Monthly Archives: December 2020

A novel CAR T-cell therapy developed by researchers at UCL and designed to target cancerous tumours, has shown promising early results in children with neuroblastoma, a rare form of childhood cancer.

For this proof-of-principle study, researchers at the UCL Great Ormond Street Institute for Child Health (GOS ICH) and the UCL Cancer Institute modified the patient's own T-cells (a type of immune cell), equipping them to recognise and kill neuroblastoma tumour cells.

Twelve children with relapsed or refractory (where the disease does not respond to treatment) neuroblastoma were treated as part of the Cancer Research UK-funded phase I clinical trial.

The research, published in Science Translational Medicine, is one of the first studies to demonstrate CAR T-cells achieving rapid regression against a solid cancer (non-blood cancer). Although the beneficial effects only lasted a short while, the study provides important evidence that this specific CAR T-cell treatment could be used as a future treatment for children with solid cancers.

Neuroblastoma is a rare type of cancer that mostly affects babies and young children and develops from specialised nerve cells (neuroblasts) left behind from a baby's development in the womb.

Up to 100 children in the UK are diagnosed with neuroblastoma each year. Current treatment for children with an aggressive type of neuroblastoma includes surgical removal, chemotherapy with stem-cell transplant, radiotherapy and antibody therapy. Despite this intensive treatment long-term survival is between 50-60 per cent.

In CAR T-cell therapy, a type of immunotherapy, T-cells are engineered to contain a molecule called a chimeric antigen receptor (CAR) on their surface which can specifically recognise cancerous cells.

For this study the patients' own T-cells were modified with a CAR to target the GD2 surface protein, which is highly abundant on almost all neuroblastoma cells, but found at very low levels in healthy cells.

Researchers found that when using a sufficient dose* of the modified CAR T-cells, this treatment induced rapid reduction in tumour size in some of the patients treated. These effects were transient. Importantly, in all patients the CAR T-cells did not cause any harmful side effects in healthy tissues that express the GD2 molecule.

Lead author, Dr Karin Straathof, Research group leader at UCL GOS ICH and Consultant Paediatric Oncologist at Great Ormond Street Hospital NHS Trust said: "It's encouraging to see the anti-tumour activity induced by these modified T-cells in some of the patients on this study.

"While the anti-tumour activity seen was only transient, it provides an important proof-of-principle that CAR T-cells directed at the GD2 molecule could be used against solid cancers in children.

"New treatments are needed for high-risk neuroblastoma and with more research we hope to develop this further into a treatment that results in lasting responses and increases the number of patients that can be cured."

Senior author, Dr Martin Pule (UCL Cancer Institute) said: "Targeting of solid cancers by CAR T-cells is dependent on their infiltration and expansion within the tumour microenvironment, and thus far fewer clinical responses have been reported.

"The rapid regression in neuroblastoma cells is promising, particularly as this activity was observed in the absence of neurotoxicity which occurs with antibody-based approaches that target GD2."

Dr Pule added: "Targeting neuroblastoma with GD2 CAR T-cells appears to be a valid and safe strategy but requires further modification to promote CAR T-cell longevity."

Dr Sue Brook, medical advisor at Cancer Research UK, said: "Children who have hard to treat cancers like neuroblastoma have limited treatment options open to them, especially when the cancer returns.

"The early results for the GD2 CAR-T treatment look promising, especially due to the initial safety data. However more work is needed on making the response last longer, and we are looking forward to seeing the next steps in its development."

The research team are preparing for their next clinical study in collaboration with Autolus, a clinical-stage biopharmaceutical company developing next-generation, programmed T-cell therapies for the treatment of cancer. This study will evaluate AUTO6NG, which builds on this approach utilising the same GD2 CAR alongside additional programming modules designed to enhance efficacy and persistence.

Reference:Straathof K, Flutter B, Wallace R, et al. Antitumor activity without on-target off-tumor toxicity of GD2chimeric antigen receptor T cells in patients with neuroblastoma.Sci. Transl. Med.2020;12(571). doi:10.1126/scitranslmed.abd6169This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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CAR T-Cell Therapy Shows Promising Early Results in Children With Neuroblastoma - Technology Networks

New Jersey, United States: Market Research Intellect has added a new report to its huge database of research reports, entitled Cell Therapy And Tissue Engineering Market Size and Forecast to 2027. The report offers a comprehensive assessment of the market including insights, historical data, facts, and industry-validated market data. It also covers the projections using appropriate approximations and methods.

Cell Therapy And Tissue Engineering Market Overview

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Cell Therapy And Tissue Engineering Market: Competitive Landscape

The Cell Therapy And Tissue Engineering Market report consists of the Competitive Landscape section which provides a complete and in-depth analysis of current market trends, changing technologies, and enhancements that are of value to companies competing in the market. The report provides an overview of sales, demand, futuristic costs and data supply as well as a growth analysis in the forecast year. The key vendors in the market that are performing the analysis are also clearly presented in the report. Their development plans, their growth approaches, and their merger and acquisition plans are also identified. Information specific to a keyword in each of these regions is also provided. This report also discusses the submarkets of these regions and their growth prospects.

Prominent players operating in the market:

Cell Therapy And Tissue Engineering Market Segmentation

The report contains the market size with 2019 as the base year and an annual forecast up to 2027 in terms of sales (in million USD). For the forecast period mentioned above, estimates for all segments including type and application have been presented on a regional basis. We implemented a combination of top-down and bottom-up approaches to market size and analyzed key regional markets, dynamics and trends for different applications.

Cell Therapy And Tissue Engineering Market Segment by Type:

Cell Therapy And Tissue Engineering Market Segment by Application:

Cell Therapy And Tissue Engineering Market Regional overview:

In the report, experts analyze and forecast the Cell Therapy And Tissue Engineering market on a global as well as regional level. Taking into account all aspects of the market in terms of regions, the focus of the report is on North America, Europe, Asia Pacific, the Middle East and Africa, and South America. The prevailing trends and various opportunities in these regions are studied that can convince the growth of the market in the forecast period 2020 to 2027.

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Cell Therapy And Tissue Engineering Market Size, Analysis, Growth, Trends, Outlook And Forecast By 2027 - The Haitian-Caribbean News Network

The latest market intelligence study, called Global Cell Therapy Market Forecast to 2027, jots down some of the most prominent growth potentials of the global Cell Therapy market. The report is primarily targeted at the industry stakeholders looking to capitalize on this reports contents to make improved business decisions. The report is further intended to help the readers gain vital insights into the global market, particularly the prevailing growth opportunities and competitive scenario. The insightful data & information provided by this report are gathered from various primary and secondary sources.

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Competitive Terrain:

The global Cell Therapy market witnesses the significant presence of a large number of companies performing consistently to achieve optimal market growth. The current market standing of these companies, their past performances, the demand & supply graphs, sales network, production & consumption patterns, and distribution channels have been extensively discussed in this report. Furthermore, the report points out the effective business approaches undertaken by the market players to enhance their product portfolios and prosper considerably.

Market segments by Top Manufacturers:

JCR Pharmaceuticals Co. Ltd., Fibrocell Science, Inc., Kolon TissueGene, Inc., Osiris Therapeutics, Inc., PHARMICELL Co., Ltd., MEDIPOST, Stemedica Cell Technologies, Inc., Cells for Cells, Vericel Corporation, and ANTEROGEN Co., Ltd., have been profiled in the report. They are the major manufacturers of the product.

Global Cell Therapy Market report COVID-19 Impact Assessment:

Reports and Datas latest report sums up the significant changes in the global business sector that followed the COVID-19 outbreak. The pandemic has also had an enormous impact on the global Cell Therapy market, disrupting the market dynamics and trends. The global health crisis has gravely affected the Cell Therapy industry, disrupting the global supply chains and bringing about volatility in prices and product demand. However, industry experts believe that the global Cell Therapy market will regain traction in the post-COVID scenario. The report further offers a preliminary and a future assessment of the pandemics impact on this lucrative business space.

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Therapy Type Outlook (Revenue, USD Billion; 2017-2027)Allogenic Stem Cell TherapyAutologous Stem Cell Therapy

Therapeutic Area Outlook (Revenue, USD Billion; 2017-2027)MalignanciesAutoimmune DisordersMusculoskeletal DisordersDermatologyOthers

Cell Type Outlook (Revenue, USD Billion; 2017-2027)Stem CellsNon-Stem Cells

End-User Outlook (Revenue, USD Billion; 2017-2027)Hospitals & ClinicsAcademic & Research Institutes

Browse the full report description, along with the ToCs and List of Facts and Figures @ https://www.reportsanddata.com/report-detail/cell-therapy-market

Geographical Segmentation:

The report essentially evaluates the significant presence of the global Cell Therapy market across the worlds major regions. The global Cell Therapy market has been categorized into several key geographical regions. North America, Asia Pacific, Europe, Latin America, and the Middle East & Africa are the leading Cell Therapy market regions. In this section of the report, the authors have examined the market share, market size, revenue contribution, sales network, distribution channels, and numerous other aspects of each geographical segment.

The report also provides an extensive analysis of the key market elements, such as drivers, constraints, opportunities, limitations, threats, and micro and macro-economic factors. The exhaustive SWOT analysis, Porters Five Forces analysis, feasibility analysis, and investment return analysis included in the report are intended to help the reader tactfully formulate business growth strategies. Strategic recommendations for the established market players assist them in fortifying their financial positions in the market.

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Cell Therapy Market Growth and Current Status of Industry Surveyed in New Research Report | (2020-2027) - Murphy's Hockey Law

WORCESTER, Mass., Dec. 01, 2020 (GLOBE NEWSWIRE) -- Mustang Bio, Inc. (Mustang) (NASDAQ: MBIO), a clinical-stage biopharmaceutical company focused on translating todays medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases, today announced that it will host a key opinion leader (KOL) call on MB-106 for the treatment of relapsed or refractory B-cell non-Hodgkin lymphoma on Wednesday, December 9, 2020, at 1:00 p.m. EST.

The call will feature presentations by KOLs Mazyar Shadman, M.D., M.P.H., Fred Hutchinson Cancer Research Center (Fred Hutch), and Brian Till, M.D., Fred Hutch, who will discuss the interim Phase 1/2 data on MB-106, a CD20-targeted, autologous CAR T cell therapy for patients with relapsed or refractory B-cell non-Hodgkin lymphoma that the company is developing in collaboration with Fred Hutch. Data from this study have been selected for a poster presentation at the 62nd American Society of Hematology Annual Meeting.

During the call, Drs. Shadman and Till will also discuss the modified cell manufacturing process that was co-developed by Fred Hutch and Mustang Bio, as well as the correlative science observed in the study to date. The Mustang team will then give a corporate update on its pipeline and future plans. Following the formal presentations, the Mustang team, along with Drs. Till and Shadman, will be available for questions.

To register for the call, please click here.

About Dr. ShadmanMazyar Shadman, M.D., M.P.H., is an associate professor at the University of Washington (UW) and Fred Hutch. He is a hematologic malignancies expert who specializes in treating patients with lymphoma / chronic lymphocytic leukemia (CLL). He is involved in clinical trials using novel therapeutic agents, immunotherapy (CAR T cell), and stem cell transplant for treatment of lymphoid malignancies with a focus on CLL. He also studies the clinical outcomes of patients using institutional and collaborative retrospective cohort studies. Dr. Shadman received his M.D. from Tehran University in Iran. He finished internal medicine internship and residency training at the Cleveland Clinic in Cleveland, Ohio. He completed his training in hematology and medical oncology fellowships at UW and Fred Hutch. Dr. Shadman also earned an M.P.H. degree from UW and was a fellow for National Cancer Institutes cancer research training program at Fred Hutch, where he studies cancer epidemiology.

About Dr. TillBrian Till, M.D., is an Associate Professor in the Clinical Research Division of Fred Hutch and Department of Medicine at UW. His laboratory focuses on developing chimeric antigen receptor (CAR)-based immunotherapies for non-Hodgkin lymphoma and understanding why CAR T cell therapies work for some patients but not for others. He led the first published clinical trial testing CAR T cells as a treatment for lymphoma patients. Dr. Till also has a clinical practice treating patients with lymphoma and attends on the stem cell transplantation and immunotherapy services at the Seattle Cancer Care Alliance.

About Mustang BioMustang Bio, Inc. is a clinical-stage biopharmaceutical company focused on translating todays medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases. Mustang aims to acquire rights to these technologies by licensing or otherwise acquiring an ownership interest, to fund research and development, and to outlicense or bring the technologies to market. Mustang has partnered with top medical institutions to advance the development of CAR T therapies across multiple cancers, as well as a lentiviral gene therapy for X-linked severe combined immunodeficiency (XSCID), also known as bubble boy disease. Mustang is registered under the Securities Exchange Act of 1934, as amended, and files periodic reports with the U.S. Securities and Exchange Commission (SEC). Mustang was founded by Fortress Biotech, Inc. (NASDAQ: FBIO). For more information, visit http://www.mustangbio.com.

ForwardLooking StatementsThis press release may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on managements current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995.

Company Contacts:Jaclyn Jaffe and William BegienMustang Bio, Inc.(781) 652-4500ir@mustangbio.com

Investor Relations Contact:Daniel FerryLifeSci Advisors, LLC(617) 430-7576daniel@lifesciadvisors.com

Media Relations Contact:Tony Plohoros6 Degrees(908) 591-2839tplohoros@6degreespr.com

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Mustang Bio to Host Key Opinion Leader Call on MB-106 for the Treatment of Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma - GlobeNewswire

SAN CARLOS, Calif., Dec. 01, 2020 (GLOBE NEWSWIRE) -- BioCardia, Inc.[Nasdaq: BCDA] today announced that the Companys proprietary Helix Biotherapeutic Delivery System (the Helix System) demonstrated the best safety profile among clinical transendocardial catheter injection systems used for cardiac cell therapy delivery in an in-press corrected proof published in the journal, Cardiovascular Revascularization Medicine. The Helix System is being used in the pivotal Phase III CardiAMP Heart Failure Trial currently enrolling nationwide for infusion of BioCardias CardiAMP cell therapy to the myocardium.

The study, which can be accessed here, analyzed clinical trials encompassing 1,789 patients that underwent transendocardial injections using either a helical needle (BioCardias Helix System), or one of three other clinical use designs developed by BioCardia competitors: an electro-anatomically tracked straight needle, a straight needle without tracking elements, or a curved needle. The paper, titled Clinical safety profile of transendocardial catheter injection systems: a plea for uniform reporting,1 was authored by Amish N. Raval, MD, of the University of Wisconsin and Carl J. Pepine, MD, of the University of Florida.

The article reported the combined transendocardial injection-associated serious adverse event (SAE) rate was 3.4% across all four catheters, with the Helix System demonstrating the lowest SAE rate of only 1.1%. The next-closest delivery system had three times as many reported adverse events as the Helix System, with one system having 8.3 times as many adverse events as the Helix System.

In the paper, the authors concluded, the helical needle designed catheter is associated with a particularly low reported rate of death, myocardial infarction, stroke, cardiac perforation causing death or requiring surgical or percutaneous evacuation, serious arrhythmia, and vascular complications.

This rigorous, independent review of the scientific literature follows earlier data showing that Helix has the lowest risk to patients2 and most efficient cell delivery3 compared to other leading delivery routes evaluated. Having the safest and highest performance delivery platform enhances the probability that our clinical cell therapy programs will become valuable therapies for millions of patients suffering from cardiac disease, said BioCardia Chief Executive Officer Peter Altman.

About BioCardiaBioCardia, Inc., headquartered in San Carlos, California, is developing autologous and allogenic cell-based therapies to treat cardiovascular disease. CardiAMP and CardiALLO cell therapies are the Companys biotherapeutic product candidates in clinical development. The Company has also developed a portfolio of approved enabling products that optimize delivery of its cell therapies.

Forward Looking Statements This press release contains forward-looking statements that are subject to many risks and uncertainties. Forward-looking statements include, among other things, references to the safety and efficiency of cell delivery using the Companys delivery systems.

We may use terms such as believes, estimates, anticipates, expects, plans, intends, may, could, might, will, should, approximately or other words that convey the uncertainty of future events or outcomes to identify these forward-looking statements. Although we believe that we have a reasonable basis for each forward-looking statement contained herein, we caution you that forward-looking statements are not guarantees of future performance and that our actual results may differ materially from the forward-looking statements contained in this press release. As a result of these factors, we cannot assure you that the forward-looking statements in this press release will prove to be accurate. Additional factors that could materially affect actual results can be found in our documents filed with the SEC, including our recent filings on Form 8-K, Form 10-K and Form 10-Q, particularly any statements under the caption entitled Risk Factors therein. BioCardia expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law. References

Media Contact: Michelle McAdam, Chronic Communications, Inc.Email:michelle@chronic-comm.comPhone: 310-902-1274

Investor Contact: David McClung, Chief Financial OfficerEmail:investors@BioCardia.comPhone: 650-226-0120

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BioCardia Reports Published Study Showing Helix Biotherapeutic Delivery System Used in CardiAMP Phase III Heart Failure Trial Has Fewest Adverse...

A study published in Blood Advances observed that extranodal involvement and lymphoma burden are risk factors for early progression at the time of diagnosis and time of treatment for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) being treated with chimeric antigen receptor (CAR) T-cell therapy.

Researchers sought to identify factors that may predict CAR T-cell failure, particularly early progression, within the first month after infusion. The study included 116 patients (median age, 60.7 years) with relapsed/refractory DLBCL who were analyzed at the time of decision to use commercial CAR T-cell treatment and at the time of treatment. Patients were treated at five French Lymphoma Study Association centers between June 2018 and January 2020.

Median time from decision to apheresis was nine days (range, 5.5-16.5 days), and the median time between apheresis and infusion was 40 days (range, 36-45 days). After a median follow-up of 8.2 months, 55 patients relapsed; 49% of relapses (n=27) occurred within the first month after infusion.

The estimated 12-month progression-free survival (PFS) and overall survival (OS) were 47.2% (95% confidence interval [CI], 38.0-58.6) and 67.0% (95% CI, 57-79), respectively.

Univariate analyses for PFS and OS found that the following characteristics predicted CAR T-cell failure: Eastern Cooperative Oncology Group performance status score of 2, stage III/IV disease, two or more extranodal sites, elevated lactate dehydrogenase (LDH), increased C-reactive protein (CRP), high International Prognostic Index at time of decision and time of treatment, as well as increased CRP, bulky mass, and high total metabolic tumor volume at time of treatment.

Multivariate analyses for early progression, PFS, and OS identified elevated LDH and two or more extranodal sites at time of decision and the same predictors at time of treatment (i.e., increased CRP, two or more extranodal sites, and total metabolic tumor volume >80 mL), the authors noted.

Our risk model identifying early failure [risk factors] should assist in better selection of these patients for CAR T-cell therapy, the researchers concluded.

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These Factors Predict Early Progression Following CAR-T Therapy in DLBCL - DocWire News

The latest report on global Cell Therapy market is concentrating on the merchant territory, geographical expanse, product and service variations and potent strategies and functionalities that amount to massive growth in the foreseeable future. With thorough examination of chief players each of the companies is methodically estimated and measured with detailed reference of their SWOT performance. Each of the emphasized players has been carefully examined to infer the inferences of their growth rendering strategies and futuristic competences to ensure plentiful remunerative returns.

The study profiles and examines leading companies and other prominent companies operating in the Cell Therapy Market industry.

List of key players profiled in the report:

JCR Pharmaceuticals Co., Ltd., Kolon TissueGene, Inc.; and Medipost and many more.

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The Cell Therapy Market research study considers the present scenario of the Cell Therapy Market industry and its market dynamics for the period 20202026. The report covers both the demand and supply aspects of the market. Cell Therapy Market research report provides market sizing, share, forecast estimation & approach, Covid19 aftermath Analyst view, strategic analysis, revenue opportunities, industry trends, competition outlook, insights and growth relevancy mapping, growth drivers, and vendor analysis.

Cell Therapy Market reports under the Cell Therapy industry are supported by various macro and microeconomic factors impacting the industry. We browse through historical data and provide an overview of the emerging markets and the next big opportunities for investors within the niche market. After COVID pandemic, there are increasing demand from emerging countries provides a good business opportunity for companies to invest in coming years. Our reports are updated with changing industry regulatory policies and offer insight depending on clients requirement.

Market Segmentation

Besides including versatile details on ample growth opportunities, revenue predictions and market specific dimensions and sales volume, global Cell Therapy market report also includes actionable information on segment stratification and revenue generation potential of each of the segments in steering uninterrupted growth trail. The report houses specific details on product and application-based segmentation. Type and end-use specifications remain crucial market segments. End-use preferences and industry requirements remain critical in segment diversification. Each of the segments is meticulously assessed to understand market share, technological advancements, and regulatory alterations that influence segment diversification, followed by holistic growth.

Points Covered in the Report:

* The report presents a granular outlook of global Cell Therapy market, entailing crucial details in vendor landscape. Besides harping on core information pertaining to key market veterans.

* Elaborate details about these frontline market players, complete with assessment of their growth strategies, and positioning on the global growth curve have been intrinsically mentioned in the report.

* Actionable insights on other relevant market players active at the regional and local levels have also been discussed at length.

* Requisite information revealing details on product manufacturers, product innovations, application portfolios of all the major players have been etched in the report to inculcate growth proficient business decisions.

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Cell Therapy Market Market Segmentation as per below:

Based on Product Types:

By Use & Type Outlook, (Clinical-use,By Cell Therapy Type,,Non-stem Cell Therapies,Stem Cell Therapies,BM, Blood, & Umbilical Cord-derived Stem Cells,Adipose derived cells,Others), By Therapeutic Area, (Malignancies,Muscoskeletal Disorders,Autoimmune Disorders,Dermatology,Others,Research-use), By Therapy Type, (Allogenic Therapies,Autologous Therapies)

Segmentation Overview:

Significant details comprising sales overview as well as revenue generation trends across specific geographical pockets have also been highlighted in the report.

IN terms of geographical diversification, global Cell Therapy market has an extended regional diaspora, that is widely spread across various growth-beds comprising North and South American nations, European countries as well as several other countries across MEA and APAC that demonstrate promising growth opportunities and pathbreaking avenues.

Our seasoned team of researchers have entailed diversified information mix about dominant industry trends, novel product portfolios, corporate activities as well as collaborations prevalent amongst players in the competitive isle.

Subsequent sections of the report reveal indispensable information on the competition intensity prevalent amongst various market players. A dedicated section on leading players and other aspiring market participants have all been highlighted at length.

Based on Market Segmentation, the report also sheds light on crucial market segments concerning product and service type, existing applications and scope for novelties in the application domain have also been widely discussed in this elaborate report.

Key Market Insights:

*The report provides the following insights into the Cell Therapy Market for the forecast period 20202026.

*Offers market sizing and growth prospects of the Cell Therapy Market for the forecast period 20202026.

*Provides comprehensive insights on the latest industry trends, market forecast, and growth drivers in the Cell Therapy Market.

*Includes a detailed analysis of market growth drivers, challenges, and investment opportunities.

*Delivers a complete overview of market segments and the regional outlook of the market.

*Offers an exhaustive summary of the vendor landscape, competitive analysis, and key market strategies to gain a competitive advantage in the Cell Therapy Market.

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Cell Therapy Market Global Research Report Information by Product, by Distribution Channel, and by Region Forecast Till 2025 - Cheshire Media

The Global CAR-T Cell Therapy Market is anticipated to expand at a CAGR of around XX% during the forecast period, 20202026. Growing adoption of cloud-based solutions and rising need for amalgamating health records on a single platform is anticipated to boost the market CAR-T Cell Therapy growth. These are some of the major factors, which has an impact on the CAR-T Cell Therapy market. The use of technology has transformed the its uses in different sector. This drives the growth of CAR-T Cell Therapy market. Technology is used for the transformation of this sector, and to reduce the burden on employees.

List ofTop Key Playersof CAR-T Cell Therapy Market:Novartis International AG, Kite Pharma, Inc. (Gilead Sciences, Inc.), Legend Biotech (Genscript Biotech Corporation), CARsgen Therapeutics, Ltd., Mustang Bio, Inc., Sorrento Therapeutics Inc.

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CAR-T Cell Therapy is an advanced integrated information system for the management of all the aspects involved in operations such as financial, medical, administrative, legal, and compliance. These are some of the factors, which contribute to the CAR-T Cell Therapy market. The report on CAR-T Cell Therapy market also includes business intelligence, revenue cycle management, and electronic health records. Across the globe, various health organizations have installed CAR-T Cell Therapy software in order to streamline their business and operation process, better manage projects of all sizes, and boost their work efficiency across the management or board. These are some of the factors, which contribute to the growth of the CAR-T Cell Therapy market.

Market Trends, Drivers, Restraints, and Opportunities:

Increasing adoption of cloud-based solutions and integration of emerging technologies such as Artificial Intelligence (AI) and Machine Learning (ML) with hospital management solutions for data analysis is a major factor driving the growth of the CAR-T Cell Therapy market. Rising adoption of latest technologies such as online report generation that helps in cost cutting and improves the communication with patients is expected to boost the demand for an integrated software. This, in turn, is driving the growth for the CAR-T Cell Therapy market.

Growing demand for maintaining transparency across different departments and flexibility to access data at any time and from anywhere has increased the demand for innovative solutions and thus fueling the growth of the CAR-T Cell Therapy market. Shifting organizations preference from traditional ways of management, rising demand for automated systems and solutions, and streamlining all the aspects of business management is propelling the CAR-T Cell Therapy market growth.

Growing need to manage regulatory compliance through effective utilization of workforce management systems is propelling the market growth. Rising expenditure in the healthcare industry and government initiatives to upgrade healthcare facility infrastructure is fueling the CAR-T Cell Therapy market growth. Growing concerns for data security and high costs of deployment has been restraining the CAR-T Cell Therapy market growth.

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Key Businesses Segmentation of CAR-T Cell Therapy Market:

By Types, the CAR-T Cell Therapy Market can be Splits into:CD 19, CD 20, GD2, CD22, CD30, CD33, HER1, HER2, Meso, EGFRvlll

By Applications, the CAR-T Cell Therapy Market can be Splits into:Acute Lymphocytic, Leukemia, Chronic Lymphocytic Leukemia, Non Hodgkin Leukemia, Multiple Myeloma, Pancreatic Cancer, Neuroblasta, Breast Cancer, Acute Myeloid Leukemia, Hepatocellular Carcinoma, Colorectal Cancer

Why Choose Us:

We offer industry-leading critical reports with accurate insights into the future of the market. Our reports have been evaluated by some industry experts in the market, thus making them beneficial for the companys to maximize their return on investments. We provide a comprehensive pictorial representation of the information, strategic recommendations, outcomes of the analytical tools to offer an elaborate landscape, highlighting the key market players, and also provide SWOT analysis, product life cycle of the products. A detailed information of the external factors are covered on the PESTEL analysis. We also provide detailed information on COVID-19. This detailed assessment of the market will help the company increase efficiency of the CAR-T Cell Therapy market. The demand and supply dynamics offered in the report give a 360 degree view of the CAR-T Cell Therapy market.

Our report helps readers decipher the current and future constraints in the CAR-T Cell Therapy Market, and help them formulate optimum business strategies to maximize growth in the CAR-T Cell Therapy market.

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Originally posted here:
Impact of Covid-19 on CAR-T Cell Therapy Market 2020-2028 Novartis International AG, Kite Pharma, Inc. (Gilead Sciences, Inc.), Legend Biotech...

FLORHAM PARK, N.J., Dec. 1, 2020 /PRNewswire/ -- Celularity announced today that the independent Data Monitoring Committee (DMC) completed the first assessment of the ongoing Phase I/II CYNK-001-COVID-19(CYNKCOVID) study (https://clinicaltrials.gov/ct2/show/NCT04365101) with CYNK-001 off-the-shelf, allogeneic, natural killer (NK) cell therapy in adults with COVID-19. The DMC confirmed the absence of dose-limiting toxicities and recommended to move forward with the trial. Additionally, there was no evidence of worsening of inflammatory biomarkers observed. The observed clinical findings justify the continuation of the trial. Enrollment is ongoing in this multi-center clinical study with active sites in Arizona, Arkansas, California, New Jersey, and Washington.

"We are encouraged that an esteemed group of independent experts in COVID-19 and cellular therapy determined that CYNK-001 was safe in the first participants receiving the treatment on the multi-site national study. Our goal now is to rapidly complete enrollment of the study so we can determine the efficacy of this promising treatment for COVID-19 with the epidemic resurging in the United States and few good treatment options for many patients,"said the national PI for the CYNKCOVID clinical trial, Corey Casper, M.D., M.P.H.

"The administration of NK cells may have the potential to both control viral infection while also coordinating a more effective immune response that could lead to strong and lasting protection against viruses. With the increasing incidence of COVID-19 nationwide, Celularity reaffirms our commitment to the development of CYNK-001 as a potential therapeutic treatment for patients with limited treatment options. Through our collaboration with investigators, we anticipate rapid enrollment culminating in the next DMC review of safety and efficacy data," said Robert J. Hariri, M.D., Ph.D., Celularity's Founder, Chairman and Chief Executive Officer.

The Phase I/II CYNK-001-COVID-19 (CYNKCOVID) clinical trial investigating CYNK-001 is continuing to enroll to the next evaluation milestone where the external, independent DMC will review the phase I data for both safety and efficacy. Celularity continues to accumulate safety data on CYNK-001 across a broad platform of programs including COVID-19, as well as hematologic and solid tumor malignancies.

About NK Cells NK cells are innate immune cells with an important role in early host response against various pathogens. Multiple NK cell receptors are involved in the recognition of infected cells. Studies in humans and mice have established that there is robust activation of NK cells during viral infection, regardless of the virus class, and that the depletion of NK cells aggravates viral pathogenesis.

About CYNK-001 CYNK-001 is an investigational cryopreserved allogeneic, off-the-shelf NK cell therapy developed from placental hematopoietic stem cells. CYNK-001 is being investigated as a potential treatment option in adults with COVID-19, as well as for various hematologic cancers and solid tumors. NK cells are a unique class of immune cells, innately capable of targeting cancer cells and interacting with adaptive immunity. CYNK-001 cells derived from the placenta are currently being investigated as a treatment for acute myeloid leukemia (AML), multiple myeloma (MM), and glioblastoma multiforme (GBM).

About Celularity Celularity, headquartered in Florham Park, N.J., is a next-generation Biotechnology company leading the next evolution in cellular medicine by developing off-the-shelf allogeneic cellular therapies. Celularity's innovative approach to cell therapy harnesses the unique therapeutic potential locked within the cells of the post-partum placenta. Through nature's immunotherapy engine the placenta Celularity is leading the next evolution of cellular medicine with placental-derived T cells, NK cells, and pluripotent stem cells to target unmet and underserved clinical needs in cancer, infectious and degenerative diseases. To learn more visit celularity.com

Media Contact Factory PR Email: [emailprotected]

SOURCE Celularity, Inc.

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Celularity Announces Positive DMC Safety Review and Continuation of its Phase I/II CYNK-001-COVID-19 Study - PRNewswire

With the success of first vaccine to reach phase I clinical trial and turning out to be safe, well-tolerated, and capable of generating an immune response against the virus in humans, a lot of hope has been created with this vaccine. However, the research is still ongoing to develop novel therapeutic treatments that could aid infected patients in the meantime. One such growing area of interest is the use of cell therapy.

Cell Therapy: A Potential Treatment for COVID-19?

Cell therapies represent highly innovative therapeutic approaches that have revolutionized healthcare practices. Several studies from all over the world has proposed stem-cells based therapy, specifically mesenchymal stem cells, as a suitable remedial approach in the treatment of acute respiratory distress syndrome (ARDS), which is the leading cause of death in COVID-19 patients. Even though there are no approved cell therapy-based approaches for the prevention or treatment of COVID 19, however, many clinical trials have begun, and scientists are trying relentlessly to develop a therapeutic to treat this disease.

Companies Engaged in the Manufacturing of Cell Therapies

Presently, over 100 industry players and 60 non-industry players are involved in the manufacturing of cell therapies; of these, 52% have the required capabilities for manufacturing T-cell therapies.

The Key Hubs of Cell Therapy Manufacturing

Majority of the industrial stakeholders (41%) are based in North America, followed by those based in Europe (31%) and the remaining in Asia Pacific. It is worth mentioning that within Asia Pacific, Japan (8) emerged as a popular hub for cell therapy manufacturers.

Demand for Cell Therapies (in terms of number of patients) is Anticipated to Grow at a CAGR of >21%, During 2019-2030

Given that advanced therapeutic medicinal products (ATMPs) is relatively a niche domain, the overall commercial demand for cell therapies is estimated to be more than 18,500 patients in 2019 and this value is likely to grow to close to 0.4 billion patients by 2030.

To get a detailed information on the key players, recent developments, capacity available, demand and the likely market evolution, visit this link

Cell Therapy: A Potential Treatment for COVID-19?

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