Monthly Archives: April 2022

RECELL System Data to be Presented at the American Burn Association Annual Meeting – GlobeNewswire

Posted: April 6, 2022 at 1:53 am

VALENCIA, Calif. and MELBOURNE, Australia, April 04, 2022 (GLOBE NEWSWIRE) -- AVITA Medical, Inc. (NASDAQ: RCEL, ASX: AVH), a regenerative medicine company that is developing and commercializing a technology platform that enables point-of-care autologous skin restoration for multiple unmet needs, announced today that fifteen presentations highlighting the clinical and cost-savings benefits of the RECELL Autologous Cell Harvesting Device (RECELL System) for the treatment of burn wounds will be shared at the American Burn Association (ABA) Annual Meeting. The conference will be held in Las Vegas, April 5-8, and will bring together more than 2,000 multi-disciplinary burn care professionals from across the globe to discuss burn care and the latest research related to burn injuries.

The depth and breadth of the RECELL System data being presented at the American Burn Association Annual Meeting highlights the impact this platform is having on the treatment protocol for burn injuries, said Dr. Mike Perry, Chief Executive Officer of AVITA Medical. Given the substantial and growing body of data supporting the efficacy of the RECELL System for treatment of burn wounds, coupled with the real-world treatment of more than 15,000 patients globally, we look forward to building on this strong track record to expand use of the RECELL System to encompass broader indications, including soft-tissue repair and vitiligo, following the completion of our clinical trials and approval by the FDA.

RECELL System PresentationsIn the U.S., the RECELLSystem is indicated for the treatment of acute thermal burn wounds in patients 18 years of age and older or application in combination with meshed autografting for acute full-thickness thermal burn wounds in pediatric and adult patients. Physician-initiated research beyond the FDA approved indicationis not sponsored by AVITA Medicaland contains independentdata.

The RECELL System is indicated in the U.S. for treatment of acute thermal burns. The frequency of burn-related injuries and the cost of treatment are high. The Centers for Disease Control and Prevention (CDC) reported that 486,000 patients receive emergency medical treatment for burns annually. Burn injuries result in approximately 3,400 deaths each year, the third-leading cause of accidental home injury deaths. Burns covering up to 90 percent of a persons body surface area, once considered fatal injuries, have become survivable with appropriate treatment. Although split-thickness autografts are the current standard treatment, grafting is often associated with significant donor site pain, delayed healing and scarring.

ABOUT AVITA MEDICAL, INC.AVITA Medical is a regenerative medicine company with a technology platform positioned to address unmet medical needs in burns, chronic wounds, and aesthetics indications. AVITA Medicals patented and proprietary collection and application technology provides innovative treatment solutions derived from the regenerative properties of a patients own skin. The medical devices work by preparing a RES REGENERATIVE EPIDERMAL SUSPENSION, an autologous suspension comprised of the patients skin cells necessary to regenerate natural healthy epidermis. This autologous suspension is then sprayed onto the areas of the patient requiring treatment.

AVITA Medicals first U.S. product, the RECELL System, was approved by the U.S. Food and Drug Administration (FDA) in September 2018 and a new ease-of-use design was approved in 2022. The RECELL System is indicated for use in the treatment of acute thermal burns. The RECELL System is used to prepare Spray-On Skin Cells using a small amount of a patients own skin, providing a new way to treat severe burns, while significantly reducing the amount of donor skin required. The RECELL System is designed to be used at the point of care alone or in combination with autografts depending on the depth of the burn injury. Compelling data from randomized, controlled clinical trials conducted at major U.S. burn centers and real-world use in more than 10,000 patients globally reinforce that the RECELL System is a significant advancement over the current standard of care for burn patients and offers benefits in clinical outcomes and cost savings. Healthcare professionals should read the INSTRUCTIONS FOR USE - RECELL Autologous Cell Harvesting Device (https://recellsystem.com/) for a full description of indications for use and important safety information including contraindications, warnings, and precautions.

In international markets, our products are marketed under the RECELL System brand to promote skin healing in a wide range of applications including burns, chronic wounds, and aesthetics. The RECELL System is TGA-registered in Australia and received CE-mark approval in Europe. To learn more, visit http://www.avitamedical.com.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This press release includes forward-looking statements. These forward-looking statements generally can be identified by the use of words such as anticipate, expect, intend, could, may, will, believe, estimate, look forward, forecast, goal, target, project, continue, outlook, guidance, future, other words of similar meaning and the use of future dates. Forward-looking statements in this press release include, but are not limited to, statements concerning, among other things, our ongoing clinical trials and product development activities, regulatory approval of our products, the potential for future growth in our business, and our ability to achieve our key strategic, operational and financial goal. Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Each forward-looking statement contained in this press release is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statement. Applicable risks and uncertainties include, among others, the timing of regulatory approvals of our products; physician acceptance, endorsement, and use of our products; failure to achieve the anticipated benefits from approval of our products; the effect of regulatory actions; product liability claims; risks associated with international operations and expansion; and other business effects, including the effects of industry, economic or political conditions outside of the companys control. Investors should not place considerable reliance on the forward-looking statements contained in this press release. Investors are encouraged to read our publicly available filings for a discussion of these and other risks and uncertainties. The forward-looking statements in this press release speak only as of the date of this release, and we undertake no obligation to update or revise any of these statements.

This press release was authorized by the review committee of AVITA Medical, Inc.

FOR FURTHER INFORMATION:

O.U.S. MediaRudi Michelson Phone +61 (0)3 9620 3333 Mobile +61 (0)411 402 737 rudim@monsoon.com.au

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RECELL System Data to be Presented at the American Burn Association Annual Meeting - GlobeNewswire

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DefenAge 6-Week Perfection Neck Cream Named NewBeauty Award Winner – PR Newswire

Posted: April 6, 2022 at 1:53 am

"The often-neglected area gets some serious TLCfrom DefenAge6-Week Perfection Neck Cream, an intense, treatment-like cream that has the ability to strengthen fragile skin on the neck," states Santa Monica, CA dermatologist Ava Shamban, M.D., in the NewBeauty Magazine inaugural Award article.

Each year, the NewBeauty Awards showcase the most innovative and noteworthy products with the distinct ability to solve beauty's biggest problems. NewBeauty editors and medical experts rigorously test nearly 10,000 products over six months to hand-pick the top performers in beauty.

With 19 clinical studies to support the safety and efficacy of DefenAge's formulas and Age-Repair Defensins, the 6-Week Perfection Neck Creamsignifies a breakthrough in topical skincare for tightening and moisturizing neck skin. Rich moisturization technologies, combined with the unique mechanism of action of DefenAge's exclusive Defensin-molecules, enable a multiplication effect and lead to quickly appearing results for neck skin that looks firmer, smoother, and more even-toned.

A great retinol alternative, the neck cream addresses brightness, improves the visible thickness of the skin, and reduces the appearance of the wrinkles on the neck where aging is often more noticeable.

With an extended clean beauty profile, the 6-Week Perfection Neck Cream does not contain parabens, fragrances, formaldehydes, and phthalates. A leader in clinically clean beauty, DefenAge is the only physician-dispensed brand that makes both claims 'free from animal- and human- derived ingredients.'

"We are thrilled to receive the NewBeauty honor for the third time," shares Nikolay Turovets, Ph.D., CEO of DefenAge. "The NewBeauty Awards are a leading and trusted program in the beauty space and we're privileged to be recognized as skincare technology leaders by NewBeauty editors, physicians, and readers."

Theneck tightening creamretails online on the brand's website,defenage.com, and through dermatologists and aesthetic surgeons, med spas, and other professional aesthetic service providers.

About DefenAge:DefenAge is an American company founded in 2014 by a team of regenerative medicine experts whose anti-aging discovery became the heart and soul of its formulas. DefenAge's products are widely recommended by dermatologists as a high-performing, anti-aging cosmetic skincare for visible skin rejuvenation and as a safe alternative for retinol. DefenAge complies with or exceeds the Clean Beauty standards and its products have never been tested on animals. Honesty, transparency, and excelling in every way possible are the company's standards.

http://www.defenage.com@defenageskincare

CONTACT:KELZ MEDIASheila McCrink[emailprotected] (646) 450-5359 @KELZPR

SOURCE DefenAge

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Penn Researchers Develop Injectable Microtissue to Preserve Muscle Function in Rats with Severed Sciatic Nerves – Penn Medicine

Posted: April 6, 2022 at 1:53 am

A TE-NMI in vitro and reinnervated muscle fiber after delayed nerve repair following TE-NMI excision.

PHILADELPHIA Researchers engineered the first injectable microtissue containing motor and sensory neurons encased in protective tissue, called tissue engineered neuromuscular interfaces (TE-NMIs). The TE-NMI neurons provide a source of axons to muscles in rats who suffered nerve injuries, and babysit the muscles to prevent degeneration and loss of function, while the damaged nerve regrows, according to researchers at the Perelman School of Medicine at the University of Pennsylvania. Their findings were published in Bioactive Materials.

The TE-NMIs are comprised of nerve cells encapsulated in a protective hydrogel, and the entire microenvironment is injected in close proximity to muscles. This ship in a bottle method protects the neurons and increases the likelihood that a greater quantity of axons will connect with the muscle and maintain regenerative pathways.

Researchers severed the sciatic nerve in rats, and injected them with either a TE-NMI or a microtissue without any neurons. In the group that received TE-NMIs, researchers were able to electrically stimulate the nerve stump being babysat by the TE-NMI and record a muscle response up to five months after the tissue was implanted. No muscle response was detected in the control group.

There are hundreds of thousands of patients who undergo surgery to repair nerve injuries every year, and even if a surgeon performs a perfect procedure, they cant make axons regrow faster than about one inch per month. For nerve injuries in the upper arm or upper leg, regeneration could take years; however, the pathway leading to the muscle and the muscle itself will irreparably degenerate after six to 12 months without connections from axons, resulting in permanent loss of motor and sensory function, said senior author D. Kacy Cullen, PhD, an associate professor of Neurosurgery. By increasing the time window for a patients axons to reconnect to muscle, this research has potential to improve the extent of recovery for patients without causing further damage.

For example, patients who suffer from a brachial plexus injury a nerve root avulsion where nerves are pulled away from the spinal cord may regain elbow function, but will likely never regain function of their hand. In these cases, a neurosurgeon would typically split a healthy nerve near the hand, and reroute it to stimulate the hand muscles to restore partial function while the nerve regrows. TE-NMIs would potentially do a more thorough job, without having to damage a patients healthy nerve, researchers suggest.

Working closely with clinicians at Penns Nerve Center, we identified a potential surgical paradigm that would be most helpful to them and their patients, said first author Justin Burrell, PhD, a postdoctoral research fellow in the Department of Neurosurgery and the Institute for Translational Medicine and Therapeutics. Whats more, as we continue to test and reaffirm our findings, we will continue our partnership with the Nerve Center to ensure that our research is providing them with the technology they need to provide the best possible care for patients.

This study was primarily supported by the U.S. Department of Defense (W81XWH-16-1-0796, W81XWH-19-1-0867), the National Institutes of Health (R44-NS108869, TL1-TR001880), and the Department of Veteran Affairs (I01-BX003748).

Editors Note: Dr. Cullen is a co-founder of Axonova Medical, LLC, and Innervace, Inc., which are both University of Pennsylvania (Penn) spinout companies focused on the translation of advanced regenerative therapies to treat nervous system disorders. Dr. Cullens laboratory at Penn receives sponsored research funding from Axonova Medical. Penn and Dr. Cullen each own equity interests in both companies, have received license-related financial consideration and may receive additional financial consideration in the future related to the licensing of certain Penn intellectual property to these companies.

Penn Medicineis one of the worlds leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of theRaymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nations first medical school) and theUniversity of Pennsylvania Health System, which together form a $9.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according toU.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $546 million awarded in the 2021 fiscal year.

The University of Pennsylvania Health Systems patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Centerwhich are recognized as one of the nations top Honor Roll hospitals byU.S. News & World ReportChester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nations first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 52,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2021, Penn Medicine provided more than $619 million to benefit our community.

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Jasper Therapeutics to Present Updated Data on JSP191 Conditioning in SCID Patients at the 2022 Clinical Immunology Society Annual Meeting – Yahoo…

Posted: April 6, 2022 at 1:51 am

Jasper Therapeutics

REDWOOD CITY, Calif., March 31, 2022 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ: JSPR), a biotechnology company focused on hematopoietic cell transplant therapies, today announced that updated data from the Companys ongoing study of JSP191 as single agent conditioning prior to allogeneic hematopoietic stem cell (HSC) re-transplant in patients with severe combined immunodeficiency (SCID) has been accepted for presentation as a late-breaking poster at the 2022 Clinical Immunology Society (CIS) Annual Meeting, to be held in Charlotte, North Carolina from March 31 to April 3, 2022.

Title: Update: Single-Agent Conditioning with Anti-CD117 Antibody JSP191 Shows Donor Engraftment, Nave Lymphocyte Production, and Clinical Benefit in Patients with Severe Combined Immunodeficiency (SCID)Date and Time: Friday, April 1, 2022, 1:00-2:00 p.m. ET

This updated data indicates that JSP191 at 0.6mg/kg can deplete blood stem cells, leading to long-term donor cell engraftment, immune reconstitution which positively affects the clinical status of SCID patients who suffer from poor T cell and negligible B cell immunity because they failed their first transplant, said Wendy Pang, MD, Ph.D., Senior Vice President of Research and Translational Medicine of Jasper Therapeutics. This population of SCID patients is largely without treatment options and rely on supportive therapies like life long IVIG to provide some level of immune protection. JSP191 based conditioning may provide these patients with the best chance of a safe and successful transplant and reconstituted immune system.

CIS attendees are the primary caregivers for the immune deficient patient population, we are pleased to be able to present this data at the 2022 CIS annual meeting, Ronald Martell, CEO of Jasper. We believe that with our successful clinical efforts, we are one step closer, and uniquely positioned to deliver a targeted non-genotoxic conditioning agent to patients with SCID.

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About JSP191

JSP191 is a humanized monoclonal antibody in clinical development as a conditioning agent that blocks stem cell factor receptor signaling leading to clearance of hematopoietic stem cells from bone marrow, creating an empty space for donor or genetically modified transplanted stem cells to engraft. To date, JSP191 has been evaluated in more than 100 healthy volunteers and patients. Three clinical trials for myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), severe combined immunodeficiency (SCID) and Fanconi anemia are currently enrolling. The Company plans a new study of JSP191 as a second-line therapeutic in lower risk MDS patients in 2022 as well as to a pivotal study in MDS/AML transplant in early 2023. Enrollment in additional studies are planned in patients with sickle cell disease, chronic granulomatous disease and GATA2 MDS who are undergoing hematopoietic cell transplantation.

About Jasper Therapeutics

Jasper Therapeutics is a biotechnology company focused on the development of novel curative therapies based on the biology of the hematopoietic stem cell. The company is advancing two potentially groundbreaking programs. JSP191, an anti-CD117 monoclonal antibody, is in clinical development as a conditioning agent that clears hematopoietic stem cells from bone marrow in patients undergoing hematopoietic cell transplantation. It is designed to enable safer and more effective curative allogeneic hematopoietic cell transplants and gene therapies. In parallel, Jasper Therapeutics is advancing its preclinical mRNA engineered hematopoietic stem cell (eHSC) platform, which is designed to overcome key limitations of allogeneic and autologous gene-edited stem cell grafts. Both innovative programs have the potential to transform the field and expand hematopoietic stem cell therapy cures to a greater number of patients with life-threatening cancers, genetic diseases and autoimmune diseases than is possible today. For more information, please visit us at jaspertherapeutics.com.

Forward-Looking Statements

Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements are sometimes accompanied by words such as believe, may, will, estimate, continue, anticipate, intend, expect, should, would, plan, predict, potential, seem, seek, future, outlook and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding the potential long-term benefits of hematopoietic stem cells (HSC) engraftment following targeted single-agent JSP191 conditioning in the treatment of severe combined immunodeficiency (SCID) and Jaspers ability to potentially deliver a targeted non-genotoxic conditioning agent to patients with SCID. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of Jasper and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. Many actual events and circumstances are beyond the control of Jasper. These forward-looking statements are subject to a number of risks and uncertainties, including general economic, political and business conditions; the risk that the potential product candidates that Jasper develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; risks relating to uncertainty regarding the regulatory pathway for Jaspers product candidates; the risk that clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release; the risk that Jasper will be unable to successfully market or gain market acceptance of its product candidates; the risk that Jaspers product candidates may not be beneficial to patients or successfully commercialized; patients willingness to try new therapies and the willingness of physicians to prescribe these therapies; the effects of competition on Jaspers business; the risk that third parties on which Jasper depends for laboratory, clinical development, manufacturing and other critical services will fail to perform satisfactorily; the risk that Jaspers business, operations, clinical development plans and timelines, and supply chain could be adversely affected by the effects of health epidemics, including the ongoing COVID-19 pandemic; the risk that Jasper will be unable to obtain and maintain sufficient intellectual property protection for its investigational products or will infringe the intellectual property protection of others; and other risks and uncertainties indicated from time to time in Jaspers filings with the SEC. If any of these risks materialize or Jaspers assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. While Jasper may elect to update these forward-looking statements at some point in the future, Jasper specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Jaspers assessments of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements.

Contacts:John Mullaly (investors)LifeSci Advisors617-429-3548jmullaly@lifesciadvisors.com

Jeet Mahal (investors)Jasper Therapeutics650-549-1403jmahal@jaspertherapeutics.com

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Jasper Therapeutics to Present Updated Data on JSP191 Conditioning in SCID Patients at the 2022 Clinical Immunology Society Annual Meeting - Yahoo...

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A juicy tomato this summer begins with starting sturdy transplants now. – Vermont Public Radio

Posted: April 6, 2022 at 1:50 am

The wait is over! The time to start tomatoes in our region is here.

If you garden in the Champlain Valley or lower Connecticut River Valley, begin planting tomato seeds indoors now.

If you're in the mountains, give it just one more week or so till mid-April to start them.

And as tomato varieties are nearly endless, if you're starting from seed, try some unusual types this season.

Once you've chosen a few varieties, take the seeds and sow them into two-inch diameter pots filled with potting soil. Place a couple tomato seeds in each pot.

As they germinate, thin them out to just one seedling per pot.

At this point in your seed-prep, you'll need to veer a bit from the usual practice of placing the seedlings to grow in a sunny spot indoors.

Placing your seedlings under grow lights will be a game-changer.

Grow lights placed just a couple of inches above the seedlings will be essential for the seedlings to grow strong and stay small and stocky.

Though tall, leggy seedlings grown on your sunny windowsill can certainly be transplanted into your garden, it might take them longer to catch up.

So to get a small, stocky and fast-growing seedlings, grow lights are the way to go.

Once the seeds begin germinating, keep moving the lights as they grow so they are about two inches above the seedlings.

You can also mimic the natural world by brushing your hand across the new seedlings, almost like you're petting a cat! This motion imitates the wind that would brush against the seedling outdoors.

Once they're about two and a half inches tall, start brushing them with your hand about 10 times once per day.

Doing this practice daily basis helps stimulate the cells on the sides of the stem to get bigger and doing so helps the plants stay shorter and stockier. You can actually reduce the height of your seedlings by about 20%.

Once the seedlings' height is three times the diameter of the container, repot them into a larger container and keep them growing strong, using your brushing technique!

When you're ready to transplant them into your garden or raised bed, you can harden them off by first taking them outside for an hour or so the first day. Then extend that period for about five or six days until you can leave them outside full time.

Hardening the seedling transplants will help prevent any kind of sunscald or stress due to the wind, weather or cold.

Once they are full-time outdoor residents, pop them into the garden soil and you'll be eating tomatoes in the summertime!

A: Try to pull fig tree out of the container and knock off a bunch of the soil. It might mean taking out most of the potting soil to get rid of the any colony.

Then clean the inside of the container with a 10% bleach solution. Once clean, repot the fig with fresh potting soil and hopefully that will keep the ants away.

If you can evict the queen from the colony that has formed in your fig tree container, that will prevent them from coming back and recolonizing.

Virtually any vegetable does well in a grow bag! Grow bags are made from a breathable fleece material and come in bright colors and a variety of sizes.

As the plant's roots get big, they get naturally air-pruned and won't become rootbound in a grow bag.

Another bonus to using grow bags is you can move them as needed into the sunniest spots in your yard.

Then when the season is over, dump out the compost or potting soil, wash the grow bags out if you like, then fold and stack them until next season!

All Things Gardening is powered by you, the listener! Send your gardening questions and conundrums and Charlie may answer them in upcoming episodes. You can also leave a voicemail with your gardening question by calling VPR at (802) 655-9451.

Hear All Things Gardening during Weekend Edition Sunday with VPR host Mary Engisch, Sunday mornings at 9:35.

Have questions, comments or tips?Send us a messageor get in touch by tweeting us@vprnet.

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How Can You Help Patients Use New Diabetes Technologies? | NIDDK – National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Posted: April 6, 2022 at 1:49 am

New technologies can improve diabetes outcomes. Learn how health care professionals can help patients access and use these tools.

Diabetes technologies arent reaching everyone who could potentially benefit. Dr. Tamara K. Oser, a primary care doctor and diabetes researcher, discusses how health care professionals can put diabetes technologies into practice.

Q: What technology tools are available for people with diabetes?

A: Weve seen an expansion in the world of diabetes technologies that, if used the right way, can improve diabetes care. We now have continuous glucose monitors (CGMs), insulin pumps that are increasingly automated, connected insulin pens, and apps. Health care professionals and people with diabetes can use technology in many ways to foster diabetes self-management education and support.

Q: How can new technologies benefit people who have diabetes?

A: More evidence is emerging about the benefits of diabetes technologies. For instance, continuous glucose monitoring is associated with improved clinical, psychosocial, and behavioral outcomes, especially for people who have type 1 diabetes or type 2 diabetes that requires intensive insulin therapy. Evidence is also emerging about the benefits of continuous glucose monitoring for people with type 2 diabetes on basal insulin, and even for people with type 2 diabetes who are not on insulin.

However, just having a technology tool doesnt necessarily improve outcomes. Health care professionals and patients with diabetes also need education about how to use the device, how to engage with the data, and how to communicate with each other about the data. For example, when patients start to use CGMs, health care professionals should ask them how often they want to receive CGM alarms. If you dont have this conversation, patients may get too many alarms and develop alarm fatiguemeaning they no longer respond appropriately to alarmsand stop using the device.

There are also exciting advances in insulin pump therapy, including automated insulin delivery systems and work being done to expand access to these technologies as well.

Q: Are diabetes technologies made available to everyone who could benefit from them?

A: No. One study found that continuous glucose monitoring reached about 30% of people with type 1 diabetes in the T1D Exchange Registry, who mostly received care from endocrinologists at academic medical centers. However, we can assume that continuous glucose monitoring is less common among people who receive care from community medical practices, which is where most Americans receive care. We know that about 50% of adults with type 1 diabetes and 90% of adults with type 2 diabetes receive diabetes care from primary care providers, but most of the studies on diabetes technologies are conducted through endocrinology practices at academic medical centers.

So, there may be a geographic disparity in access to diabetes technologies. Our research team is working on many projects to address that geographic disparity and help implement diabetes technologies in primary care.

Q: Are there other disparities in the use of diabetes technologies? How do social determinants of health affect how people with diabetes access and use technology tools?

A: There are also socioeconomic, racial, and ethnic disparities in the use of diabetes technologies. Compared with the white population, racial and ethnic minority groups have higher rates of diabetes and often have worse diabetes outcomes. Patients from racial and ethnic minority groups and patients of lower socioeconomic status are less likely to be offered diabetes technologies.

However, studies have shown that when these patients are given access to diabetes technologies, they have outcomes that are similar to those of white patients or patients with higher socioeconomic status. At the Federally Qualified Health Center where I care for a large immigrant and refugee population, Ive used CGMs with my patients, and theyve done brilliantly.

One reason for disparities in access to diabetes technologies may be implicit bias that affects which patients are offered diabetes technologies. As health care professionals, we need to address our unconscious biases about which patients may or may not benefit from technologies. Other reasons for disparities include physician shortages and restrictive insurance eligibility criteria.

We have a lot of work to do to address disparities. This is a topic Im very passionate aboutmaking sure certain populations arent left behind as diabetes technologies advance.

Q: What are the barriers to using diabetes technologiesboth for health care professionals and for people with diabetes?

A: Compared with endocrinology practices in academic medical centers, primary care practices and community endocrinology practices have different resources and workflows, and how we implement diabetes technology in each setting will be different.

One way that primary care practices can address limitations, in terms of time and workflow, is to engage the entire health care teamincluding diabetes care and education specialists, clinical pharmacists, health coaches, and patient navigatorsin implementing diabetes technologies. A recent Association of Diabetes Care and Education Specialists technology summit brought together a multidisciplinary group of health care professionals to discuss broadening access to diabetes technologies. I also worked with the American Academy of Family Physicians on a Transformation in Practice Series course that provides a comprehensive approach to implementing continuous glucose monitoring in primary care.

For patients with diabetes, one barrier is lack of access, either because they arent offered diabetes technologies or because they lack insurance coverage for technologies. However, even if patients have access, lack of education and support can be a barrier to using diabetes technologies effectively.

Q: What role can a diabetes care and education specialist (DCES) play in helping people with diabetes overcome barriers to using new technologies?

A: A DCES can serve as a technology champion. Any practice that has a DCES is set up for a much greater likelihood of success. The DCES can partner with the patient and the rest of the health care team to address issues related to diabetes technologies, including

However, our team, in partnership with the American Academy of Family Physicians National Research Network and other practice-based research networks, conducted a national survey of 656 primary care providers, and only 36% had a DCES in their practice, even part time. Because the majority of primary care practices dont have access to that valuable resource, we need to consider how a DCES may be able to support multiple practices through telehealth or other novel ways of providing care.

Q: How can other health care professionals integrate technology into diabetes care?

A: Practices that dont have a DCES might have a pharmacist, a health coach, or a case manager who can serve as a technology champion or work as part of a multidisciplinary team to help integrate technology into diabetes care.

Health care professionals can also tailor their approach. If your primary care practice isnt currently using diabetes technology, you might start by choosing a technology that will be most relevant to your patient population. You can then identify members of your health care team who can help implement diabetes technology with patients.

Also, patients may benefit from a diabetes technology even if they arent able or dont want to use every aspect of the technology. I have patients who don't have a smartphone or dont want to use an app, and they just use a reader for continuous glucose monitoring. The reader captures important metrics that we go over together, and Ive seen huge improvements in diabetes management.

Q: What research is being conducted on the use of diabetes technologies?

A: This is an exciting field, and lots of research is going on right now. My research group is studying ways to implement CGM and automated insulin delivery systems in primary care. Other research groups are conducting a study to compare fingerstick blood glucose monitoring to CGMs in primary care practices. Other studies are looking at insulin dosing algorithms in patients using CGMs or fingerstick blood glucose monitoring in a wide range of practice settings.

Many studies are looking at how to use diabetes technology to help patients with self-management and education. The COVID-19 pandemic has demonstrated the benefits of remote monitoring and alternative care models outside the clinic walls.

How do you help patients with diabetes learn about and use diabetes technologies? Tell us below in the comments.

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Diabetes and hearing loss: Link, treatment, and more – Medical News Today

Posted: April 6, 2022 at 1:49 am

Diabetes is a chronic condition that affects a persons blood glucose levels. While the exact cause is still unclear, people living with diabetes may be at a higher risk of hearing loss. This might be due to high sugar levels potentially causing nerve damage to the inner ear.

Diabetes is a condition that affects blood sugar regulation in the body. This can cause fluctuations in blood glucose, known as hypo- and hyperglycemic episodes.

If a person is unable to maintain their blood sugar levels within a healthy range, this may increase their risk of complications, which could include hearing loss.

The exact relationship between diabetes and hearing loss still remains unclear. However, health experts believe that chronic hyperglycemia, which can raise blood pressure and cause damage to several parts of the body, may damage the blood vessels and inner ear structures, which could lead to hearing loss.

In this article, we look at the link between diabetes and hearing loss and suggest steps people with diabetes can take to protect their hearing.

Evidence suggests that individuals with diabetes are twice as likely to have hearing loss as those without diabetes. According to the Centers for Disease Control and Prevention (CDC), uncontrolled high blood sugar levels may lead to hearing loss.

This is because chronic high blood sugar levels may damage the nerves and small blood vessels in the inner ear. Over time, low blood sugar levels may also affect how nerve signals travel from the inner ear to the brain.

The CDC also states that prediabetes can be a risk for hearing loss. People whose blood sugar levels are elevated may be at a 30% higher risk of hearing loss than those with healthy blood sugar levels.

Health experts do not know the exact cause of hearing loss in individuals with diabetes. However, research suggests that sustained high blood sugar levels could lead to damage in the inner ear.

High blood sugar levels may affect blood supply to the small blood vessels and nerves in the inner ear, resulting in damage and affecting hearing. Nerve damage can occur in both type 1 and type 2 diabetes.

Blood sugar levels outside a healthy range may also affect how nerve signals travel to the brain from the inner ear. This damage can also lead to hearing loss.

Other risk factors for hearing loss may include:

To diagnose hearing loss, a doctor, such as an audiologist, may take a persons medical history and assess any symptoms.

Possible symptoms of hearing loss can include:

A doctor may then carry out a hearing exam. This may include a number of different hearing tests, such as:

A doctor may also test blood glucose levels. An A1C test is a useful tool to help monitor diabetes, as it measures the bodys average blood sugar levels over the past 3 months.

The aim of treatment is to improve peoples hearing and their ability to communicate with others.

The type of hearing loss usually associated with diabetes is sensorineural hearing loss (SNHL). This is a type of hearing loss that occurs due to damage to the inner ear or the nerves between the inner ear and the brain.

Treatment for SNHL may include:

If hearing loss is due to nerve damage from diabetes, treatment will also involve close monitoring of blood sugar levels. This may also include lifestyle changes, such as following a balanced diet and getting regular exercise.

While managing blood sugar may help stop progression, it will not reverse existing damage to hearing.

Keeping blood sugar levels within healthy ranges may help protect hearing and prevent damage to the inner ear and hearing nerves.

The National Institute of Diabetes and Digestive and Kidney Diseases offers the following suggestions to help people with diabetes control their blood sugar levels:

Learn more about managing diabetes here.

It is also important that individuals with diabetes attend a hearing test when they first receive a diabetes diagnosis. It is then advisable that they regularly test their hearing every year.

People can also take other steps to protect their hearing, such as using earplugs or ear defenders around loud noise.

Health experts do not know the exact cause, but evidence points to a relationship between diabetes and hearing loss.

Researchers suggest that blood sugar levels outside of healthy ranges may damage nerves and small blood vessels in the inner ear. Over time, this damage may affect hearing and result in hearing loss.

If people have diabetes or prediabetes, they need to attend regular hearing tests and manage their blood sugar levels. If a person has any symptoms of hearing loss, they should contact a doctor as soon as possible to find out the cause and start any treatment.

Individuals can also attempt to prevent hearing loss by using earplugs around loud noise.

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Diabetes and hearing loss: Link, treatment, and more - Medical News Today

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Diabetes and me: Wrestling with the causes of diabetes – RNZ

Posted: April 6, 2022 at 1:49 am

In Diabetes and Me, RNZ's Megan Whelan shares her journey of learning to live with type 2 diabetes.

It's not a particularly productive question, but it's the one that plagues me: How much is this my own fault?

Photo: 123rf

If I hadn't eaten those cheeseburgers, would I be here? If the sport that spoke to me was marathon running and not yoga, might my pancreas have been in better shape?

I try to resist being that person who talks about my diet all the time because, my God, those people are boring, but I also can't help it. How to best eat for this condition, and the many hours of exercise I do, and how many grams of protein is in an egg (about six) occupies a pretty large part of my brain space.

And so I feel myself turning into a person I would have avoided a few months ago - and asking questions that I know I won't like the answers to.

To get some good answers, I spoke to Dr Jeremy Krebs, an endocrinologist. Endocrinology is the specialty of "glands and hormones" and diabetes is one of the areas endocrinologists study. He did a doctorate at the UK's prestigious Cambridge University investigating obesity, and he's now a consultant in Wellington, and researches nutrition, obesity and diabetes. So, a very good person to talk to, and - I promise, I wasn't trying to get some free medical advice.

Here's our conversation (edited for length and clarity, and to cut a massive discussion about exercise, which is a whole other column).

RNZ Head of Content Megan Whelan. Photo: RNZ / Rebekah Parsons-King

Megan: I think prior to my diagnosis, if someone had said "hormones" to me, I probably would have thought of progesterone and estrogen and maybe cortisol if I was having a good day. But there are so many, and they're so important, right?

Jeremy: The key one here is obviously insulin and that comes from the pancreas. But when you're thinking about type 2 diabetes, there are many, many different organs and hormones that are involved in the process, and there are many many different versions of it. And so not everybody with type 2 diabetes is the same, whereas type 1 diabetes, which is fundamentally about the failure of the beta cells in the pancreas because of an autoimmune process, is a much more homogeneous condition.

And that's partly what makes type 2 diabetes such a harder beast for people to get their head around. And I mean people in the broader sense, both people with diabetes, but also health professionals and people trying to, you know, find solutions and help and support because there's no one size fits all.

Megan: So, then, what is type 2 diabetes?

Jeremy: The simple version is that diabetes, by definition, is an increase in blood glucose, or blood sugar.

Blood sugar is controlled by two key hormones, the most important being insulin and the other being its counterpart or its counter-hormone, glucagon. The balance of glucose in the body is determined by how good your pancreas is at making insulin, and secondly, how good your tissues are (your liver and your muscle and other tissues in your body) - how good they are at responding to insulin and taking up and storing and using glucose.

So there's two main sides to the equation and type 2 diabetes is where you get a problem, usually on both sides of the equation, but one may dominate the other. So what I mean by that is, if your body becomes resistant to the action of insulin, which is something we generally see as people gain weight, then your pancreas can respond to that by simply pumping out more and more insulin. And it does. [It] does that incredibly well.

But there comes a point where the pancreas says 'bugger, this, I've had enough of that I'm going on strike,' and that's when it can't keep up with that demand. And that's when your blood sugar starts going up.

There's a researcher by the name of Defronzo, who coined a phrase called the ominous octet. It incorporates all of these sorts of ideas that we're talking about: the various hormones that are involved, but it also incorporates ideas of physical activity or inactivity, and then the other key thing which we haven't touched on yet, which is genetics and the role of family history and genes in terms of who might develop diabetes.

So we often think about some of these risk factors in terms of what is modifiable and what's not modifiable, and clearly your genes are not modifiable. There are modifiable things which can influence ... your chance of getting diabetes or your journey with diabetes.

Megan: In my journey I've kind of been swinging wildly between 'you're such a piece of shit, this is your own fault. You absolutely should have known that this was going to happen', it's in my family, I had allowed myself to become inactive, and I have a really stressful job and would come home every night and get takeaways because it's easier than cooking. I look back now and think 'how the hell did you let it get like this?'

And I guess one of the reasons I want to do this whole column is so someone like you can say "well, because you're a human being and that's what happens and it's not your own fault," but also it kind of is my own fault and maybe the ominous octet is a really nice way to do it. Maybe there's bits of it that were my own fault and bits of it that aren't my fault?

Endocrinologist, professor Jeremy Krebs. Photo: Otago University Wellington

Jeremy: There is no question that there are things we have conscious control over and that we can influence, but there's a heck of a lot we don't. Appetite is an incredibly subtle thing. How does anyone maintain a vaguely constant weight in the world that we live in? It's a miracle, frankly.

When we're bombarded with readily available - I used to say cheap, but that's changing - calorie dense, cleverly marketed food that appeals to the palate (because people understand what our tastebuds respond to) and a physical environment that has become less and less demanding for us to do things.

Megan: By doing this column, I'm gonna get some emails that are really, really nasty. What's the best response to those people who will say you should regret every cheeseburger you have eaten?

Jeremy: In a clinical environment that's very much where I start to talk about the genetic side of this and the subtleties of the influence of genes on our appetite regulation. Of course, those people will simply say, 'well, everyone says that, everyone hides behind that, but at end of the day, you know it's still [that] you're still sticking it in your mouth'.

And as you said there are bits of truth to some of that. I wish I hadn't had that 4th glass of red wine last night, but I did. And I had to spend an extra half hour on the treadmill this morning because of it.

But people who would hide behind those sorts of emails to you are lying to themselves, frankly, if they don't think they're not human, and aren't fallible to some of those choices.

Everyone makes choices they know retrospectively weren't the best choices. God, we're human.

Megan: I was doing my grocery order last night and a cauliflower was $7.50 and I thought to myself 'that's a happy meal, that's a combo at a fast food restaurant.' I'm incredibly lucky. I earn a decent amount of money. I don't have kids, so I have disposable income. I can spend $7.50 to buy a cauliflower, but lots of people can't, and that has to be really difficult.

Jeremy: There's no question about it. I was reviewing a paper last night from a group in Auckland and one of the key determinants of both developing diabetes, but also outcomes of diabetes, that overrode ethnicity was deprivation (and we know that ethnicities are a really important factor, which is largely driven by genetics).

You can know till the cows come home what you should be buying in the supermarket. But if the prices keep doing what they're doing at the moment, then you know we're all going to be buying white bread.

Megan: I am aware I am going to anger some people when I ask this, but I watched a talk of yours, and you had a graph of the overwhelming correlation between obesity and type 2 diabetes. And I wonder if there's a disconnect between what we want to believe about weight and what's actually true.

Jeremy: You're right, you will anger a lot of people by that. But there are some truths that you just have to accept. And unfortunately excess fat mass is not healthy. In a number of ways, not just metabolically, in terms of joints, in terms of the hormones of fertility, there's a whole range of stuff.

But turning that into self-blame and self-loathing is not going to achieve anything or help anybody. So if you have to frame it in a way that a person can still live with themselves and make some change which is taking them in a healthier direction, then I'm totally on board with that.

But where you have to be careful is where someone hides behind that and denies some of the harder effects.

Megan: If I had been honest with myself, I knew I wasn't healthy - that is no fault of the people who talk about this, and the really important activism that's happening in that space. But I think the people who think this is all my own fault might miss a point, which is that every experience I've ever had with a GP was negative because of my size. And so of course, I didn't look after myself [by getting help when I need it] because I would have to go to see my GP, who would weigh me and say something and that [made me] felt like shit.

Jeremy: Yep, it's not in any way supporting you.

Megan: So how do we bridge that gap between wanting to help people and not making them feel awful for needing help.

Jeremy: I think in the last 20-plus years of doing this there will be people that I have met that I've tried to help where I've got it right and it's helped them and there will be people where I've tried to help and for whatever reason for that person, I've got it badly wrong and they've gone away hating me because for whatever reasons we didn't quite manage to get that balance, that connection. It's tricky. It's very emotive.

***

Dr Krebs tells a story that many people will recognise. He was overweight, and a child poked him in the stomach, and said "you're fat". For him, that was the trigger to start running and losing weight.

It feels comforting to me that at least one doctor understands that feeling. I have countless stories like that. Like the time a woman walked past me in the supermarket carpark and said "see, that's why we don't buy chocolate biscuits. You don't want to end up like that." As I type this, I can feel the shame that pricked my cheeks, the tears I fought back that someone could be so casually cruel. But it certainly didn't make me want to don my leggings and hit the treadmill.

The question I want to ask isn't "is it my fault?" It isn't the "is being fat unhealthy" that I asked Dr Krebs, because I couldn't, in the moment, articulate what I meant. It's, did I get diabetes because I am fat, or because my fatness meant I couldn't access the care I needed that would have helped me avoid getting it?

That's a question that's much bigger than me, but it's one worth asking - and I am going to keep asking it in this column.

Diabetes and me will be a weekly column on Wednesday mornings.

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Diabetes and me: Wrestling with the causes of diabetes - RNZ

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First case of infection from diabetes medication in India – The Hindu

Posted: April 6, 2022 at 1:49 am

State drug controllers told to include warning for patients using SGLT2 inhibitors

State drug controllers told to include warning for patients using SGLT2 inhibitors

After the U.S. and Canada, India too has admitted incidence of a rare but serious infection of the genitals and area around the genitals among Type-2 diabetes patients using sodium-glucose cotransporter-2 (SGLT2) inhibitors .

This serious rare infection, called necrotizing fasciitis of the perineum, is also referred to as Fourniers gangrene.

As a precautionary measure the Central Drugs Standard Control Organization (CDSCO) has requested all State Drug Controllers to direct the manufacturers of SGLT2 inhibitor class drugs named Canagliflozin, Dapagliflozin, Empagliflozin, under their jurisdiction to include warnings in the package insert and promotional literature of these drugs.

The Health Ministry, responding to a question on the adverse reaction to the anti-diabetes medicine by MP P. Velusamy, submitted the information recently.

Sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase IV (DPP-IV) inhibitors are recommended as preferred add-on oral anti-diabetic drugs (OADs) after metformin among type-2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and chronic kidney disease (CKD). They are generally many times costlier than other OADs, note experts.

The Ministry submitted in Parliament that CDSCO was notified about a Health Canada communication to all those authorised to market sodium-glucose co-transporter-2 (SGLT2) inhibitors regarding a summary safety review (SSR) on the potential risk of pancreas inflammation (acute and chronic).

United States Food and Drug Administration (USFDA) in its drug safety communications (DSC) has cautioned about cases of rare but serious infection of the genitals and area around the genitals bring reported with use of SGLT2 inhibitors.

This serious rare infection, called necrotizing fasciitis of the perineum, is also referred to as Fourniers gangrene. USFDA has revised the labels of SGLT 2 inhibitors to include new warnings about the risk to patients, noted the Ministry.

It added that the issue was examined in consultation with Subject Expert Committee (SEC) of CDSCO and information available under the Pharmacovigilance Programme of India (PvPI) has also been obtained.

Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar), which leads over time to serious damage to the heart, blood vessels, eyes, kidneys and nerves. The most common is type-2 diabetes, usually in adults, which occurs when the body becomes resistant to insulin or doesnt make enough insulin. In the past three decades the prevalence of type-2 diabetes has risen dramatically in countries of all income levels, according to the World Health Organisation.

Union Health Minister Dr. Mansukh Mandaviya had stated in Parliament that while the exact number of patients suffering from diabetes in India is not known, however, as per 10th edition of Diabetes Atlas 2021 of International Diabetes Federation (IDF), the estimated number of patients with diabetes between the age group of 20-79 years is 74.2 millions in year 2021 and it is estimated to be increased to 124.8 millions in year 2045.

Continued here:
First case of infection from diabetes medication in India - The Hindu

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Around the Diabetes Online Community in March 2022 – Healthline

Posted: April 6, 2022 at 1:49 am

The diabetes social media sphere has been active as ever this past month, from recognizing international conflict to learning to fine-tune our insulin doses.

Heres our monthly roundup of posts that caught our eye throughout March 2022, in no particular order.

March marked Womens History Month, and we were honored to share this tribute to a host of women whove made an incredible impact on the Diabetes Community through the years.

With the continuing attack on Ukraine, our Diabetes Online Community (DOC) has extended the grassroots #SpareARose campaign through March to raise an impressive amount of money to help those with diabetes in that part of the world. The nonprofit org Beyond Type 1 also has this great resource listing ways to help.

People with diabetes often feel like were under pressure with the demands of daily life alongside handling this condition. This fun Instagram post touches on that topic, as advocate Kylie talks about her life with a lesser-known type of diabetes and how demanding it can be for her. Sure, were told to not strive for perfection, but its easier said than done right?!

We couldnt help but smile at our friend Mila Clarke, who shared on Instagram a recent win of nailing her insulin pre-bolus before a meal. For those on multiple daily injections (MDI) or even using an insulin pump, this is a challenge that so often leaves us missing the mark. Way to go, Mila! (btw: Make sure to turn your volume on, to hear the perfectly-fitting sound choice Mila used to mark the moment).

Tom Karlya over at Diabetes Dad had a great post marking the history of diabetes treatments and advocacy, honoring those whove paved the way and helped shape the community and world of diabetes through the years.

Actor Noah AK, who starred in Star Trek: Discovery with his wife Mary Wiseman, launched a successful crowdfunding campaign during the month, raising money for a new type 1 diabetes-themed movie that envisions the apocalypse, while addressing the important issue of insulin affordability. Many people donating were from the Star Trek community, as well as the #insulin4all movement online. You can read more about his plans on the Kickstarter campaign page.

It wouldnt be March without the madness of college basketball, and keeping with that theme are our friends at Integrated Diabetes Services whove created their own brackets with a diabetes spin. Who do you think will make it to the Sweet Sixteen, Elite Eight, Final Four, and get to the top spot in our D-Community?

The Juicebox Podcast featured an eye-opening episodein which host D-Dad Scott Benner delves into a controversial topic: being a stripper or sex worker who also happens to have type 1 diabetes. This may not be for everyone, but its a worthwhile listen.

Life with diabetes can be everything from frustrating, challenging, adventure-like, or easy-to-handle no big deal all in the same day. We loved this latest post from Molly Johannes at Hugging the Cactus, about a recent rookie mistake that she made in managing her own long-term diabetes. No matter how many years one lives with the big D, it seems were always facing new issues that can make it a bumpy ride.

*We share our favorites each month, and DiabetesMine would love to hear from you via email or on Facebook, Instagram or Twitter.*

Originally posted here:
Around the Diabetes Online Community in March 2022 - Healthline

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