Monthly Archives: July 2022

Smoking, vaping linked to higher risk of severe COVID-19 complications, including death – American Heart Association

Posted: July 27, 2022 at 2:57 am

Researchers used data from the American Heart Associations COVID-19 CVD Registry to determine the impact of smoking or vaping among people hospitalized with COVID-19

DALLAS, July 26, 2022 People who reported smoking or vaping prior to their hospitalization for COVID-19 were more likely than their counterparts who did not smoke or vape to experience severe complications, including death, from the SARS-CoV-2 infection. The findings are from a new study based on data from the American Heart Associations COVID-19 CVD Registry and published in PLOS ONE, a peer-reviewed, open access scientific journal published by the Public Library of Science.

Researchers examined data on people over 18 years of age who were hospitalized with COVID-19 in 107 registry-participating hospitals across the nation between January 2020 to March 2021. Smoking status was self-reported and people were classified as smoking if they reported currently using either traditional, combustible cigarettes or e-cigarette products, with no distinction between the two and no information on duration of smoking or former smoking status. For the final analysis, records were selected for 4,086 people with a 1:2 ratio of people who smoked (1,362) to people who did not smoke (2,724), with the two groups matched for no statistically significant difference in age, sex, race, medical history or medication.

The study findings indicate smoking or vaping are associated with more severe COVID-19 independent of age, sex, race or medical history:

In general, people who smoke or vape tend to have a higher prevalence of other health conditions and risk factors that could play a role in how they are impacted by COVID-19. However, the robust and significant increase in the risk of severe COVID-19 seen in our study, independent of medical history and medication use and particularly among young individuals, underscores the urgent need for extensive public health interventions such as anti-smoking campaigns and increased access to cessation therapy, especially in the age of COVID, said the studys senior author, Aruni Bhatnagar, Ph.D., FAHA, a professor of medicine, biochemistry and molecular biology at the University of Louisville in Louisville, Kentucky. These findings provide the clearest evidence to date that people who smoke or vape have a higher risk of developing severe COVID-19 and dying as a result of SARS-CoV-2 infection.

Bhatnagar is co-director of the American Heart Associations Tobacco Center for Regulatory Science which supported the study in part with funding from the U. S. National Institutes of Health and the Food and Drug Administration research grants.

We established the COVID-19 CVD Registry early on in the pandemic to better understand the link between COVID-19 and cardiovascular disease, specifically, to identify increased risk to help inform the diagnosis and care of people who are at highest risk for complications, said Sandeep R. Das, M.D., M.P.H., M.B.A., FAHA, co-chair of the steering committee for the American Heart Association COVID-19 CVD Registry Powered by Get With The Guidelines and director for Quality and Value in the Cardiology Division at UT Southwestern Medical Center in Dallas, Texas. The findings of this study deliver on that goal and provide invaluable information individuals and their health care teams.

The American Heart Association launched the registry in 2020 to gather data specific to all patients hospitalized with COVID-19 as part of the Get With The Guidelines quality improvement program. Registry participation was offered at no cost to all U.S. hospitals caring for adults with active COVID-19 and with the infrastructure to support accurate data collection. More than 160 hospitals provided data on more than 79,000 patient records between 2020 and June 2022.

The American Heart Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers and the Associations overall financial information are available here.

Additional Resources:

About the American Heart Association

The American Heart Association is a relentless force for a world of longer, healthier lives.We are dedicated to ensuring equitable health in all communities.Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public's health and share lifesaving resources.The Dallas-based organization has been a leading source of health information for nearly a century.Connect with us onheart.org,Facebook,Twitteror by calling 1-800-AHA-USA1.

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For Media Inquiries: 214-706-1173

Cathy Lewis: cathy.lewis@heart.org; 214-706-1324

Michelle Rosenfeld: michelle.rosenfeld@heart.org; 214-706-1099

For Public Inquiries: 1-800-AHA-USA1 (242-8721)

heart.org and stroke.org

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Smoking, vaping linked to higher risk of severe COVID-19 complications, including death - American Heart Association

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Experts still torn on whether you should swab your throat when taking COVID tests – Salon

Posted: July 27, 2022 at 2:57 am

In January 2022, the U.S. Food and Drug Administration (FDA) cautioned the public against a peculiar method for testing oneself COVID-19 tests.

"FACT: When it comes to at-home rapid antigen #COVID19 tests, those swabs are for your nose and not your throat," the agency said Friday.

The anti-throat-swabbing warning came amid the first omicron surge in the United States. The reason? Anecdotal reports surfaced about people who were testing positive for COVID-19 only after they swabbed their throats. (A typical COVID-19 at-home test involves swabbing one's nose exclusively.)

Nearly seven months later, as the country faces yet another surge due to omicron subvariant BA.5, the FDA warning has yet to put an end to this off-label collection method. Anecdotal reports continue to surface on social media regarding symptomatic people who received negative results on an at-home test with nasal swabs, followed by a positive test only after they poked the back of their throat with the long swab instead.

Other countries' health agencies do call for testing one's throat for viral residue. Canadian provinces, including Ontario and Nova Scotia, have updated their recommendations for at-home testing to include swabs of both throat and nose.

"To collect a sample for a rapid antigen test (RATs), users should follow the instructions described in the kit insert," Ontario Health, a government health agency, advises in an information sheet updated in February 2022. "In addition to the collection method option approved by Health Canada (as described in the kit insert), users may choose to perform combined oral and nasal sampling as it may increase test sensitivity." The health agency proceeds to instruct people how to properly collect a sample from one's throat.

The collection method of throat swabbing remains a divisive issue among experts in infectious disease.

Despite the FDA's warning, many Americans are apt to wonder who to believe. Is this a collection method that does indeed "increase test sensitivity," as Ontario Health claims?

The answer depends on who's asked as the collection method of throat swabbing remains a divisive issue among experts in infectious disease.

Nathaniel Hafer, an assistant professor in molecular medicine at University of Massachusetts' Chan Medical School who has researched both at-home antigen tests and polymerase chain reaction (PCR) tests, told Salon he believes it is best for people to follow the instructions of their specific test. In other words, if the test calls for throat swabbing, do it; if not, avoid it.

"I come down on the side that people should really do what's indicated in the test kit itself, which for all kits that are authorized in the U.S., the collection should be from the nose only," Hafer. "I think people should be following the instructions in the kits."

Yet Dr. Amesh Adalja, a senior scholar at the Johns Hopkins Center, disagreed. He told Salon via email he's been "recommending this for months" as in, swabbing one's throat when using an at-home tests "especially when sore throat is a prominent symptom."

As for lab-based PCR tests, Dr. Adalja said he doesn't recommend that physicians swab throats unless the instructions call for that method, which some do. For example, the Rheonix COVID-19 test does involve throat swabs. In other parts of the world, it is more common for PCR tests to be performed using throat swabs.

Going off-instructions could lead to some weird gray areas that raise new questions. For instance, say an individual swabs one's throat when doing an at-home test that doesn't call for throat swabbing and then tests positive. Does that imply the result would be inaccurate?

Hafer said there is some "anecdotal evidence" that the location of the tropisms of SARS-CoV-2 have changed over time with different variants.

"People are speculating that there's just more virus in the throat. I mean, that might be true, but the kits have not been tested for that kind of collection method, and so people might be getting actually true results," Hafer said. "But when people don't use the kids according to the instructions, they're opening the door to not get accurate results and that's both in the positive direction and the negative direction."

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William Schaffner, a professor of infectious diseases at the Vanderbilt University Medical Center, told Salon he believes when a person swabs their throat with an at-home antigen test and they're positive, that means definitively that they are indeed positive no question.

"They've been infected with the virus," Schaffner said. He noted that he thinks people should be following the test's instructions, but he's not surprised that people are swabbing their throats and getting positive test results.

"If you swab the throat, which is way in the back and you can consider that the back of the nose also, we call that the nasopharynx, way back there in the throat this is a virus that does cause sore throats, and indeed it gets down into your chest."

Indeed, as Schaffner pointed out, if the virus is lingering in the cavity where the nose and throat meet that is likely why positive results are appearing after throat swabs.

Notably, most of this adviceis based anecdotal reports. There have not been any scientific papers with peer-reviewed evidence that confirm or deny the efficacy of throat swabbing with at-home tests that don't call for it. One study,published on medRxiv by researchers in Cape Town, South Africa, concluded that saliva swabs were the preferred sample-collection method for detecting omicron infections.

In the meantime, everyday people may take it upon themselves to swab their throats when self-testing. If that yields a positive result, it's time to contact a doctor and isolate from people.

In that scenario, "they should obviously contact their healthcare provider, particularly if they're in a high risk group," Schaffner said.

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The Elite Coup to Kill or Enslave Us: Why Can’t Governments, Legal Actions and Protests Stop Them? – PRESSENZA International News Agency

Posted: July 27, 2022 at 2:56 am

In 2020, under cover of the virus/vaccine narrative, the Global Elite launched its long-planned coup to capture total control of the human population.

Building on a history that dawned with human civilization some 5,000 years ago, and at least 50 years in the final planning, progressive efforts by elites in local, national and now the global context to kill off undesired populations and enslave those left alive are now culminating. See The Final Battle for Humanity: It is Now or Never in the Long War Against Homo Sapiens.

Unfortunately, however, awareness of what is really happening remains extraordinarily low, even among those who are resisting the ongoing destruction of our rights and freedom as well as the rapidly-mounting vaccine death toll. See Terrified of Freedom: Why Most Human Beings Are Embracing the Global Elites Technotyranny.

So let me briefly explain, again, exactly what is happening and why the most popular responses lobbying governments, contesting elections or forming new political parties, legal challenges and protests (in one form or another) by those concerned cannot succeed. And what we must do, if we wish to defeat this coup.

What is Happening?

If one reads the website of the World Economic Forum as well as primary documents produced by that organization, and listens to the organizations key spokespeople, such as Klaus Schwab see Now is the time for a great reset and Yuval Noah Harari see Read Yuval Hararis blistering warning to Davos in full the elite agenda is quite clear.

Under the overall title of the Great Reset, the World Economic Forum has launched a series of deeply interrelated agendas which will impose substantial changes on 200 areas of human life for those left alive.

These interrelated agendas include implementation of the elites eugenics program see The Global Elites Kill and Control Agenda: Destroying Our Food Security along with various programs in relation to the fourth industrial revolution and transhumanism that will deliver them total control of the remaining transhuman population in a world run by technocrats. See Killing Off Humanity: How the Global Elite is using Eugenics and Transhumanism to Shape Our Future.

These programs include efforts to develop and deploy relevant technologies including those in relation to 5G (and, soon enough, 6G), military weapons, artificial intelligence [AI], digital identity, big data, nanotechnology and biotechnology, robotics, the Internet of Things [IoT], the Internet of Bodies [IoB], the Internet of Senses [IoS], quantum computing, surveillance and the metaverse that will subvert human identity, human freedom, human dignity, human volition and/or human privacy. Among other adverse outcomes, these technologies will deprive us of control over our own banking and finances. See Taking Control by Destroying Cash: Beware Cyber Polygon as Part of the Elite Coup.

To reiterate: The net outcome of these programs will be a substantial human depopulation of Earth and the transhuman enslavement and imprisonment of those left alive, primarily in their smart cities.

As Mark Steele concluded in his extensive expert report on 5G Directed Energy Radiation Emissions, The prima facie evidence of this globalist depopulation agenda is unequivocal This is the greatest crime ever to be perpetrated on mankind and all of Gods creation. See Expert Report: Fifth Generation (5G) Directed Energy Radiation Emissions in the context of Nanometal-contaminated Vaccines that include Covid-19 with Graphite Ferrous Oxide Antennas.

Obviously, this is being done without any consultation with those of us who would identify as ordinary people.

Who is Orchestrating This?

The coup has been planned by the Global Elite and its primary agents. It is being implemented through elite control of key international organizations (such as the World Health Organization and United Nations), relevant corporations (including those in the technology, pharmaceutical and media industries) and national governments.

The first point to note is simply this: The Global Elite is too wealthy and powerful to bother participating personally in well-known fora such as the World Economic Forum or even those that are less well-known such as the Council for Inclusive Capitalism. The people who front organizations of this nature are elite agents. Wealthy and powerful, at one level, and happy to be publicly identified, but not the masters shaping our destinies, even if they work out many of the details. For one discussion of this, see What Is The Council For Inclusive Capitalism? Its The New World Order.

But because this Global Elite is both insane and criminal, its members have no concept of what it means to experience ordinary human life, with its daily struggles and occasional triumphs, its routine fears and simple joys. See The Global Elite is Insane Revisited. There is more information in Why Violence? and Fearless Psychology and Fearful Psychology: Principles and Practice.

So let me briefly explain, yet again, why governments, legal challenges and protests in their various guises cannot save us from what is happening, although the elite is delighted to have us waste our energy on such efforts, as they intend.

Constitutions, Governments and the Delusion of Democracy

While so-called democratic processes have long been a sham, even the sham elements of democracies the constitutional separation of powers (the division of the legislative, executive and judicial functions of government supposedly to limit the possibility of arbitrary excesses by government), respect for human rights (including freedom of speech, assembly and movement), obedience of laws and adherence to legal process have been ignored by virtually all governments (national, provincial and local) around the world as measures decided by the elite and promulgated through its international organizations such as the World Economic Forum and the World Health Organization have simply been implemented by governments despite violating constitutional provisions in various ways and without so much as a public (or, in many cases, even a parliamentary) debate.

To reiterate this point more bluntly: given the eminent roles being played by elite organizations such as the World Economic Forum and the World Health Organization in the past two-and-a-half years, do you have much sense that governments are adhering to national constitutions and making independent decisions? Or are they just following orders?

And despite supposedly having the right to freedom of speech, even dissenting politicians attempting to present an alternative view in any mainstream forum, and plenty of progressive ones besides, leads to one of a range of outcomes such as, at their most benign, censorship with corporate and major social media leading the way or howls of accusation such as conspiracy theorist and anti-vaxxer to discredit the dissenting voice.

This has happened, of course, because politicians are not beholden to voters, which is why lobbying politicians is a waste of time, unless the issue is of little significance geopolitically, militarily, economically and environmentally. As implied above, the elite controls the political fate of politicians, most of whom are well aware that their political survival has nothing to do with pleasing ordinary voters. Politicians are beholden to the elite that manipulates levers of power such as the corporate media and education systems, employs an army of lobbyists to ensure that elite preference is clearly understood (while using bribes where necessary), and has ready access to removal options such as, at its most basic, withdrawal of preselection endorsement.

Of course, the ultimate sanction, paid by five national presidents so far in this current context, is assassination. See Five Presidents Who Opposed Covid Vaccines Have Conveniently Died, Been Replaced by Pro-Vaxxers.

And Emanuel Pastreich makes a compelling argument that Shinzo Abe, the powerful immediate-past Prime Minister of Japan, suffered the same fate because of his ongoing resistance to fundamental elements of the Elite agenda. Moreover, there are other key political figures who are probably in this category, not to mention those sidelined rather than assassinated.

Abe was the highest ranking victim so far of the hidden cancer eating away at governance in nation states around the world, an institutional sickness that moves decision making away from national governments to a network of privately-held supercomputer banks, private equity groups, for-hire intelligence firms in Tel Aviv, London and Reston, and the strategic thinkers employed by the billionaires at the World Economic Forum, NATO, the World Bank and other such awesome institutions.

In parallel with the removal or sidelining of non-compliant leaders, elite wealth has long been deployed to create invisible networks for secret global governance, best represented by the World Economic Forums Young Global Leaders program and the Schwarzman Scholars program. These rising figures in policy infiltrate the governments, the industries, and research institutions of nations to make sure that the globalist agenda goes forth unimpeded. See The Assassination of Archduke Shinzo Abe: When the Globalists Crossed the Rubicon.

As a result of formal political submission to the elite agenda, supposedly basic human rights such as freedom of speech, assembly and movement have been eviscerated under the various lockdown, curfew and martial law measures with many people attempting to exercise these rights quickly discovering that they no longer exist except, perhaps, in the very narrowest of circles or in particular contexts.

But perhaps constitutional lawyer John W. Whitehead, in collaboration with Nisha Whitehead, captures the true depth of what has transpired in these two paragraphs about the United States but equally applicable to other countries:

Not only have the federal and state governments unraveled the constitutional fabric of the nation with lockdown mandates that sent the economy into a tailspin and wrought havoc with our liberties, but they have almost persuaded the citizenry to depend on the government for financial handouts, medical intervention, protection and sustenance.

This past year under lockdown was a lesson in many things, but most of all, it was a lesson in how to indoctrinate a populace to love and obey Big Brother. See After a Year Under Lockdown, Will Our Freedoms Survive the Tyranny of COVID-19?

But Big Brother isnt the government. It is those elite figures who are largely, or completely, hidden from public view and about whom you hear nothing of substance, if you hear anything at all.

Still, this doesnt stop their agents, such as those in the Council for Inclusive Capitalism, from telling you what they are doing. Its just that not many people are paying attention.

As noted by Brandon Smith: Members of the CIC, including the head of Bank of America, openly suggest that they dont actually need governments to cooperate in order to meet their goals. They say corporations can implement most social engineering without political aid. In other words, it is the very definition of shadow government A massive corporate cabal that works in tandem to implement social changes without any oversight. See What Is The Council For Inclusive Capitalism? Its The New World Order.

If you still believe that we can get out of this mess by lobbying governments or electing a different political party into government, you can read more on how the world really works in Killing Democracy Once and for All: The Global Elites Coup dtat That Is Destroying Life as We Know It.

Legal Challenges

While the law and legal processes are shrouded in a delusion suggesting that they play a role in making societies just, in fact, it has long been known that elite control of governments ensures that laws are written to consolidate predatory corporate control and that elite control over legal systems ensures that they function to maintain elite power, corporate profit and the personal privilege of that tiny minority that benefits enormously from the global system of violence, exploitation and destruction.

In 1748, Baron de Montesquieu penned The Spirit of Laws in which he noted There is no greater tyranny than that which is perpetrated under the shield of the law and in the name of justice. Since that time, a notable and diverse series of authors starting well over 100 years ago, including Karl Marx, Leo Tolstoy and Mohandas K. Gandhi, have all written critiques exposing the injustice and violence of legal systems. Despite this, the delusion that the law is a neutral agency that delivers justice still widely prevails.

As a result, enormous time, energy and resources are wasted by fine, well-intentioned people who fail to make the distinction between what they have been led to believe and the truth: The legal system is designed to deliver an occasional win for justice in some relatively minor context in order to maintain the widespread popular delusion that justice prevails while functioning to maintain elite social control over the population, oppress exploited constituencies and those who resist, and conceal and defend the vast network of elite and corporate criminality that pervades every facet of planetary life. This delusion is reinforced by films and television programs based on legal settings which often feature the little person winning.

And this is why you have never heard the rallying cry Fight for Justice: Abolish Legal Systems.

If you think the law is really concerned with justice, then ask yourself why poverty and homelessness are not made illegal and those who suffer poverty and homelessness immediately provided with social housing and an adequate income. Of course, this would be easy if military budgets for killing were eliminated (and international conflicts were addressed meaningfully) or the estimated $US32 trillion of illegal wealth hidden in offshore tax havens was made available for the benefit of humanity. See Elite Banking at Your Expense: How Secretive Tax Havens are Used to Steal Your Money.

The bottom line is simple: The Global Elite operates beyond the rule of law. It will not be contained or held to account, in any way, by legal systems. Ever heard of a Rothschild, a Warburg, a Rockefeller or even a Windsor in court? Or organizations like the World Economic Forum and the United Nations?

And while any investigation will quickly reveal that attempts are sometimes made to hold to account a corporation for some illegal activity in a national context, the record also shows that the predominant outcomes in court cases against corporations are protracted legal battles seeking ways out of, or long delays in, being held accountable, fines that are easily written off as a cost of doing business see Pfizers History of Fraud, Corruption, and Using Nigerian Children as Human Guinea Pigs as well as refusal to pay fines and/or retribution against complainants and/or their agents. See How the Environmental Lawyer Who Won a Massive Judgment Against Chevron Lost Everything.

Of course, there is no international legal infrastructure that can hold corporations or international organizations accountable in any meaningful way either.

If you want to read more about this subject, see The Rule of Law: Unjust and Violent.

Demonstrations, Blockades, Convoys and other Mass Mobilizations

If we do not thoroughly analyze a conflict, it is impossible to develop a sound strategy, which includes identifying the appropriate strategic foci for action, and then planning tactics that address each focus. This inevitably means that we are essentially guessing what to do, not knowing in advance, as we should, the nature of the strategic impact the action will have.

Moreover, guessing what action to take, usually on the basis of what is familiar or what feels good perhaps because we get out with a bunch of good people virtually inevitably leads to poor choices like organizing a mass mobilization, in one form or another (whether with people, trucks, tractors), focused on governments. And elite agents love ignoring these, as the long record demonstrates!

As former US Secretary of State Alexander Haig once noted about a massive anti-war demonstration: Let them march all they want, as long as they continue to pay their taxes. See Alexander Haig. As a four-star general, Haig, not regarded as the most intelligent Secretary of State in US history, certainly understood the importance of tactical choice. Most activists have no idea.

Which illustrates why demonstrations are notoriously ineffective, as world historys largest demonstration on 15 February 2003 involving demonstrations in more than 600 cities around the world, involving up to 30,000,000 people, against the imminent US-led war on Iraq see The World Says No to War: Demonstrations against the War on Iraq illustrated yet again.

The point is simple: Single actions and numbers are not determinative; strategy is determinative. Obviously, large gatherings, in whatever form they take, could be effective, if they were strategically focused never on governments though. See Why Activists Fail.

In essence, if any gathering is to have any strategic value whatsoever, it must be used to raise awareness of strategic means of resistance.

So if we want to take action that will be strategically effective, we must identity an appropriate strategic goal for the context and then plan an action that will achieve that goal. Anything else is guesswork. See Nonviolent Action: Why and How it Works.

Resisting the Elite Agenda Effectively

If you have the thoughtful courage to strategically resist the Great Reset and its related agendas, you are welcome to participate in the We Are Human, We Are Free campaign which identifies a list of 30 strategic goals for doing so.

In addition and more simply, you can download a one-page flyer that identifies a short series of crucial nonviolent actions that anyone can take. This flyer, now available in 17 languages (Czech, Danish, Dutch, English, Finnish, French, German, Greek, Hebrew, Hungarian, Italian, Polish, Romanian, Russian, Serbian, Spanish & Slovak) with several more languages in the pipeline, can be downloaded from here: The 7 Days Campaign to Resist the Great Reset.

If strategically resisting the Great Reset (and related agendas) appeals to you, consider joining the We Are Human, We Are Free Telegram group (with a link accessible from the website).

And if you want to organize a mass mobilization in some form, at least make sure that one or more of any team of organizers and/or speakers is responsible for inviting people to participate in this campaign and that some people at the event are designated to hand out the one-page flyer about the campaign.

If you like, you can also watch, share and/or organize to show, a short video about the campaign here: We Are Human, We Are Free video.

Finally, while the timeframe for this to make any difference is now in doubt, if you want to raise children who are powerfully able to investigate, analyze and act, you are welcome to make My Promise to Children.

Conclusion

As the elite is well aware, critiques of what it is doing and advice regarding effective strategy to defeat it are not sought by those who arent interested in analysis, understanding and strategic impact. And this information is easily suppressed so that few of those who might be interested ever hear of it.

Hence, a primary challenge is getting relevant information to those keen to resist in ways that make a difference.

At the moment, virtually all effort being spent by those opposed to the various mandates and restrictions on our freedom and other rights is, strategically-speaking, wasted.

And the time to resist effectively is running out fast.

So I gently encourage all of you resisting to spend some time evaluating what you are doing and consider participating in the alternative offered just above.

If human beings are to have a future worth living, we must take on the Global Elite directly and undermine their power to impose their agenda upon us. No one else can save us.

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The Elite Coup to Kill or Enslave Us: Why Can't Governments, Legal Actions and Protests Stop Them? - PRESSENZA International News Agency

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Transhumanism to humankind’s rescue? A new book claims we face a ‘make or break’ century, so let the technological remake begin – Genetic Literacy…

Posted: July 27, 2022 at 2:56 am

Ageing cured. Death conquered. Work ended. The human brain reverse-engineered by AI. Babies born outside of the womb. Virtual children, non-human partners. The future of humanity could be virtually unrecognisable by the end of the 21st century, according to Elise Bohan and thats if we get the transition right. If we get it wrong, well.

The future is wildly scary, says the young philosopher-macrohistorian-futurist with a smile. I cant lie to you about that. In ten years time its all going to look pretty different, and in another ten years thats a total event horizon for me I think its eminently plausible at that point that the game has changed in some very fundamental way, whether for good or bad.

Bohan, 31, is speaking from a sunny Mosman apartment, where she is house-sitting and looking after the plants. Its a distance away from the Hawkesbury river on the outskirts of Sydney where she grew up; a place with pretty spots but where it was tough to be a smart kid. And it is a half world away from Oxford University where she forms part of the Future of Humanity Institute.

Shes in Sydney seeing family and promoting her new book Future Superhuman: Our Transhuman Lives in a Make-or-Break Century. The subtitle isnt a gambit. I believe that, she says. We are in the century that defines the future of humanity like no other.

Transhumanism is a movement that aims to address or end what Bohan calls the tragedies of reality: ageing, sickness and involuntary death. It is, she writes, a philosophy and a project that aims to make us more than human.

Whether we recognise or understand it, that project has already begun, she says, and it will transform our world and minds and bodies within our lifetimes. Not only is it happening, she says, but this transition is necessary if humanity is to survive in perpetuity.

For Bohan,it is no great to leap to imagine that a baby born in 2030 may have its entire genome mapped at birth, that data uploaded to a central health record and cross-referenced at any medical appointment throughout its life. It is no great stretch to think that AI will become the most powerful intellectual force of the century. That human consciousness might be transferred from our meat sacks (bodies) into a technological sphere. That the rise of AI and automation might render great swathes of human labour redundant, and that maybe if we get it right that could leave more time for leisure, big thinking, meditation, connection.

Experiments are already underway in the realm of artificial wombs, and Bohan is sure when viable women will be clamouring to be freed from the shackles of pregnancy, childbirth and breastfeeding.

The book, she writes, is a love letter to humanity, but hers is a tough love. A love which sees a future for humanity, but not necessarily for human beings as we know it.

When Bohan first encountered transhumanism, at around the age of 21, her first reaction was, Its crazy. Its science fiction. Its so far out. How weird, she says. But also how interesting.

Her brother had bounded down the stairs and insisted they watch the documentary Transcendent Man, about godfather of transhumanismRay Kurzweil. He thought theyd find it hilarious which we did but it introduced Bohan to the idea of rapid acceleration of growth in computer technology, technological singularity (the theoretical point at which the force of technological change becomes out of human control and can shape human civilisation), and the idea that there was a future for humanity beyond what she calls our ape-brained meat sacks.

At the time she was an English literature undergrad, obsessed with poetry and the written word.

It was a point of sadness for me as a young person, recognising that there were so many wonderful things that had already been written forgetting all the things that would be written in the future that I would never live long enough to encounter, to explore, and to put all these things together, she says.

Fiction began to bore her as her interest in transhumanism increased. If fiction was all about exploring the human experience, it became evident that there was a tragic repetition. We work, we learn, we love, we lose, we die, she writes. Transhumanism offered something better.

By the age of 28, she had written the worlds first book-length history of transhumanism for her PhD. Its ironic, she says, to have cleaved to this shes always had an aversion to isms. They have a ring of cult-like fascination to them.

Transhumanism is perhaps best known for preoccupation with achieving human immortality.A deathless life, however, is a confronting concept. As scarcity determines value, does not the fact that our time on earth is finite give that time its value? What exactly is tragic about death?

For me, it is the loss of everything that matters. Its a loss of all things of value, she says.

On the contrary, she says, if humans could go on in a state of robust health, could keep learning, youd have this cumulative effect where our experiences and knowledge would accumulate much faster. The things that our species could do with that! The mysteries of the universe that we could unlock. The problems we could solve. And the depths of each others souls that we could explore.

Souls, she admits, is a loaded word. But without an alternative vocabulary for what makes consciousness, she is not averse to using spiritual language.

Is transhumanism encroaching on domains that religion has traditionally held? I think yes.

When Bohan was a PhD student, she gave her first big paper at a conference. Afterwards, a biologist came up to her and congratulated her on her work.

Then he looked me in the eye and whispered to me: Were building God, you know, she chuckles. I looked back at him and I said: Yeah, I know.

They knew they didnt mean it as religion, she says. But a lot of what has been talked about in religion omniscience, omnipotence, hopefully omni-benevolence we are at least getting closer to that all seeing, all knowing, all exploring [force].

Who controls that force or those forces is, of course, a critical question. The early 21st centurys rapid growth in technology has seen power and wealth accumulate and concentrate among a small number of predominantly white men. A criticism levelled at transhumanists is that they never quite stopped clinging to the sci-fi that fascinated them as young boys.

There is a degree to which many of them probably still are little boy fantasists, says Bohan. But they happen to be very, very clever little boy fantasists who also have engineering degrees and are very capable at building reusable rockets and what have you. I dont think we can dismiss the real tangible, species-advancing projects theyre actually at the helm of.

Regulating technology during this transhuman transition, argues Bohan, is not a good idea.

All things being equal, would I rather a politician or cluster politicians ruling the nuclear powers of the nation states, or would I rather someone with a PhD from MIT whos really really smart and understands the technological systems as best as a human being can? she asks. Id rather it be the tech geek.

But that said, Id rather it not be a human at all. A technological solution to regulation would free decision-making from human biases, short-termism and tribalism if done right, she says. It might not go like that.

The worst case scenario she imagines sounds drawn from the pages of science fiction dystopias. A future where ruling AI does not share the values of human beings, nor value human beings at all.

The best case scenario for the end of the century? Bohan fully expects to still be alive (shed be 110). My honest answer is that I think the best case scenario is that by the end of the century humans are done. But humanity is not done, right? So intelligence goes on, she says.

There is a utopianism associated with that ideal of just being incredibly intelligent, being able to see farther than any intelligent human being has ever seen, to know more, to experience more, to feel more, to discover more.

But this imagining, she has come to believe, is beyond the capacity of most mortals. For them, there are the Cliffs Notes.

I think the comfortable version is: we have really good health care and everyones rich. And theres lots of equality, she laughs.

But, 2100 I dont think thats where were going to be. I think were going to be much farther ahead in the game.

Celina Ribeiro is Guardian Australias assistant editor for features, culture and lifestyle. Find Celina on Twitter @Celina_Ribeiro_

A version of this article was published at the Guardian and is reposted with permission. Find the Guardian on Twitter @Guardian

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Mutants are Coming to the MCU, But Where Does Krakoa Fit In? – Gizmodo

Posted: July 27, 2022 at 2:56 am

Image: Mark Brooks/Marvel Comics

The X-Men and the rest of mutantkind coming to the Marvel Cinematic Universe has been heavily discussed ever since the ink dried on the Disney/Fox buyout back in 2019. During Comic-Con of that same year, Kevin Feige declared that yes, they and the Fantastic Four would be brought into the fold with Spider-Man, the Avengers and the Inhumans various TV characters.

And now that San Diego Comic-Con is this weekendand Marvel Studios is attending for the first time in three yearseveryones got mutants on the brain.

Ask anyone with a passing interest for the X-Men or MCU, and theyve likely got a list of three or more theories for how the mutants will show up. Were they snapped into existence via Thanos or Bruce Banner? Are they being ported over from the multiverse or in a pocket dimension? Will we just start in 2024 with Charles Xavier making an attempt to gather mutants and start from there? These are just some of the more common theories floating around. Theres so many X-Men, and even more mutants generally that in theory, any possibility for how they get introduced is valid. We already know that some will get brought in via other movies or TV shows rather than a proper X-Men film, but the larger mutant race presents a much bigger hurdle than a handful of individuals.

Image: Pepe Larraz/Marvel Comics

Complicating matters further is the state of mutants outside of the films. While the upcoming X-Men 97 series serves as a nice hit of nostalgia, the mutants of the comics are going full steam ahead towards the future. In 2019, Marvel launched House of X, a miniseries by Jonathan Hickman, RB Silva, Pepe Larraz, and Marte Garcia that upended the mutant mythos. The sentient island of Krakoa has become home to nearly all the mutants, While still hated and feared by the larger Marvel universe, mutants are now taking matters into their own hands, and even taking the time to celebrate their greatness. Over the last three years, various comics have delved into mutantkinds unique experiences with magic, transhumanism, religion, and ascension to cosmic prominence.

Mutants living on their own island and just not caring about the outside world is an interesting concept, one with the potential for exciting stories isolated from the various plates spinning during Phase Four. But whats made the mutants taking their destiny (of X) into their own hands so satisfying is that it was the kind of soft reboot the characters needed. Recall that prior to this, Marvel was basically treating the mutants like redheaded stepchildren due to not owning the rights to those characters, leading to the creative decision to underpromote the X-books and gradually kill the species off by way of a war with the Inhumans. And even what that war eventually ran its course, the mutants still had to get beaten down a little bit more before they were allowed to have a utopia and repopulate their people.

Hated and feared is the theme of Marvels mutants, which neither Foxs films nor Marvels comics in the early to mid 2010s knew entirely what to do with. In the comics, this was especially egregious, since superpowered people save the world with a reliable regularity that mutant discrimination feels even sillier. Mutant as metaphor already began to grow tiresome long before 2019, and will feel even more in poor taste now as Marvel tries to make bigger, often uneven grasps at social commentary in their films and TV series. An evolution is required, but to adapt House and do it justice wouldadmittedly require a decent runup so as to feel appropriately triumphant when Krakoa is revealed in its seemingly idyllic splendor.

To us, our X-Men of 2022!Image: Russell Dautermann/Marvel Comics

At Marvel, movies and comics influence each other an equal amount, and the MCU has shown a desire to get considerably stranger now more than it did a decade ago. An island of superpowered people sounds like the right way for these mutants to feel distinct from Foxs batch and avoid just retreading the same ground. Whether Marvel Studios is willing to give that a shot and let the mutants be as weird as theyre purported to be in universe remains to be seen, either this weekend, or at D23 in September.

Want more io9 news? Check out when to expect the latest Marvel and Star Wars releases, whats next for the DC Universe on film and TV, and everything you need to know about House of the Dragon and Lord of the Rings: The Rings of Power.

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Epigenetics Market is Predicted to Hit $6460.5 Million Value by 2030, says P&S Intelligence – PR Newswire UK

Posted: July 27, 2022 at 2:55 am

NEW YORK, July 22, 2022 /PRNewswire/ -- According to the market research report published by P&S Intelligence, the epigenetics market was worth around $1,563.8 million in 2021, which is predicted to touch $6,460.5 million value by 2030, advancing at a 17.1% CAGR between 2021 and 2030. The field of epigenetics involves research on how the environment and behavior affect gene function. It is expected that increasing the usage of epigenetics in non-oncology applications would present a lucrative potential for market expansion.

Moreover, it has long been assumed that epimutations, which are epigenetic changes brought on by epigenetic silencing and hypermethylation, play a role in the development of cancer. Numerous R&D efforts are focusing on epimutations, particularly those related to the activation of oncogenes and the deactivation of tumor suppressor genes.

Get the sample pages of this report at: https://www.psmarketresearch.com/market-analysis/epigenetics-market/report-sample

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Browse detailed report on Epigenetics Market Size, Share, and Demand Forecast Report 2030

For pharmaceutical and biotechnology companies, players in the field of epigenetics have been continually developing a wide range of products. These key players are PerkinElmer Inc., F. Hoffmann-La Roche Ltd., New England Biolabs Inc., QIAGEN N.V., Bio-Rad Laboratories Inc., Active Motif Inc., Abcam plc, Pacific Biosciences of California Inc., Illumina Inc., Merck KGaA, and Thermo Fisher Scientific Inc.

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Generic Drugs Market Analysis and Demand Forecast to 2030

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P&S Intelligence provides market research and consulting services to a vast array of industries across the world. As an enterprising research and consulting company, P&S believes in providing thorough insights on the ever-changing market scenario, to empower companies to make informed decisions and base their business strategies with astuteness. P&S keeps the interest of its clients at heart, which is why the insights we provide are both honest and accurate. Our long list of satisfied clients includes entry-level firms as well as multi-million-dollar businesses and government agencies.

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ORYZON Collaborates with the CMT Research Foundation in the US – Yahoo Finance

Posted: July 27, 2022 at 2:55 am

Oryzon Genomics, S.A.

MADRID and BOSTON, July 26, 2022 (GLOBE NEWSWIRE) -- Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, announced today the start of a preclinical collaboration with the CMT Research Foundation (CMTRF), a U.S.-based patient-led, non-profit organization focused on delivering treatments and cures for Charcot-Marie-Tooth (CMT) disease, to explore Oryzons histone deacetylase 6 (HDAC6) inhibitors.

CMT is a progressive, degenerative disease involving the peripheral nerves. It affects one in 2,500 people (about the same prevalence as multiple sclerosis), including 150,000 Americans and more than 3 million people around the world. It is one of the most prevalent conditions among rare diseases and currently lacks effective treatments or cures. CMT is caused by a variety of genetic mutations. CMT1A is the most prevalent of all, accounting for approximately half of all people with CMT.

HDAC6 inhibitors have been previously described as potentially effective treatments for CMT. Oryzon has recently completed an HDAC6 discovery program leading to the selection of two potential preclinical candidates with promising efficacy, selectivity and safety. Under this collaboration, CMTRF will be financing a series of in vivo tests with Oryzons HDAC6 candidates in a murine model of CMT1A, which reliably recapitulates many of the symptoms of this condition in humans.

Dr. Jordi Xaus, Oryzons CSO, said: CMT is the most promising indication for our HDAC6 precandidates. CMTRF is the perfect ally to explore our compounds in this indication, as it has a strong connection with the CMT patient community, a very experienced Scientific Advisory Board and a strong commitment to finding treatments for CMT. We are delighted to start this collaboration. If the results are positive, our HDAC6 program would be closer to clinical development and to offering hope to CMT patients. This program would become our second epigenetic program in nervous diseases.

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"We are excited to collaborate with Oryzon on this important project," said Cleary Simpson, CEO of the CMT Research Foundation. "HDAC6 inhibitors are promising as potential therapeutics for several forms of CMT, including the most common formCMT1A. With funding from the CMT Research Fountation, Oryzon will be able to rapidly test their newly discovered HDAC6 inhibitors in CMT1A model mice, paving the pathway for further development. People with CMT currently have no effective treatments or cures, and we believe this project has the potential to change that for millions of families.

The CMT Research Foundation (CMTRF) is focused solely on delivering treatments and cures for CMT. Founded by two patients who are driven to expedite drug delivery to people who live with CMT globally, the organization funds research for drug development. The 501(c)(3) federal tax-exempt organization is supported by personal and corporate financial gifts.

About OryzonFounded in 2000 in Barcelona, Spain, Oryzon (ISIN Code: ES0167733015) is a clinical stage biopharmaceutical company considered as the European leader in epigenetics. Oryzon has one of the strongest portfolios in the field, with two LSD1 inhibitors, iadademstat and vafidemstat, in Phase II clinical trials, and other pipeline assets directed against other epigenetic targets. In addition, Oryzon has a strong platform for biomarker identification and target validation for a variety of malignant and neurological diseases. For more information, visit http://www.oryzon.com

FORWARD-LOOKING STATEMENTS This communication contains, or may contain, forward-looking information and statements about Oryzon, including financial projections and estimates and their underlying assumptions, statements regarding plans, objectives and expectations with respect to future operations, capital expenditures, synergies, products and services, and statements regarding future performance. Forward-looking statements are statements that are not historical facts and are generally identified by the words expects, anticipates, believes, intends, estimates and similar expressions. Although Oryzon believes that the expectations reflected in such forward-looking statements are reasonable, investors and holders of Oryzon shares are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Oryzon that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include those discussed or identified in the documents sent by Oryzon to the Spanish Comisin Nacional del Mercado de Valores (CNMV), which are accessible to the public. Forward-looking statements are not guarantees of future performance and have not been reviewed by the auditors of Oryzon. You are cautioned not to place undue reliance on the forward-looking statements, which speak only as of the date they were made. All subsequent oral or written forward-looking statements attributable to Oryzon or any of its members, directors, officers, employees or any persons acting on its behalf are expressly qualified in their entirety by the cautionary statement above. All forward-looking statements included herein are based on information available to Oryzon on the date hereof. Except as required by applicable law, Oryzon does not undertake any obligation to publicly update or revise any forwardlooking statements, whether as a result of new information, future events or otherwise. This press release is not an offer of securities for sale in the United States or any other jurisdiction. Oryzons securities may not be offered or sold in the United States absent registration or an exemption from registration. Any public offering of Oryzons securities to be made in the United States will be made by means of a prospectus that may be obtained from Oryzon or the selling security holder, as applicable, that will contain detailed information about Oryzon and management, as well as financial statements.

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What is schizophrenia? Common myths and misconceptions around the mental illness – The Mirror

Posted: July 27, 2022 at 2:55 am

In England, approximately one adult in every 100 lives with a schizophrenia diagnosis. Despite this, there are several myths and misconceptions surrounding the mental health condition

Image: Getty Images)

Society has evolved in many ways, but certain things continue to remain taboo. Schizophrenia is one mental health condition that's been stigmatised and misunderstood.

Every year on National Schizophrenia Awareness Day, which is marked on July 25, the charity Rethink Mental Illness aims to break the stigma around the diagnosis and raise awareness on what it's like to live with the illness.

Dr John Read , professor in clinical psychology at the University of East London and editor of the scientific journal Psychosis and author of Models of Madness: Psychological, Social and Biological Approaches to Psychosis (Routledge), explains the most common myths and misconceptions around schizophrenia.

Image:

Schizophrenia is a severe long-term mental health condition which causes a range of psychological symptoms.

Some symptoms of the condition including hallucinations - hearing or seeing things that do not exist outside of the mind - delusions, muddled thoughts, disinterest in everyday activities, withdrawing from people and social isolation.

Doctors often describe the illness as a type of psychosis, which means a person may not always be distinguish their own thoughts and ideas from reality.

Image:

Here are six common myths and misconceptions about schizophrenia, according to expert Dr John Read.

There is a common perception that those with schizophrenia have a tendency towards violence. Dr Read explains that having schizophrenia does not make someone more violent than other people.

However, they are more at risk of harming themselves, he says: "It does make them more likely to commit suicide and be the victims of violent crimes."

It's often believed that there is a strong genetic component for schizophrenia. However, Dr Read reveals there's little evidence to back up this theory.

He explains: "Researchers have been looking for "schizophrenic" genes for 50-years. What they should be focussing on is epigenetics, the science of how our social environment turns our genes on and off."

Though a common belief suggests that schizophrenia is not related to adverse events in childhood, many studies have proven otherwise.

Studies show that child abuse and bullying are strongly predictive of psychosis in later life. Dr Reads adds:"Adults diagnosed with schizophrenia have often experienced some form of trauma as a child and or adult."

Having schizophrenia doesn't mean that someone has split personality - that is dissociative identity disorder. Both of these are two different mental health conditions.

Schizophrenia is a form of psychosis, usually characterised by hallucinations and/or delusion and other symptoms of psychosis.

There is no evidence for the theory that schizophrenia is caused by an overactive dopamine system, except for those people who might be on antipsychotic drugs, which can cause overactivity.

In most cases, schizophrenia is caused by adverse life experiences, both in childhood and adulthood.

Schizophrenia is a long-term condition, but it is treatable and many people can recover from the condition - even if they may have relapses of symptoms occasionally - if given proper psychological therapy and social support.

If schizophrenia is well managed, it's even possible to reduce the chance of severe relapses.

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DiPersio receives awards recognizing contributions to cancer care, research Washington University School of Medicine in St. Louis – Washington…

Posted: July 27, 2022 at 2:54 am

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Oncologist honored for outstanding work on leukemia

DiPersio

John F. DiPersio, MD, PhD, the Virginia E. and Sam J. Golman Endowed Professor of Oncology and director of the Division of Oncology at Washington University School of Medicine in St. Louis, has been named by OncLive as part of the Giants of Cancer Care inductee class of 2022.

The Giants of Cancer Care honor recognizes oncologists who have made groundbreaking contributions to research and clinical practice. OncLive is a news and multimedia resource for oncology professionals. DiPersio, one of 14 honored this year, was recognized for his contributions to the understanding and treatment of leukemia.

DiPersio who also serves as deputy director of Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine is a leader in developing novel therapies for leukemia and in understanding how such therapies work. Among other accomplishments, he has developed strategies to optimize CAR-T cell therapies, a type of cell-based immunotherapy that attacks cancer cells. His work also includes improving management of graft-versus-host disease, a sometimes life-threatening condition that some patients develop after a stem cell transplant.

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Virtual integrative medicine consults with Christopher Shapley – DVM 360

Posted: July 27, 2022 at 2:51 am

Telehealth consultations provide a quick and easy way to incorporate integrative medicine modalities

Subscribe to The Vet Blast Podcast on Apple Podcasts, Spotify, or wherever you get your podcasts.

Christopher Shapley, DVM, CVA, joins this episode of The Vet Blast Podcast with Adam Christman, DVM, MBA. Shapley shares plans for a telehealth platform that helps busy clinicians add integrative medicine into their treatment plans with only a quick, virtual consultation.

Below is a partial transcript. Listen to the full podcast for more.

Christopher Shapley, DVM, CVA: We're developing a platform for tele-integrative medicine. So basically, it's for veterinarians to call me...for those clients that want to do integrative medicine. So, they want to integrate herbs into the treatment modality; or they just want to exclusively do herbal medicine; or they've tried everything on the western side and it's time to crack open the eastern side of the medicine.

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