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Category Archives: Epigenetics

Cambridge Epigenetix and NuGEN Technologies Sign Agreement … – Technology Networks

Posted: August 19, 2017 at 5:42 pm

Co-exclusive global licence covers manufacture and integration of CEGX TrueMethyl technology for oxidative bisulfite sequencing (oxBS-Seq) with Targeted Methylation and NuGEN Ovation Methyl-Seq systems.

Cambridge Epigenetix (CEGX) and NuGEN Technologies, leaders in innovative epigenetic technologies, have announced that they have entered into a partnership agreement to integrate the CEGX TrueMethyl technology for oxidative bisulfite sequencing (oxBS-Seq) with NuGENs innovative NGS library preparation kits. The signing of the agreement will enable CEGX to focus on its epigenetic biomarker discovery programmes, both in-house and in partnership with leading biopharma companies, and will further strengthen NuGENs epigenetics portfolio of whole genome Methyl-Seq, Reduced Representation Bisulfite Sequencing (RRBS), and patented SPET target enrichment systems.

The epigenetic DNA modifications 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) play very different roles in gene regulation. Cambridge Epigenetix enhanced the appreciation of 5hmC through the introduction of its TrueMethyl oxBS-Seq system. Their developments have enabled researchers to further elucidate the role of DNA methylation in disease occurrence and progression, highlighting the potential for such epigenetic marks in the development of improved diagnostic and prognostic assays. The integration of TrueMethyl oxBS and NuGENs patented library preparation technologies will broaden the scope of accessible samples for the detection of these emerging markers.

Jason Mellad, CEO at Cambridge Epigenetix, commented: This partnership will enable both CEGX and NuGEN to leverage our strengths to facilitate advances in the epigenetics field. CEGX is committed to realising the promise of epigenetics through the development of improved, minimally invasive diagnostic and prognostic tests for accurate and early detection of a range of diseases, including cancer. We are working with leading biopharma companies as well as progressing our own high-value internal programmes, applying our expertise and advanced proprietary technology for robust biomarker identification, particularly from liquid biopsy samples. NuGENs reach and reputation for delivering high-quality genomics solutions to the market makes them the ideal partner to further develop TrueMethyl technology to deliver a range of new products to enhance epigenetics research.

Nitin Sood, CEO at NuGEN Technologies, said: We are delighted to be working with CEGX to provide the tools to improve the understanding and appreciation of epigenetics in cellular function. The goal of all of our products has always been to maximize the information that our customers obtain from their nucleic acid samples. By combining the TrueMethyl oxBS technology with our NGS library preparation kits, we will provide our customers with whole genome and targeted methylation products to unlock the tremendous potential of epigenetics. The combination provides access to more detailed, higher resolution epigenetic information in an integrated, cost-effective solution. The technology complements our Methyl-Seq and Single Primer Enrichment Technology product lines, and we are delighted to provide researchers with the most comprehensive solution for epigenetics research.

New products resulting from this partnership are anticipated by the end of the year and will be available directly from NuGEN. TrueMethyl products should still be ordered through CEGX until further notice. For more information about TrueMethyl, including how to order, please visit https://www.cambridge-epigenetix.com/products.

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More Than Just Genes: How Environment, Lifestyle, and Stress Impact ADHD – ADDitude

Posted: August 19, 2017 at 5:42 pm

Our understanding of ADHD has grown by leaps and bounds over the past 30 years. What started as hyperkinetic impulse disorder its primary symptom excessive hyperactivity over time shifted to attention deficit disorder and a focus on problems with inattention, then to reward functioning, and later to executive functioning. None of these translations was wrong, in and of itself;each set of highlighted symptoms is a distinct and important part of the disorder we now call ADHD. But the facets were poorly integrated with one another, and thus painted an incomplete picture of a highly complex condition.

Now, researchers understand that ADHD is primarily a disorder of self-regulation. Self-regulation weaves together all the older theories of ADHD into one cohesive picture; it is also what allows humans to manage impulses, engage or disengage attention, and navigate between deliberate and automatic responses to different situations. The ability to self-regulate is managed across the brain in highly interconnected ways; similar brain nodes regulate both attention and emotion and when one area isnt performing well, the others suffer, too.

The newest theories of ADHD, then, dont focus on a single underperforming area of the brain, as older ones did. Its now understood that ADHD manifests when neurons misfire in the ever-shifting communications and connections between multiple areas of the brain. Emerging research also suggests that these neurological wrinkles may be driven by the environment as much (or more) than they are by genes.

[Quiz: Can You Tell the Difference Between ADHD Myths and ADHD Facts?]

This new framework provides a much more nuanced and complex view of ADHD, but it also provides hope: If ADHD symptoms can be worsened by environmental causes, they can be improved by them, too. Read on to find out how.

Researchers have long known that ADHD can be passed down genetically. But the idea that we can find the single gene responsible for ADHD and fix it is now understood to be outdated. The newest theory of ADHD, as a disorder primarily related to self-regulation, relies on something called epigenetics.

Epigenetics refers to biological traits or changes that cannot be explained by a persons genetic code. Epigenetic mechanisms actually create a physical mark on the DNA when a person undergoes an important experience, whether its positive or negative. These marks which can be added methyl molecules, or a modified histone tail adjust the individuals gene function, changing what the genes do or how strongly they express themselves. In a nutshell, environment and experiences affect a humans development and behavior in an enduring fashion actually altering regions of DNA, with effects that may last for an entire lifetime.

How does it work? It starts with genes the building blocks of who we are and who we become. But beginning at conception, everyone is exposed to different environmental toxins and advantages and after were born, psychological inputs like stress, adversity, and even trauma begin to factor in. Epigenetics takes this input and uses it to change how genes are expressed meaning a genes output isnt fully known until environment and personal history are factored in.

[Free Resource: What to Eat (and Avoid) for Improved ADHD Symptoms]

Epigenetics paints a much more complicated view of ADHD, but also a much more optimistic one; genes do not solely determine an individuals fate. In fact, while genes may make someone more prone to certain diseases or disorders, including ADHD, the entire genetic system is highly dynamic and responsive to input. This means its possible to change the expression of a persons ADHD genes by making certain environmental changes.

Credible and robust epigenetics research confirms these assertions. One experiment1 took two genetically identical mice embryo and, during the prenatal stage, fed their mothers diets that included the toxic element bisphenol-A (BPA). The diet of one mouses mother, however, was supplemented with nutrients like choline, folic acid, and B12; that mouse was later able to avoid the negative effects of the BPA, including obesity and a higher risk of cancer. This phenomenon can be explained by epigenetics the additional nutrients were able to turn off the genes that respond to BPA, and thus protect the mouse from its harmful effects.

Another experiment2 this one involving humans tested whether taking an omega-3 supplement during pregnancy would impact the attention abilities of a mothers child. The study found that children whose mothers had randomly received the supplement had stronger attention at 6 and 12 months, and later had better-developed mental abilities, than did children whose mothers had not taken the supplement. Since this experiment was randomized and the effect was so great, researchers were able to determine a causal effect and again, one that was influenced by epigenetics. Food dyes, artificial preservatives, and lead yielded similar results3 the introduction of each into a childs pre- or post-natal environment had real, causal effects on his or her attention, hyperactivity, and emotional regulation.

Similar experiments have been done on stress and adversity and how exercise can counteract those negative effects. One experiment4 placed rats into a stressful situation for a period of time each day, which resulted in significant epigenetic changes that decreased healthy function. However, when those same rats were also allowed to exercise while still experiencing the stressor the negative effects on the brain were completely eliminated. The study provided a clear example of how exercise can reverse the harmful brain-based effects of a negative early-life experience.

[Daily Exercise Ideas to Boost Focus]

This research suggests that lifestyle changes may help to offset the effects of ADHD genes activated by genetic, chemical, dietary, or other factors. More epigenetic research is needed, however a few things are clear: Omega-3 supplementation, aerobic exercise, and stress management can have real, positive effects on ADHD symptoms in both children and adults.

How big are these effects? Some changes, like reducing the amount of TV a child watches each day, have very small effects on ADHD symptoms only slightly noticeable in a familys everyday life. Others, like increasing omega-3 intake or introducing an exercise regimen, have significantly larger effect sizes up to twice or three times as large as reducing screen time.

Researchers now recommend that anyone with ADHD follows these strategies:

Continuing research is creating an ever-growing body of evidence regarding which lifestyle changes improve ADHD symptoms, and which are less useful. Though findings are still preliminary, the evidence is already strong enough to make them actionable. Simple changes, like exercising more or taking a fish oil supplement, can have real, lasting effects on an individuals ADHD symptoms in other words, genes do not seal your fate.

Learn more in Dr. Niggs book, Getting Ahead of ADHD: What Next-Generation Science Says about Treatments That Work and How You Can Make Them Work for Your Child

1Dolinoy DC, Huang D, Jirtle RL. Maternal Nutrient Supplementation Counteracts Bisphenol A-Induced DNA Hypomethylation in Early Development. PNAS, vol. 104, 2007, pp. 1305613061.2Colombo, John, et al. Maternal DHA and the Development of Attention in Infancy and Toddlerhood. Child Development, vol. 75, no. 4, 2004, pp. 12541267., doi:10.1111/j.1467-8624.2004.00737.x.3 Stevenson, J, et al. The Role of Histamine Degradation Gene Polymorphisms in Moderating the Effects of Food Additives on Childrens ADHD Symptoms. The American Journal of Psychiatry, vol. 167, no. 9, Sept. 2010, pp. 11081115.4 Kashimoto, R.K., et al. Physical Exercise Affects the Epigenetic Programming of Rat Brain and Modulates the Adaptive Response Evoked by Repeated Restraint Stress. Behavioural Brain Research, vol. 296, 2016, pp. 286289., doi:10.1016/j.bbr.2015.08.038.

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‘Magical’ Mushroom Could Fight off Cancer with Epigenetics – WhatIsEpigenetics.com

Posted: August 19, 2017 at 5:42 pm

A certain type of mushroom might epigenetically prevent tumor growth, according to a study published in the Journal of Cancer Research and Treatment. A medicinal mushroom, Phellinus linteus (PL), could come with magical anticancer properties. Researchers from New York Medical College found that histone deacetylase (HDAC) inactivation and histone acetylation led to the death of bladder cancer cells.

Chemotherapy and immunotherapy often come with severe side effects, and for those suffering from bladder cancer, the use of these therapies is limited and often ineffective in the long run. Because of this, a group of scientists sought to find a possible alternative therapy, one that relies on extracts of a very special type of fungus.

According to the researchers, Phellinus linteus has been used in Asian countries for centuries to prevent or treat ailments, including gastroenteric dysfunction, diarrhea, hemorrhage, rheumatoid arthritis, and cancers. In the wild, this mushroom can be found growing on mulberry trees. Interestingly, it is consumed in the form of hot tea in Korean traditional medicine.

Previous articles on What is Epigenetics detail the epigenetic effects and potential cancer-fighting benefits of broccoli, fruits, and other plants. Research has even found that a natural compound in cypress trees could protect against cancer and that green tea might be able to turn genes on or off in women. However, we are still in the beginning stages of understanding and researching these effects and whether they translate to humans in a practical manner.

Now the focus is on mushrooms. The group of researchers aimed to measure the epigenetic effect of this well-known mushroom on the growth of urothelial cell carcinoma(UCC), the most common type of bladder cancer. Those suffering from this particular cancer have limited therapeutic options. Often, the tumor returns, and the side effects brought on by chemotherapy or immunotherapy are a significant drawback.

In one of the first studies assessing the potential benefits of mushrooms against bladder cancer, these researchers found that the growth of human cancer cells was reduced from 60 to 90 percent and that histone deacetylase activity was significantly lost. The results were obtained by examining the effects of three distinct PL extracts on UCC cells in vitro.

HDACs are epigenetic enzymes that remove chemical groups, known as acetyl groups, from histone proteins. DNA wraps around these histones and the expression of our genes is changed depending on how loose or tight the structure is. Read more about chromatin remodeling and the impact it has on gene expression.

Removing an acetyl group will allow the histones to wrap around the DNA more tightly, which will prevent the expression of certain genes. Often times, cancer cells are treated with HDAC inhibitors (HDACi) because HDACs can cause aberrant transcription of key genes that regulate cell functions often linked to cancer, such as cell proliferation, cell-cycle regulation, and apoptosis.

In this study, HDAC activity was reduced as a result of cancerous cells being treated with mushroom extracts and histone acetylation was increased. The researchers used the Epigenase HDAC Activity/Inhibition Direct Assay Kit from EpiGentek to measure HDAC activity. They found that greater than 60% of HDAC activity was reduced after treatment with three distinct extracts or fractions of the mushroom (PL-I, -II, and -III). In addition, both histones H3 and H4 were highly acetylated, which indicated alterations in the chromatin structure.

The present study shows that all three PL-fractions, PL-I, -II, and -III, have anticancer effects on [bladder cancer] cells, although PL-III appears to be the most potent, reported the researchers. Such an anticancer mechanism is attributed to a p21-mediated cell cycle arrest with epigenetic modifications involving HDAC inactivation and hyperacetylation of H3 and H4, ultimately leading to apoptotic cell death.

Overall, the mushroom extracts reduced cell viability through anticancer activity, and histone modifications were thought to induce cell cycle arrest. In light of these results, this mushroom could modify the chromatin structure consisting of histones and DNA ultimately reducing cancer cell viability via a cell cycle arrest. The researchers suggest that DNA methylation, another popular epigenetic mechanism, should be investigated in terms of possible epigenetic effects of these fungus fractions.

This study raises new questions about whether nontraditional medicines could help those suffering from cancer. As we continue to conduct more research and investigate the epigenetic effects of various natural substances on human health and well being, we can begin to understand the potential benefits of alternative medicine and consider developing new therapies in the future.

Source: Bhalodi, A. et al. (2016). Alternative Therapeutic Approach to Urothelial Cell Carcinoma with Medicinal Mushroom Extracts. Journal of Cancer Research and Treatment, 4(5): 73-79.

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'Magical' Mushroom Could Fight off Cancer with Epigenetics - WhatIsEpigenetics.com

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Epigenetics: How Your Mind Can Reprogram Your Genes

Posted: August 14, 2017 at 2:47 am

By Dr. Mercola

How much control do you really have over your own life in general, and your health in particular? These questions have puzzled many since the beginning of time. Now, the emerging science of epigenetics is offering some answers that put true control within your reach.

According to some scientists, changing your health may be as "simple" as changing your thoughts and beliefs.

"Contrary to what many people are being led to believe, a lot of emphasis placed on genes determining human behavior is nothing but theory and doctrine," writes Konstantin Erikseni . "We are free to make decisions that impact our lives and those of others. Our beliefs can change our biology. We have the power to heal ourselves, increase our feelings of self-worth and improve our emotional state."

Eriksen goes on to discuss something called "The Central Dogma" of molecular biology, which states that biological information is transferred sequentially and only in one direction (from DNA to RNA to proteins).

The ramification of buying into the central dogma is that it leads to belief in absolute determinism, which leaves you utterly powerless to do anything about the health of your body; it's all driven by your genetic code, which you were born with.

However, scientists have completely shattered this dogma and proven it false. You actually have a tremendous amount of control over how your genetic traits are expressedfrom how you think to what you eat and the environment you live in.

You may recall the Human Genome Projectii , which was launched in 1990 and completed in 2003. The mission was to map out all human genes and their interactions, which would than serve as the basis for curing virtually any disease. Alas, not only did they realize the human body consists of far fewer genes than previously believed, they also discovered that these genes do not operate as previously predicted.

In the featured article, Eriksen describes the experiments of John Cairns, a British molecular biologist who in 1988 produced compelling evidence that our responses to our environment determine the expression of our genes. A radical thought, for sure, but one that has been proven correct on multiple occasions since then.

Eriksen writesiii :

"Cairns took bacteria whose genes did not allow them to produce lactase, the enzyme needed to digest milk sugar, and placed them in petri dishes where the only food present was lactase. Much to his astonishment, within a few days, all of the petri dishes had been colonized by the bacteria and they were eating lactose. The bacterial DNA had changed in response to its environment. This experiment has been replicated many times and they have not found a better explanation than this obvious fact that even primitive organisms can evolve consciously.

So, information flows in both directions, from DNA to proteins and from proteins to DNA, contradicting the "central dogma." Genes can be activated and de-activated by signals from the environment. The consciousness of the cell is inside the cell's membrane. Each and every cell in our bodies has a type of consciousness. Genes change their expression depending on what is happening outside our cells and even outside our bodies."

As if genes changing expression in response to environmental factors such as nutrients wasn't enough, other researchers have demonstrated that this "environment" that your genes respond to also includes your conscious thoughts, emotions, and unconscious beliefs. Cellular biologist Bruce Lipton, PhD., is one of the leading authorities on how emotions can regulate genetic expression, which are explained in-depth in his excellent books The Biology of Belief, and Spontaneous Evolution.

Science has indeed taken us far beyond Newtonian physics, which says you live in a mechanical universe. According to this belief, your body is just a biological machine, so by modifying the parts of the machine, you can modify your health. Also, as a biological machine, your body is thought to respond to physical "things" like the active chemicals in drugs, and by adjusting the drugs that modify your machinery, doctors can modify and control health. However, with the advent of quantum physics, scientists have realized the flaws in Newtonian physics, as quantum physics shows us that the invisible, immaterial realm is actually far more important than the material realm. In fact, your thoughts may shape your environment far more than physical matter!

According to Dr. Lipton, the true secret to life does not lie within your DNA, but rather within the mechanisms of your cell membrane.

Each cell membrane has receptors that pick up various environmental signals, and this mechanism controls the "reading" of the genes inside your cells. Your cells can choose to read or not read the genetic blueprint depending on the signals being received from the environment. So having a "cancer program" in your DNA does not automatically mean you're destined to get cancer. Far from it. This genetic information does not ever have to be expressed...

What this all means is that you are not controlled by your genetic makeup. Instead, your genetic readout (which genes are turned "on" and which are turned "off") is primarily determined by your thoughts, attitudes, and perceptions!

The major problem with believing the myth that your genes control your life is that you become a victim of your heredity. Since you can't change your genes, it essentially means that your life is predetermined, and therefore you have very little control over your health. With any luck, modern medicine will find the gene responsible and be able to alter it, or devise some other form of drug to modify your body's chemistry, but aside from that, you're out of luck The new science, however, reveals that your perceptions control your biology, and this places you in the driver's seat, because if you can change your perceptions, you can shape and direct your own genetic readout.

This new science also reveals that you are in fact an extension of your environment, which includes everything from your thoughts and belief systems, to toxic exposures and exposure to sunlight, exercise, and, of course, everything you choose to put onto and into your body. As Dr. Lipton is fond of saying, the new biology moves you out of victimhood and into Masterymastery over your own health.

It is a supreme confirmation of my favorite saying, "You Can Take Control of Your Health."

Two years ago, a study performed by the Linus Pauling Institute at Oregon State University was showcased at the annual Experimental Biology convention. The study demonstrated how "histone modifications" can impact the expression of many degenerative diseases, ranging from cancer and heart disease to biopolar disorder and even aging itself. According to Rod Dashwood, a professor of environmental and molecular toxicology and head of LPI's Cancer Chemoprotection Program, as quoted in a press releaseiv:

"We believe that many diseases that have aberrant gene expression at their root can be linked to how DNA is packaged, and the actions of enzymes such as histone deacetylases, or HDACs. As recently as 10 years ago we knew almost nothing about HDAC dysregulation in cancer or other diseases, but it's now one of the most promising areas of health-related research."

In a nutshell, we all have tumor suppressor genes, and these genes are capable of stopping cancer cells in their tracks. These genes are present in every cell in your body, but so are proteins called "histones." As Dr. Jean-Pierre Issa at the M.D. Anderson Cancer Center explainsv , histones can "hug" DNA so tightly that it becomes "hidden from view for the cell." If a tumor suppressor gene is hidden, it cannot be utilized, and in this way too much histone will "turn off" these cancer suppressors, and allow cancer cells to proliferate.

Now here's where epigenetics comes in certain foods, such as broccoli and other cruciferous vegetables, garlic, and onions contain substances that act as histone inhibitors, which essentially block the histone, allowing your tumor suppressor genes to activate and fight cancer. By regularly consuming these foods, you are naturally supporting your body's ability to fight tumors.

Certain alternative oncologists also tap directly into the epigenetic mechanism, such as Dr. Nicholas Gonzalez, who uses a three-pronged approach to cancer based primarily on nutrition and detoxification, and Dr. Stanislaw Burzynski, who treats cancer with a gene-targeted approach. His treatment uses non-toxic peptides and amino acids, known as antineoplastons, which act as genetic switches that turn your tumor suppressor genes "on."

So the good news is that you are in control of your genes You can alter them on a regular basis, depending on the foods you eat, the air you breathe, and the thoughts you think. It's your environment and lifestyle that dictates your tendency to express disease, and this new realization is set to make major waves in the future of disease prevention -- including one day educating people on how to fight disease at the epigenetic level. When a disease occurs, the solution, according to epigenetic therapy, is simply to "remind" your affected cells (change its environmental instructions) of its healthy function, so theycan go back to beingnormal cells instead of diseased cells.

You can begin to do this on your own, long before you manifest a disease. By leading a healthy lifestyle, with high quality nutrition, exercise, limited exposure to toxins, and a positive mental attitude, you encourage your genes to express positive, disease-fighting behaviors.

This is what preventive medicine is all about. It's not about taking any one particular nutrient as a supplement to fix one specific "part" of your biological machinery... The more people become willing to embrace this simple truth, the healthier everyone will get.

It's also worth pointing out that epigenetic effects begin before birth.

Epigenetic research from 2009 showed that rat fetuses receiving poor nutrition in the womb become genetically primed for a nutrition-poor environment. As a result of this genetic adaptation, the rats tended to be smaller. They were also at higher risk for a host of health problems throughout their lives, such as diabetes, growth retardation, cardiovascular disease, obesity, and neurodevelopmental delays. Again, while some are tempted to blame such "predispositions" on bad genes, the KEY factor is nutrition, i.e. the cellular environment.

If you're ready to address your dietary choices, read through my comprehensive nutrition plan, which will give you tips and tools for eating healthy, dealing with stress, and living a lifestyle that will support your epigenetic health.

You can also turn your genes off and on with your emotions too. Many, if not most people carry emotional scars; traumas that can adversely affect health. Using techniques like energy psychology, you can go in and correct the trauma and help regulate your genetic expression. My favorite technique for this is the Emotional Freedom Technique (EFT), but there are many others. Choose whichever one appeals to you, and if you don't sense any benefits, try another, until you find what works best for you.

Please, remember that 'You CAN Take Control of Your Health.'

References:

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Epigenetics: How Your Mind Can Reprogram Your Genes

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A Super Brief and Basic Explanation of Epigenetics for …

Posted: August 14, 2017 at 2:47 am

In simplified terms, epigenetics is the study of biological mechanisms that will switch genes on and off. What does that mean? Well, if you are new to this whole thing, we first need a quick crash course in biochemistry and genetics:

Now that you understand genetics, lets learn about epigenetics. Epigenetics, essentially, affects how genes are read by cells, and subsequently how they produce proteins. Here are a few important points about epigenetics:

Heres an analogy that might further help you to understand epigenetics. Think of the human life span as a very long movie. The cells would be the actors and actresses, essential units that make up the movie. DNA, in turn, would be the script instructions for all the participants of the movie to perform their roles. Subsequently, the DNA sequence would be the words on the script, and certain blocks of these words that instruct key actions or events to take place would be the genes. The concept of genetics would be like screenwriting. Follow the analogy so far? Good. The concept ofepigenetics, then, would be like directing. The script can be the same, but the director can choose to eliminate certain scenes or dialogue, altering the movie for better or worse. After all, Steven Spielbergs finished product would be drastically different than Woody Allens forthe same movie script, wouldnt it?

* Editors Note: Be wary of self-help claims that exploit epigenetics and seem too good to be true. We recommend you read about the abuseof epigenetics and pseudoscience.

Ready to learn epigenetics in further detail? Read on:Fundamentals of Epigenetics

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Epigenetics and Cancer 2017 | Epigenetics Conferences …

Posted: August 8, 2017 at 6:41 pm

Sessions & Tracks

Track 1 : Cancer

Canceris an abnormal growth of cells which have a tendency to multiply in an uncontrolled way. They have a property to metastasize. The branch of medicine that deals with the prevention, diagnosis and treatment of Cancer is called Oncology.

RelatedOncology Conferences|Cancer Conferences|Cancer meetings

16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 2 : Types of Cancer

Cancers are classified and named depending upon the type of cell they originated and have different forms. Some examples are as follows:

RelatedCancer meetings |Oncology Conferences|Cancer Conferences

9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; 16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 3 : Cancer Genetics

Certain changes to genes can alter and control the functioning of the body cells, their growth and division. This causesCancer.

Cancercausing genetic changes :

RelatedCancer Conferences|Cancer meetings|Oncology Conferences

Track 4 : Cancer : Diagnostics and Staging

Canceris suspected in a view of a persons symptoms ,screening tests. Affirmation thatCanceris present requires diagnostic tests which is followed by staging. Staging is way of analysing the tumor, its size, location and the treatment depending on theCancerstage.It helps to determine the Prognosis of the patient i,e treatment prediction ,disease outcome and patients recovery chances.

RelatedCancer Conferences|Cancer meetings|Oncology Conferences

Track 5 : Cancer: Treatment and Therapy

There are many sorts ofCancertreatment. The treatment varies depending on the type of Cancer and its stage.The following are the main types ofCancertreatment :

Related Oncology Conferences|Cancer Conferences|Cancer meetings

InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK;16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA;.

Track 6 : Cancer Stem Cells

Cancer Stem Cells areCancercells present in the tumors. They possess the normal stem cells characteristics i,e their ability to proliferate into different cell types by differentiation.Cancer stem cells are tumorigenic and develops tumors. They also lead to metastasis and relapse thus giving rise to the formation of new tumor cells.Hence there is a need to develop specific therapies targeted at Cancer stem cells to increase the chances of survival of Cancer patients.

Related Cancer Conferences|Cancer meetings|Oncology Conferences

Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK;16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain;

Track 7 : Cancer Epigenetics

The study of epigenetic modifications to theCancercells genome is calledCancer Epigenetics, that does not bring a change in the nucleotide sequence. Risk expectation and prediction andCancerprevention, growth counteractive action are also promising and encouraging areas of Epigenetics.A high adequacy of demethylating agents were accounted for essentially in hematological malignancies in view of new conventions with low dose and long exposure, and their utilization is presently being striven for strong tumors.

During the cellstransformation to Cancerous cell, Epigenetic modifications are also mor important like genetic mutations. Their manipulation brings a great promising approach to for preventing , detecting and therapy of Cancer.

RelatedOncology Conferences|Cancer Conferences|Cancer meetings

19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France;16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 8 : Epigenetics

Epigeneticsdeals with the study of heritable changes in gene , that does not include changes to the basic DNA arrangement an adjustment in phenotype without an adjustment in genotype which influences how cells read the genes.Epigeneticschange is a normal, natural and characteristic occurence yet can likewise be affected by a few factors including age, the environment/lifestyle, and illness state. Epigeneticsmodifications can show as normally as the way in which cells terminally separate to differentiate as liver cells, skin cells, etc.Alternately, epigenetic change can have all the more harming impacts that can bring illnesses, disease.

example :Cancer.

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Track 9 : Developmental and Nutritional Epigenetics

Epigeneticfactors are also called as epigenetic marks control many functions of cells in our bodies. From time to time,Epigeneticmarks cause certain genes to be turned on or off at various phases of the body's development and growth in a way that prompts to a disease onset

In this way, researchers and scientists have been able to find the thin line which is connecting the following diseases to Epigenetics

This track also deals with the modifications and changes that greatly affects the processes such as DNA methylation and histone modifications like embryonic development, aging, and carcinogenesis

Epigenetics plays a key role in wide range of diseases like type 2 Diabetes Mellitus, Obesity, inflammation, and neurocognitive disorders. Nutritional Epigenetics can be considered as an attractive tool to anticipate and prevent Cancer and pediatric developmental diseases

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16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 10 : Transgenerational Epigenetic inheritance

Transgenerational epigenetic inheritance is the transmittance of information from one generation to another ,for example :from a parent to child.This affects the offspringstraits without changing the primary structure of DNA.In multicellular organisms the epigenetic inheritance has different mechansisms.

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Track 11 : Epigenetics - Neurodevelopmental and Neurodegenerative disease

Neurodegenerative disorders are among the major difficulties and among the most medical issues that should be withstanded by the world, particularly in light of expanding population age. They cause the degeneration and death of nerve cells as they form incurable conditions for treatment. According to a collaborative study of the WHO, the World Bank and the Harvard School of Public Health by 2020 neurodegenerative diseases,dementia will be the eighth cause of disease among developed regions.It is also estimated that they will occupy the worlds second leading cause of death by 2050, overtaking Cancer During embryogenesis and for differentiation of neural cells Epigenetic mechanisms are essential required. Thus, precise understanding of epigenetic mechanisms, including DNA methylation and histone modification, is important to elucidate the pathogenic pathways in neurodevelopmental disorders

Most common neurodegenerative diseases

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Track 12 : Epigenetic Diseases, Clinical Applications , Pharmacogenomics

This particular track deals with the onset of diseases and the required clinical applications and theraphy related to those diseases.

Pharmacogenomics is a combination of pharmacology and genomics.this branch of study is concerned with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacodynamics and pharmacokinetics. The genetic disorder occurrence is quite rare in polutaion.Some might be hereditary while the others are caused by mutations.

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Track 13 : Biomarkers and Bioinformatics Development in Epigenetics

Histones and DNA are chemically altered with epigenetic markers. They influence chromatin structure by changing the electrostatic nature of the chromatin or by altering the affinity of chromatin-binding proteins. DNA can be modified by methylation of cytosine bases

This track also deals with Bioinformatics role inEpigenetics.This branch is expected to make significant contributions to Epigenetics research. Studies in computational Epigeneticsinvolves the improvement and utilization of bioinformatics strategies for resolving the epigenetic questions, and in addition computational information examination and hypothetical displaying with regards to Epigenetics. This incorporates the effects of histone and DNA CpG island methylation.

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15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK; 16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan.

Track 14 : Epigenomic Effects of Environmental Exposures

Environmental contaminants and toxicants are far reaching all through the world, and can incorporate different materials and chemicals, from by results of ignition to contaminationg trace metals and organic natural mixes utilized as a part of day by day life. Presentation to changing sums and sorts of these contaminants is connected to impacts on human wellbeing .The fields of natural wellbeing and toxicology have concentrated on bettering the comprehension of how these contaminants affect biological prcocesses so that their wellbeing effects can be lessened or anticipated.

Numerous diseases are brought about by various types of alterations among dfifferent genes. Some of these progressions are hereditary changes that are passed along in families while some are mutations that happen due various hazardous environmental factors .

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Track 15 : World Cancer Market

Oncology Market is increasing and will be paced on a wide scale.The world wide oncology market is expected to grow in upcoming years due to expanded industry R&D and high investments by multinational companies in the Cancer research.

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Track 16 : Entreprenuers Investment Meet

A stage planned to associate Entrepreneurs, Proposers and the Investors around the world. It's expected to make and encourage the most streamlined and reasonable meeting place for drawing in individuals in worldwide business disdcussions, assessment and execution of promising business thoughts. A financial specialist might discover the most astounding potential venture openings all around, which give great quantifiable profit. For business visionaries, this would be a perfect place to discover appropriate speculators and accomplices to begin or potentially extend their business. Hence it is an impeccable place to associate Entrepreneurs, Business Owners, Early Stage Companies and Established Corporates with National or International Investors, Corporate Investors and Potential Business Partners.

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In the last few years, the market forCancerprofiling in Asia-Pacific region has seen huge development as a result of increasing incidence ofCancer, high demand for better healthcare services .

High prevalence ofCancer; expanding R&D subsidizing; expanding power of research exercises; expanding application for non-oncology illnesses; and developing organization between scholarly, biotechnology and pharmaceutical organizations are driving components of theCancergenomics and epigenetics market

CancerProfiling Market is divided by Application ,Diagnosis, Technique, Technology etc.

ByApplicationit consists of :

Diagnostic,

Personalized Medicine,

Research.

By Technique, it consists of :

Genomics,

Proteomics,

Metabolomics,

Epigenetics.

By Technology, it consists of :

It is estimated that the worldwide Cancer Profiling business sector is ready to achieve USD 61.87 Billion by 2021 from USD 25.82 Billion in 2016 according to the "Cancer Profiling Market".The following graph depicts the data pictorially.

Central point powering market development are increasing number of malignancy cases over the globe.

Components, for example, the expanding interest for personalized medicine and point-of-care diagnostic tests inCancerprofiling are required to offer an extensive variety of development open doors for players in the tumor profiling market. The personalized medicine segment to represent the biggest share of the worldwide cancer profiling application showcase in 2016.

Across the board continuous research in the part ofEpigeneticsin diseases and disorders in humans is fuelling the worldwide epigenetics drugs, diagnostic technologies and indicative advances.

In light of research territories, the market for Epigenetics is fragmented into developmental biology, drug discovery, oncology and other research areas. Other research areas include genome-wide regulatory mechanisms and research related to several metabolic and genetic diseases.

In light of geology, the market of Epigenetics is divided into North America, Europe, Asia, and the Rest of the World. North America is further sub-segmented into U.S. furthermore, Canada. In Asia, the degree for this present market's development is extending quickly. Asia represents about a large portion of all cancer cases analyzed around the world. This makes helpful conditions for the development of the Epigenetic medications and diagnostics advertise in Asian nations, particularly China, Japan, Australia, and South Korea, with Japan in theprevailing position.

As per the National Cancer Institute, malignancy is among the main sources of death around the world, for which according to a recent review, epigenetic inhibitors comprise of the attributes and capacities which have the potential in cancer prevention and control. This element has given an impulse to the examination directed on epigenetics in the oncology business

In the estimated period between 2015 to 2020 the Epigenetics market is relied upon to stay as the quantity of new participants in this market will continue ascending with the consistent appearance of new innovations combined with upgraded highlights.

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Session/ Tracks

Conference series LLC invites all the participants and attendees from all over the world to attendThe 2nd International Congress onEpigenetics & ChromatinduringNovember 06 - 08, 2017which is the only bench to bedside review of the drug discovery and development process.

The live format of this educational activity will be accredited with CME and CPD Credits

It will help scientific leaders from academia, pharma and biotech drive advances in novel epigenetic based therapeutics through the latest updates in pre-clinical and clinical translational research from oncology to new exciting disease areas.

Join us inFrankfurt, Germanyto delve deeper into mechanistic understanding, lead compound discovery and development, and methods for forging and promoting collaboration to achieve the translational progression of the next wave of epigenetic therapeutics.

Attendance at this meeting will enable you to:

Be part of a rich scientific programme incorporating the latest developments in preclinicalGenetic Disorders

Understand the shift towards prevention and early diagnosis ofGenetic Disordersas the future of research in the field

Join key opinion leaders in discussing regulatory and ethical implications of this research in clinical practice.

Network with speakers and other leading experts across disciplines.

Track 1.Epigenetics

Epigeneticsrefers to heritable changes in gene expression that occur without alteration in DNA sequence. These changes may be induced spontaneously, induced by environmental factors or as a consequence of specific mutations. There are two primary and interconnected epigenetic mechanisms:DNA methylationand covalent modification of histones.

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