Monthly Archives: June 2022

Monthly information related to total number of voting rights and shares composing the share capital _May 31, 2022.

Posted: June 4, 2022 at 2:45 am

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Monthly information related to total number of voting rights and shares composing the share capital _May 31, 2022.

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Immutep Reports Positive Overall Response Rate in its Phase II Clinical Trial in 1st line NSCLC for PD-L1 All-Comers

Posted: June 4, 2022 at 2:45 am

SYDNEY, AUSTRALIA, June 04, 2022 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), a biotechnology company developing novel LAG-3 related immunotherapy treatments for cancer and autoimmune disease, announces new data from 1st line NSCLC patients (Part A) of the Phase II TACTI-002 trial evaluating Immutep’s lead product candidate, eftilagimod alpha (“efti” or “IMP321”) in combination with MSD’s anti-PD-1 therapy KEYTRUDA® (pembrolizumab) in 114 patients.

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Immutep Reports Positive Overall Response Rate in its Phase II Clinical Trial in 1st line NSCLC for PD-L1 All-Comers

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 Inventiva announces the presentation of a scientific abstract at the 82nd Scientific Sessions of the American Diabetes Association

Posted: June 4, 2022 at 2:45 am

Daix (France), Long Island City (New York, United States), June 3, 2022 – Inventiva (Euronext Paris and Nasdaq: IVA), a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of non-alcoholic steatohepatitis (NASH) and other diseases with significant unmet medical needs, today announced that the abstract “The Pan-PPAR agonist lanifibranor improves nonalcoholic steatohepatitis (NASH) and glycemic control” has been selected for poster presentation during the American Diabetes Association’s 82nd Scientific Sessions taking place on June 3-7, 2022 New Orleans, United States.

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 Inventiva announces the presentation of a scientific abstract at the 82nd Scientific Sessions of the American Diabetes Association

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Freeline Receives Nasdaq Deficiency Notice Regarding Minimum Bid Price Requirement

Posted: June 4, 2022 at 2:45 am

LONDON, June 03, 2022 (GLOBE NEWSWIRE) -- Freeline Therapeutics Holdings plc (Nasdaq: FRLN) (the “Company” or “Freeline”) today disclosed the receipt of a notice (the “Notice”) on May 31, 2022 from the Nasdaq Stock Market LLC (“Nasdaq”) that the Company is not currently in compliance with the $1.00 minimum bid price requirement for continued listing of the Company’s American Depositary Shares (the “ADS”) on the Nasdaq Global Select Market, as set forth in Nasdaq Listing Rule 5450(a)(1) (the “Minimum Bid Price Requirement”). Each Freeline ADS represents one ordinary share with a nominal value of £0.00001. The Notice indicated that, consistent with Nasdaq Listing Rule 5810(c)(3)(A), the Company has 180 days, or until November 28, 2022 (the “Compliance Deadline”), to regain compliance with the Minimum Bid Price Requirement by having the closing bid price of the Company’s ADSs meet or exceed $1.00 per ADS for at least ten consecutive business days.

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Freeline Receives Nasdaq Deficiency Notice Regarding Minimum Bid Price Requirement

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Sutro Biopharma Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

Posted: June 4, 2022 at 2:45 am

SOUTH SAN FRANCISCO, Calif., June 03, 2022 (GLOBE NEWSWIRE) -- Sutro Biopharma, Inc. (“Sutro” or the “Company”) (NASDAQ: STRO), a clinical-stage drug discovery, development and manufacturing company focused on the application of precise protein engineering and rational design to create next-generation cancer therapeutics, today announced that on June 3, 2022, the Compensation Committee of Sutro’s Board of Directors granted 75,000 shares of Sutro Biopharma stock options and 80,000 Restricted Stock Units of Sutro common stock to three new employees. The grants were made as an inducement material to the employees’ acceptance of employment with Sutro and were approved by the Compensation Committee of Sutro’s Board of Directors in accordance with Nasdaq Listing Rule 5635(c)(4).

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Sutro Biopharma Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

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Advaxis, Inc. Announces 1-for-80 Reverse Stock Split

Posted: June 4, 2022 at 2:45 am

MONMOUTH JUNCTION, N.J., June 03, 2022 (GLOBE NEWSWIRE) -- Advaxis, Inc. (OTCQX: ADXS) (the “Company”), a clinical-stage biotechnology company focused on the development and commercialization of immunotherapy products, today announced that it has filed a Certificate of Amendment to the Amended and Restated Certificate of Incorporation of the Company to implement a one-for-80 reverse split of its issued and outstanding common stock (the “Reverse Stock Split”). The Reverse Stock Split will become effective as of 12:00am Eastern Time on June 6, 2022, and the Company’s common stock is expected to begin trading on a split-adjusted basis when the market opens on June 6, 2022.

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Immune Therapeutics, Inc. Announces Expansion of its Board of Directors

Posted: June 4, 2022 at 2:45 am

ORLANDO, Fla, June 03, 2022 (GLOBE NEWSWIRE) -- Immune Therapeutics, Inc. (OTC:BB IMUN), a specialty pharmaceutical company involved in the development, commercialization, distribution and marketing of novel, patented therapies to combat chronic, life-threatening diseases through the activation and modulation of the body’s immune system, today announced that it will expand its Board of Directors from two to five members.

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Miller School Researchers on the Trail to Unraveling Long COVID-19 – Florida Hospital News and Healthcare Report – South Florida Hospital News

Posted: June 4, 2022 at 2:43 am

Long COVID-19 syndrome, in which symptoms last a year or longer beyond infection, impacts about 30 percent of survivors of the coronavirus. It is a multifaceted systemic condition characterized by fatigue, cognitive fog, and often heart, lung and neurological complications.

Lina Shehadeh, Ph.D., professor of medicine in the Interdisciplinary Stem Cell Institute and Division of Cardiology at the University of Miami Miller School of Medicine, received a $1 million grant from the American Heart Association to study long COVID. Recognizing the substantial public health impact and burden of this syndrome, the American Heart Association awarded three-year grants to 10 research programs in the nation with proposals for unraveling long COVIDs etiology and molecular mechanisms.

(l-r) Dr. Leo Tamariz, Dr. Shathiyah Kulandavelu, Dr. Lina Shehadeh, and Dr. Jose Condor

When you have an impact that is systemic not confined to certain organs you think about the circulatory system, since its function affects everything else, Dr. Shehadeh said. We have observed signs that the endothelial function of the blood vessels is abnormal in preclinical models of long COVID. Now, we are working to connect the dots and explain this cascade.

As part of her research, Dr. Shehadeh is using a mouse model and human blood samples to interrogate a chain of events that may account for symptoms seen in people with long COVID. This chain begins with virus-induced lung inflammation and defective cholesterol homeostasis, and ultimately leads to endothelial dysfunction.

The team is investigating evidence that there is an overzealous inflammatory response from the mating of protein spikes on the SARS-CoV-2 virus with low-density lipoprotein receptors (LDLr) on the infected cells. Central to this response is the formation of neutrophil extracellular traps (NETs), which are net-like structures composed of DNA-histone complexes and proteins. These form as the immune system activates an overabundance of neutrophils in the lungs.

While they form as an overreaction to real pathogens like the SARS-CoV-2 virus, they are also complicit in a number of autoimmune diseases, coagulation disorders and thrombus, diabetes, atherosclerosis, vasculitis, sepsis and cancer.

In COVID-19, when these neutrophils are overwhelmed or defeated by the virus, they burst in the lungs, releasing their DNA material [netosis], Dr. Shehadeh explained. From there we think the NETs are carried through the systemic circulation and become stuck and then embedded in the vessel walls in the limbs and in the organs. This would explain the loss of normal homeostasis in the vascular walls and the tendency toward thrombus we see so often in COVID long-haulers.

Dr. Shehadeh is working with Jeffrey Goldberger, M.D., M.B.A., professor of medicine and chief of the Cardiovascular Division, and Leonardo J. Tamariz, M.D., an internist in the COVID-19 Long-haulers Clinic at the Miami Veterans Affairs Healthcare System. Dr. Tamariz is obtaining blood samples and heart and lung MRI images of 150 or so patients from the clinic to sample the neutrophils and check for markers of netosis, while Dr. Goldberger is examining the MRIs and other cardiac readouts to assess visible vessel anomalies.

This ties in with work we have done for years in studying battle fatigue in veterans, which can persist long after they return from the field, Dr. Tamariz said.

Other key team members are Shathiyah Kulandavelu, Ph.D., a junior faculty member at the Interdisciplinary Stem Cell Institute whose expertise is in endothelial function, and Jose Manuel Condor Capcha, Ph.D, a postdoctoral associate who is spearheading the lab work.

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American Diabetes Association Symposium to Bring to Light the Impact of Suicide and Depression on Adolescents with Type 1 Diabetes – PR Newswire

Posted: June 4, 2022 at 2:41 am

Suicide is a leading cause of deathamong young people ages 20 to 24 in the United States, and the risk is even higher in individuals with type 1 diabetes. In fact, up to 7% of deaths in individuals with type 1 diabetes are a result of suicide. However, current screening tools for depression and suicide often miss individuals at risk of suicide and the risk among the type 1 diabetes patient population is greatly underestimated.

The symposium will highlight the work of RESCUE and address solutions for two distinct uncertainties faced by health care providers in the management of people with type 1 diabetes at risk of suicide: how to identify those at risk and the best way to prevent and reduce that risk.

Discussion topics will include:

"Suicide and self-harm are an all-too-common reality for young adults with type 1 diabetes, but it doesn't have to be. With a multi-pronged approach to awareness, education, and identification, we have the opportunity to intervene on the link between suicide and diabetes," said Professor Katharine Barnard-Kelly, PhD., RESCUE Collaborative Community. "With this symposium, it is our hope that we can reach stakeholders with awareness and arm them with messages that can ultimately save a young person's life if adopted in clinical practice and through mental health screenings."

Professor Katharine Barnard-Kelly, PhD and the RESCUE team will present during the symposium, Suicide and Self-InjuryUnveiling and Addressing the Hidden Nightmare in Diabeteson Friday, June 3 from 4:156:15 p.m. CT.

For more information, please contact the ADA Scientific Sessions media team onsite at the Ernest N. Morial Convention Center from June 37 by phone at 504-670-4902, or by email at [emailprotected].

About the ADA's Scientific SessionsThe ADA's 82nd Scientific Sessions, the world's largest scientific meeting focused on diabetes research, prevention, and care, will be a hybrid event held June 37, 2022 at the Ernest N. Morial Convention Center in New Orleans, LA. Leading physicians, scientists, and health care professionals from around the world will unveil cutting-edge research, treatment recommendations, and advances toward a cure for diabetes. We are eager to get back to safely participating in person and networking with colleagues while hearing the latest scientific advances and groundbreaking research presentations. Learn more and register atscientificsessions.diabetes.organd join the Scientific Sessions conversation on social media using #ADA2022.

About the American Diabetes AssociationThe American Diabetes Association (ADA) is the nation's leading voluntary health organization fighting to bend the curve on the diabetes epidemic and help people living with diabetes thrive. For 81 years, the ADA has driven discovery and research to treat, manage, and prevent diabetes while working relentlessly for a cure. Through advocacy, program development, and education we aim to improve the quality of life for the over 133 million Americans living with diabetes or prediabetes. Diabetes has brought us together, what we do next will make us Connected for Life. To learn more or to get involved, visit us atdiabetes.orgor call 1-800-DIABETES (1-800-342-2383). Join the fight with us on Facebook (American Diabetes Association), Spanish Facebook (Asociacin Americana de la Diabetes),LinkedIn (American Diabetes Association), Twitter (@AmDiabetesAssn), andInstagram (@AmDiabetesAssn).

SOURCE American Diabetes Association

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American Diabetes Association Symposium to Bring to Light the Impact of Suicide and Depression on Adolescents with Type 1 Diabetes - PR Newswire

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Can a person pass their CDL if they have type 2 diabetes? – Medical News Today

Posted: June 4, 2022 at 2:41 am

A commercial drivers license (CDL) is a drivers license necessary to operate trucks and drive interstate. Previously, people with diabetes may not have met the criteria to get a CDL. However, while a person needs to meet numerous health requirements, it is possible for those living with diabetes to become truck and bus drivers.

Prior to 2003, there was a ban on trucking for individuals with insulin-treated diabetes, both type 1 and type 2.

In 2003, the Federal Motor Carrier Safety Administration (FMCSA), the agency regulating the trucking industry in the United States, began a system known as the Diabetes Exemption Program. Through this lengthy process, a person with insulin-treated diabetes could obtain an exemption to operate large trucks.

However, in 2018, the FMCSA ended the program. Instead, a person living with diabetes can obtain a Medical Examiners Certificate (MEC), a standard certification other drivers need to provide to confirm they are physically able to operate a commercial vehicle.

An individuals treating clinician completes the assessment form attesting that they have a stable insulin regimen and properly controlled diabetes.

In this article, we discuss how a person with type 2 diabetes can pass their CDL, what it involves, and how long it is valid. We also suggest tips for driving with diabetes.

Following the new ruling by the FMCSA for people living with diabetes in 2018, a person with type 2 diabetes can obtain their CDL.

The new rule reflects modern diabetes management and means there is no longer a blanket exclusion against insulin use.

Previously, it was more difficult for people with insulin-treated diabetes to obtain their CDL. However, the new ruling supports that people with diabetes can safely operate commercial motor vehicles.

According to the new regulations, individuals with type 2 diabetes who do not require insulin only need to follow their state guidelines to obtain and keep a CDL.

If a person with type 2 diabetes requires insulin, they will now only need to obtain a MEC to confirm they have a stable insulin regimen and are able to manage their condition.

Under the new ruling, a listed certified medical examiner (CME) can grant a person with insulin-treated diabetes a MEC for up to 12 months.

To do so, the healthcare professional who manages and prescribes insulin for the person provides the assessment form to the CME. The CME will then determine if the person meets the FMCSAs qualification standards.

These standards include:

The assessment will also detail whether the person has recently experienced a severe hypoglycemic episode or any potential complications due to type 2 diabetes.

The FMCSA estimates that the annual cost to comply with this ruling is $332, which is significantly lower than the cost prior to the 2018 rule change.

The maximum period of medical certification under the new rule is 12 months. This new ruling is applicable in every state and U.S. territory.

To be eligible for the maximum 12 months, an individual needs to be able to provide sufficient evidence that they are able to manage their condition.

This includes being able to provide at least the preceding 3 months of blood glucose self-monitoring records. Without this, a CME may only be able to provide them a 3-month certificate to allow them to collect the necessary records.

Living with diabetes can affect a persons ability to drive, as they need to ensure their blood sugars are at suitable levels and may develop complications that may make it more difficult to drive.

Some tips for driving may include:

For individuals living with type 2 diabetes, it may be advisable to try the following:

Following the new ruling the FMCSA introduced in 2018, it is easier for people with type 2 diabetes to obtain a CDL. Individuals with insulin-treated diabetes need to obtain a MEC to operate commercial motor vehicles.

The FMCSA keeps a registry of CMEs. These healthcare professionals determine whether a driver meets the FMCSAs physical qualification standards to hold a CDL. This certification is valid for 12 months and enables a person to obtain a CDL.

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