Monthly Archives: June 2022

The two-compartment nanoparticles as seen with structured illumination microscopy. The green compartment contains the immune drug while the red compartment brings the tumor-killer. Credit: Ava Mauser and Nahal Habibi, Lahann Lab, University of Michigan.

A new nanomedicine that crosses the blood-brain barrier, engages the immune system and kills cancer cells may offer hope for treating the most aggressive form of brain cancer, glioblastoma.

With $2.38 million in funding from the National Institutes of Health, the medicine will soon be tested in mice at the University of Michigan.

Led by a nano-engineer and neuro-oncology researchers at U-M, the study is the first to test the two drugs together, packaged so that they can be delivered through the bloodstream rather than a hole in the skull. It builds on previous success eliminating cancer in seven out of eight mice by packaging just the immune drug in the protein that crosses the blood-brain barrier so that it could be delivered intravenously. The five-year survival rate for glioblastoma in humans is about 5%.

The standard of care for glioblastoma is surgery and radiation, and the median survival hasnt improved for several decades. A systemically delivered nanomedicine that can prolong survival and prevent recurrence is the dream, said Maria Castro, the R.C. Schneider Collegiate Professor of Neurosurgery and professor of cell and developmental biology.

Her team leads the mouse studies in collaboration with Pedro Lowenstein, the Richard C. Schneider Collegiate Professor of Neurosurgery and professor of cell and developmental biology.

As the team tests out the nanoparticles timed to release the immune drug followed by a tumor-killing drug, developed and produced by project lead Joerg Lahanns group, one of the key questions is how well the drugs cooperate.

Are they working much better than either drug alone? Thats what were hoping for. Or is it just a small improvementor are they actually competing with each other and making the treatment worse or increasing the side effects? said Lahann, the Wolfgang Pauli Collegiate Professor of Engineering and director of the U-M Biointerfaces Institute.

The advanced nanomedicines are delivered intravenously and combined with radiation therapy, as they would be in a future clinical trial.

To get the nanomedicine from the bloodstream to the brain, Lahanns team packages the drugs in a protein called human serum albumin, which is present in blood and can cross the blood-brain barrier. Once there, the drugs must wake up the immune system to prevent recurrence and death, which frequently follow conventional treatments like surgery, radiation and chemotherapy.

Tumors grow and regrow because cancer cells have ways of suppressing the immune system. The 2020 study and the new grant use a drug that blocks STAT3, a signaling molecule that cancer cells use to tell immune cells not to attack them. This gave the immune system of the mice the ability to identify the cancer cells as targets for destruction.

In a study just out in May, the team used a drug that blocks CXCR4, an immune receptor that receives orders to send killer T-cells away. Blocking CXCR4 helps keep T-cells in the brain, where they do their work of killing brain cancer cells. Three out of five mice survived long term, and all of those survivors cleared new tumors during the recurrence challenge.

While the new grant wont use this drug, the team is interested in a future study exploring whether two immune approaches together might be more effective.

Tumors have a lot of variation, so we need to attack them from many directions, Lowenstein said.

After initial testing of the new two-compartment nanomedicine in lab-grown cell cultures that mimic human tumors and their surroundings, the team will begin testing in mice as the next step toward clinical trials in humans. They will find out how much of the nanomedicine makes it into the brain, how well it fights the cancer, how well it leaves the body and what the side effects are like.

Previous studies suggest that the nanoparticles home in on tumor cells, infiltrating them more often than healthy cells, and one of the goals for this one is to better understand how that works. For nanomedicines to advance into clinical trials as experimental treatments for glioblastoma, we must understand the mechanisms by which they accumulate in tumor and other tissues, said Colin Greineder, U-M assistant professor of emergency medicine, who will lead studies of how the nanomedicine distributes in the body.

More:
$2.38M to test nano-engineered brain cancer treatment in mice - University of Michigan News

Amrita Hospitals announced on Thursday that its new 2,400-bed campus will soon be open to the public in Faridabad in August this year. During the press conference on Thursday, hospital management announced that the new Amrita Hospital is spread across 133 acres of land in Faridabad and it will be the biggest private sector hospital in India.

This would be the second large-scale Amrita Hospital in India after the iconic 1,200-bed Amrita Hospital in Kochi, Kerala, which was established 25 years ago by the Mata Amritanandamayi Math.

The new hospital is located at Sector 88, Faridabad and it will have a total built-up area of 1 crore sq. ft., including a 14-floor-high tower that will encompass the key medical facilities and patient areas. During the press conference, Swami Nijamritananda Puri, Head, Mata Amritanandamayi Math, Delhi announced that the 81 specialties at the hospital will include eight centers of excellence, such as oncology, cardiac sciences, neurosciences, gastro-sciences, renal sciences, bone diseases and trauma, transplants, and mother and child.

The hospital will become operational in stages, with 500 beds opening in August this year. In two years, this number will rise to 750 beds, and further to 1,000 beds in five years. When fully operational, the hospital will have a staff of 10,000 people, including over 800 doctors.

On how the new hospital has incorporated the aspects of pandemic-induced demands, Dr. Sanjeev K Singh, Medical Director, Amrita Hospital, Faridabad told Financial Express.com: We have learned a lot from the pandemic. The construction of the hospital began 5-6 years ago and the learnings from the pandemic also got incorporated along the way. For example, any patient who comes in an emergency gets facilitated in a 40-bed setup. In that set-up, we have a decontaminated area in which anyone who needs to shower will be sent there. We have four negative pressure rooms and if we have any suspected cases of covid or covid-like diseases we can send them to concerned specialists. The mechanism of shifting is also planned and implemented. In all critical care units, there are positive pressure isolation rooms.

The massive facility will also include 534 critical care beds which is the highest in India, the hospital management claims. The hospital campus will also include 64 modular operation theaters, most advanced imaging services, fully automated robotic laboratory, high-precision radiation oncology, most updated nuclear medicine, and state-of-the-art 9 cardiac and interventional cath lab for clinical services. Cutting-edge medical research will be a strong thrust area, with a dedicated research block spread across a 7-floor building totaling 3 lakh sq. ft with exclusive Grade A to D GMP lab with focus on identifying newer diagnostic markers, AI, ML, Bioinformatics etc.

Dr. Singh also told Financial Express.com that they want to integrate all aspects of medical science and bridge the gap between clinicians and scientists.

In Kochi, we have established tissue engineering, a nano-medicine-based cardiac stent, bone growth, and lots more. What we are looking at Faridabad campus is developing something new in stem-cell therapies. We want to create techniques like creating human cells on our own in our GMP labs as generally, we rely on international counterparts for such procedures. Recently, we conducted research in which we found that we can use patient pluripetin stem cells in tumours and it will destroy them. For us, oncology is the big thrust area but other areas will be a focus too. The intent of our research facility will be to make the high-end expensive equipment and treatments cost-effective for the common man. We want to integrate medicine, engineering, biotechnology, and other segments altogether, Dr. Singh told Financial Express.com.

Dr. Singh also said that they have already been awarded the Advanced ICMR Clinical Trial Unit and this will enable them to conduct their trials in the new facility.

Mata Amritanandamayi has allocated a certain amount of seed money to initiate research. On the basis of submitted proposals, things will materialise and start, he added.

Dr. Singh also told Financial Express.com that the new hospital will also be empaneled. There is a process of 3-6 months and then after medical facilities will be available under all panels like ECHS, CGHS and other TPAs, he added.

During the press conference, Dr Singh also informed that the hospital will be among the very few facilities in the country to conduct hand transplants, a specialty pioneered by Amrita Hospital in Kochi. We will also do transplants of liver, kidney, trachea, vocal cords, intestine, heart, lung, pancreas, skin, bone, face and bone marrow, he said.

Training of medical students and doctors will be a strong focus area. The hospital will have state-of-the-art robotics, haptic, surgical-medical simulation centre spread across 4 floors and 1.5 lakh sq. ft area, the biggest such learning & development facility for doctors in the country. The facility will also host a medical college and the countrys biggest allied health sciences campus, he stated.

Moreover, the management also informed that ultra-modern Amrita Hospital at Faridabad would be one of Indias largest green-building healthcare projects with a low carbon footprint. It is an end-to-end paperless facility, with zero waste discharge.

There is also a helipad on the campus for swift transport of patients and a 498-room guest house where attendants accompanying the patients can stay, they said.

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New Amrita Hospital is all set to open in Faridabad in August this year; 2,400-bed facility will become Indias biggest private hospital - The...

The new report by Expert Market Research titled, Global Advanced Functional Materials Market Report and Forecast 2021-2026, gives an in-depth analysis of the globaladvanced functional materials market, assessing the market based on its type, end-use, and major regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analyzing the market based on the SWOT and Porters Five Forces models.

Note 1: For a snapshot of the primary and secondary data of the market (2016-2026), along with business strategies and detailed market segmentation, please click on request sample report. The sample report shall be delivered to you within 24 hours.

Request a free sample copy in PDF or view the reportsummary@https://bityl.co/CaqF

The key highlights of the report include:

Market Overview (2016-2026)

The growth in the global advanced functional materials market is induced by the medical device technology which is advancing at a rapid pace. With increased focus on imaging techniques, implantable devices, and regeneration technologyin medicine, drug delivery industrial equipment, and biomedical engineering, the adoption of advanced functional materials is increasing rapidly, that aims to augment growth of the market. Advanced functional materials supersede conventional materials by having superior characteristics such as durability, toughness, durability, and elasticity. The advanced functional material industry for low carbon emissions applications is anticipated to be driven by rising lightweight vehicles demandcombined with improved fuel efficiency.

Explore the full report with the table ofcontents@https://bityl.co/CaqC

Industry Definition and Major Segments

Usingeffective power and signaltransmission to every object, advanced functional materials serve to minimise total power usage. Thin conductors or interlinks used within advanced functional material-based mini electronics aid in countering signal propagation and power failure concerns associated with large PCBs and thick interconnects.

Based on its types, the market is divided into:

Based on end-use, the market is divided into:

On the basis of region, the market is divided into:

Market Trends

In the years ahead, the manufacturing of lighter weight, handy, and adaptable substrate technological tools will boost adoption ofadvanced functional materials. One of the crucial industry trends in the advanced functional materials marketis the strong market for microelectronics andminiaturisation. The healthcare industry has a huge demand for advanced functional materials. In the industry, nanomaterials are the dominant type of material. The use of nano materials in the nanotechnological sector of the healthcare industry is consistently expanding. Nanomedicine is the use of nanotechnology to diagnose, monitor, deliver drugs, treat, and regulate biological systems. Although, an absence of expansion plans and technological innovation is anticipated to stymie the industrys growth over the forecast period.

Key Market Players

The major players in the market are Morgan Advanced Materials plc, KYOCERA Corporation, Hexcel Corporation, Nanophase Technologies Corporation, KURARAY CO., LTD, Murata Manufacturing Co., Ltd., and Henkel AG & Co. KGaA (OTCMKTS: HENKY), among others. The report covers the market shares, capacities, plant turnarounds, expansions, investments and mergers and acquisitions, among other latest developments of these market players.

About Us:

Expert Market Research is a leading business intelligence firm, providing custom and syndicated market reports along with consultancy services for our clients. We serve a wide client base ranging from Fortune 1000 companies to small and medium enterprises. Our reports cover over 100 industries across established and emerging markets researched by our skilled analysts who track the latest economic, demographic, trade and market data globally.

At Expert Market Research, we tailor our approach according to our clients needs and preferences, providing them with valuable, actionable and up-to-date insights into the market, thus, helping them realize their optimum growth potential. We offer market intelligence across a range of industry verticals which include Pharmaceuticals, Food and Beverage, Technology, Retail, Chemical and Materials, Energy and Mining, Packaging and Agriculture.

Media Contact

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*We at Expert Market Research always thrive to give you the latest information. The numbers in the article are only indicative and may be different from the actual report.

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Global Advanced Functional Materials Market To Be Driven By The Surging Demand From Medical Sector In The Forecast Period Of 2021-2026 Designer Women...