Category Archives: Colorado Stem Cells

This study provides the first long term evidence of the safety and feasibility of utilizing a patient's own bone marrow concentrate stem cells to treat severe low back pain

Fort Collins, Colorado (PRWEB) April 03, 2017

Retired orthopedic spine surgeon, Kenneth Pettine, M.D. is excited to release the three year results of his bone marrow stem cell treatment study. Dr. Pettine has been a pioneer in the use of bone marrow concentrate stem cell injections. He was the first surgeon to inject biologics into the human spine as part of an FDA Study in the U.S. almost seven years ago. He has the only U.S. Patent on the method of treating orthopedic and spine pathology with a patient's own stem cells.

This study provides the first long term evidence of the safety and feasibility of utilizing a patient's own bone marrow concentrate stem cells to treat severe low back pain, said Dr. Pettine. Thats terrific news for patients who up until now only had the option of undergoing expensive and invasive back fusion or artificial disc surgery.

Degenerative disc disease is a common back pain diagnosis in the United States and affects millions of patients. The symptoms of the condition can become so painful that patients may be forced to miss work and are prevented from participating in regular daily activities. Treatment is often limited to palliative care such as chiropractic, physical therapy, narcotics, injections or invasive surgical procedures to try to decrease the daily chronic low back pain. Numerous studies have shown surgery improves back pain in the average patient only 40%. Stem Cell therapy improved the average patient 70% with long term follow up.

Dr. Pettines treatment uses a patient's own bone marrow concentrate stem cells to help reduce inflammation in the spine and stimulate the creation of new tissue in the spinal disc to help reverse the effects of the disease. The office procedure is performed with I.V. sedation and usually takes 45 minutes. The study noted that patients who received higher concentrations of stem cells in their injections saw a greater improvement in their back pain.. This three year follow-up research study shows utilizing a patient's own stem cells can provide long-term back pain relief and prevented the need for invasive surgery in 77% of the patients.

If you live in the Northern Colorado area and are experiencing neck or back pain due to degenerative disc disease, you can learn more about Dr. Pettines treatment and research by visiting his website at http://www.KennethPettine.com.

About Dr. Kenneth Pettine Dr. Pettine has been the principal investigator of 18 FDA studies about stem cells and their uses and is considered a pioneer in the field. He founded The Rocky Mountain Associates in Orthopedic Medicine in 1991 to offer patients a non-fusion surgical option for their neck and back pain. He co-invented the FDA-approved Prestige cervical artificial disc and the Maverick Artificial Disc. He is currently focused on the use of Mesenchymal stem cell therapy for patients desiring to avoid orthopedic or spine surgery. You can learn more about the therapy and Dr. Pettine at his website, http://www.KennethPettine.com.

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Northern Colorado Surgeon Releases Three Year Results of Bone Marrow Stem Cell Treatment - PR Web (press release)

Screenshot of Taigas website.

A startup at University of Colorado Anschutz is in the middle of a substantial capital raise.

Taiga Biotechnologies, which is developing new therapies for cancer, HIV and other diseases, has raised $6 million and is looking for an additional $14 million, according to a recent SEC filing.

The date of the first sale was March 16, and so far, the startup has 14 individual investors.

Founded in 2006, Taiga creates therapies for cancer, immune diseases and other serious medical conditions using stem cells, proteins and other molecular compounds.

In 2012, the firmreceived a patent to produce significant amounts of adult blood stem cells using blood from umbilical cords or bone marrow. Blood samples could be stored and expanded to be used after chemotherapy or radiation treatment, instead of having multiple bone marrow transplants.

Last summer, Taiga developed a product to help children with severe immune deficiencies, forcing them to live in protected and sterile environments. The product, which garnered an Orphan Drug Designation from the Food and Drug Administration, was approved for clinical trial in Israel.

Taiga is led by co-founders Brian Turner and Yosef Refaeli.

The company received $12 million in a raise ending in 2015, as well as $246,000 in 2010, according to SEC filings.

Taiga is basedat 12635 E. Montview Blvd. at the University of Colorado Anschutz Medical Campus.

Kate Tracy is a BusinessDen reporter who covers nonprofits, startups and the outdoors industry. She is a graduate of Corban University. Email her at kate@BusinessDen.com.

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UC Anschutz startup gets $6M boost to fight disease with stem cells - BusinessDen

Dr. Kenneth Pettine, a retired Orthopedic surgeon and founder of The Rocky Mountain Associates in Orthopedic Medicine in Northern Colorado, has released new information about treating neck pain due to cervical disc degeneration with non-surgical methods. Dr. Pettine is using injections of bone marrow concentrate to treat the pain, finding that patients experienced an improvement in their neck pain after six months, one year, and two years after treatment.

Loveland, Colorado (PRWEB) March 29, 2017

Millions of patients in the United States suffer from chronic neck pain due to degenerated cervical discs, the six discs in the spine that support the neck. Patients suffering from degeneration in one disc may be able to try a surgical solution such as a cervical disc fusion or the insertion of an artificial disc. If the pain originates in two or more of the cervical discs, though, many patients discovered that their surgical options were limited and they might be left with only palliative care options to mask their painful symptoms.

One Northern Colorado doctor is out to change that. Retired orthopedic surgeon Dr. Kenneth Pettine has been researching the use of using injection of bone marrow concentrate to treat degenerative diseases of the cervical spine. Bone marrow concentrate contains stem cells, which can help stimulate the growth of bone and tissue within the body. Dr. Pettine is specifically interested in the use of mesenchymal stem cells, which have anti-inflammatory properties and may be able to help with the degeneration of the discs.

In a recent study, Dr. Pettine tested the bone marrow concentrate on 182 patients from ages 18 to 80, giving them injections into the cervical discs causing them pain. Patients showed improvement at follow up appointments at six months, one year, and two years after the injections were given. No patients experienced complications from the injections and none had to have surgery.

"The results indicate a bone marrow concentrate injection may be a reasonable non-surgical treatment option for patients with degenerative cervical disc neck pain," said Dr. Pettine. "That's great news for those who were suffering painful symptoms and left without promising treatment options."

If you are interested in learning more about Dr. Pettine's research and how it could benefit your chronic neck pain, visit his website at http://www.KennethPettine.com. The site provides easy-to-understand information about mesenchymal stem cells and their use in treating orthopedic degenerative disc issues.

About Dr. Kenneth Pettine Dr. Pettine has been the principal author of 18 FDA studies about stem cells and their uses and is considered a pioneer in the field. He founded The Rocky Mountain Associates in Orthopedic Medicine in 1991 to offer patients a non-fusion surgical option for their neck and back pain. He co-invented the FDA-approved Prestige cervical artificial disc and the Maverick Artificial Disc. He is currently focused on the use of Mesenchymal stem cell therapy for patients DESIRING TO AVOID ORTHOPEDIC OR SPINE SURGERY. You can learn more about the therapy and Dr. Pettine at his website, http://www.KennethPettine.com.

For the original version on PRWeb visit: http://www.prweb.com/releases/2017/03/prweb14195867.htm

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Northern Colorado Doctor Exploring New Non-Surgical Methods for Treating Neck Pain - Benzinga

Posted on March 24, 2017, 6 a.m. in Cancer Exercise

New study reveals that lactate, a molecule produced during intense exercise, plays a key role in cancer cell formation.

Medical researchers are on a quest to develop a comprehensive understanding of the mechanism that causes the process in which cells become cancerous. This process is known as oncogenesis. A recent study keys in on the molecule generated amidst intense exercise known as lactate. The purpose of this research is to explain lactate's role in the creation of cancer cells. The latest study's findings were published in the popular journal Carcinogenesis. About Lactate

Lactate is the byproduct of glycolysis, a chemical process that breaks apart sugar into smaller molecular components with the ultimate aim of generating energy. Lactate builds up in the blood and tissues when one engages in intense physical activity. If enough lactate accumulates, it can cause diminished physical performance as well as muscle tightness.

A famous German scientist named Otto Warburg first noticed that cancer cells consume an abundance of glucose compared to regular cells. Known as the Warburg effect, this phenomenon is a reference to the fact that cancer cells proceed through more glycolysis and generate more lactate than regular cells. The Latest Research

New research on this subject matter has been spearheaded by the director of the Sports Performance Department and physiology laboratory at the University of Colorado-Boulder's Sports Medicine and Performance Center. The director, Inigo San Millan, was determined to figure out why the Warburg effect occurs. Cancer research has deviated from cell metabolism study to genetics since Warburg's heyday in the early 20th century. However, the latest research might shift the spotlight back to lactate's role in the context of cancer development. Lactate and Oncogenesis

San Millan's research team suggests that lactate is the sole metabolic compound necessary and involved in the nearly half-dozen stages that stem from carcinogenesis. Their study analyzed the role of lactate in the process through which new blood vessels develop within tumors. This medical term for this process is angiogenesis. The study also examined the role of lactate in immune escape. This term refers to the cancer cells' eluding of the human body's natural immune responses. It also delves into the role of lactate in cell migration, self-sufficient metabolism, and metastasis.

San Millan's paper details how lactate assists in the creation of an acidic microenvironment outside of the cancer cell during metastasis. This phenomenon triggers the spread of additional cancer cells. The study also explores the connection between genetic components and lactate. The research team hypothesized that three transcription factors (p53, cMYC and HIF-1) common in the majority of cancers catalyze the deregulation of lactate. Can Halting Lactate Stop Cancer?

The important role of lactate in cancer cell creation helps explain why people who exercise on a regular basis have a low risk of cancer development. Individuals who exercise enjoy a body that is trained to transfer lactate to an energy source for the body, preventing an excessive accumulation of the metabolic compound. The findings allow for speculation that an idle lifestyle combined with an excessive consumption of sugar might lead to an abundance of lactate that leads to cancer. These findings show that lactate is not only present when cancer develops but required for each step of its development. What's Next?

San Millan hopes to team up with the University of Colorado Hospital to analyze the effects of custom tailored physical fitness programs created for cancer patients. At the moment, San Millan is studying the nuances of breast cancer cell lines. His hope is that additional research will ameliorate the quest to develop drugs that prevent the accumulation of lactate. These drugs will likely help key in on monocarboxylate transporters that transmit lactate between the body's cells.

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Lactate May Drive Cancer Development | Worldhealth.net Anti ... - Anti Aging News

Add road show. That's my open definitely probably would have brought that's my old. Query where you don't know what you're stupid. Brad broad show. That's delicious. Another addition of Brad show up here with a third base coach or infield instructor. Patriots. Number one fan Brian Butterfield and I was thinking of who would be the next person I'm on the preferential podcasts and I know that water your decision making and your instincts are probably at this point Keener than anybody. So what who who would you like to see. On this part with a I think it would be droop over its without ego oh you're your wishes are net. Making its first appearance on the right foot so that means for teacher congratulations drew Palmer and here at jetBlue park drew gradually since not only be in the podcast but being married this offseason. Think it is a big big off season for me. This is this is an every offseason where you get married. You go to Australia aren't being briefed on truly private islands off ostrich. The a lot of fun in married and in a couple different spots in Austria lost because of so. Take me through the end of the ads starting at the end of the season you have. You you pitch in the playoffs you've thrown only six miles an hour you get married you go to Australia. Com is that it was it in and all the sudden you have a stem cell watch yet the stem cell injection before you got married right. Today. Done matches season and then decides them. Knowing that some relaxing time coming out of his deputies here a couple of months after there is no better. Wedding present that happening themselves successor immediately after. The playoffs where you knew that you were gonna get this stem cell injection. And take me through if you can't get we've talked a lot about the process he took. To heal your elbow. Take me through that decision was made in September and then. These him to do this in October. And then I'm gonna go to Australia. We again talked about it towards the end of the year. So definitely do a few years to oh. The partners in recovery for the next season knowing that I had some you know the doctors had to take some time off and lots and like on. I developed and lights anyways those as the perfect situation for and I know we've talked about this before but we haven't talked about it here. Why stem cell why not PRP played in platelet rich plasma which is usually the way it the last few years anyway. That's the way a lot of guys are gone when the instead of having surgery. To heal your Opel wise and so. It's this Intel's previous month. More experimentally colleges because the yet to use like those who are harder begin. If that take him out of the body in my own body and my case. That your hip yeah from about them. Big hit bone in my become lower back area they journal on there and extracted it and spun it kind of the same as Pierre. And and then just then injected it into the clincher. Again this is not on something you know enough to worry about getting married you have to grow in your you have to take your mind off giving the China patterns in the and they in the guest list and everything. Yeah. I didn't have much to do and in my life my elected miss the planning so just. And zipped off to LA for a couple days had it done and then came right back in the mean you know their radio get married. That's weird that's like when when you my wife asked me when viewing induce the child before your house or after you run the marathon. So today her how long did it hurts or when you're when you're exchanging vows to do you feel your elbow healing or did it was it's still a little bit in pain or how does that. Happened so little. It was two Bennett and it was it was so little sore for awhile after. You know I guess that's part of the healing process. I felt that. You know for about 22. And a half months after that prime pro about two months after that after had a done and then from there to kind of progressively get better. So when was the moment where you said this works this feels like it actually work. When a first it's Roland. You know I was still little soreness from. You know all the dealing going on there probably use this kind of tightness from from resting. What's got their own throwing very passively in the beginning just to see in my arm movement and get things on for a really started you know thrown the ball put some force effort into it. Probably. Had a it. It's sort of film way better we'll probably take two weeks ago to be honest. They say it takes about three months anyway it's three months wouldn't let me like. I guess late. January sometime and then affiliate hit a few different points where it's gotten better and kind of broke through and got better better. And right now it's pretty. So two weeks ago you said it's a return wasn't in the bullpen wasn't just throwing wasn't like oh my goodness. This feels a lot better than that hasn't long long time the out of a fierce and from where everything feels maybe everything's just tell us you know all that stem cells that are. That it just feel a little tighter rules. A little stiff. We've been doing our normal treatment just kind of loose and stretch him. Loan sizes. And I don't know I threw he tacked on Monday Croats play catch and it just felt better so I don't know if against them good blood flow in and broker giving up through. It was effectively use difference to review some stem cells about five different types of spring training. When did you feel the worst last year so obviously when you go down this road. They had to fell in and when you were moved to the bullpen the end of the year there was a reason why you word in jeweler drawn back when did it. When did a start hurting and be really feel like no this isn't good. Who's got an ongoing thing for her. Probably over half the year she says everyone knows something you know and in on my mind there was anything those nonstop mail us here seven best years ever it's you know my career was clear on things now. You know it's just one of those things you got to figure out how to make work go off there and you know feel good enough team did its job done every once or five days that's a lot of pressure though I mean just because you make the all star team you get traded. You come to a new team and anybody can Boston in the middle pennant races. This is a lot of pressure than there was then having to deal with that must've been pulled onto yeah I mean. Like instead everyone's deal with something and in. You know. And most the time where they'll where the ones that know what's going on you know wherever it's no no announcement and knows what we're doing when. Like I said I just you know our. Come on mine right to pitch every five days and you know it was recovered enough to to feel good enough to pitch every five days and go out there. And that still feel good. It can be tough it's it's you know. It's in the dailies in itself it's tough enough where especially when you things going on but he just can't stay focused and not let any you know anything. You think you know yourself so you have to stay within yourself. Dude you know you're capable of doing and step and not worry about the rest of any point in the resides in the uterus is uniform and when you came over did you feel. As good as you did. When you were cruising to the Ulster mean. You know I know listen I know you were her I you know making excuses this is degree in farther in this question goes to the reality of looking back at last. The I don't know some players said it was an ongoing issue for. A lot of most of the year so. I don't members you know. My thoughts up to display a fill up an announcement did then but also threw a lot of things and you know whatever about a foot feels strong right now. And right now it's just me feed my you know find in my delivery none of them driving the ball and you know after that. Breakthrough couple weeks ago. And this. You know trying to trying to you know get my rhythm down through them. Key for me that's the thing you do you go through all of that into as you said two weeks ago. On the triceps thing aside as we see here right now you must have some sense of gratification. Thing what I did and worked back in terms of how it feels. And does it feel like you did like to say at this time last year because I would imagine you felt OK last year this time. I feel great and I'm lost here you know as the situation. Had thrown a lot for him came in spring training because it's. I was going until went starters job but this year I had to take it easier and you know. Counted. You know let that come to nothing you know since I've come always every bearer of the events already come and then I've never had to do this before some kind of some of the things that I had to figure out before I get spring training room figure experience. If anything so that's the that's another. You know obstacle itself. In from here and like I say title goes along with last year and I. Thought there and pitch now and I'm not too much focus on results I am mean. You know no one's okay with going out there it's about spring training volunteers you know. What they tell you but. You wanna do we should also understand where you're at in the process and if you know if it was just yeah if I gave up five runs. It felt good and it was a step up for a figure something out that's a win for spring training is and I think if you're out there. It's giving unit itself to run you know what it's going on that's not. But that's not a woman in profits that that's not a good thing did you did you sense or ruin freaked out the other day. Probably you know I'd. And you know I it's and I tried to make a point to say you know I I don't think he was inning serious you know it's. This does that still part of me trying to find my mechanics down and find some inputs and a lot of effort into throwing. Really driving the ball of the played. It's just you know I was searching for that feeling in morrow mr. Graham I'm a little bit and that's. You know you're gonna feel stuff when your buddies in the wrong position especially when you get out of slot sort of put pressure on. Others your body. Wasn't that wasn't a big deal something and I went watch video of that night and next day and fear level is on. Takes effect today and yet been perfected the next day of figured out what I need to do announced it's not repeat that. Was a human nature because you know you don't know like if ones connected to the other and everything else 41 sack him feeling days. I don't want any sort of hiccups. Use something I knew wasn't related to the other so it's kind of Ali's. It was more frustrating for me because. You know everything that I did last year felt great you know everything I did you know took care of assaults is it felt great. And it was just another you know finally we think those two minutes this this is like insists that annoying little thing. You know what if the next morning and I didn't feel anything resting so wasn't like I was throbbing son knows this little thing that. So that I felt much support mama behind my body. And so I was really worried about it's. You know this is probably good thing crummy me in there and what the heck was going on and I kind of honed in on one. That some of the things and delivered in the it to him to polish. The one thing I think last year where you take away from last year there's confidence there's unity we've talked before about. Getting a chance probably getting your chance to start. Coming getting them making the most of that opportunity. Making the all star team and if I would imagine for you it's just about oh. I did this I proved they can do this in the major leagues it doesn't matter what part what division one league. If I'm healthy I can do this is that is that something that you having your back pocket that maybe you hadn't had your back pocket for his entire career. It's instant play nice. They years to think about but at the same time not she was last year and this year I need to focus on doing my job. Every time out like I did luster. Could duo. Draw on the past too much you know really. That does nothing Bashir. You know why go there and get shelled for five things and thank you would think that less here the other guy who gives a (%expletive) you know service. It's just the way goes. I you if you think about it you you try and take your pick was. What was what made me do well let's hearing panel ruled that over trying to roll that over into this year antenna can pick up where you left off and continued that on throughout the season. But did it's it's useful which can't you can't rely on the. It's you noted this is a thing is that when we look at this rotation. For Salem. David Price and the Cy Young award winner. Stephen Wright you all started at water re use you know great stuff for most it's a no hitter in all star in all star troops farmer. Then and this is I would imagine that one of the next up for you is being. Not helping people remind people all star drew pom rants is just being lumped in with the other guy com. You know it's it's. Great to be around those yeah it's. You know I mean this account learn from. You know the way they go about things everyday on their bus some. On and off the field there and here. Take care what they need to take care very thing you learn from being being this spring training him. Maybe there's learned so from the U I don't know by presenting you the picked up because these are pretty. Accomplished. Today kiss. It's more their preparation known you know Billy guys' preparations they have they have the preparations. To go into each start they know they wanna do it and make an excuse that's what makes them leave you know I. Sometimes do you know smeared anyone can agree on profanity dismiss this they give this guy out he knew how to get her gal but if you can't excuses that you're not going to be. Successful those guys are really good at that the sitting down on paper this this I know how to get this guy out this guy out this guy out they go out there and do it and you know we're gonna great position every time out. Yeah let's say it's not a lot of guys can do that some guys even going like going off scouting report trade via you know. And it knowing what's your round a little while yeah it's you remember how. And you start to learn how to get guys out there and you know when you're on even longer hitter knows we're trying to do it and it's about executioner. You know you can. Maybe maybe not execution and notes you're trying to do any message you get amount that's just based on notes that's. If that a definite thing you know they're the best game plan world. And executed. And still you have to Iran's analysis that way you know sometimes you don't you retire by human nature and human nature about the about wanting to impress coming to Boston and all that. The fire was rated one of the things that from my humiliation would be following the guy who has traded lower. Have you Google leaders just in Mosul and now on the ice ice I still follow. Him on the on Twitter you ought. Then at five team for five teens now so I've followed the suppose and that's what are some things that I see your stuff that pops up because it's you know. And treated three cup four times and there it is so. He's Celsius guys via trade or have popped up and you panel don't look around now I don't know with this situation has. In niners get pictures we have a give me the power rank of guys who treated for our youth who loses and who are some of the guys these that we know Anderson Espinoza last year. Anniversary goes straight to you bother menace from Colorado. And then I think I'm ready for Brett Anderson. And then. Oh and then Yonder Alonso was San Diego. It's news that first time your traded which was the ball little mantra remember that that was a big deal because a Red Sox are actually. There was some thought that they might try to trade for menace and the union stepped and when the when that first happened was it was at the shark tournament was that night and day compared to when you retreated last year because he had gone through it. Yeah now's a crazy actually. I was in Dublin after I was warming up for the gained house fits in and night. And you know it's the gains in ten minutes on the out compliments you know. From being ready to go in the game and its phone rings the bullpen then coached like they. You'd then take it and went with ten minutes before the game starts some walking across the field in some earlier starts throne warm up. I'm walking across to some homeless for decades centuries it's a missed. I just slow again remember the slow walk across the whole field stadiums full everyone's aaron's time thinking like. What the hell does this mean Mike what's going on that first year playing. I I didn't really it was crazy knows crazy so that the first your first professional years. That was my first year Provo 2011 for sites get adjusted to those and Simon did play. And then those efforts you're playing well. On 31 against a fuel it forever ago that does lots of squeeze them between NC times there between that first one. Filling us ten minutes when he hears film also. Very rich and it was there a time in that time because you had just sort of morphed into were reliever was ever a time. Where you felt like I'm not gonna get my chance to do what you end up doing last year. I didn't you know. I'd bounce around them. You know idol always known I could be a good starter. And you're not always Clinton situation I didn't really have choice and fifty mile from the bullpen. Our bullpen was doing very well and I got a heard ninja who is there wasn't really. You know. They didn't raises a demotion for his yes we need help down there and we think you can do it didn't move it much here. You know. Do you wanna do you wanna be the guy down there so I went down both men's. Pretty much. The first guy out every you know there's so if I was up that day and some snow on on boom Europe the matter when it was seventh 89 whatever. I was. But I I always in my head you know I always news that. I can be successful. As the star and decide to figure out how to get myself back there and kind of simplifies things. Just consume my mind all. On base audiences on my own time anyway offseason doesn't matter they united you know that's that's all I think about this ways to improve. It was always an honor because you know else you know if yes shouldn't be the best. Anywhere than you know and you lose your edge. Live with the so if that's the case then last argues in September and October. Must've been a complete mind you know why. Right I mean if if you're seeing there. They are in the ceiling thinking about baseball typically then when you're thinking about my elbow I think and about impressing people in Boston with a lot of generates that must have been. Like how I don't I can't imagine them. I was autos a lot like going on. I had some good games in there it's bagged games he nearly you can expect to be perfect every time mountain discount. It's part of us to this offseason time. Don't think about like whoa what was different between when I got traded on the games that I didn't do very rural. You know I mean I think there's there's a few things. Just execution wise sewer by playing going into the gains did a little different. You know supposedly stuff going on to its does that and to be you know it's going to be like it's right in a can have a you know it's not going to be in no pressure situation ever you know baseball is always. You know in a position to get out of things that. We've just got to slow the game down and the biggest thing I'm the tart brokerage and Boston and president is that if you had to look back and everything. And where the world when they went through last year is that just something as simple as this is slow everything down. Is that one of the biggest things where you said media didn't do that it's much issue and it's a big fan I think it. I just went a different direction and some of the things that may be good. You know a syndicate curve ball. Good. You know good forcing fastball. I didn't I don't think it through my two seamer it suited to some changes in their couple games that begin. You know it's it's I had a really good. You know game playing going and saying most of us that game to San Diego I had some bad means obviously. You're gonna have ups and downs of offseason. And video search teams are more times and but. In had a lot of good games you know I think you learn a line about. It's you know me sometimes you have some good gains from new going to connect Augustus and then. Doesn't go away one what the hell happened city cast analyzed. You know you know. He goes a little fuel to be going in today those little aggressive for me stand back when I don't say about him in trouble. And when I feel good offensive jam him at the front. And Carolina did there is a guy I realize that can. That's recess this. It slowed it down a little bit you know the law came comeback album is suffering is to stay back tonight some Ford when you have. I don't know when you can win but friendly parcel will be different industrial park the FBI wouldn't say that it was you know. Too much pitching there it was different you know as a a lot more innings and me. You know you know whatever it is seen on a hike is on the line can't find one specific thing wide I didn't you know. It's like I would have liked to. But it's a different league to increase in the studio and it's a fix it and certainly to. That right now. Do. It's. Excited about a person all the that's the thing is who finally due to wrap things up present as you see here right now all of this you've come through all of this. And here you are you're sitting here as perceived as the pitcher who's gonna silence of the rotation. Who is going to be the guy that they traded for him and you can feel. Confident that you don't have all the stuff that's going on last year yeah I think confidence is the you know if they can definitely make things a lot more. A lot more complicated deal with them and there's all these other things behind the scenes are Dilma. A feel good this year and didn't you know unsolicited and get them work on things alone like too because I had been. Because of the shorter thrown for and I had. You know didn't get to throw off and on anything before I came here but you know it's at the challenge and welcome challenge you know it's it's another you know it. When you there's nothing challenging it's a little boring you know and so I'm I'm excited to. Figured out these next film segment cited an excellent tomorrow and then you know I I normally don't. Answering fan only gets trying to pull together in the last of sorts anyway. Is kind of it over the new games gains gains. It's kind of bring in the other for the season. Not too far away drew thanks so much and and good luck and it's it's it's been. It's been a crazy couple months but things seemed to be settling down and now we can focus on 2200. That's.

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Bradfo Sho, Ep. 19: Being Drew Pomeranz - WEEI.com

Dr. Kenneth Pettine, a board-certified retired Orthopedic Surgeon in Northern Colorado, is researching new methods of treating back pain due to degenerative discs through the use of mesenchymal stem cell therapy. Patients with three or more degenerative discs are traditionally left with palliative options such as medication, but Dr. Pettine's research reveals that patients who received stem cell therapy reported better results than those who underwent surgical procedures.

(PRWEB) March 20, 2017

Northern Colorado residents suffering from back pain due to degenerative discs may soon have new treatment options. Dr. Kenneth Pettine, founder of The Rocky Mountain Associates in Orthopedic Medicine, has been researching the use of mesenchymal stem cells to alleviate back pain, reduce swelling, and give patients relief without the use of surgery.

"Back pain is the second most common reason for physician visits in the United States and the most common cause of missed work," said Dr. Pettine. "The consensus among spine surgeons is patients with more than two segments of discogenic back pain have no surgical options and poor prognosis. This mesenchymal stem cell therapy could change that."

Dr. Pettine has been researching the use of mesenchymal stem cells in back pain treatment for years and has been releasing exciting findings about the potential relief for back pain sufferers. Mesenchymal are one type of stem cell and are responsible for modulating the immune system, has anti-inflammatory properties, and is the main cell that's responsible for helping the body recover from back and neck injuries. It can also help treat degenerative disc diseases, which is central to Dr. Pettine's research.

In recently released research, Dr. Pettine tested mesenchymal stem cell therapy by injecting 146 patients suffering from back pain originating in three or more discs. He concluded that that the results are superior to those reported for surgery done on one or two discs. The patients getting the treatment reported better improvement in their condition and had fewer complications versus surgical patients.

"The economic and emotional impact of chronic low back pain on both society and the individual patient is significant," said Dr. Pettine. "Many of these patients are unable to work due to their condition and treatment can cost millions of dollars over a lifetime. This new therapy could be a new option for them that promises better results and greater recovery.

If you are interested in learning more about Dr. Pettine's research about mesenchymal stem cells to treat degenerative back pain, you can visit his website http://www.KennethPettine.com for more information.

About Dr. Kenneth Pettine Dr. Pettine has been the principal author of 18 FTA studies with Biologics and non-fusion implants and is considered a pioneer in the field. He founded The Rocky Mountain Associates in Orthopedic Medicine in 1991 to offer patients a non-fusion surgical option for their neck and back pain. He co-invented the FDA-approved Prestige cervical artificial disc and the Maverick Artificial Disc. He is currently focused on the use of Mesenchymal stem cell therapy. You can learn more about the therapy and Dr. Pettine at his website, http://www.KennethPettine.com.

For the original version on PRWeb visit: http://www.prweb.com/releases/2017/03/prweb14141149.htm

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Northern Colorado Doctor Researching New Treatment Options ... - Benzinga

Introducing a handful of genes to adult cells can turn them into pluripotent stem cells, which can develop into any other cell. Houston Methodist researchers have unpacked the mechanism by which this pluripotency is induced.

Induced pluripotent stem cells (iPSCs) have tremendous promise: They could be used to generate new tissues and organs for transplantation, and because they are made from adult cells, they could be used to grow genetically matched organs for individual patients. But scientists working on stem cell therapies have struggled with quality control.

The Houston Methodist team, led by John Cooke, chair of cardiovascular sciences at Houston Methodist Research Institute, discovered that activating innate immunity boosts nuclear reprogramming, the first step in developing new tissues from a single cell.

"We found that activating the innate immune system opens up the DNA," said Cooke, the study's senior author, in a statement. "This open state enhances the formation of induced pluripotent stem cells (iPSCs) or cells that can have the ability to regenerate into other cell types and tissues, such as that of the brain, heart or liver." (See video below for further details.)

No iPSC-based therapy has earned FDA approval, but the technology has become important in drug discovery and disease modeling.

Several companies are working on tissue regeneration, including Johnson & Johnson and Orthocell, which recently teamed up to develop a stem cell-based approach to grow tendons. In December, BlueRock Therapeutics reeled in $225 million to advance its iPSC-based therapies. Meanwhile, researchers at New York University and the University of Colorado at Boulder pinpointed a gene in mice that prompts the repair of injured muscle by adult stem cells.

While Cookes findings have obvious implications for growing artificial tissues and organs, the research could also be useful for any situation where a cell faces a challenge, Cooke said. His team plans to apply the activation of innate immunity to the regeneration of damaged tissues to improve wound healing, or to promote recovery after a heart attack.

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Houston Methodist IDs immune pathway that promotes tissue ... - FierceBiotech

TRUCKEE, Calif. Many schools in the Truckee-Tahoe area were closed on Monday after yet another major storm left residents of the Sierra Nevada gasping. It's been quite a winter, with snowpack 179 percent of average at Sierra-at-Tahoe, one of the many local ski areas.

The snow has dripped with moisture: 53.4 inches, not far behind the record of 56.4 inches set in 1983. Homes have been flooded, and not just with water. Mice, squirrels and other creatures have been seeking sanctuary in homes.

"And it's never just one. They bring the family and friends. The females can leave a scene behind. This draws the guys. Mice can have upward of a dozen babies. Then it's pretty much an infestation," explains the Lake Tahoe News.

After five years of too little water in California, the problem now is too much, said National Public Radio.

Noah Diffenbaugh, a climate scientist at Stanford University, said this cycle of extreme dry and wet is the result of warming climate, exactly as has been predicted by scientists for at least 30 years.

For about that same time, scientists have been warning that more rain and especially more intense rain poses challenges for California water infrastructure. The dams and pipelines were built with the assumption of a somewhat colder climate, with the snowpack melting slowly. In a warming climate, more of the "atmospheric rivers" will produce more rain and less snow.

If dams must be emptied to make room for floods, they are less useful for water storage. Is the solution more dams? Jay Lund, who directs the Center for Watershed Sciences at the University of California-Davis, tells NPR that even if dams are big enough to handle floods, the channels downstream may not be able to.

During the drought, California relied heavily on water in aquifers. In a drought year, about 60 percent of the state's water is pulled from the ground. In the absence of drought, 38 percent comes from groundwater, explains the Wall Street Journal.

California's Central Valley, which produces a quarter of the nation's food, was drained of about 40 million acre-feet during the four years of intense drought. That decrease is about a third of the total loss to the Central Valley aquifers in the prior 50 years. They don't fill as easily as they get exploited.

In other words, despite the big winter that has sent mice scrambling for cover, California is still pinched for water.

Steamboat propping up an iconic old barn

STEAMBOAT SPRINGS, Colo. Ed Quillen, the late columnist for The Denver Post, once described the branding of Steamboat Springs, including its marquee resort, as "cowboyland." Billy Kidd, the resort's ambassador, wore a cowboy hat, and an old barn was an icon used frequently in marketing photos, ski trails in the background.

Now comes news of a different barn, this one built in the late 1920s on a dairy farm. It's also a visual link to the agriculture heritage of the Yampa Valley. Just one problem: This visual link is on the verge of falling down. To prevent that from happening, the Steamboat Springs City Council has moderated a deal that ensures the barn gets stabilized and perhaps restored.

Owners of the property have agreed to pay $25,000 toward the work, but the ski area accepts caretaking responsibilities for at least a decade. A local group has also raised several thousand more dollars to help.

"The goal was to get the barn to not collapse," City Council President Walter Magill told Steamboat Today. "I like the way things have turned out."

As good as dead, skier survives a heart attack

JACKSON, Wyo. Imagine having a heart attack in the backcountry. Just what do you think your odds are?

Mike Connolly, 61, was skiing on a ridge of Maverick Peak, in Grand Teton National Park, when he reported chest pains. Because they had cellphones, members of his party were able to summon help. A helicopter with three members of the Teton County Search and Rescue was dispatched.

At the scene, Connolly went into cardiac arrest. He ceased breathing and he had no pulse. Members of his group began CPR. Then rescuers arrived with an automated defibrillator. They shocked Connolly once, and he regained a pulse and began breathing again. A short time later, he was able to verbally communicate with those around him.

Uber drivers now ply roads in Jackson Hole

JACKSON, Wyo. Because of new state legislation, Uber and Lyft are now allowed to operate in Wyoming. Uber took just hours after the bill was signed before opening its car doors for business in Jackson Hole, reports the News&Guide.

Uber drivers must have valid licenses, registration, proof of insurance and a passing grade on an online safety screening. Uber allows drivers to use their own cars or commercially licensed vehicles.

Are elk starving or just hoping for a free lunch?

KETCHUM, Idaho Deep snow has challenged herds of big-game animals in the Rocky Mountains this year.

Elk and deer are being fed in 24 sites south of Ketchum, where the mountains give way to rolling, sagebrush-covered hills. But between Ketchum and Hailey, several homeowners have been prohibited from feeding elk.

Blaine County has sued several residents in the Golden Eagle Ranch subdivision in an attempt to end feeding of elk. A plat governing the subdivision bars such feeding, but several homeowners have persisted, explains the Idaho Mountain Express.

One of the defendants, at a meeting in late February, said he feared the elk calves would perish in a final cold snap of winter. Idaho Department of Fish and Game officials think the elk will survive.

Four to five hours away in Jackson Hole, the News&Guide reports something similar. There, 40-some elk have been congregating in the corral of Brit Ross. Instead of shooting the elk, to drive the rest away, he continues to allow the elk to feed there. "You shoot them, and where are they going to go," Ross told the newspaper. "The snow is 4 feet deep out there. If you're going to shoot them, you're going to have to shoot them all."

Wyoming game officials think the elk can survive in that part of Jackson Hole, but elsewhere in the broad valley they have started feeding 250 elk under an "emergency" declaration. The News&Guide explains that in some areas of the valley, elk always try to feed on the hay harvested for horse and cattle. Other places, this is a first.

Americans, Canadians & Cambrian-era fossils

BANFF, Alberta A mystery has been solved in the Canadian Rockies in the quarries of the world-famous treasure trove of fossils called the Burgess shale.

The shale contains specimens from more than 500 million years ago, during an explosion of life in the Cambrian Period. The famous shale is especially known for preservation of the soft parts of the marine creatures.

But what to make of the bizarre skeletal remains called hyoliths? Scientists long believed they were from the same family as snails, squid and other mollusks.

Not so, according to a recent report published in the scientific journal Nature. A team of scientists led by a 20-year-old University of Toronto student determined they weren't mollusks at all, but rather more closely related to brachiopods.

Are you yawning yet? The Rocky Mountain Outlook says that shrugging off this distinction is akin to saying a Canadian is no different than an American.

"Outwardly, many mollusks and brachiopods at least the shelly ones do look very similar. Both have two shells, but, like Canadians and Americans, once you get beyond the similar exterior, they are two very different things."

And just how do Canadians and Americans differ?

When feds and local cops cooperate, and when not

ASPEN, Colo. Three law-enforcement officials in the Aspen area have told the Aspen Daily News that, if approached by U.S. Immigration and Customs Enforcement, they would not permit federal agents to tell people they are from a local police agency.

ICE agents can legally use that fib in an effort to apprehend someone or get a family member to talk, but only if the local agency acquiesces. The thinking is that if ICE agents are seen as local authorities, people will tend to speak more freely. The ruse was used in Los Angeles recently.

That won't happen in Aspen and Pitkin County, and it's unlikely to occur in Garfield County, local officials tell the newspaper.

"It puts us in a bad spot," said Pitkin County Sheriff Joe DiSalvo. "They interact with our citizens and do something boneheaded, it erodes trust in the Pitkin County sheriff's office. I want my community members to trust us, whether they're illegal or not."

There is no evidence that local ICE agents had contacted law-enforcement agencies in the Aspen area to seek permission to use their agencies' names as parts of investigations.

ICE agents can only enforce federal law, whereas police officers and sheriff's deputies enforce local and state laws.

But there is interaction between local cops and the feds. Garfield County Sheriff Lou Vallario says his deputies occasionally accompany ICE agents when operating as the multi-agency Threat Assessment Group, which is focused on illegal residents who are gang members.

Vallario said that "it's sort of a given" that enforcement of federal immigration laws will pick up.

A particularly ticklish area is whether immigrants who have had children born in the United States, and hence legal residents, can be forced to leave. An Argentine woman who arrived in the United States in 1991 illegally has taken refuge in the basement of a Denver church, afraid to leave for fear of being deported. She has both children and grandchildren in Colorado, but under federal law, she could be forced to leave.

Lots of water in the deep snow in Sun Valley area

KETCHUM, Idaho The snowpack in February was eighth deepest on record at the Ketchum Ranger station since measurements began in the 1937-38 winter, a year after the Sun Valley Resort began operations.

But by a different metric, water content, this may be an even more unusual winter. The Natural Resources Conservation Service reported that February precipitation water, not snow was almost 400 percent of average. The Idaho Mountain Express reports that the snowpack contains more water than in any winter since record-keeping began in 1961.

Vail clinic advancing research on stem cells

VAIL, Colo. In 1988, George Gillett, who then owned what has become Vail Resorts, persuaded Dr. Richard Steadman to relocate his medical practice from Lake Tahoe to Vail. The Steadman Clinic soon became the go-to-place for athletes with knee and other joint problems.

It still is. Football quarterback Tom Brady has been there, soccer icon Pele and basketball power Yao Ming. Plus John Elway, Mario Lemieux, and Alex Rodriguez. Big-names from the ski world, obviously. But also the drummer for the rock band U2, Larry Mullen Jr.

Now, the clinic will be getting a new, 26,000-square-foot research lab courtesy of the Vail Valley Medical Center. The $68 million facility will house the Steadman Philippon Research Institute's labs for surgical skills, robotics, regenerative medicine, and bio-motion. The clinic and associated research institute together employ 190 people.

Research being conducted there is getting attention. A recent report in The Denver Post by staff writer John Meyer suggests you may have a stake in the work at the base of Vail Mountain. The story focused on the work of Dr. Johnny Huard, the chief scientific officer and director of the Center for Regenerative Sports Medicine.

Huard is trying to advance the techniques that allow people to heal more rapidly. The field is called biologics. Cells from the patient's own body are used in concentrated injections to hasten repair of tissue at the site of the injury.

Stem cells and platelet-rich plasma therapy will some day delay age-related diseases and cut the recovery time from serious injuries, such as to the knee, in half.

"I don't think we can reverse aging, but I think we can age better and recover from injury better," said Dr. Marc Philippon, managing partner of the Steadman Clinic.

"As a surgeon, my biggest challenge is, if I cut on you there's always that healing phase. We want you to recover faster. But the most important thing is prevention of injury. If your cells are aging better, you'll have less injury."

Before moving to Vail two years ago, Huard directed the Stem Cell Research Center at the University of Pittsburg. In Vail, the researchers think injections of stem cells and PRP can help delay or prevent the need for joint replacements. At the adjacent Steadman Clinic, they can test the theories in clinical trials. Animal studies have already shown that young stem cells can rejuvenate old stem cells.

Huard advocates passionately harvesting stem cells from the umbilical cord of a newborn, freezing them at minus-80 degrees Fahrenheit. Those cells can later be thawed and reintroduced into the body as younger and more robust stem cells than the ones that have aged in the patient.

All this could dramatically change the recovery time for injuries. An athlete who blows out an anterior cruciate ligament in training camp currently loses a full year. But being able to return to action during the regular season remains a distinct possibility as a result of these advances.

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Mountain Town News: Mice invades houses as Sierra copes with water - Summit Daily News

The Re-Brand Premier Regenerative Stem Cell and Wellness Centers, recently rebranded their business from Premier Stem Cell Institute, in response to expanding locations, technology, and treatments. This move reflects the growth and success this company has undergone recently and goals for the future.

PRSC and Wellness Centers President, Kandace Stolz said, This rebrand is the culmination of the years of work weve put into stem cell medicine. Were growing and healing more patients than we ever have before, this new name reflects those accomplishments and gives us room grow. We are so thrilled for this move and cant wait to do even more for our patients going forward.

Premier Regenerative Stem Cell and Wellness Centers will continue to partner with the NFL Alumni Association and treat current and former professional athletes. PRSC remains dedicated to studying stem cell treatment by collecting and tracking data to further stem cell progress and maximize results for all patients. PRSCs commitment to being a leader in stem cell and regenerative medicine is unwavering and will continue to innovate and learn to heal and improve the quality of life for all patients.

About Premier Regenerative Stem Cell and Wellness Centers: PRSC is a leading research and treatment facility in Colorado, providing innovative medicine and therapies for those in pain by harnessing the bodys own natural healing power of stem cells. As team of cutting-edge medical experts, PRSC is dedicated to treating patients by using their own stem cells to heal, improve quality of life, and battle the acute pain of chronic illnesses. Premier Regenerative Stem Cell and Wellness Center locations include Loveland Colorado, Dallas Texas, St. Louis, Missouri, and Jacksonville, Florida. PRSC has plans to expand to other major cities across the United States in the near future.

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Stem Cell Therapy - Premier Regenerative Stem Cell

In this May 2016 photo provided by Kite Pharma, cell therapy specialists at the company's manufacturing facility in El Segundo, Calif., prepare blood cells from a patient to be engineered in the lab to fight cancer. The experimental gene therapy, called CAR-T cell, turns a patient's own blood cells into specialized cancer killers and worked in the study, with more than one third of very sick lymphoma patients showing no sign of disease six months after a single treatment, its maker said Tuesday, Feb. 28, 2017. (Kite Pharma via AP)

An experimental gene therapy that turns a patient's own blood cells into cancer killers worked in a major study, with more than one-third of very sick lymphoma patients showing no sign of disease six months after a single treatment, its maker said Tuesday.

In all, 82 percent of patients had their cancer shrink at least by half at some point in the study.

Its sponsor, California-based Kite Pharma, is racing Novartis AG to become the first to win approval of the treatment, called CAR-T cell therapy, in the U.S. It could become the nation's first approved gene therapy.

A hopeful sign: the number in complete remission at six months 36 percent is barely changed from partial results released after three months, suggesting this one-time treatment might give lasting benefits for those who do respond well.

"This seems extraordinary ... extremely encouraging," said one independent expert, Dr. Roy Herbst, cancer medicines chief at the Yale Cancer Center.

The worry has been how long Kite's treatment would last and its side effects, which he said seem manageable in the study. Follow-up beyond six months is still needed to see if the benefit wanes, Herbst said, but added, "this certainly is something I would want to have available."

The therapy is not without risk. Three of the 101 patients in the study died of causes unrelated to worsening of their cancer, and two of those deaths were deemed due to the treatment.

It was developed at the government's National Cancer Institute and then licensed to Kite. The Leukemia and Lymphoma Society helped sponsor the study.

Results were released by the company and have not been published or reviewed by other experts. Full results will be presented at the American Association for Cancer Research conference in April.

The company plans to seek approval from the U.S. Food and Drug Administration by the end of March and in Europe later this year.

The treatment involves filtering a patient's blood to remove key immune system soldiers called T-cells, altering them in the lab to contain a gene that targets cancer, and giving them back intravenously. Doctors call it a "living drug" permanently altered cells that multiply in the body into an army to fight the disease.

Patients in the study had one of three types of non-Hodgkin lymphoma, a blood cancer, and had failed all other treatments. Median survival for such patients has been about six months.

Kite study patients seem to be living longer, but median survival isn't yet known. With nearly nine months of follow-up, more than half are still alive.

Six months after treatment, 41 percent still had a partial response (cancer shrunk at least in half) and 36 percent were in complete remission (no sign of disease).

"The numbers are fantastic," said Dr. Fred Locke, a blood cancer expert at Moffitt Cancer Center in Tampa who co-led the study and has been a paid adviser to Kite. "These are heavily treated patients who have no other options."

One of his patients, 43-year-old Dimas Padilla of Orlando, was driving when he got a call saying his cancer was worsening, chemotherapy was no longer working, and there was no match to enable a second try at a stem cell transplant.

"I actually needed to park ... I was thinking how am I going to tell this to my mother, my wife, my children," he said. But after CAR-T therapy last August, he saw his tumors "shrink like ice cubes" and is now in complete remission.

"They were able to save my life," Padilla said.

Of the study participants, 13 percent developed a dangerous condition where the immune system overreacts in fighting the cancer, but that rate is lower than in some other tests of CAR-T therapy. The rate fell during the study as doctors got better at detecting and treating it sooner.

Roughly a third of patients developed anemia or other blood-count-related problems, which Locke said were easily treated. And 28 percent had neurological problems such as sleepiness, confusion, tremor or difficulty speaking, but these typically lasted just a few days, Locke said.

"It's a safe treatment, certainly a lot safer than having progressive lymphoma," and comparable to combination chemotherapy in terms of side effects, said the cancer institute's Dr. Steven Rosenberg, who had no role in Kite's study. The first lymphoma patient Rosenberg treated this way, a Florida man, is still in remission seven years later.

There were no cases of swelling and fluid in the brain in this or any other study testing Kite's treatment, company officials said. That contrasts with Juno Therapeutics, which has had a CAR-T study put on hold twice after five patient deaths due to this problem.

Company officials would not say what the treatment might cost, but other types of immune system therapies have been very expensive. It's also being tested for some other types of blood cancer.

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Online:

Lymphoma info: http://seer.cancer.gov/statfacts/html/nhl.html

CAR-T therapy: http://www.cancer.gov/about-cancer/treatment/research/car-t-cells

Gene therapy: http://ghr.nlm.nih.gov/primer/therapy/availability

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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP .

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New gene therapy for cancer shows promise in major test - Colorado Springs Gazette