when modern farmers started using ultra-modern technologies to cultivate their lands.

The Atlantic came up with a panel of eminent figures who compiled a list of 50 innovations which have been most important to the agricultural sector. In this blog post, we tell you about 6 of these great breakthroughs in agriculture that changed the world.

The German chemist Fritz Haber, who is also known as the father of chemical weapons, won a Nobel Prize for developing an ammonia synthesis process. This process was used to create fertilizers which ultimately led to the green revolution. This brings us to the second breakthrough.

The fertilizers development in the early twentieth century combined with scientific plant breeding methods led to a huge increase in world's food output. The world remembers this landmark turn as the green revolution. Norman Borlaug, the man behind the green revolution, was an agricultural economist who saved 1 billion people from hunger and starvation.

Gregor Mendel, who is also known as the father of genetics, discovered how plant breeding and human genetics works. It was he who deserves the credit for the development of hundreds of high yielding varieties which were made possible only by his research.

The combine harvester has become very essential to farming. However, what we do not realize is the fact that it wasn't always there. Before its invention, farmers had to perform a number of tasks manually. Its invention ensured that more and more hands were free to do other kinds of work.

We have water pumps today which can give off litres and litres of water in a single minute. The first ever water pump was made by Archimedes. The Greek scientist is said to have designed a rotating corkscrew which could push water up a tube. It completely changed the way irrigation was done and it still remains in use in sewage treatment plants.

Refrigeration changed the way food was stored and used forever. One cannot even imagine the difficulties faced in storing food by people who lived in a world where refrigeration was not yet discovered. Its discovery transformed food transport, food safety, and food preservation.

Read this article:
6 Greatest Breakthroughs in Agriculture that Changed the World - Krishi Jagran

As anyone who has ever lived with a dog will know, it often feels like we don't get enough time with our furry friends. Most dogs only live around ten to 14 years on average though some may naturally live longer, while others may be predisposed to certain diseases that can limit their lifespan.

But what many people don't know is that humans and dogs share many genetic similarities including a predisposition to age-related cancer. This means that many of the things humans can do to be healthier and longer lived may also work for dogs.

Here are just a few ways that you might help your dog live a longer, healthier life.

One factor that's repeatedly linked with longevity across a range of species is maintaining a healthy bodyweight. That means ensuring dogs aren't carrying excess weight, and managing their calorie intake carefully.

Not only will a lean, healthy bodyweight be better for your dog in the long term, it can also help to limit the impact of certain health conditions, such as osteoarthritis.

Carefully monitor and manage your dog's bodyweight through regular weighing or body condition scoring where you look at your dog's physical shape and "score" them on a scale to check whether they're overweight, or at a healthy weight. Using both of these methods together will allow you to identify weight changes and alter their diet as needed.

Use feeding guidelines as a starting point for how much to feed your dog, but you might need to change food type or the amount you feed to maintain a healthy weight as your dog gets older, or depending on how much activity they get.

Knowing exactly how much you are feeding your dog is also a crucial weight-management tool so weigh their food rather than scooping it in by eye.

More generally, good nutrition can be linked to a healthy ageing process, suggesting that what you feed can be as important as how much you feed. "Good" nutrition will vary for each dog, but be sure to look for foods that are safe, tasty and provide all the nutrients your dog needs.

Exercise has many physiological and psychological benefits, both for our dogs (and us). Physical activity can help to manage a dog's bodyweight, and is also associated with anti-ageing effects in other genetically similar species.

While exercise alone won't increase your dog's lifespan, it might help protect you both from carrying excess bodyweight. And indeed, research suggests that "happy" dog walks lead to both happy dogs and people.

Ageing isn't just physical. Keeping your dog's mind active is also helpful. Contrary to the popular adage, you can teach old dogs new tricks and you might just keep their brain and body younger as a result.

Even when physical activity might be limited, explore alternative low-impact games and pursuits, such as scentwork that you and your dog can do together. Using their nose is an inherently rewarding and fun thing for dogs to do, so training dogs to find items by scent will exercise them both mentally and physically.

Other exercise such as hydrotherapy a type of swimming exercise might be a good option especially for dogs who have conditions which affect their ability to exercise as normal.

Like many companion animals, dogs develop a clear attachment to their caregivers. The human-dog bond likely provides companionship and often, dog lovers describe them as a family member.

A stable caregiver-dog bond can help maintain a happy and mutually beneficial partnership between you and your dog. It can also help you recognize subtle changes in your dog's behavior or movement that might signal potential concerns.

Where there is compatibility between caregiver and dog, this leads to a better relationship and even benefits for owners, too, including stress relief and exercise. Sharing positive, fun experiences with your dog, including playing with them, are great for cementing your bond.

Modern veterinary medicine has seen substantial improvements in preventing and managing health concerns in dogs. Successful vaccination and parasite management programs have effectively reduced the incidence of disease in both dogs and humans including toxocariasis, which can be transmitted from dog feces to humans, and rabies, which can be transmitted dog-to-dog or dog-to-human.

Having a good relationship with your vet will allow you to tailor treatments and discuss your dog's needs. Regular health checks can also be useful in identifying any potential problems at a treatable stage such as dental issues or osteoarthritis which can cause pain and negatively impact the dog's wellbeing.

At the end of the day, it's a combination of our dog's genetics and the environment they live in that impacts their longevity. So while we can't change their genetics, there are many things we can do to improve their health that may just help them live a longer, healthier life.

Jacqueline Boyd, Senior Lecturer in Animal Science, Nottingham Trent University.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Animal Expert Shares 5 Things That Will Help Your Dog Live a Longer, Healthier Life - ScienceAlert

Hyderabad: A new study has revealed that Roman Catholics of Goa, Kumta, and Mangalore regions are the remnants of very early lineages of the Brahmin community of India, majorly with Indo-European-specific genetic composition.

Conducted by Dr Kumarasamy Thangaraj, Chief Scientist, CSIR-Centre for Cellular and Molecular Biology (CCMB), and Director of Centre for DNA Fingerprinting and Diagnostics, Hyderabad; and Dr Niraj Rai, Senior Scientist, DST-Birbal Sahni Institute of Palaeosciences (BSIP), Lucknow, and the researchers analyzed the DNA of 110 individuals from the Roman Catholic community of Goa, Kumta, and Mangalore.

They compared the genetic information of the Roman Catholic group with previously published DNA data from India and West Eurasia. They put this information alongside archaeological, linguistic, and historical records. All of these helped the researchers fill in many of the key details about the demographic changes and history of the Roman Catholic population of South West of India since the Iron Age (until around 2,500 years ago), and how they relate to the contemporary Indian population.

They concluded that the Roman Catholics of Goa, Kumta and Mangalore regions are the remnants of very early lineages of the Brahmin community of India, majorly with Indo-European-specific genetic composition.

The study found consequences of the Portuguese inquisition in Goa on the population history of Roman Catholics. They also found some indication of the Jewish component. This finding has been published in "Human Genetics" on 23 August 2021.

"Our genetic study revealed that the majority of Roman Catholics is genetically close to an early lineage of the Gaur Saraswat community. More than 40 per cent of their paternally inherited Y chromosomes can be grouped under the R1a haplogroup. Such a genetic signal is prevalent among populations of north India, the Middle East, and Europe and unique to this population in the Konkan region," said Dr. Kumarasamy Thangaraj, senior author of the study.

Dr. Niraj Rai, the co-corresponding author, said this study strongly suggests profound cultural transformations in the ancient South West of India. "This has mostly happened due to continuous migration and mixing events since last 2500 years", he said.

Lomous Kumar, first author of the paper, said the origins of many population groups in India like the Jews and Parsis are not well-understood.

"These are gradually unfolding with advances in the modern and ancient population genetics. Roman Catholics are one of them with much-debated history of the origin based on inferences of anthropologists and historians", he said

Dr Vinay K Nandikoori, Director, Centre for Cellular and Molecular Biology, Hyderabad, said this multi-disciplinary study using history, anthropology and genetics information have helped them in understanding the population history of Roman Catholics from one of the most diverse and multicultural region of our country.

The other institutes involved in this study are Mangalore University, Canadian Institute for Jewish Research, and Institute of Advanced Materials, Sweden.

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Roman Catholics of Goa, Mangalore have early lineages of Brahmin community: Study - NewsMeter

Changing your diet to improve your health is nothing newpeople with diabetes, obesity, Crohns disease, celiac disease, food allergies, and a host of other conditions have long done so as part of their treatment. But new and sophisticated knowledge about biochemistry, nutrition, and artificial intelligence has given people more tools to figure out what to eat for good health, leading to a boom in the field of personalized nutrition.

Personalized nutrition, often used interchangeably with the terms precision nutrition or individualized nutrition is an emerging branch of science that uses machine learning and omics technologies (genomics, proteomics, and metabolomics) to analyze what people eat and predict how they respond to it. Scientists, nutritionists, and health care professionals take the data, analyze it, and use it for a variety of purposes, including identifying diet and lifestyle interventions to treat disease, promote health, and enhance performance in elite athletes.

Increasingly, its being adopted by businesses to sell products and services such as nutritional supplements, apps that use machine learning to provide a nutritional analysis of a meal based on a photograph, and stool-sample tests whose results are used to create customized dietary advice that promises to fight bloat, brain fog, and a myriad of other maladies.

Nutrition is the single most powerful lever for our health, says Mike Stroka, CEO of the American Nutrition Association, the professional organization whose mandate includes certifying nutritionists and educating the public about science-based nutrition for health care practice. Personalized nutrition will be even bigger.

In 2019, according to ResearchandMarkets.Com, personalized nutrition was a $3.7 billion industry. By 2027, it is expected to be worth $16.6 billion. Among the factors driving that growth are consumer demand, the falling cost of new technologies, a greater ability to provide information, and the increasing body of evidence that there is no such thing as a one-size-fits-all diet.

The sequencing of the human genome, which started in 1990 and concluded 13 years later, paved the way for scientists to more easily and accurately find connections between diet and genetics.

When the term personalized nutrition first appeared in the scientific literature, in 1999, the focus was on using computers to help educate people about their dietary needs. It wasnt until 2004 that scientists began to think about the way genes affect how and what we eat, and how our bodies respond. Take coffee, for instance: Some people metabolize caffeine and the other nutrients in coffee in a productive, healthy way. Others dont. Which camp you fall into depends on a host of factors including your genetics, age, environment, gender, and lifestyle.

More recently, researchers have been studying connections between the health of the gut microbiome and conditions including Alzheimers, Parkinsons, and depression. The gut microbiome, the bodys least well-known organ, consists of more than 1000 species of bacteria and other microbes. Weighing in at almost a pound, it produces hormones, digests food that the stomach cant, and sends thousands of different diet-derived chemicals coursing through our bodies every day. In many respects the microbiome is key to understanding nutrition and is the basis of the growth in personalized nutrition.

Blood, urine, DNA, and stool tests are part of the personalized nutrition toolkit that researchers, nutritionists, and health care professionals use to measure the gut microbiome and the chemicals (known as metabolites) it produces. They use that data, sometimes in conjunction with self-reported data collected via surveys or interviews, as the basis for nutrition advice.

Read more here:
The Poop About Your Gut Health and Personalized Nutrition - WIRED

Jul 13, 2021 11:00 AM

Author: Doug M Dollemore

Suicide isnt just about a bad day, week, month, or year. Its not just about sadness or feeling hopeless. Nor is it just the predictable end result of schizophrenia, post-traumatic stress, or other mental disorders. In truth, death by suicide can be attributed to any or all of these things, plus a multitude of other factors that, in combination, can lead someone to end their own life.

Among the least understood of these factors is genetics. Research, much of it conducted at University of Utah Health, strongly suggests that risk for suicide death is partially inheritable and tracks in families independent of the effects of a shared environment. Identifying these genetic risk factors, scientists say, could lead to better ways to predict who might be at risk of suicide and new strategies for preventing the worst from happening.

Understanding the underlying factors involved in suicidal behaviors is key, says Eric Monson, M.D. Ph.D., a chief resident psychiatrist at U of U Health. Suicide is inherently preventable, indicating that the more we know about its risks, the more potential lives that could be saved.

To address this growing interest, University of Utah Health scientists are collaborating on an investigation called the Utah Suicide Genetic Risk Study (USGRS). The researchers, in cooperation with the state Office of the Medical Examiner, has collected nearly 8,000 DNA samples from Utahans who died by suicide, one of the largest DNA collections from suicide victims in the world.

This DNA resource is linked to the Utah Population Database (UPDB), which contains medical, demographic, and genealogic information, then de-identified for the research team. Together, these databases are helping U of U Health researchers identify specific gene variants, or SNPs (pronounced snips), and other genetic mutations that could contribute to suicide risk.

Among their latest findings are:

Variants in nerve signaling gene may play a role in risk of death by suicide

A pair of newly discovered variants in a gene that plays a key role in the transmission of nerve signals in the brain could help explain why death by suicide is more prevalent in some families, according to a study published in Molecular Psychiatry and led by U of U Health scientists.

Neurexin-1 (NRXN1) is a gene that helps regulate synapse activity in the brain. Synapses, also known as neuronal junctions, are where electronic signals pass from one nerve cell to another. In a previous genome-wide study of Utah families spanning several generations, NRXN1 was identified as a gene that could potentially elevate the risk of death by suicide. Other research suggests that NRXN1 is also associated with schizophrenia, autism, and other psychiatric disorders. These disorders may be linked to increased suicide risk.

In this new study, the researchers conducted laboratory experiments comparing the effects of normalNRXN1to variant NRXN1. They discovered that NRXN1 variant synapses were twice as active as normal ones, suggesting that genetic alterations in this synapse pathway may play a role in increasing risk of suicide.

This result gives us a clue about one of likely many gene pathways that may lead to increased risk, says Hilary Coon, Ph.D., senior author of the study and a research professor in the Department of Psychiatry. However, more study will be needed to understand how these changes might interact with environmental risk factors and additional genetic risks that are yet to be discovered.

Prior trauma and a genetic predisposition for PTSD among those with bipolar disorder may increase risk of death by suicide

Individuals with bipolar disorder who are genetically predisposed to develop post-traumatic stress disorder following distressing events in their lives could be at greater risk of death by suicide than others who attempt it, according to a study in Translational Psychiatry led by U of U Heath scientists. The researchers say the finding could lead to better screening measures to detect prior trauma among bipolar disorder patients and identify those who are at greatest risk of suicide death.

The study, the largest combined clinical and genetic effort to investigate risk factors for death by suicide in bipolar disorder, is among the first to find differing risk factors for suicide attempts and death, according to Eric Monson, M.D., Ph.D., lead author of the study.

Rates of death by suicide are 10 to 30 times higher for people with bipolar disorder than for the general population, Monson says. What we found in this study is that a combination of prior trauma, a genetic predisposition for PTSD, and a diagnosis of bipolar disorder is almost a perfect storm that puts an individual at greater risk of death by suicide.

Rare genetic variants could help scientist pinpoint genes linked to suicide risk

Five newly discovered rare but potent genetic variants could help scientists identify specific genes and genetic pathways associated with suicide death, according to a study published in the American Journal of Medical Genetics Part B. The study, led by Emily DiBlasi, Ph.D., a research instructor in the Department of Psychiatry, is among the first comprehensive examinations of rare genetic variations linked to suicide death.

Rare variants represent less than 1% of the genetic variations in humans. Unlike more common variants, which usually are found near or adjacent to generalized regions of the human genome, rare variants are found within specific genes. These variants can alter proteins and adversely affect how a gene functions; ultimately, they may have a powerful and damaging influence on the risk of death by suicide.

Rare variants are a compelling source of the unaccounted genetic variation in suicide risk, DiBlasi says. Identifying these risk markers within specific genes could help us better understand some of the more puzzling aspects of the complex role that genetics might have in suicide death.

However, while evidence for the role that genetics might play in suicidal behaviors is growing, DiBlasi and her U of U Health colleagues emphasize it shouldnt be mistaken for destiny.

Were really in the early stages of genetic discovery, DiBlasi says. But based on what we know so far, its important to keep in mind that even if an individual has all of the variants that weve identified, it doesnt mean they are going to die by suicide. It just means that their risk might, and I must stress might, be elevated.

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Latest Research Strengthens Link Between Genetics and Suicidal Behaviors - University of Utah Health Care

Since the human genome was first mapped, scientists have discovered hundreds of genes influencing illnesses like breast cancer, heart disease and Alzheimers disease. Unfortunately, Black people, Indigenous people and other people of color are underrepresented in most genetic studies. This has resulted in a skewed and incomplete understanding of the genetics of many diseases.

We are two researchers who have been working to find genes that affect peoples risk for various diseases. Our team recently found a genetic region that appears to be protective against Alzheimers disease. To do this, we used a method called admixture mapping that uses data from people with mixed ancestry to find genetic causes of disease.

In 2005, researchers first used a groundbreaking method called a genomewide association study. Such studies comb through huge datasets of genomes and medical histories to see if people with certain diseases tend to share the same version of DNA called a genetic marker at specific spots.

Using this approach, researchers have identified many genes involved in Alzheimers disease. But this method can find genetic markers only for diseases that are common in the genomes of the study participants. If, for example, 90% of participants in an Alzheimers disease study have European ancestry and 10% have Asian ancestry, a genome-wide association study isnt likely to detect genetic risks for Alzheimers disease that are present only in individuals with Asian ancestry.

All peoples genetics reflect where their ancestors came from. But ancestry manifests as both genetic variation and social and cultural experiences. All of these factors can influence risk for certain diseases, and this can create problems. When socially caused disparities in disease prevalence appear across racial groups, the genetic markers of ancestry can be mistaken for genetic markers of disease.

African Americans, for example, are up to twice as likely as white Americans to develop Alzheimers disease. Research shows that much of this disparity is likely due to structural racism causing differences in nutrition, socioeconomic status and other social risk factors. A genome-wide association study looking for genes associated with Alzheimers might mistake genetic variations associated with African descent for genetic causes of the disease.

While researchers can use a number of statistical methods to avoid such mistakes, these methods can miss important findings because they are often unable to overcome the overall lack of diversity in genetic datasets.

Disentangling race, ancestry and health disparities can be a challenge in genome-wide association studies. Admixture mapping, on the other hand, is able to make better use of even relatively small datasets of underrepresented people. This method specifically gets its power from studying people who have mixed ancestry.

Admixture mapping relies on a quirk of human genetics you inherit DNA in chunks, not in a smooth blend. So if you have ancestors from different parts of the world, your genome is made of chunks of DNA from different ancestries. This process of chunked inheritance is called admixture.

Imagine color-coding a genome by ancestry. A person who has mixed European, Native American and African ancestry might have striped chromosomes that alternate among green, blue and red, with each color representing a certain region. A different person with similar ancestry would also have a genome of green, blue and red chunks, but the order and size of the stripes would be different.

Even two biological siblings will have locations in their genomes where their DNA comes from different ancestries. These ancestry stripes are how companies like Ancestry.com and 23andMe generate ancestry reports.

Because genome-wide association studies have to compare huge numbers of tiny individual genetic markers, it is much harder to find rare genetic markers for a disease. In contrast, admixture mapping tests whether the color of a certain ancestry chunk is associated with disease risk.

The statistics are fairly complicated, but essentially, because there are a smaller number of much larger ancestral chunks, it is easier to separate the signal from the noise. Admixture mapping is more sensitive, but it does sacrifice specificity, as it cant point to the individual genetic marker associated with disease risk.

Another important aspect of admixture mapping is that it looks at individuals with mixed ancestry. Since two people who have similar socioeconomic experiences can have different ancestry at certain parts of their genomes, admixture mapping can look at the association between this ancestry chunk and disease without mistaking social causes of disease for genetic causes.

Researchers estimate that 58% to 79% of Alzheimers disease risk is caused by genetic difference, but only about a third of these genetic differences have been discovered. Few studies have looked for genetic links to Alzheimers risk among people with mixed ancestry.

Our team applied admixture mapping to a genetic dataset of Caribbean Hispanic people who have a mix of European, Native American and African ancestry. We found a part of the genome where Native American ancestry made people less likely to have Alzheimers disease. Essentially, we found that if you have the color blue in this certain part of your genome, you are less likely to develop Alzheimers disease. We believe that with further research we can find the specific gene responsible within the blue chunk and have already identified possible candidates.

One important note is that the genetic diversity that plays a role in disease risk is not visible to the naked eye. Anyone with Native American ancestry at this particular spot in the genome not just a person who identifies as or looks Native American may have some protection against Alzheimers disease.

Our paper illustrates that gaining a more complete understanding of Alzheimers disease risk requires using methods that can make better use of the limited datasets that exist for people of non-European ancestry. There is still a lot to learn about Alzheimers disease, but every new gene linked to this disease is a step toward better understanding its causes and finding potential treatments.

Link:
Mixed-ancestry genetic research shows a bit of Native American DNA could reduce risk of Alzheimer's disease - The Conversation US

This Virus Will Evolve: Concerns Grow Over Variants, New Surge Among the Unvaccinated

Just as public health officials feared, the combination of too many unvaccinated people and the more contagious delta strain of the coronavirus has led to new COVID-19 surges across the nation.

The vast majority of patients being hospitalized now for COVID-19 are unvaccinated, explains Sergio Segarra, M.D., the chief medical officer with Baptist Hospital, part of Baptist Health South Florida. And many of them are young adults in their 20s and 30s who are getting extremely sick.

Sergio Segarra, M.D., chief medical officer with Baptist Hospital, part of Baptist Health South Florida.

From the very beginning, that was a concern of mine that we do not get a substantial portion of the population vaccinated, said Dr. Segarra, who was interviewed by CNN this week on the latest surge in COVID-19 hospitalizations in Florida and nationwide.

The latest update from the Florida Health Department shows that 58 percent of the states population over the age of 12 has been vaccinated. Among the most populated South Florida counties, Miami-Dade registered a 73 percent vaccination rate; Broward 66 percent, and Palm Beach 62 percent, according to the latest data.

But there is a persistent group of people who, for whatever reason, are not getting vaccinated. The more people that get infected, the greater the likelihood that the virus evolves into more variants, said Dr. Segarra.

On Thursday, U.S. Surgeon General Vivek Murthy, M.D, released the first surgeon generals advisory of his time with the Biden administration, describing the urgent threat posed by the rise of false information about COVID-19 and vaccines. Misinformation has caused confusion and led people to decline COVID-19 vaccines, reject public health measures such as masking and physical distancing, and use unproven treatments, states the advisory.

The U.S. Centers for Disease Control and Prevention said this week that the delta variant is responsible for 58 percent of newly confirmed cases nationwide from June 20 through July 3. The COVID-19 vaccines approved for use in the U.S. effectively protects people from severe illness if they are infected with the delta strain of the virus, the CDC says.

With more people getting the virus, whether they get minor symptoms or get significantly ill and end up in the hospital, theres a greater chance that a variant is going to occur, explains Dr. Segarra. The virus will evolve.

The worse-case scenario, which fortunately has not occurred, says Dr. Segarra, is the emergence of a variant that is resistant to the currently available vaccines.

That hasnt happened yet, but thats something that does keep me up, says Dr. Segarra. Thats something that makes me worry. And I would hate to think that 10 years from now theyre going to say, Wow, those people back in 2021 could have gotten the vaccine, but they didnt. And now theres some terrible variant out there that is creating all kinds of havoc. So, that does worry me.

For more than a year since the beginning of the pandemic, researchers and clinicians have been trying to understand why some people develop severe COVID-19 illness, while others show few if any symptoms. Risk factors have included age and underlying medical conditions.

However, variations in the human genome have not been thoroughly investigated as a possible risk factor that determines a mild or severe response to a COVID-19 infection. That is, until now.

A new study published in Nature, led by the COVID-19 Host Genomics Initiative (HGI), confirms or newly identifies 13 genes that appear to play a role in susceptibility to the coronavirus, or that have an affect on the severity of illness. The researchers established international collaboration when the pandemic started to focus on genetics. This collaboration included about 3,000 researchers and clinicians and data from 46 studies involving more than 49,000 individuals with COVID-19.

HGI teams involved in the analysis include both academic laboratories and private firms from two dozen countries, including the U.S. Several of the 13 significant genes identified by researchers had previously been linked to other illnesses, including autoimmune diseases.

One example is the gene TYK2. Variants of this gene can increase susceptibility to infections by other viruses, bacteria and fungi, the studys authors write. Individuals who carry certain mutations in TYK2 are at increased risk of being hospitalized or developing critical illness from COVID-19. Another example is the gene DPP9. The authors found a variant in this gene that increases the risk of becoming critically ill with COVID-19. It is the same variant that can increase the risk of a rare pulmonary disease characterized by scarring of the lung tissue.

This study is important not only for advancing our understanding of human susceptibility to COVID-19; it also underlines the value of global collaborations for clarifying the human genetic basis of variability in susceptibility to infectious diseases, states a supplemental article to the study published in Nature.

Children represent a growing share of COVID-19 infections in the United States, while severe illness from the coronavirus remains rare among young kids and adolescents. Researchers caution, however, that studies are needed to determine long-term health effects of COVID-19 on children.

According to the American Academy of Pediatrics (AAP), children accounted for about 2 percent of infections at the onset of the pandemic last year. By the end of May of this year, kids accounted for 24 percent of new weekly infections, the AAP said. The cummulative percentage of COVID-19 cases involving children is about 14 percent, the organization states.

More than 4 million children have tested positive for COVID-19 in the U.S., 18,500 were hospitalized and 336 have died from the disease, according to the latest update from the AAP.

At this time, it still appears that severe illness due to COVID-19 is rare among children, the AAP states. However, there is an urgent need to collect more data on longer-term impacts of the pandemic on children, including ways the virus may harm the long-term physical health of infected children, as well as its emotional and mental health effects.

The U.S. Centers for Disease Control and Prevention (CDC) recommends everyone 12 years and older should get a COVID-19 vaccination to help protect against COVID-19. At this time, children 12 years and older are able to get the Pfizer-BioNTech COVID-19 vaccine. In May, the CDC and U.S. Food and Drug Administration approved the use of the Pfizer vaccine for adolescents after a clinical trial involving 2,260 12-to-15-year-olds found that the Pfizer-BioNTEch vaccines efficacy was 100 percent. This official CDC action opens vaccination to approximately 17 million adolescents in the United States and strengthens our nations efforts to protect even more people from the effects of COVID-19, stated CDC Director Rochelle Walensky in a statement.

Tags: COVID-19, COVID-19 vaccines

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COVID-19 Roundup: The Unvaccinated Fuel Hospitalizations; Genetic Link to Severe Illness; and Children's Infection Rate - Baptist Health South Florida

Philipp Koellinger| Milwaukee Journal Sentinel

Here is a thought experiment for you. How much praise do you deserve for the good things that have happened in your life? And how much blame do you deserve for the bad? As a scientist who specializes in social genomics the study of how the interplay of genetics and social environments influences our lives I argue that much of what happens to us in life is really a matter of luck.

Many types of luck affect our lives: who our parents are; when and where we are born; whether the tornado that passed through our hometown hit our house or not. All of these types of luck are beyond our control. And yet, they shape who we are and what happens to us throughout our lives.

One fundamental example of luck is the set of genes we get from our parents. Everyone starts with a random combination of their parents genes that are fixed at conception and remain unchanged from that day forward. In other words, we get our start in life through a genetic lottery in which many outcomes are possible, but only one materializes.

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The results of this lottery have a big effect on your life. But they dont control everything. The relationship between our genes and the shape of our lives is far more complicated than that.

Lets start with what our approximately 22,000 genes do control. Among other things, they determine whether were born in a male or female body, if our eyes are blue or brown, and if we have freckles.

Genes also influence other things, such as how tall well grow and whether were prone to obesity, cancer, dementia, or other health conditions much later in life. We say genes influence rather than control these outcomes, because other factors like the quality of healthcare we receive in childhood and whether we eat enough good food in our early years also play a part.

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The influence of genes also extends to the human brain, which is probably the most complex organ that exists in any living creature on our planet. More than half of our genes seem to influence the brain in one way or another. They pre-wire the brain, and then our experiences and activities throughout childhood and adulthood rewire and adapt this amazing organ to our circumstances.

A useful analogy is to think of the brain as a book with thousands of pages. When were born, the book has chapter names and preliminary notes and themes scribbled throughout. As we grow up, we fill in the blanks with what weve learned and experienced. Sometimes, an entire chapter of the book may be erased or rewritten (perhaps because of a stroke or injury). But, for the most part, the main themes of the original book continue to develop throughout our lives.

The partial influence of genes on virtually every aspect of who we are is so well-known that scientists started referring to it as the first law of behavioral genetics. In the past few years, tremendous technological progress has made it possible to read a persons genetic code reliably, quickly, and inexpensively. This allowed scientists around the globe to collect samples of genetic data from millions of people. My team and our colleagues used that data to look for associations between genes and the many behavioral and socioeconomic outcomes such as educational attainment, risk-taking, happiness, or alcohol consumption.

Our results reliably show that genes seem to influence all of these outcomes. And yet, there is no single gene that makes a person smart, or start a business, or reach for a bottle of wine the moment they get a chance to do so. My teams research tells us that the real story is more complex and subtle than anyone would have thought just a few years ago.

It turns out that most outcomes are influenced by thousands of genetic variants, each of which has only a tiny effect by itself. But adding up all these tiny effects begins to explain a substantial part of the differences among the people we observed. We call some of these differences such as whether people go to college or are willing to take risks genetically complex traits because they are linked to a large number of genes and because the biological function of those genes is often still unknown.

Adding to the complexity, most genes influence more than one outcome. We found that some of the genes associated with educational attainment are also related to health outcomes such as dementia, cancer, and cardiovascular diseases, but we dont know why exactly. It could be that some genes that make us perform well in school early in life also protect our brains later in life from cognitive decline. It also may be that the protective effect of these genes actually works via schooling. Maybe a better education helps you afford a healthier lifestyle and also leads to a challenging job that requires you to exercise your brain constantly, which in turn may reduce the chance of being diagnosed with dementia later in life.

We still have a lot to learn. For example, how do genes and environments interact to give rise to the behaviors and traits we observe in people later in life? But one thing we already know for sure is that behavior and health are tightly related, and that these links can often be traced back to the specific genes we were born with, at least to some extent.

My long experience studying how life outcomes are affected by the random results of our individual genetic lottery makes me feel humbled by the good things that have happened to me. It also makes me skeptical when others claim that they deserve something or when they blame bad fortune on the person unlucky enough to be its victim. Instead, I find that modesty and sympathy for others are the most natural responses to the lessons that modern genetics continues to teach us.

Philipp Koellinger is a professor of public affairs at theLa Follette School of Public Affairs, University of Wisconsin-Madison.

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Luck of the draw: How the random results of the genetic lottery can influence a host of your life's outcomes - Milwaukee Journal Sentinel

We are rapidly approaching the day when scientists will have the technology to alter the genome of embryos to cure genetic diseases such as Huntingtons disease, sickle cell anemia, and cystic fibrosis before they take their painful toll. For good or ill, Chinese researcher He Jiankui has shown that it is possible to safely make simple edits to a babys genome in vitro.

A friend of mine has cystic fibrosis. Shes spent more time in the hospital than anyone I know. But her health battles, agonizing as they are, have also made her deeply empathetic, kind, artistic, and persevering. Would I spare her a life of pain by making a genetic correction at conception knowing that it might take from her some of what makes her special? Yes. Am making a judgment call that health is of greater value than depth of character? Also yes.

Perhaps Im wrong.

But the ability to make multiple, complex edits to enhance a childs DNA rather than to cure a disease is the next scientific frontier. Scientists will be able to edit a babys genetics to make her smarter, more athletic, prettier, whatever her parents value most.

Most people would agree it is better to be healthy than sick. Is being taller better than being short? Will 10 IQ points make someone happier? Which physical characteristics are most beautiful? Should we make these choices for someone else? What happens to those who arent upgraded?

The creation of a class of improved humans through genetic modification isnt much different than similar efforts attempted through eugenics in the last century. It will most certainly widen the gulf between the haves and have-nots. Only those who afford in vitro fertilization with genetic enhancement treatment would have access.

While genetic engineering has great potential to solve significant health, environmental, and agricultural challenges, it also has the potential for harm. Can the harms be mitigated? Time will tell. In the meanwhile, we have an obligation to examine the potential benefits and unintended consequences.

If you read one book this summer, make it Walter Isaacsons The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. You dont have to know anything about genetic modification to dive.

Isaacson paints a vivid picture of the process of scientific discovery, the people who discovered CRISPR and harnessed it for gene modification, and the potential costs and benefits of this revolutionary biotechnology. By the end of the book, youll wish you could meet Jennifer Doudna, the scientist who, along with Emmanuelle Charpentier won the 2020 Nobel Prize in chemistry and the other scientists responsible for this discovery.

Beginning in the 1990s, scientists began to note an oddity in bacterial DNA. All DNA is made up of four different molecules called nucleotides: adenine, thymine, guanine, and cytosine. Think of them as an alphabet of four letters A, T, G, and C. From the smallest bacteria to the largest whale, the DNA of all living organisms and viruses contain anywhere from thousands to billions of base pairs of these same four nucleotides. They spell out, like a recipe book, how to make and maintain every living thing.

Scientists noticed that bacterial DNA contained segments of repeated letters which they called CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). In between these repeated clusters are segments of DNA that match the DNA of the viruses that attack bacteria. Were not the only creatures to catch a virus; bacteria get infected by viruses, too. One would think that a tiny, one-celled bacterium would be defenseless against a virus but its not. Because of these special DNA sequences, bacteria can locate and slice up viral DNA that has invaded the cell.

Having made this discovery, scientists asked themselves: if bacteria can use this bio-mechanism to alter viral DNA, can we use it to alter DNA?

Turns out we can and CRISPR is faster and in many cases better than existing biotechnology used for this purpose. Scientists can snip out segments in the DNA of living cells. The process of adding DNA, however, requires additional steps.

The most promising use of CRISPR biotechnology, in my opinion, is in agriculture where there are fewer ethical concerns and extraordinary potential benefits for human health and the environment. By 2050, the world population will be 9 billion and genetic modification will provide the key to ensuring there is enough food to go around. Scientists are using CRISPR biotechnology to increase food production, to make plants and animals naturally resistant to disease (thereby decreasing pesticides and antibiotics), and to bolster plant resistance to adverse environmental factors such as hotter temperatures, drought, and flooding which are likely to increase due to global warming.

While those benefits certainly outweigh the potential for harm, some questions remain: Should we bring back extinct animals and plants? How will they impact other animals and plants?

These questions, however, are easier to answer than the heavier questions regarding editing the human genome, which must be addressed if the scientific community is going to reach an international consensus on limits.

Krista L. Kafer is a weekly Denver Post columnist. Follow her on Twitter: @kristakafer.

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Kafer: The scary, promising and not too distant future of gene editing technology - The Denver Post

In absorbing new popular science title The Genome Odyssey, Stanford University Professor of Medicine and Genetics Dr Euan Angus Ashley reveals how our understanding of the human genome is revolutionizing medicine, finally unlocking the answers to mystery illnesses and leading to exciting new treatments for many of todays most devastating diseases.

In 2003, an international project to sequence the entire human genomeall thegenetic instructions found within thehuman bodywas finally completed.

It had taken a decadeof research,and had costseveral billion dollars to realise, but the effort was rightly recognised as one of the greatest scientific achievements in history, on a par with the first Moon landing.

It was nothing short of a giant leap in our understanding of genetics and came with theexpectationthat this knowledge couldone daybe used to treat or even prevent thousands of diseasesfrom the most common killers to the rarest conditions, affecting only a handful of people across the planet.

AsThe Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Themreveals, that early promise is now fast becoming reality, opening up a bold, exciting new era of genomic-based medicine that willtotallytransformsociety and our quality of life.

And who better to provide a guided tour to thisunfoldingmedical revolution than one of the worlds leading experts on genetic-based medicine: Dr Euan Ashley.

Dr Ashley, who was born in Scotland but who is now based in the United States,is recognised as apioneerin the application of gene sequencing in medicineandis right at the forefront of the field, beingProfessor of Medicine and Genetics at Stanford University, the Head of Stanford Center for Undiagnosed Diseases,andthe founding director of the Center for Inherited Cardiovascular Disease as well as Stanfords Clinical Genomics Program.

He joinedStanford totrain as a cardiologist in 2006, after completinga Ph.D. at Oxford University in cardiovascular biology, and has witnessed first-hand how rapidly genomic medicine has become integrated into healthcare.

Early on in the book, which has just been published through St. Martins Press, Dr Ashley observes through analogy that the growth of the sector has all been made possible thanks to the huge drop in the cost of sequencing an individuals DNA. He writes

My commute, at the time, took me past the Ferrari-Maseratidealership near Athertonbillionaire territory inthe heart of Silicon Valley. I would oftencast a sideways glance at thosecars as I waited in traffic. One day, I wassitting at the stoplight doingrandom math in my head, as one does, and realized that if the Ferrariin the window had dropped in priceas much as human sequencing haddropped in price in the eight years since the Human Genome Projectsdraft sequence was released, instead of $350,000 it would cost less than forty cents. A forty-centFerrari! A millionfold reduction in price.

He goes on to say that this incredible reduction in cost has fuelled a tsunami of scientific discovery which has given the medical profession an unparalleledopportunityto change lives for the better.

The Genome Odysseyunderlines just how dramatic that change has been, bringingnewfound hopeto people around the world.

Running to around 400 pages in length, the book is divided into four sectionswith the first,The Early Genomes, introducing the readerto the medical team that Dr Ashley leads and providing an account of their first steps into genomic-based diagnosis.

In anothers hands the subject could easily have become complex, dry,and off-putting but Dr Ashley wisely makes the patient the focusfrom the get-go , presenting thepersonal stories ofthosewho have benefitted from thisnew era of medical treatments to illustrate clearly how genomic medicine is actually making aprofounddifference to peoples lives.

Take, for instance, Parkera young boy who hadseemingly been a healthy babyupon deliverybut who, asthe weeks and months progressed,began to showclearand worryingsigns of developmental delay.

By the time his parents met with Dr Ashley and his teamfive years laterthey had gone from pillar to post to try to find out what was wrong with their son, who was alsonowsuffering alarming seizures. Despite numerous and often painful tests, all the medical professionals had drawn a complete blank.

Dr Ashleys team sequenced Parkers DNA from a blood sample and from this were finally able to give his parents the answers they had desperately been seeking.It turned out that he had a new type of genetic mutationdisruptingagene called FOXG1.

With this diagnosis, which would never have been possible before the Human Genome Project, Parkers parentscould tap intoa small yet international support network offamilies suffering fromFOXG1 syndromeand, more importantly, have his medication modified, resulting in their childs symptoms beingdramatically reduced.

As quickly becomes clear,the dedicated teams at the forefront of genetic medicine are akin to detectives, finding the culprits behind diseases within our genes.

Fittingly, then, the second section ofThe Genome Odysseyis entitled Disease Detectives and covers the fascinating procedural work involved in solving rare, mysterious diseases and, by so doing, ending the agonising diagnostic odysseysthat these patients have been sent on, such as was the case with Parker.

Here, we meet other families such as theparents of Carson and Chase Miller, whose two young sons had been losing their mobility yet the reason for this was unclear. They were referred to Dr AshleysCenter for Undiagnosed Diseases, which is itself part of a wider Undiagnosed Diseases Network in America, whereboth children and parents had their DNA sequenced.

From this they found that Carson and Chase had both inherited one faulty copy of geneMECRfrom each of their parents. That, in itself, did not solve the crime but this swiftly followed as the team interrogated the evidence, working out that this gene was essential to the smooth running of mitochondriathe energy-producingpowerhouses of the celland, with other possible causes for the boys condition being ruled out, the wrongdoer in question.

The case closed, attention could turn to treatment. Remarkably, it was deduced that a cheap over-the-counter supplementcould compensate for the missing protein that MECR would normally produce. The boys were placed on this and, as Dr Ashley writes with delight, they have sincestabilisedand even shown signs of improvement.

When not working on unsolved diseases, Dr Ashley deals with patients with genetic-based heart problems. This is the focus of the third part ofThe Genome Odyssey, Affairs of the Heart and, again, presents many moving patient stories, such as that of a baby girl,Jazlene,whose dangerously abnormal heart rhythm was rapidly traced to a genetic cause.

Thanks to the advent of cheap, fast genetic testing, new and fine-tuned treatments can now be provided to patientsbut this is only the beginning.

The final section ofThe Genome Odyssey, Precisely Accurate Medicine,projects forward, examining where genomic medicine will progress from here.

While gene therapy, replacing missing or faulty genes, is already available for a very limited number of conditions, ongoing research and refinements looks set to expand the scope for this treatment significantly in the coming years, potentially finding new, more effective ways to deal with a host of diseases including heart disease, multiple sclerosis, and certain types of cancer.

Key to this, it turns out, will be sequencing the DNA of genetic superhumans whose unique genomeprotects them from certain diseases or provides other physiological advantages.

Dr Ashley recounts, for instance,he story ofFinnishcross-country skier Eero Mantyranta, whose blood contained far moreoxygen-carrying red blood cells than the average person, allowing far greater levels of endurance.

We also learn about American womanSharlayne Tracy, who was found to have a superhuman ability to remove bad cholesterol from her body. Her genetic code has, in turn, led to new drugsfor treatingthose who are genetically prone tohigh cholesterol.

And in a very timely section, Dr Ashley reveals how genome sequencing can also be used on viruses to help us track and avoid future pandemics, just as it has been crucial in the development of vaccines for Covid-19.

Its amazing to discover just how far-reaching the unlocking of our genetic secrets will be for 21stcentury medicine, allowing doctors to move fromreactive disease care to proactive preventive health carethat will undoubtedly save many lives and allow us all to stay healthy for much longer.

The Genome Odysseytells this story in such an engaging way that the chapters just fly by. This is all helped by Dr Ashleys personable, almost conversational style, his passion for the subject, and his admiration for the heroes of this book, as he describes themhis patients and their families.

You come away from thishighlyinformative, entertaining, and unforgettable scientific journeywith the sense that we are heading into brighterdaysand all thanks to figures such as Dr Ashley who are tirelessly peeling back the mysteries of our DNA to overcome the diseases that have plagued us as long as mankind has existed.

The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them(St. Martin's Press)by DrEuan Angus Ashleyis out now onAmazon in hardcover, eBook, and audiobook formats, priced 22.99, 9.49, and 20.47 respectively. For more information visitwww.genomebook.info.

Q&A INTERVIEW WITH DR EUANANGUSASHLEY

We speak with Dr EuanAngusAshley,Associate Dean and Professor of Cardiology andGenetics at Stanford University,to find out more about his new work of popular science,The Genome Odyssey, and the genomic medicine revolution taking place right now.

Q. Why was the decoding of the human genome essential for the development of genetic medicine?

Its hard to think of a time in the history of biomedical science whena technology has moved so fast,from requiring multiple countries, hundreds of people, and billions of dollars to something that can be routinely ordered by a physician in clinic for $500.

But while the scientific narrative is exciting, its the human impact that made me want to write the book. I get to see every day how this technology can solve medical mysteries for kids and adults afflicted with devastating genetic diseases. I see how it can provide answersand provide a path to treatment (or if not, at least towards support groups and help). These are the medical odysseys of thetitle, a word derived from the epic Greek poem of the same name where the lead character takes 10 years and multiple shipwrecks and battles with, among others, one-eyed giants to get back to his home and his wife.

Q. Why was the decoding of the human genome essentialfor the development of geneticmedicine?

The genome is where it starts and ends. The genome connects us to every living organism on the planet. It contains the history of the human race. The history of your family. And yet each one is unique. Not even your identical twin has the same genome (though its very similar). Decoding the genome was a monumental feat in history akin to the Moon landing. Butlittle-known factit didnt truly get finished until this year when many of the complicated regions and holes from 20 years ago got filled in.

Q. Why does genetic-based medicine provide a better approach to curing diseases thanour current models?

All diseases have a genetic component, but some diseases are mostly genetic. These are often referred to asMendelianafterthe Austrian monk Gregor Mendel,who discovered the fundamental laws of genetics while cultivating pea plants. For these Mendelian diseaseswith minimal environmental component (mostly nature, very little nurture) to understandunderstandingthe genetic basis of the disease isfinallytounderstand, at the deepest level,how the disease comes about. It also has to be the starting point of finding truly effective medicines, something we refer to as precision medicine.

Q. Are there any limits to how far genetic medicine can take us in the quest to eradicatehuman diseases?

Absolutely. For example, all diseases have an environmental component. Heart disease,for example,is half nature and half nurture. We have to pay attention to both. Also, somediseases are caused by pathogens and some by our immune system. Fortunately, for these diseases, genetic sequencingof the pathogen or the immunecellscan also be very useful.

Q. There have been numerous false starts in the field gene therapy. Do you think weshould remain cautious for now about the futureprospect of a genomic medicinerevolution?

The false starts have mostly been with genetic therapy,where the early promise of the 1990sgave way after one or two high-profile deaths to 20 yearsof introspection and hard work;a time where our community really addressed the challenges head on. As a result, we are now in a golden age of genetic therapy. We still need to be cautiousthis is powerful technologybut every day more and more diseases become susceptible to genetic approaches.

Q. Some people get worried about the advent of genetic medicine, just as some were at one time concerned about genetically-modified crops. Is there any justification for such fears?

A. I think a better way to think about genetic therapy is like a more long-lasting form of a traditional medicine. Traditional medicines reprogram towards health how our cells work from the surface or through changing signals inside the cell. They work as long as the medicine is still present. Genetic therapy, on the other hand works, at the level of the genetic code (DNA) or its messenger (RNA). So therapies can be given perhaps every few months, or even like a vaccine, just once. That is very convenient! However, it also means we have to be very careful that we have tested the process thoroughly before testing it in humans. It is important to note that genetic therapy today is not about designer babies. Our community is universally opposed to this sort of genetic modification of our inheritance line. The current therapies are delivered to certain cells in one person at a time and those changes are never passed on to future generations.

Q. How has genetic medicine been instrumental in the fight against Covid-19?

A. Genetic sequencing has been the most fundamental technology in our fight against Covid-19. All the diagnostic tests we have are based at some level on knowledge of the genome of SARS-CoV-2. Also, all the vaccines approved to date are genomic vaccines, based upon the sequence of the virus. Sequencing also allows us to track the virus and its evolution to new variants around the globe. Most importantly, sequencing the virus will allow us to prevent the next pandemic by helping us understand which pathogens are most likely to cause disease and even perhaps allowing us to develop vaccines before the diseases the pathogens might cause ever come to light.

Q. The Genome Odyssey talks of ongoing studies into genetic superhumans and how their rare genes could result in all manners of new treatments in the coming years. In some respects, it sounds similar to the rush to find new medicinal plants in the Amazon rainforest. Is that a fair comparison, and what do you think will be the fruits of these ongoing investigations, in terms of future treatments?

A. Its a great question. In so many ways, the answer to many of our medical conundrums is likely out there in the world, whether in the rainforest or in the genomes of our fellow humans. Large-scale studies where altruistic individuals share their medical and genetic data for the good of the world allow us to identify a small number who are resistant to disease. By understanding why and how they are resistant we can start to design new medications that mimic these superhuman qualities. With immune (antibody)-based and genetic-based therapies we can go from human genome to human medicine even faster than ever.

Q. Still on the topic of superhumans, do you think that we could one day all receive a simple jab that would give us the strength and stamina of an Olympic-medal athlete?

A. Well, just because something is possible doesnt mean we should do it! In reality, however, we are so far away from knowing enough about the genetics of what makes our Olympians jump higher and run faster that even if someone wanted to genetically engineer superhumans, we simply dont have the knowledge to do that. I think a much better idea is to focus on how to prevent devastating diseases and improve quality of life for everyone around the globe. Realising that some people are resistant to disease and dedicating ourselves to understanding that would be a far bigger service to humanity than making a few lucky (?) people run faster.

Q. Your book is full of incredible medical success stories that you have been involved with. If you were asked to single out just one, which one would it be, and why?

A. I think that the little baby, Astrea, whose heart stopped multiple times on the first day of her life was among the most memorable adventures Ive ever been involved in. And not just for the fact we were able to sequence and analyse her genome faster than anyone had previously donethat was just the start. It was memorable because a whole village of scientists, entrepreneurs, geneticists, cardiologists, surgeons, and computer scientists from academia and industry came together to find answers for a little baby in distress. People simply dropped what they were doing and dedicated themselves to this. It really took my breath away.

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MUST READ OF THE WEEK: THE GENOME ODYSSEY BY DR EUAN ANGUS ASHLEY - Blackpool Gazette