Category Archives: Biotechnology

What is Biotechnology?

Biotechnology is a group of related technologies that use biological agents in a broad spectrum of applications to provide goods and services. In only a few years, biotechnology has revolutionized many disciplines including:

The Biotechnology Technician Program provides students of diverse backgrounds with the knowledge and skills needed to perform competently in a life sciences laboratory environment. The industry is a large and growing contributor to regional and national economic output. As such, Biotechnology is an important emerging industry that is expected to contribute dramatically to the 21st century economy and is thus an excellent career choice for students.

Program personnel seek to foster a sense of excitement for scientific discovery, teamwork, critical thinking, effective communication, and a positive attitude in students. In addition, partnerships with local industries provide students with the most current and cutting edge knowledge and techniques in the field. The program provides hands-on experience with over 100 hours spent in the laboratory, beginning in the first semester.

DNA manipulation and analysis

Expression and purification of proteins

Cell culture techniques

Enzyme and antibody assays

Lab safety

Critical thinking and problem solving

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Salt Lake Community College - Biotechnology

What is Biotechnology

Biotechnology is most briefly defined as the art of utilizing living organisms and their products for the production of food, drink, medicine or for other benefits to the human race, or other animal species.

Technically speaking, humans have been making use of biotechnology since they discovered farming, with the planting of seeds to control plant growth and crop production.

Animal breeding is also a form of biotechnology. More recently, cross-pollination of plants and cross-breeding of animals were macro-biological techniques in biotechnology, used to enhance product quality and/or meet specific requirements or standards.

The discovery of microorganisms and the subsequent burst of knowledge related to the causes of infectious diseases, antibiotics and immunizations could probably be counted among mans most significant, life-altering discoveries.

However, the most modern techniques in biotechnology owe their existence to the discovery of DNA and the protein products of genes, most importantly, enzymes. The discovery of the techniques essential for gene cloning allowed scientists to manipulate enzyme structure and function for specific purposes. Current scientific methods are more specific than historical techniques, as scientists now directly alter genetic material with atomic precision, using techniques otherwise known as recombinant DNA technology.

As technology advances, the many roles biotech plays in our lives increases. Since George Washington Carver, scientists have been learning how to use biochemicals isolated from plants, to produce chemical products for everyday use around the house, the first "green biotech products".

Since then, biotechnological advances can be found in nearly all sectors of industry. There are, of course, the obvious medical, pharmaceutical and food industries. Biotechnology is being used to determine cause and effect of various diseases and are used in the production of drugs.

The production of foods is enhanced by biotechnological advances that improve crop yields, introduce in-situ insect resistance and provide new ways of food preservation.

Other advances include packaging consisting of biomass plastics, or bioplastics, and built-in bioindicators for detecting contamination.

In the environmental sector, biotech has played a role in remediation of contaminated land, water and air, pest control, treatment of industrial effluents and emissions, and acid mine drainage. Bioremediation and phytoremediation are used to restore brownfields for redevelopment.

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Biotechnology - Biomedical - Industrial Enzymes

Biotechnology,genetic engineering: recombinant DNAEncyclopdia Britannica, Inc.the use of biology to solve problems and make useful products. The most prominent area of biotechnology is the production of therapeutic proteins and other drugs through genetic engineering.

People have been harnessing biological processes to improve their quality of life for some 10,000 years, beginning with the first agricultural communities. Approximately 6,000 years ago, humans began to tap the biological processes of microorganisms in order to make bread, alcoholic beverages, and cheese and to preserve dairy products. But such processes are not what is meant today by biotechnology, a term first widely applied to the molecular and cellular technologies that began to emerge in the 1960s and 70s. A fledgling biotech industry began to coalesce in the mid- to late 1970s, led by Genentech, a pharmaceutical company established in 1976 by Robert A. Swanson and Herbert W. Boyer to commercialize the recombinant DNA technology pioneered by Boyer and Stanley N. Cohen. Early companies such as Genentech, Amgen, Biogen, Cetus, and Genex began by manufacturing genetically engineered substances primarily for medical and environmental uses.

For more than a decade, the biotechnology industry was dominated by recombinant DNA technology, or genetic engineering. This technique consists of splicing the gene for a useful protein (often a human protein) into production cellssuch as yeast, bacteria, or mammalian cells in culturewhich then begin to produce the protein in volume. In the process of splicing a gene into a production cell, a new organism is created. At first, biotechnology investors and researchers were uncertain about whether the courts would permit them to acquire patents on organisms; after all, patents were not allowed on new organisms that happened to be discovered and identified in nature. But, in 1980, the U.S. Supreme Court, in the case of Diamond v. Chakrabarty, resolved the matter by ruling that a live human-made microorganism is patentable subject matter. This decision spawned a wave of new biotechnology firms and the infant industrys first investment boom. In 1982 recombinant insulin became the first product made through genetic engineering to secure approval from the U.S. Food and Drug Administration (FDA). Since then, dozens of genetically engineered protein medications have been commercialized around the world, including recombinant versions of growth hormone, clotting factors, proteins for stimulating the production of red and white blood cells, interferons, and clot-dissolving agents.

In the early years, the main achievement of biotechnology was the ability to produce naturally occurring therapeutic molecules in larger quantities than could be derived from conventional sources such as plasma, animal organs, and human cadavers. Recombinant proteins are also less likely to be contaminated with pathogens or to provoke allergic reactions. Today, biotechnology researchers seek to discover the root molecular causes of disease and to intervene precisely at that level. Sometimes this means producing therapeutic proteins that augment the bodys own supplies or that make up for genetic deficiencies, as in the first generation of biotech medications. (Gene therapyinsertion of genes encoding a needed protein into a patients body or cellsis a related approach.) But the biotechnology industry has also expanded its research into the development of traditional pharmaceuticals and monoclonal antibodies that stop the progress of a disease. Such steps are uncovered through painstaking study of genes (genomics), the proteins that they encode (proteomics), and the larger biological pathways in which they act.

In addition to the tools mentioned above, biotechnology also involves merging biological information with computer technology (bioinformatics), exploring the use of microscopic equipment that can enter the human body (nanotechnology), and possibly applying techniques of stem cell research and cloning to replace dead or defective cells and tissues (regenerative medicine). Companies and academic laboratories integrate these disparate technologies in an effort to analyze downward into molecules and also to synthesize upward from molecular biology toward chemical pathways, tissues, and organs.

In addition to being used in health care, biotechnology has proved helpful in refining industrial processes through the discovery and production of biological enzymes that spark chemical reactions (catalysts); for environmental cleanup, with enzymes that digest contaminants into harmless chemicals and then die after consuming the available food supply; and in agricultural production through genetic engineering.

recombinant DNA technology: genetically modified organism productionEncyclopdia Britannica, Inc.Agricultural applications of biotechnology have proved the most controversial. Some activists and consumer groups have called for bans on genetically modified organisms (GMOs) or for labeling laws to inform consumers of the growing presence of GMOs in the food supply. In the United States, the introduction of GMOs into agriculture began in 1993, when the FDA approved bovine somatotropin (BST), a growth hormone that boosts milk production in dairy cows. The next year, the FDA approved the first genetically modified whole food, a tomato engineered for a longer shelf life. Since then, regulatory approval in the United States, Europe, and elsewhere has been won by dozens of agricultural GMOs, including crops that produce their own pesticides and crops that survive the application of specific herbicides used to kill weeds. Studies by the United Nations, the U.S. National Academy of Sciences, the European Union, the American Medical Association, U.S. regulatory agencies, and other organizations have found GMO foods to be safe, but skeptics contend that it is still too early to judge the long-term health and ecological effects of such crops. In the late 20th and early 21st centuries, the land area planted in genetically modified crops increased dramatically, from 1.7 million hectares (4.2 million acres) in 1996 to 160 million hectares (395 million acres) by 2011.

Overall, the revenues of U.S. and European biotechnology industries roughly doubled over the five-year period from 1996 through 2000. Rapid growth continued into the 21st century, fueled by the introduction of new products, particularly in health care.

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biotechnology | Britannica.com

Biotechnology is the use of biological processes, organisms, or systems to manufacture products intended to improve the quality of human life. The earliest biotechnologists were farmers who developed improved species of plants and animals by cross pollenization or cross breeding. In recent years, biotechnology has expanded in sophistication, scope, and applicability.

The science of biotechnology can be broken down into subdisciplines called red, white, green, and blue. Red biotechnology involves medical processes such as getting organisms to produce new drugs, or using stem cells to regenerate damaged human tissues and perhaps re-grow entire organs. White (also called gray) biotechnology involves industrial processes such as the production of new chemicals or the development of new fuels for vehicles. Green biotechnology applies to agriculture and involves such processes as the development of pest-resistant grains or the accelerated evolution of disease-resistant animals. Blue biotechnology, rarely mentioned, encompasses processes in marine and aquatic environments, such as controlling the proliferation of noxious water-borne organisms.

Biotechnology, like other advanced technologies, has the potential for misuse. Concern about this has led to efforts by some groups to enact legislation restricting or banning certain processes or programs, such as human cloning and embryonic stem-cell research. There is also concern that if biotechnological processes are used by groups with nefarious intent, the end result could be biological warfare.

Also see nanotechnology and genetic engineering .

This was last updated in May 2007

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What is biotechnology? - Definition from WhatIs.com

Hemolysins or haemolysins are lipids and proteins that cause lysis of red blood cells by destroying their cell membrane. Although the lytic activity of some microbe-derived hemolysins on red blood cells may be of great importance for nutrient acquisition, many hemolysins produced by pathogens do not cause significant destruction of red blood cells during infection. Although hemolysins are capable of doing this for red blood cells in vitro.

As mentioned above, most hemolysins are protein compounds, but others are lipids biosurfactants.[1]

Many bacteria produce hemolysins that can be detected in the laboratory. It is now believed that many clinically relevant fungi also produce hemolysins.[2] Hemolysins can be identified by their ability to lyse red blood cells in vitro.

Not only are the erythrocytes affected by hemolysins, but there are also some effects among other blood cells, such as leucocytes (white blood cells). Escherichia coli hemolysin is potentially cytotoxic to monocytes, lymphocytes and macrophages, leading them to autolysis and death.

Visualization of hemolysis (UK: haemolysis) of red blood cells in agar plates facilitates the categorization of Streptococcus.

In the next image we can see the process of hemolysis by a Streptococcus:

One way hemolysin lyses erythrocytes is by forming pores in phospholipid bilayers.[3][4] Other hemolysins lyse erythrocytes by hydrolyzing the phospholipids in the bilayer.

Due to the importance of hemolysins and the formation of pores, this part looks forward to enhance some more aspects of the process. Many hemolysins are pore-forming toxins (PFT), which are able to cause the lysis of erythrocytes, leukocytes, and platelets by producing pores on the cytoplasmic membrane.

But, in which way does this kind of protein carry out this process?

Hemolysin is normally secreted by the bacteria in a water-resoluble way. These monomers diffuse to the target cells and are attached to them by specific receivers. After this is already done, they oligomerize, creating ring-shaped heptamer complexes.[5]

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Hemolysin - Wikipedia, the free encyclopedia

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Biotechnology

At its simplest, biotechnology is technology based on biology - biotechnology harnesses cellular and biomolecular processes to develop technologies and products that help improve our lives and the health of our planet. We have used the biological processes of microorganisms for more than 6,000 years to make useful food products, such as bread and cheese, and to preserve dairy products.

Modern biotechnology provides breakthrough products and technologies to combat debilitating and rare diseases, reduce our environmental footprint, feed the hungry, use less and cleaner energy, and have safer, cleaner and more efficient industrial manufacturing processes.

Currently, there are more than 250 biotechnology health care products and vaccines available to patients, many for previously untreatable diseases. More than 18 million farmers around the world use agricultural biotechnology to increase yields, prevent damage from insects and pests and reduce farming's impact on the environment. And more than 50 biorefineries are being built across North America to test and refine technologies to produce biofuels and chemicals from renewable biomass, which can help reduce greenhouse gas emissions.

Recent advances in biotechnology are helping us prepare for and meet societys most pressing challenges. Here's how:

Biotech is helping toheal the worldby harnessing nature's own toolbox and using our own genetic makeup to heal and guide lines of research by:

Biotech uses biological processes such as fermentation and harnesses biocatalysts such as enzymes, yeast, and other microbes to become microscopic manufacturing plants. Biotech is helping tofuel the worldby:

Biotech improves crop insect resistance, enhances crop herbicide tolerance and facilitates the use of more environmentally sustainable farming practices. Biotech is helping tofeed the worldby:

Source: Healing, Fueling, Feeding: How Biotechnology is Enriching Your Life

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What is Biotechnology? | BIO

Bacteria are the unicellular organisms and cannot be seen with naked eye. There is no particular method of cell division, they simply divide by binary fission in which cell divides into two daughter cells. They do not have proper nucleus within the cell but the genetic material is attached to the cell membrane in an irregular form. They are found everywhere like top of the mountains, rivers, on land and in ice. Bacteria have the property of living in extreme weathers like extreme cold and extreme heat. They are able to live long because they become inactive for a long period of time.

Bacteria play an important role in the environment: Decomposition of Dead/Complex Organic Matter:

Ever imagined the fate of nature with dead matter of animals/plants lying around? Bacteria play a very crucial role of silently getting the nature rid of the dead matter through the decomposition of dead organic matter by the micobes. Bacteria use them as a source of nutrients, and in turn help in recycling the organic compounds trapped in the dead matter. Through this process, other organisms also get benefited, who can use the simpler forms of organic compounds/nutrients released from the dead matter by various bacteria.

Bioremediation by bacteria Bioremediation refers to the process of depletion/degradation of toxic compounds present in the natural environment by living organisms. Bacteria are one of the key players in Bioremediation. For example, oil spills due to oil digging operations or accidents on oil transport channels in the ocean or on the soil, is highly determinant to the healthy environment. Bacteria like Pseudomonas have been well known for the degradation of oil spills on oceans/soils.

Similarly, Contamination of heavy metals in the environment is a major global concern because of their toxicity and

threat to human life and environment. Bacteria like Alcaligenes faecalis (Arsenic),Pseudomonas fluorescens and Enterobacter clocae (Chromium) are well known for heavy metal uptake/compound metabolism. Waste Water Treatment Owing to their characteristics of degrading harmful chemicals and pollutants, bacteria naturally (as well as deliberately used by industries), help in treatment of waste water.

Image source: biologia.laguia2000.com

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Role of Bacteria in Environment - Biotechnology Forums

A disruptive technology that saves lives and improves patient care Main menu Marx Biotechnology is developing a proprietary first-in-class molecular diagnostic kit for the early detection of Graft versus Host Disease (GVHD). GVHD is a life threatening complication of allogeneic (non-self) stem cell transplantation such as bone marrow, peripheral blood or cord blood transplantation

and solid organ transplantations. The cells from the donor react

adversely to the cells in the patient. GVHD affects approximately 50% of all such transplant patients, frequently resulting in death. https://www.youtube.com/watch?v=c_8PcfZSkrI Marx Bios approach has 5 clear advantages:

Incorporated in Jerusalem in January 2011, the Marx Bio team has completed proof of concept in animal studies, has published in a peer reviewed journal, and has filed three patents. It is commencing a Phase 1 clinical trial in humans in Tel Aviv.

Marx Bio has a clear work schedule to deliver a validated and cleared product, ready for market entry within 36 to 48 months. The company is looking for strategic partners to join in that journey.

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Marx Biotechnology A disruptive technology that saves ...