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Monthly Archives: March 2022
Global In-situ Hybridization Markets Report 2022-2026 – Increasing Research on Application of ISH in infectious Disease Diagnostics to Drive Growth -…
Posted: March 25, 2022 at 2:32 am
DUBLIN, March 24, 2022 /PRNewswire/ -- The "In situ Hybridization - Global Market Trajectory & Analytics" report has been added to ResearchAndMarkets.com's offering.
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Global In Situ Hybridization (ISH) Market to Reach $1.1 Billion by 2026
Global market for In Situ Hybridization (ISH) estimated at US$846.6 Million in the year 2020, is projected to reach a revised size of US$1.1 Billion by 2026, growing at a CAGR of 5.8% over the analysis period.
The process involved in in situ hybridization is subjecting the cells to some kind of stress to denature the DNA, followed by incubation of the cells containing the denatured DNA in a solution containing labeled probes or sequences whose position on the chromosome is to be determined. In-situ hybridization helps in the precise localization of a specific nucleic acid segment in a histologic specimen.
Fluorescence In Situ Hybridization (FISH), one of the segments analyzed in the report, is projected to grow at a 5.6% CAGR to reach US$885.4 Million by the end of the analysis period. After a thorough analysis of the business implications of the pandemic and its induced economic crisis, growth in the Chromogenic In Situ Hybridization (cish) segment is readjusted to a revised 6.2% CAGR for the next 7-year period. This segment currently accounts for a 28.6% share of the global In Situ Hybridization (ISH) market.
The U.S. Market is Estimated at $361 Million in 2021, While China is Forecast to Reach $79.5 Million by 2026
The In Situ Hybridization (ISH) market in the U.S. is estimated at US$361 Million in the year 2021. The country currently accounts for a 41.52% share in the global market. China, the world second largest economy, is forecast to reach an estimated market size of US$79.5 Million in the year 2026 trailing a CAGR of 7.1% through the analysis period.
Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 5% and 5.5% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 5.6% CAGR while Rest of European market (as defined in the study) will reach US$85.7 Million by the end of the analysis period.
The market is poised to post healthy growth over the coming years, driven by various favorable factors steering market expansion. Increasing incidence of cancer and genetic abnormalities, need for rapid disease diagnosis through genetic techniques, as well as higher funding (both public and private) leading to introduction of highly advanced cytogenetic techniques and their broadening applications are some of the key factors poised to contribute to future growth.
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Significant rise in target patient population across the world, and rising preference for CGH in clinical diagnosis, is expected to drive the market further, providing players with lucrative opportunities.
Growing awareness levels of genetic disorders and expanding pool of research laboratories would be beneficial for cytogenetics solutions. Rise in incidence of cancer and the subsequent demand for personalized medicine, is likely to enhance market prospects in a major way.
Key Topics Covered:
I. METHODOLOGY
II. EXECUTIVE SUMMARY
1. MARKET OVERVIEW
Influencer Market Insights
Impact of Covid-19 and a Looming Global Recession
Clinical Diagnostics: Challenges and Opportunities Amid the Pandemic
Research Efforts Underway for Using ISH in COVID-19 Detection
ISH in Molecular Detection of COVID-19 Causing SARS-CoV-2
Immuno RNA Fluorescence ISH for Visualization of COVID-19 Causing SARS-CoV-2
French Research Team Develops CoronaFISH
In Situ Hybridization: A Prelude
Future Prospects Remain Favorable for Insitu Hybridization
Chromogenic ISH: Gaining Over FISH
FISH Technology Continues to Find Favor
How is FISH Better than Conventional Techniques?
Probe Types and Application
Fluorescent In Situ Hybridization Emerges as Cytological Tool of Choice for Plethora of Scientific Applications
Recent Market Activity
World Brands
2. FOCUS ON SELECT PLAYERS (Total 38 Featured)
Abbott Laboratories
Abnova Corporation
Advanced Cell Diagnostics, Inc.
Agilent Technologies Inc
Bio SB
Biocare Medical, LLC
BioGenex Laboratories
Bio-Techne Corporation
Genemed Biotechnologies, Inc.
Leica Biosystems Nussloch GmbH
Thermo Fisher Scientific
Merck KGaA
Oxford Gene Technologies
PerkinElmer Inc.
3. MARKET TRENDS & DRIVERS
Rising Incidence of Cancer Drives the Demand for In-situ Hybridization
Diverse Applications of FISH Technology in Oncology
Growing Demand for Targeted Therapies in Cancer Treatment Presents Lucrative Opportunities
Growing Number of Genetic Disorders and Emphasis on Genetic Testing Bodes Well for the Growth of ISH Market
List of Genetic Disorders by Event, Genetic Manifestation and Prevalence
Top Ten Genetic Diseases Worldwide
Rise in Prenatal Testing Drives Opportunities
FISH in Detection of Prenatal Genetic Abnormalities
In Situ Hybridization Advances Present Perfect Tools to Detect Genetic Anomalies
Uptrend in Companion Diagnostics Market Augurs Well
Companion Diagnostics Lead the Way to Personalized Medicine
State-Sponsored Molecular Research Initiatives Bode Well for Market Growth
Increasing Research on Application of ISH in infectious Disease Diagnostics to Drive Growth
FISH in Detection of Microbiological Pathogens
Growth in In-vitro Diagnostics (IVD) for Diagnosis of Chronic Diseases Promise Opportunities
High Demand for IVD Devices Promises Opportunities for FISH Probes
Rising R&D Investments in the Biotech Sector Drives Gains
Emergence of Automated Diagnostic Kits
Novel Approach of Highly-Multiplexed FISH for In-Situ Genomics
Technology Advancements & Improvements Bolster Growth
Rise in Healthcare Expenditure to Drive Growth
Ageing Demographics to Drive Demand
4. GLOBAL MARKET PERSPECTIVE
III. REGIONAL MARKET ANALYSIS
IV. COMPETITION
For more information about this report visit https://www.researchandmarkets.com/r/1lbes0
Media Contact:
Research and Markets Laura Wood, Senior Manager press@researchandmarkets.com
For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900
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Rheumatoid Arthritis Linked to Development of Glaucoma – MD Magazine
Posted: March 25, 2022 at 2:31 am
The relationship between rheumatoid arthritis (RA), the most prevalent autoimmune disease, and the risk of developing primary open-angle glaucoma (POAG) invites further investigation. While there's evidence that's indicated autoimmunity may be associated with neurodegeneration in glaucoma, evidence linking these 2 conditions is scarce.
A team of investigators, led by Seung Hoon Kim, MD, JD, Department of Preventative Medicine, Yonsei University College of Medicine, perfomed a cohort study to determine if rheumatoid arthritis is associated with increased risk of primary open-angle glaucoma among older, Korean adults.
At the conclusion of the cohort study, with hazard ratios ranging from 1.44-2.12, the results suggest that adults with rheumatoid arthritis are at a higher risk of subsequently developing glaucoma. Investigators believe in the possibility of a common pathophysiological pathway between RA and POAG that could be immune mediated and warrants further examination.
To analyze the association between these conditions, investigators conducted a nationwide propensity-matched cohort study with data from the Korean National Health Insurance Service-Senior cohort from 2002-2013. The data analysis occurred from November 2020-July 2021.
Development of primary open-angle glaucoma was the main outcome. The cumulative incidence of POAG was calculated using the Kaplan-Meier method, and its incidence rate was estimated with a Poisson regression. The association between rheumatoid arthritis and risk of POAG was examined through a Cox proportional hazards regression model.
Among the 10,245 patients, 2049 patients with seropositive rheumatoid arthritis, and 8196 time-dependent, propensity score-matched, risk-set controls were included. Most of the population was women (73.1%) and the mean age was 67.7 years.
Investigators reported that the cumulative incidence of primary open-angle glaucoma was higher among patients in the rheumatoid arhtritis group, which had a total of 86 patients develop glaucoma by the conclusion of the study. The group displayed an incidence rate of 981.8 cases of glaucoma per 100,000 person years (95% CI, 794.3-1213.7 cases per 100,000 person years).
The control group had 254 cases of glaucoma with an incidence rate of 679.5 cases per 100,000 person years (95% CI, 600.8-768.3 cases per 100000 person years). These findings led investigators to conclude that patients with RA were more likely to experience subsequent glaucoma compared with those without RA (hazard ratio [HR], 1.44; 95% CI, 1.13-1.84).
Risk of primary open-angle glaucoma was especially increased among patients with rheumatoid arthritis 2 years into the follow-up period (HR, 1.83; 95% CI, 1.28-2.61), and among patients who were 75 years of age or older (HR, 2.12; 95% CI, 1.34-3.35).
"These findings suggest that RA is associated with a higher risk of developing POAG, especially within 2 years after diagnosis or among patients aged 75 years or older," investigators wrote. "There may be a common pathophysiological pathway between RA and POAG that is possibly immune mediated, and the nature of this association warrants further investigation."
The article, "Development of Open-Angle Glaucoma in Adults With Seropositive Rheumatoid Arthritis in Korea" was published in JAMA.
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Doing This After Age 60 is Unhealthy, Say Physicians Eat This Not That – Eat This, Not That
Posted: March 25, 2022 at 2:31 am
Your 60s can be a great decade filled with many active and productive years, but making the right lifestyle choices is key to staying healthy. As you get older, facing health concerns is a reality, but practicing positive changes can help maintain good health mentally and physically. Eat This, Not That! Health spoke with experts who revealed their tips for staying in shape after 60 and explained what bad behaviors can lead to poor health. Read onand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.
Dr. Taylor Graber, an MD Anesthesiologist and owner of ASAP IVs says, "As we get older, our levels of energy decrease, including metabolic precursors to energy production (ATP) like NAD+. As these energy levels decrease, there can be a natural tendency to decrease levels of physical activity and live a more sedentary lifestyle. These can include exercising and being outside less. It is important to fight these urges as we get older and continue activities. These have several benefits including social interaction, physical fitness and improving cardiovascular health, and even decreasing age related declines in bone density and strength. This simple fact, of continuing to go for walks, low intensity weightlifting, golfing, tennis, and others, can improve Vitamin D exposure and help to preserve overall health. Stay active! Aim for 30-60 minutes of activity per day."
RELATED: Here's How to Stop Aging, Say Experts
Dr. Seema Bonney, the founder and medical director of the Anti-Aging & Longevity Center of Philadelphia says, "It's important to manage weight, blood pressure, cholesterol, and to engage in appropriate preventative screenings."
RELATED: If You Notice This on Your Body Have Your Heart Checked
"Maintaining a nutrient rich diet is critical as we age," says Dr. Bonney. "Food is medicine and thus properly fueling our bodies will provide energy, boost immunity, enrich bone, eye, and vascular health, reduce inflammation, help prevent chronic health conditions, and support weight management. It is never too late to make changes to your diet. Conversely, a diet high in sugars, unhealthy fats, processed and packaged foods contributes to poor health and can be a huge factor in the onset of chronic disease, cognitive decline, and inflammation."
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According to Dr. Bonney, "A sedentary lifestyle accelerates aging, age-related diseases and may diminish life expectancy. Exercise has been proven to help prevent heart disease and type 2 diabetes. Exercise boosts immunity, improves mood and more. Even light exercise such as walking, can be a powerful and preventative tool for disease management. There is a correlation between exercise and cognitive health. Regular moderate-intensity exercise can help improve your thinking and memory. It stimulates physiological changes such as reductions in insulin resistance and inflammation. Exercise also encourages production of growth factors, which affect the growth of new blood cells in the brain. Exercise can improve mood and sleep and thereby decrease stress and anxiety. We encourage our patients to get curious about their daily movement, track their steps, experiment with new types of exercise, and make it fun. This is a critical part of their longevity plan."6254a4d1642c605c54bf1cab17d50f1e
RELATED: If You Notice This on Your Body, Have Your Arms Checked
Dr. Bonney explains, "Social isolation can create a serious risk for future cognitive decline and emotional distress. In one study it was reported that 1/3 of adults over age 45 feel lonely and of adults over age 65 are socially isolated. This isolation may stem from living alone, loss of family/friends, loss of connection through retirement, chronic illness and more. The health risks associated with less social connection: less physical activity, increased risk of dementia, greater risk of heart disease, emotional distress such as depression and anxiety. Generally, people with healthy and supportive relationships live longer. People are generally happier, engaged and mentally sharper through meaningful interactions with others. We are social beings. Connection with family, friends, group, volunteer work, neighbors, church etc. We as physicians need to be sure to address social isolation as it can have a detrimental effect on overall health and wellbeing and certainly be a factor in disease and aging."
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Dr. Bonney says, "Everyone ages differently and lifestyle plays a major role in the changes that one may experience. Many people will notice physical changes such as; skin fragility, achy joints particularly if inactive, slower metabolism, changes to your vision/hearing, and sex-related hormones decline, but sex can be better than ever with less distractions and more time. Emotionally people in their 60's tend to be happier, they are more resilient to stress, being more experienced. With age comes an improved ability to regulate emotions. The growth of new brain cells continues well into your 60's, however memory can start to fade. You can continue to improve brain health by getting regular mental stimulation, social interaction, and physical activity."
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"Your 60's are a big decade, many times involving transition from work to retirement, giving you more time to focus on you, your health, your family, your passions and travel," says Dr. Bonney. "Optimizing your health and creating a longevity plan prior to your 60's will serve as a foundation for a decade of experiences and freedom. Nutrition, social connection, physical activity, preventative medicine, sleep and stress management will pave the way for your 60's and beyond." And to protect your life and the lives of others, don't visit any of these 35 Places You're Most Likely to Catch COVID.
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MN Zoo: Putin the tiger dies after heart fails during medical procedure – St. Paul Pioneer Press
Posted: March 25, 2022 at 2:31 am
A tiger died on Wednesday during a medical procedure, the Minnesota Zoo announced Thursday.
Its with heavy hearts that we share that on Wednesday, during a routine medical procedure, the Zoos 12-year-old male Amur tiger experienced cardiac failure, a news release states. Despite heroic emergency efforts of veterinarians, animal health technicians and zookeepers, he did not survive.
This is a profound loss.
Amur tigers, historically known as Siberian tigers, are native to the Russian Far East and neighboring areas of China. The name change reflects a portion of its current wild habitat range along the Amur River, according to the Minnesota Zoo. The Amur tiger is an endangered species, with fewer than 500 believed to remain in the wild. There are approximately 103 of these tigers in accredited zoos. The median life expectancy for tigers, both in the wild and in zoos, is approximately 14 to 16, according to the Association of Zoos & Aquariums (AZA).
Of this tigers origins, the Minnesota Zoo says that he was born at a zoo in the Czech Republic in 2009, where he was given the name Putin. He spent his first six years at a zoo in Denmark before coming to the Minnesota Zoo in Apple Valley in 2015 via Delta Airlines.
More recently, in light of the Russian invasion of Ukraine, the tigers name was a talking point since its assumed he is named after Russian president Vladimir Putin.
It is common practice to maintain the given names of adult animals that come from other zoological institutions because the animals have a history of responding to names during daily training sessions, said Zach Nugent, a zoo spokesman, in an email. Training is used to encourage recall, response, and voluntary participation in day-to-day care, enrichment activities and medical procedures. In light of recent global events, the Zoo team had discussed a change to his name but had not done so yet as he was responsive to his name and it is an important part of his training, welfare and care.
Back in 2015, Putin was brought to the Minnesota Zoo as a recommendation of the Amur Tiger Global Species Management Plan.
His genetically important legacy lives on as he has sired multiple cubs, including one born in 2017 at the Minnesota Zoo, the Minnesota Zoo said in its statement.
That cub, Vera, was born on April 26, 2017, to Sundari, an Amur tiger who had also been born at the Minnesota Zoo, in 2012. Sundari, now 9 years old, still lives at the Minnesota Zoo, while Vera was transferred to Omahas zoo in Nebraska in 2019.
Putin was considered one of the most genetically valuable Amur tigers in a North American breeding program, according to the news release about Veras birth.
It was in part because of that role thatPutin was undergoing a preventative health exam that included the collection of samples to assist with breeding efforts at the recommendation of the Association of Zoos and Aquariums (AZA) Amur Tiger Species Survival Plan.
So what happened?
This was a routine procedure that is a vital part of our care and conservation work for tigers, said Dr. Taylor Yaw, the Minnesota Zoos Chief of Animal Care, Health and Conservation, in the statement. We plan weeks ahead for these types of exams. All necessary precautions were taken, and the team did everything within their power to save this animal.
A full medical and animal care team was present throughout the entire procedure at the Zoo, Nugent said. It was led by four board-certified specialists in zoological medicine including a veterinarian certified in both zoological medicine and emergency and critical care medicine; in addition, there were animal health technicians and the animal care team on hand.
The team worked tirelessly for more than an hour administering CPR, Nugent said, but despite their rescue efforts, cardiac ultrasound revealed the left-side of the heart was no longer functional.
A necropsy, another term for autopsy, is being conducted at the Veterinary Diagnostic Lab at the University of Minnesota, according to the Minnesota Zoo.
Well continue to learn more in the days and months ahead, Yaw said in the statement.
Meanwhile, those who knew Putin are grieving.
Today is an incredibly hard day for all of us at the Minnesota Zoo and we will be mourning for quite some time, said Minnesota Zoo Director John Frawley in the statement. Our Zoo has played a key role in global tiger conservation throughout our history and we currently are co-leaders of the Tiger Conservation Campaign, which has raised millions of dollars for tiger conservation. While this loss is great, we can be proud of our efforts past, present, and future to advance tiger conservation worldwide.
Info: Learn more about the Tiger Conservation Campaign, co-led by the Minnesota Zoo, at Support.mnzoo.org/tigercampaign.
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Veteran Healthcare Executive and Reimbursement Expert Joins InterVenn Biosciences Board of Advisors – Yahoo Finance
Posted: March 25, 2022 at 2:31 am
SAN FRANCISCO, March 24, 2022--(BUSINESS WIRE)--InterVenn Biosciences, a clinical technology company leveraging AI-powered glycoproteomics to transform the future of healthcare, today announced that James Almas, MD, has joined the companys Board of Advisors. Dr. Almas, who is VP & National Medical Director of Clinical Effectiveness at Laboratory Corporation of America Holding (Labcorp), is advising InterVenn on reimbursement strategy, health economics, coding, and other foundational activities required for commercialization of novel diagnostic tests for the clinical market.
Dr. Almas is a board-certified pathologist with years of experience in hospitals, independent laboratories, and Centers for Medicare & Medicaid Services (CMS). He recently served as Medical Director of the Molecular Diagnostic Services Program (MolDX) program at Palmetto GBA, one of the nation's largest providers of high-volume claims and transaction processing, contact center operations and technical services to the federal governments Medicare program. Dr. Almas oversaw coverage and reimbursement through the program for 28 states for Medicare.
Prior to that service, Dr. Almas was a medical officer in the Coverage and Analysis Group at CMS. At CMS, he was responsible for the National Coverage Determinations in the area of laboratories and was involved with the parallel review process (with the US Food and Drug Administration) for the Foundation Medicine application. Dr. Almas also previously served as the College of American Pathologists/American Medical Associations Current Procedural Terminology (CPT) - Advisor to the CPT Editorial Panel.
"Dr. Almas is an industry reimbursement expert with a long track record and extensive experience that will be extremely valuable to InterVenn and will and help to accelerate the preparation of the suite of innovative glycoproteomics-based tests we are bringing to market," said Aldo Carrascoso, CEO of InterVenn. "Were very pleased to have Dr. Almas join our prestigious Board of Advisors, as we gear up for the next phase of our commercialization efforts."
"Im excited to join InterVenns Board of Advisors and to have the opportunity to work with the companys leadership team to help advance its glycoproteomics solutions for clinical decision support across the treatment continuum," said Dr. Almas. "InterVenns tools and technologies have the potential to transform healthcare by earlier detection of disease, significantly better predictive capabilities, and reduction of costs for providers and payors."
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InterVenn has developed the worlds first technology platform to interrogate and decode the glycoproteome which will help accelerate the shift from the healthcare industrys traditional focus on disease management to the new realm of preventive care and health management. InterVenn is using its perspectIV platform to create a robust pipeline of accessible, clinically validated tests and diagnostic applications that are designed to provide novel, accurate insights to improve patient outcomes.
About InterVenn Biosciences
InterVenn Biosciences is a clinical technology company leveraging AI-powered software to unlock the value of glycoproteomics to develop transformational healthcare solutions. The glycoproteome is a source of life-critical information about human biology that has the potential to significantly improve patient outcomes, but which has remained inaccessible due to its vast complexity. InterVenn is pioneering a new AI-powered platform to decode and unlock the potential of the glycoproteome for the first time in history. To optimize this entirely new layer of biology, the company has developed a platform, leveraged directly or through collaborations with its partners, capable of producing a robust pipeline of powerful clinical applications, ranging from early disease screening, diagnostics and disease/therapy monitoig tools to the discovery of novel drug targets and therapeutics. InterVenn will ultimately transform the concept of personalized, predictive, and preventative care into a tangible, patient-centered reality. For more information, visit http://www.intervenn.com.
View source version on businesswire.com: https://www.businesswire.com/news/home/20220324005382/en/
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Anthony PetrucciBioscribeanthony@bioscribe.com 512-581-5442
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American College of Osteopathic Family Physicians Honors Outstanding Members of the Profession – Digital Journal
Posted: March 25, 2022 at 2:31 am
ARLINGTON HEIGHTS, Ill. March 21, 2022 (Newswire.com)
TheAmerican College of Osteopathic Family Physicians (ACOFP), theACOFP Education and Research Foundation and theAuxiliary to the ACOFP recognized 2022 award winners at the ACOFP 59th Annual Convention & Scientific Seminars, March 17-20.
ACOFP award recipients include:
In addition, ACOFP bestowed Master Preceptor Awards on:
Finally, as part of the OFP Editorial Awards, ACOFP recognized Adel Elnashar, OMS-IV, and Zachary Lodato, OMS-III, as Student Authors of the Year for their article, Adult Hearing Loss: Applying the Five Models of Osteopathic Medicine to Diagnose and Treat; Justin Chin, DO, who was awarded Resident Paper of the Year for Perceptions of the Osteopathic Profession in New York Citys Korean Communities; and Jack Italiano III, DO, RT (R), and Adam Bitterman, DO, FAAOS, who were awarded Attending Paper of the Year for Heel Pain With an Osteopathic Component.
The ACOFP Education & Research Foundation honored Ravin Patel, DO, with the Sander A. Kushner, DO, FACOFP Memorial Osteopathic Family Medicine Resident Award, as well as the Namey/Burnett Preventative Medicine Writing Award winners, which include:
The Auxiliary to the ACOFP recognized Lissie Arndt, PhD, OMS-IV, as the Marie Wiseman Outstanding Osteopathic Student of the Year. Kensley Grant, OMS-II; Evan Starr, OMS-II; and Mereze Visagie, OMS-II, received the Emerging Osteopathic Student Leader Awards. Fourteen other osteopathic medical students were honored with the Osteopathic Family Medicine Student Awards.
*****
About the American College of Osteopathic Family Physicians
Founded in 1950, the American College of Osteopathic Family Physicians (ACOFP) is a community of more than 18,000 current and future family physicians that champions osteopathic principles and supports its members by providing resources such as education, networking and advocacy, while putting patients first. ACOFP empowers its members with education and resources that allow them to adapt to new models of care and quickly changing government policy. For more information, visitwww.acofp.org.
About the ACOFP Education & Research Foundation
Founded in 1986, the ACOFP Education & Research Foundation promotes osteopathic family physician leadership, strives to improve public health and advocates for greater awareness of osteopathic family medicine principles and practices. Dedicated to furthering members goals and ensuring the future of tomorrows osteopathic leaders, the ACOFP Foundation achieves its objectives by identifying and securing funds from various sources.For more information, visitacofpfoundation.org.
About the Auxiliary to the ACOFP
Spouses and significant others of osteopathic physicians formed the Auxiliary to the ACOFP, promoting and supporting public health and educational activities in national and community health endeavors.For more information, visitacofp.org/auxiliary.
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Patient counseling in regard to e-cigarettes and erectile dysfunction – Urology Times
Posted: March 25, 2022 at 2:31 am
The association of e-cigarettes, or vaping, with erectile dysfunction is another reason for urologists to advise their patients on quitting all types of tobacco use. But how can urologists get the message through to their patients when smoking is highly addictive, and oftentimes, patients misrepresent their true smoking status?
In this interview, Omar El Shahawy, MD, MPH, PhD, discusses patient counseling in regard to e-cigarette use or vaping by using data from a recent study on evaluating the association of e-cigarette use and erectile dysfunction.1 He stresses the importance of maintaining a non-judgmental outlook as a clinician and working with patients to set goals for ultimately reaching the goal of complete tobacco and nicotine cessation. Dr. El Shahawy is an assistant professor in the department of population health, and affiliated faculty in the division of global health at the New York University School of Global Public Health in New York City, New York.
My research focus is evaluating the risk and benefits of alternative tobacco products on health, in the context of smoking cessation and smoking harm reduction. While there is abundant evidence that smoking cigarettes impacts health overall, particularly with erectile dysfunction for adult men, there are [also] several [other] causes for erectile dysfunction, like cardiovascular disease, hypertension, [or] psychological distress. Tobacco use is a major cause for that as well, and there is evidence for adose response relationship. The more you smoke, then the more prone you are to experience or report having erectile dysfunction. Now with e-cigarette use being on the rise among adult smokers [who are] using it [to try] to reduce the harms of smoking or trying to quit, my co-authors and I tried to better understand whether there is a connection between e-cigarette use and erectile dysfunction. Particularly, this is important now because the e-cigarettes that are available in the market are quite efficient in delivering nicotine. Actually, some of the e-cigarettes available in the market deliver way higher nicotine than what's in combustible cigarettes at this point. So, we thought that it's imperative to try to understand what the impact of using e-cigarettes could be on a population level. And for that, we decided to do this study.
We decided to use a national dataset representing the whole United States, which is a very big strength for the study in comparison to using data from a clinical setting because it's subject to some biases. The notable finding [was] that using e-cigarettes on a daily basis posed a risk for erectile dysfunction. [Using e-cigarettes, but particualry on daily basis] was associated with more than doubling the risk of reporting erectile dysfunction. We did a lot of different types of analyses, looking at what we call sensitivity analysis in survey studies to [determine] whether there [were differences] by excluding people who've had cardiovascular disease, for example, from the sample, limiting only for patients under 65 and so forth. All different types of analysis [revealed] findings [that] were very robust, and the association was maintained throughout.
But something that was surprising is that the association with erectile dysfunction was not statically signfianct among current cigarette smokers in this study , but is was significant among former smoking. And there are several ways to look at that to really undertand the data with the known limitation of using a crossectional survey rather than a cohort design. Although this is [a] collective sample from the whole United States, you have people, for example, from states like New York or California where taxes are high and [the] frequency of smoking is low. In other settings, [maybe] that frequency per user is still high. We've looked at that, but we didn't find a particular association and there is limitations for how much we can probe to all this because of the sample sizeand the power you have with more combinations in the sample. Overall, a potential reason could be the advancements in our tobacco control efforts so far. People maybe smoking less than they used to per day, compared to 10 or 20 years ago. But there's also other possible explanations, like what we call the healthy smoker syndrome. People are more likely to quit smoking when they feel the detreimantal impact of smoking on their health in general. [daily vapiung then] could be also associated with erectile dysfunction [or] it could be the other causes that former smokers have experienced because of their smoking history or otherwise. So, that's why maybe we found that this association still exists among former smokers rather than current smokers.
A foundational component of my program of research and what we try to apply to grant funding is to try to contextualize the full risks and benefits of using e-cigarettes, whether it's for smoking harm reductions among populations where it's very hard to get them to quit, or to understand what the extent the harm would be. What kind of frequency of using e-cigarettes is relatively safe? Are there differences between types of e-cigarettes that you use and the way it can impact health? Is it just the nicotine or it could be other constituents of the E-liquid or the vape that people use that could cause bad effects on health? So, there are several plans to address some of these questions, but immediately, what we're already working on with other colluegues and [what] we're going to be submitting soon, [are] 2 papers. [One is] looking at [the] association of dual use of cigarette and e-cigarettes, which was people who maintain using cigarettes while vapingwith erectile dysfunction. [The other is looking at] the different patterns of tobacco use, like people who use one product versus multiple products, which is another proxy of frequent use of tobacco. We found significant associations in both of these studies, and we're probably going to be published in the next few months.
We should always screen for tobacco use, of course, and with that, I would say proper screening is something that needs to happen. It's not just by asking patients, "Do you smoke?" Even when you ask patients [this], some patients may perceive themselves [differently and answer] "No, I don't smoke. I just have a cigarette ocassioally and do not precieve themselves as smokers, or I just smoked last week, or something like that." So, it's good to standardize the way that we screen for that, and to also probe [about] other products. It's good to be very specific, and to ask, "Have you used any tobacco in the last 30 days?" If they say "no," probe with asking about e-cigarettes as well because a lot of people do not perceive e-cigarettes as a type of tobacco. From a regulatory perspective it is, but from the public's or the user's perspective, [they think,] "No, I'm not using tobacco; it's just e-cigarettes." It is always good to probe because e-cigarettes may be a less harmful option, for example, but it's not with no harm in the absolute sense. What we know is that e-cigarettes could be less harmful to the degree [that] it could substitute smoking for somebody who smokes. So, if you get one of your patients, for example, to switch to e-cigarettes because it's maybe less harmful than smoking cigarettes, it is really less harmful [to] the degree [that] this substitution happened. [It] doesn't mean that people could switch to e-cigarettes and just use [them] frequently because then this would present its own set of harms and detrimental effects [on] health with this frequent use. It should be basically used to get over the craving of smoking , which is how harm reduction works and then eventually it is best to stop every-tobacco at some point. So, I would say that the advice would be to probe [on] different types of tobacco and to try to advise anybody to completely quit all nicotine products eventually. Whether it is e-cigarettes or other products, the goal should be complete tobacco cessation.
I think the interaction between the patient and a physician [should not be] judgmental and be [more] from a supportive manner. [That] is really a key in getting patients to take that advice from physician [to] heart and [set goals]. So, when you apply the five A's, which [are] the framework for counseling for smoking cessation, for example, you first ask the patient very specifically whether they currently smoke any tobacco or smoked any tobacco in the past 30 days [and] probe to e-cigarettes as well. You should then move toward follow up activities, which is [when] you [advise] patients to quit [and] link this advice that you're going to give to the patient to their current health situation for example, or something that it important to them. So, if you have a patient that, for example, has erectile dysfunction, it is good to mention, "Well, this could be connected to your smoking, or this could be connected to your e-cigarette use." Explaining to [patients] how this could impact their health directly is something important for the patient to be able to have that 'ah-ha' moment. The most important thing is to do it in a non-judgmental manner, and to always bridge to be more of a goal setting with the patient. Smoking is very much a chronic disease, and there is a lot of relapse, so [it's important that we are] encouraging patients. For example, [we can ask] a simple question like, "How much do you want to quit smoking right now, on a scale from one to 10?" When a patient says, "3," which is quite low, [we] shouldn't be judgmental. Any number could be reflected upon in a positive way. [We can] say, "Okay, It's good that it's not a 2. So, how could [we] help you to make it a 5 or a 6? What would help you to try to quit next month or in the near future?" This sort of non-judgmental counseling with the patient, or advice, would usually motivate the patients eventually to try to quit and discuss their challenges openly with their doctors and encourage them if they relapse. On average, for a smoker to quit completely takes an average of 9 to 10 times of trying to quit. So, continuous support for the patient and goal setting is important.
Arranging follow up is the last point in the 5 A's. The goal setting for the patient is important. [We can] say, "When I see you in your follow-up visit the next 3 months, let's try to half [your use]. If you don't want to quit now, let's try to minimize the use or cut it by half." This supportive counseling [will have a] better impact in the long run [to get] patients to actually quit all tobacco and nicotine, rather than just giving very directive advice, and just [leaving] it at that. For the context of erectile dysfunction, in particular, there's something that we also highlighted [in this study]. Maybe it wasn't one of the big findings because it's something that's known, but it was very interesting to me to show impact of the protective factors against erectile dysfunction. We adjusted for other issues, like cardiovascular disease, hypertension, diabetes, [and] all that, in our analysis, but we also adjusted for physcial excersice frequency for example. And it was very interesting to me to see that physical exercise frequency on a weekly basis with all factors considered was incrementally and significantly protective against erectile dysfunction with increasing in frequency of physcial excersice. So, it's good to remind people to always be physically active. This is a protective factor, in general, against a lot of morbidity and disease.
I would say that [vaping] e-cigarettes is not risk free, but at the same time, we know that there is some angle of smoking harm reduction for it. So, if you have a patient that comes to you, and they've consistently tried to quit smoking cigarettes and they couldn't, and they asked about whether they [should] try e-cigarettes or not, that is a signal that they may be motivated or interested to try. Instead of say[ing], "Oh no, you should not try this. This is something that's you shouldn't do. Only use smoking cessation aids." If they've tried it before and failed, you could perhaps be more open to encourage them to try and see whatever may work. At the same time, give them clear advice to not use e-cigarettes excessively, and [emphasize that they're] using it only as a vehicle to try to quit eventually. [We can say], "If you do switch, then you shouldn't get stalled in this phase. You should try to eventually quit all nicotine and tobacco." This is more of a point that is very controversial, but so far, the evidence suggests that complete nicotine [or tobacco] cessation is the way to go of course. But if there is a phase where people could switch to a less harmful product as a way to eventually quit, that could be good advice that physicians could give at this point with the evidence that we know.
References
1. El-Shahawy O, Shah T, Obisesan OH, et al. Association of e-cigarettes with erectile dysfunction: The population assessment of tobacco and health study. Epub November 30, 2021. American Journal of Preventative Medicine. Doi: 10.1016/j.amepre.2021.08.004
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The latest item on Americas culture wars menu is … chocolate milk – Sydney Morning Herald
Posted: March 25, 2022 at 2:31 am
Parental choice is a dominant theme in this years midterm elections, so some members of Congress have thrown their weight behind proposed new laws to stop school authorities from banning flavoured milk.
Republican congresswoman Elise Stefanik, an ally of former president Donald Trump, has introduced a bill that would require all schools participating in the National School Lunch Program to offer students at least one flavoured milk option or risk losing federal funding.
New York mayor Eric Adams.Credit:AP
Instead of taking away milk choices from students, my bill will give them better access to essential dairy nutrients critical for their development, Stefanik said in a statement. Let our New York students drink chocolate milk!
The lunch program provides low-cost or free lunches to about 30 million American children. Stefanik said her legislation, known as the Protecting School Milk Choices Act, would preserve the right of students to have chocolate milk while also protecting dairy farmers from future bans in New York, which is one of the largest dairy states in the nation.
Republicans dont have the majority in the House of Representatives, and therefore any bill put forward by the partys members would require Democrat support.
However, a bipartisan congressional group of New York politicians also wrote to Adams, urging the mayor to keep chocolate milk in New York school cafeterias and warning that for many NYC families, the meals children receive in schools are their only source of many recommended nutrients.
New York congresswoman Elise Stefanik.Credit:AP
While the congressional group argues, alongside Americas dairy industry, that low-fat flavoured milk increases school meal participation and gives children important nutrients, vegans and health professionals strongly disagree about the claimed benefits.
Cows milk is already high in natural sugar. In fact, it has 8 times more sugar than soy milk. So adding further sugar to give to children is completely irresponsible, given the epidemics of obesity and type 2 diabetes, said Josh Cullimore, the director of preventative medicine at the Physicians Committee for Responsible Medicine, which promotes a plant-based diet.
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Dairy products are also the No.1 source of saturated fat in the US diet, which is known to cause heart disease and Alzheimers disease.
Racial inequality further animates the debate because far more African Americans are lactose intolerant than white children.
Former Olympic cyclist Dotsie Bausch, co-founder of the anti-dairy lobby group Switch4Good, presented this argument to members of Congress during a trip to Washington last week when she lobbied for subsidised soy milk in schools. At present, students who do not want a dairy milk product as part of their lunch must have a note from their doctor or a parent.
The chocolate milk debate is only one of the politically heated disputes about parental rights in the lead up to the midterms.
The Florida legislature recently passed a Parental Rights Education Bill, which LGBTQ activists have dubbed the Dont Say Gay bill, as it would limit what some classrooms can teach about sexual orientation and gender identity.
And school libraries across the country have been forced to remove books about race and sexuality that some parents and conservative groups find too objectionable for students.
If New York City were to ban chocolate milk, it would follow in the footsteps of Washington and San Francisco. Los Angeles also banned chocolate milk about a decade ago but reversed the policy a few years later amid a public backlash.
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Aesthetic Medicine Market to Witness Huge Growth by 2031 – Digital Journal
Posted: March 25, 2022 at 2:31 am
In the last few years, the manufacturers have created novel aesthetic gadgets, resulting in a rise in demand for aesthetic treatments. In the next few years, technologically sophisticated goods such as non-invasive body sculpting devices that employ fat freezing technology, for example, are likely to generate profitable prospects. These innovations in the beauty industry are expected to propel the global aesthetic medicine market forward.
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The outbreak of global pandemic, COVID-19, had a huge impact on the aesthetic medicine business. At first, the market was adversely damaged by social distancing norms and a significant drop in consumer income. Due to reasons such as temporary closures of beauty salons, decreased product demand, and limited operations, the industry experienced a period of short-term negative growth.
On the other hand, remote working or work from home has increased the amount of time spent on Zoom calls. People are very concerned about their aesthetic appearance. This has resulted in a rise in cosmetic surgery demand, with Botox emerging as one of the most popular treatments. Cosmetic operations are also becoming more popular among patients due to the ease with which they may heal while staying at home. As a result, during the lockdown, the market for cosmetic medicine grew significantly resulting in increased demand in the global aesthetic medicine market.
In developing countries, there is a growing desire to seem youthful and fit, which has raised demand for cosmetic treatments. In nations like South Korea and India, cosmetic treatments including Botox injections, nose reshaping, and liposuction are gaining popularity.
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Aesthetic Medicine Market: Introduction
Aesthetics has been gaining importance in all aspects of everyday life in the last few years. It is a highly innovative branch of medicine. The aim of aesthetic medicine is to improve physical appearance and satisfaction of a patient by using minimally invasive or non-invasive procedures. Aesthetic medicine is recommended to healthy individuals who are dissatisfied with some minor deficiencies. Aesthetic medicine is also utilized to treat conditions such as eczema, allergies, and acne. Moreover, aesthetic treatment includes dermal fillers, microdermabrasion, venous treatment, body countering, cellulite treatment, and chemical peels.
Key Drivers, Restrains, and Opportunities of Global Aesthetic Medicine Market
Demand for cosmetic procedures across the world is increasing. It is estimated to further propel the aesthetic medicine market. Demand for various non-invasive or minimally invasive services such as laser resurfacing, aesthetic injectable, and other services is increasing alongside an increased consumer interest in skin texture and tone improvement.
Rise in awareness and demand for preventative procedures meant to offer anti-aging benefits of injectable products in early life is further anticipated to boost the aesthetic medicine market. Moreover, focus of market players on R&D investments is projected to lead to innovations in aesthetic medicines, thereby boost their demand. However, unfavorable reimbursement policies and the high cost of aesthetic procedures are estimated to hamper the market during the forecast period.
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The COVID-19 pandemic has significantly affected the aesthetic medicine industry. The COVID outbreak may have positive implications for the industry long-term regardless of causing reduced demand from primary end-users, limited operations, and closures of major end-user facilities. The market has witnessed the negative impact of COVID for the short-term due to widespread shutdowns, leading to significant challenges in manufacturing and the supply chain.
North America to Capture Major Share of Global Aesthetic Medicine Market
North America is anticipated to account for a major share of the global aesthetic medicine market during the forecast period owing to availability of advanced healthcare infrastructure, adoption of cosmetic procedures, and rising prevalence of skin disorders
The aesthetic medicine market in Asia Pacific is likely to expand at a rapid pace during the forecast period. This is attributed to rising consumer knowledge and increased interest in cosmetic procedures, rising medical tourism, and widened acceptance of aesthetic medicines.
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Key Players Operating in Global Aesthetic Medicine Market
The global aesthetic medicine market is highly fragmented, with the presence of large number of key players. These players hold major share in their respective regions.
Major players operating in the global aesthetic medicine market are listed below:
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ND EPSCoR ND-ACES to Hold Science Caf on Education Pathways for Careers in Stem – Newswise
Posted: March 25, 2022 at 2:30 am
Newswise (FARGO, ND) ND EPSCoR (North Dakota Established Program to Stimulate Competitive Research) ND-ACES (New Discoveries in the Advanced Interface of Computation, Engineering, and Science) will host an Education Pathways for Careers in STEM virtual public Science Caf on March 30. This event will feature science, technology, engineering, and mathematics (STEM) faculty members from North Dakota Universities discussing STEM majors and STEM careers with secondary students from around the state.
In this free, public event, researchers from ND-ACES will talk about STEM majors and their connection to different career paths. Panelists will also answer audience questions and share their exciting scientific research. Students, families, educators, and staff are all welcome to attend.
This Science Caf will be moderated by Dr. Colin K. Combs, a University of North Dakota (UND) Chester Fritz Distinguished Professor and Chair of the Department of Biomedical Sciences at UND, and Dr. Kalpana S. Katti, a University Distinguished Professor in the Department of Civil, Construction and Environmental Engineering and the Graduate Program Coordinator at North Dakota State University (NDSU). Dr. Katti and Dr. Combs Co-Lead the Center for Cellular Biointerfaces in Science and Engineering (CCBSE).
This event is free and open to the public via Zoom webinar on Wednesday, March 30 at 3:00 pm CDT.
For more information on the event, please visit: https://www.ndepscor.ndus.edu/about/news/science_cafe/
To join the virtual Science Caf event via the Zoom webinar, please visit:https://ndsu.zoom.us/j/93534279178?pwd=Y09ORUZkbTU1VzJlWkpuZE9ZeXdjdz09
About the Panelists
Dr. Mark Hoffmann is a UND Chester Fritz Distinguished Professor of Chemistry and Associate Dean for Research at the University of North Dakota. In addition, Dr. Hoffman is an ND-ACES Computation, Machine Learning, and Predictive Modeling Pillar Co-Lead.
Dr. Khwaja G. Hossain is a Professor of Biology at Mayville State University. In addition, Dr. Hossain is an ND-ACES Materials Design at Biointerfaces Pillar researcher.
Dr. Dinesh R. Katti is a Jordon A. Engberg Presidential Professor in the Department of Civil, Construction and Environmental Engineering at North Dakota State University. In addition, Dr. Katti is an ND-ACES Computation, Machine Learning, and Predictive Modeling Pillar Co-Lead.
Dr. Jiha Kim is an Assistant Professor of Biological Sciences at North Dakota State University. In addition, Dr. Kim is an ND-ACES Cellular Systems at Materials Interface Pillar researcher.
Dr. Julia Xiaojun Zhao is a Professor of Chemistry at the University of North Dakota. In addition, Dr. Zhao is an ND-ACES Materials Design at Biointerfaces Pillar Co-Lead.
About ND-ACES
ND-ACES: New Discoveries in the Advanced Interface of Computation, Engineering, and Science (ND-ACES), ND EPSCoR's most recent NSF RII, is a five-year cooperative agreement with an 80/20% federal/state match.
ND-ACES builds research capacity to better understand design rules that govern in vitro biointerfaces and influence in vivo decisions surrounding the understanding of biochemistry and the cell biology of cancer cells and tumors. To address the clinical need for more robust in vivo-like biointerfaces, CCBSE will rely on a coordinated effort across three pillars of scientific inquiry: 1) Materials design at biointerfaces; 2) Cellular systems at materials interface; and 3) Computation, machine learning, and predictive modeling. Computationally created design rules can enhance the predictability of cellular responses to material surface characteristics and provide fundamental information to address many bioscience challenges. Thus, the integration of computational modeling as a prominent research partner allows for more extensive testing than possible with trial-and-error methods. This acceleration of the design, manufacture, and validation stages not only provides quicker materials authentication for use in biologic applications to produce more in vivo-like behaviors but also offers a more streamlined laboratory method of predicting cellular responses while creating a directed workflow that expedites progress.
For more information, visit the ND-ACES website.
About ND EPSCoR
North Dakota first became EPSCoR-eligible in 1985 and is one of 28 EPSCoR jurisdictions. EPSCoR is a federal program designed to broaden the science and engineering ecosystem across all jurisdictions in the US, primarily through the NSF research infrastructure improvement (RII) awards.
The North Dakota University System funds the ND EPSCoR State Office to strengthen the state's STEM infrastructure and enhance its participation in the nations competitive research and development enterprise. ND EPSCoR benefits ND by helping students, supporting quality faculty, growing research infrastructure capacity, and assisting with innovative research that positively impacts the state's economy and citizens. For more information, visit https://www.ndepscor.ndus.edu/.
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