Monthly Archives: November 2020

While 2020 has been a doozy for us humans, its been pretty sweet for the canine population. Covid-19 doesn't present much of a health threat for dogson the contrary, the pandemic has brought pups a number of benefits. Shelters are emptying out, more people are interested in fostering, and pets are getting more attention and affection, points out Heidi M. Cooley, a veterinarian at Banfield Pet Hospital in Vancouver, Washington. All of this newfound together-time means many pet owners have become as focused on their dogs wellness as they are on their ownand are increasingly interested in non-traditional therapies to help their dogs feel as good as possible. Four in ten of us routinely use treatments like yoga, herbs, meditation, Reiki, and massage to cure what ails us, so why not treat our pets to the same?

Experts say complementary therapies may indeed help pups of all ages, sizes, and breeds who are suffering from discomfort of the body or mind. Just be sure to check with your vet before proceeding. Veterinarians understand not only the potential benefits, but also the potential harm an alternative treatment can cause, says Jerry Klein, DVM, chief veterinary officer of the American Kennel Club. Plus, they should be attuned to whats best for your particular dog. Treating a six-pound geriatric Pekingese with metabolic issues can be different from treating a mostly healthy 3-year-old Newfoundland, notes Klein.

If your vet isnt open to thinking outside the box, Klein suggests getting a second opinion or consulting the American Holistic Veterinary Medical Association, a group of vets who advocate for the use of integrative medicine. Here are some popular alternative therapies for four-legged friends:

You...get pricked to nix a nagging ache. (Acupuncture is effective for neck and back pain, osteoarthritis, and frequent headaches.)

Your dog...can go under the needle, too; its been recommended for musculoskeletal pain, arthritis, asthma, allergic dermatitis, traumatic nerve injury, and some G.I. and reproductive issues. It may well be worth a try: In a study following 181 dogs for up to 24 weeks, Brazilian researchers found that regular acupuncture reduced musculoskeletal pain in the vast majority of cases.

Note: Worried about keeping your pup still while hes being poked and prodded? Dogs generally become very relaxed, most likely because of endorphin release, says Ernie Ward, DVM, founder of DogGone Healthy, a nutritional and behavioral care practice in Calabash, North Carolina. Ward says licking or pawing the needles is rare.

You...drop a tincture under your tongue or rub a cream on your lower back. Trendy CBD (or cannabidiol, a nonintoxicating compound in cannabis) is a hot area of research and is used to self-treat everything from anxiety to chronic pain.

Your dog...can swallow a pet-formulated tincture or doggy treat from one of the many brands flooding the market, such as Honest Paws, Dope Dog, and Charlottes Web. Products like these are promoted to address pet ailments like pain, anxiety, and seizures, but the scientific data on CBD use is sparse, says Tina Wismer, DVM, medical director of the ASPCA Animal Poison Control Center. Preliminary findings from a small study at Colorado State University did show that 89 percent of dogs with epilepsy had less frequent seizures after receiving CBD. A larger study funded by the American Kennel Club Canine Health Foundation is now under way.

Note: Consult your vet first, start with a low dosage, then keep a close eye on your pup. Some dogs have developed signs of toxicity after ingesting CBD products; its difficult to tell whether they might also contain THC, which can be poisonous to animals. Call your vet immediately if you notice your pet acting lethargic or disoriented, or walking or behaving strangely.

Yourun or exercise in a pool when your lower extremities cant handle the impact of less-forgiving surfaces, or soak in a tub to relieve physical aches and psychological stress.

Your dogcan trot on an underwater treadmill (or be held and assisted in the water) to recover from an orthopedic or neurological issue. This treatment, often used in pet rehabilitation centers, is a way to help pets safely heal and build muscle strength. The warm water can also ease pain and help your dog chill out.

Note: No matter how gentle this practice may seem, it could be traumatic for dogs who strongly dislike or fear water, says Cooley. Nor is hydrotherapy recommended for pets with sensitive skin, open wounds, or incisions. Your best bet is to bring your pet to a rehab facility with an underwater treadmill, but if there isn't one nearby, a vet may be able to talk you through an adapted version of the treatment that involves a pool or tub.

You...go for a monthly session to relax your muscles and nerves.

Your dog...is always up for a good rubdown. A vet specializing in rehab might recommend massage to help reduce pain and improve range of motion and circulation.

Note: If the therapist is too rough, the bodywork could wind up worsening an injury, warns Klein. Sensitive dogs may also react by biting the hand that kneads them. Klein suggests seeking a certified canine rehabilitation practitioner or a vet who is certified by the American Veterinary Chiropractic Association. Theyre trained to get pets back on their paws.

with additional reporting by Corrie Pikul

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4 Alternative Medicines for Pets and Their Benefits - Oprah Mag

STATEN ISLAND, N.Y. Months after the coronavirus (COVID-19) first ravaged Staten Island, health care workers on the borough are once again staring down a flood of infections that is slowly filling the boroughs hospital beds only this time, the mental stresses wrought by the first wave are an equally-daunting problem.

Interviews with three nurses, a hospital executive and a social-work expert have shed a light on the damaging mental effects the coronavirus outbreak has had on health-care workers as the city moves toward a new stage of the pandemic.

Those effects, coupled with the culture of the nursing profession viewed by experts as not being conducive to discussing mental health have raised questions on the effectiveness of services available to those who are suffering and concerns about a seemingly-inevitable fallout of issues exacerbated by the virus.

I think every nurse is a different person and a different kind of nurse now, said an ICU nurse at Staten Island University Hospitals (SIUH) Princes Bay campus who requested anonymity.

I dont know if its more being numb, or being more prepared, she said. I feel like theres definitely some sort of PTSD involved.

Approaching the height of the pandemic in March, nurses who spoke to the Advance/SILive.com detailed a coronavirus nightmare that saw a startling number of hospitalizations and deaths in quick succession within the Islands two health care systems.

You would just get hit with all these patients dying at the same time, and there was no time to process any of it, said the ICU nurse. You just had to keep going. Put your feelings aside and just work.

Now, as nurses are beginning to process the grief they endured during the first wave of the outbreak, a new wave is emerging as hospitalizations have now reached levels not seen since the beginning of June.

A doctor walks into Richmond University Medical Center on Wednesday, Nov. 18, 2020. (Staten Island Advance/ Alexandra Salmieri) Alexandra SalmieriAlexandra Salmieri

TOLL ON PATIENTS BECOMING CLEARER

The mental health effects of the coronavirus on patients are becoming clearer as the pandemic progresses, and the outbreak has worsened addiction issues on the Island that experts feel are being largely ignored.

A nurse in Richmond University Medical Centers (RUMC) Psychiatric Emergency Room said she has seen an increase in drug-induced patients since the onset of the pandemic and has witnessed the disastrous effects of the coronavirus on the mental health of her patients.

You have your patients who are trying to use drugs to kill themselves, to forget things to kind of like forget whats going on, the nurse said, because they have nothing to do.

That increase of patients has also placed an undue burden on the nurses on the hospital floor, she added, explaining that it has become more important than ever to communicate with her colleagues about mental health.

We learn how to not internalize it, kind of work through our problems, she said. PTSD is a big thing for nurses in psych.

Her specific field psychiatry makes speaking about mental struggles more accepted than other nursing departments, she said, which has allowed her to leave her stress at work.

We work in such population that talking about mental health is not an embarrassment for us," she said.

That is not the case, however, across the nursing profession.

Dawn Cardello, an SIUH nurse of over 33 years and member of the New York State Nurses Associations executive committee, said she witnessed the stresses her nurses experienced first-hand.

Nurses, were traditionally flexible. We deal with a lot of things we bounce back and move forward, said Cardello, But we all know this was very different. It definitely has affected most nurses.

The onslaught of concerns over personal protective equipment that plagued staff early in the pandemic, coupled with the unfathomable number of deaths in quick succession, left even veteran nurses struggling.

I truly felt it, I felt the anxiety of my co-workers, an emotional Cardello said. A lot of nurses cry alone.

The emergency room at SIUH North in Ocean Breeze on Wednesday, Nov. 18, 2020. (Staten Island Advance/ Alexandra Salmieri) Alexandra SalmieriAlexandra Salmieri

ADDRESSING CONCERNS

Dr. Timothy Sullivan, the chair of Psychiatry and Behavioral Sciences at SIUH, called the stresses nurses faced during the spring extremely difficult and said Northwell Health which operates SIUH has established multiple efforts to address growing concerns surrounding the mental-health effects of the virus on staff.

They were on the front lines, they were in rooms with patients with active COVID, Sullivan said. Theyre having to talk to families about health care decisions, and so on, and all in an environment which we had not a lot of information.

Nurses were often given a difficult burden during the height of the pandemic on the borough, when over 500 residents were hospitalized between the Islands two health care systems, said Sullivan. Since then, a web of support was created by Northwell Health that includes an employee hotline and a program that specifically addresses stress and resilience.

Northwells Center for Traumatic Stress Resilience and Recovery, which previously focused primarily on working with veterans, began providing trainings to staff that would equip them with techniques such as psychological and stress first aid that are currently used by the military.

Sullivan said that transition was an integral one, as commonalities exist within the cultures of nurses and members of the armed forces.

Nurses often treat their co-workers like a team ... kind of like troops going into a battle, he said. While he recognized that approach as important, he also admitted that it makes it hard for people to acknowledge stress.

The program, implemented by Northwell and piloted at SIUH, is centered on both addressing the current mental state of staff while also cultivating an environment that makes mental health more accessible to speak about.

Stress first aid, for example, was developed in the military as a kind of prophylactic or preventative strategy that would help teams in military to be able to help one another to do self checks, said Sullivan, and to create a culture and a language that would make awareness of and comfort speaking about stress more normal.

There are roadblocks, however, to initiating programs like this. Buy-in among staff is necessary, and toppling decades-old expectations of avoiding mental health struggles within the profession is a tall task.

Staff members saw young people dying quickly, people dying alone, their families not able to be with them, and thats not stuff were used to. Sullivan said. So, that notion that it has affected people in a lasting way ... is understandable.

Weve got to find a way for people to talk about that with one another, he said.

The hospitals coronavirus hotline for staff, according to Sullivan, has quieted down since the height of the pandemic on Staten Island, and the unknown of the mental health struggles lying just under the surface is a considerable concern.

The difficult part is not knowing exactly whats out there, he said.

To overcome this, Sullivan said the health system is training leadership on the floors of the hospital to become coaches of the program in the effort to work within the already-established team mentality. Some members of SIUH were slated to complete the training by mid-November and were expected to enact the approach shortly afterward.

By integrating these techniques within the culture of the hospital, Sullivan said the health care system hopes it will help create constructive conversation.

So far, he said theres good buy in, but acknowledged, its really the iceberg under the water that we are unsure about.

And so thats why were pressing ahead with these efforts, Sullivan said.

Scenes from SIUH North in Ocean Breeze on Wednesday, Nov. 18, 2020. (Staten Island Advance/ Alexandra Salmieri) Alexandra SalmieriAlexandra Salmieri

EMOTIONAL FALLOUT STILL TO COME

Dr. Paul Archibald, assistant professor within the School of Social Work at the College of Staten Island, said the fallout of the first wave of the coronavirus is expected to leave an aftermath of a lot of mental health issues once the PTSD kicks in.

Archibald said the timing of the second wave of coronavirus hospitalizations is especially concerning, as It takes about six to eight months for the symptoms of PTSD to start showing itself.

Its like me watching somebody get murdered and six months later Im going through treatment and working through it, symptoms start to show up, and then I see another person get murdered, Archibald said. Thats whats happening.

Nurses experience a range of traumas in their everyday routine, according to Archibald, and the effects of those mental wounds can start to alter an individuals world view causing a nurse to undergo a series of drastic changes, including becoming potentially cynical or fearful.

Even those not fully traumatized by the COVID-19 pandemic can suffer vicarious trauma, which is the result of working in the vicinity of others who have suffered immensely. That, said Archibald, could lead health-care workers to experience secondary traumatic stress or compassion fatigue.

Im really concerned for the nurses and first responders and people who are working this COVID-19 pandemic, Archibald said. We have to make sure that mental health is a major part of this.

When contacted by the Advance/SILive.com, Alex Lutz, a RUMC spokesman, said the hospital does not specifically have a program for nursing staff to address mental health; however, the hospital has created a hotline that can refer anyone who is need of ongoing treatment.

Services are provided through RUMCs Center for Integrative Behavioral Medicine at South Avenue, said Lutz, adding that the hospital has offered services to employees, their families and friends.

We have dedicated experienced Behavioral Health clinicians who are available to staff needs at all times and we also make sure staff members get immediate appointments in our clinics once the contact is made, said Dr. Joel A. Idowu, chairman of RUMCs Department of Psychiatry & Behavioral Sciences. We do the same for referrals coming from our employee health department for our services.

Commenting on the hospitals hotline, the RUMC nurse said that staff within her department are unlikely to utilize the service.

She said that collaboration between nursing departments or specific programs crafted with nurses in mind would be more effective in addressing underlying issues that are facing staff as the Island enters a period of heightened hospitalizations.

And as the second wave is coming up, the nurse said the staff are working through the same difficulties they pushed through mentally about eight months ago. Yes, were more prepared, but at the same time whos working through it?

Archibald stressed that having programs in place was an important first step, but acknowledged that just having the resources does not mean people are going to buy in to it.

You cant just have these services ..., he said. If I wasnt calling all along, Im not going to start now.

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A lot of nurses cry alone Whos watching out for mental health of medical workers in pandemic? - SILive.com

The Wildlife Defense Network combines academic expertise and government resources in a coordinated wildlife rescue effort

During the devastating and premature wildfire season this summer, one group of fire victims often went overlookedwildlife mammals. One organization, The Wildlife Disaster Network, is using veterinary expertise and other resources to address the medical concerns of wildlife impacted by fires.

The Wildlife Disaster Networka partnership between the UC Davis School of Veterinary Medicine and the California Department of Fish and Wildlife (CDFW)has a design similar to another partnership between CDFW and the UC Davis School of Veterinary Medicine: the Oiled Wildlife Care Network. Both of these partnerships combine the resources of the state government as well as the expertise of veterinarians and academics to aid animals in need. The CDFW provides resources including a physical facility in Rancho Cordova to hold large animals during an extended treatment, a wide network of employees throughout the state of California to respond to emergency calls and the legal authority to collect, hold and provide treatment to the animals.

Prior to the founding of the Wildlife Disaster Network, the CDFW had largely been able to deal with most wildlife victims of fire on a per-case basis. There were few cases of burned animals being taken in, such as Tahoes Lil Smokey in 2008. It soon became clear, however, that these cases werent going to be quite as infrequent anymore. Kirsten Macintyre, the communications manager for CDFW, explained how the CDFW entered into the partnership with the UC Davis School of Veterinary Medicine.

It became evident that these cases were no longer one-off situations, and a formal, coordinated response would be necessary if we were going to be able to manage the continuing trend of having more than one injured bear or mountain lion in our care at once, Macintyre said via email.

The UC Davis side of the partnership is led by Dr. Jamie Peyton, chief of the Integrative Medicine Service with the UC Davis Veterinary Medical Teaching Hospital. In 2017, Peyton worked on an innovative burn treatment for wildlife animalsa fish scale biological bandage. The fish scales are a sustainable byproduct: safe for animals to eat should they take it off, while also providing pain relief and protection for burn wounds.

With wildfires becoming more frequent in California, the Wildlife Disaster Network has been taking steps to refine response protocol. The network has worked with first responders to set up a Wildlife Disaster Hotline for reporting injured animals. Through this hotline, theyve been able to gather information on the impact of disasters on species and their habitats and provide burn protocol to wildlife rehabilitation centers such as the Oakland Zoo on how to assist the network when an emergency arises.

Weve been working with biologists throughout the state to prepare them for the possibility of deployment to seek out and retrieve injured wildlife, if and when we receive a report of an injured animal, Macintyre said via email.

There are still many challenges for the network to sort out and work through, such as making sure that the public is aware of the Wildlife Disaster Network and the work they do. Additionally, because the network also works in disaster areas, once the network gets word of an injured animal, it can be challenging to track and find these animals.

Finally, one of the most challenging issues for wildlife in disasters is finding the best habitat to release them since large areas are often destroyed in wildfires, Peyton said via email. Together as a team with veterinarians, biologists, wildlife carers and the public, we can help ensure that our wildlife has a chance to survive these disasters.

The work that the veterinarians, biologists and wildlife experts do in these disaster zones is grueling, but rewarding. During the North Complex Fire this summer, the Wildlife Disaster network received a call from their hotline from a passerby about an injured bear cub. A team of veterinarians and a CDFW biologist drove to the area where the cub was sighted. Following the bear tracks, they found the cub with severe burns to his face and unable to walk.

Seeing his severe injuries, I was so proud that we were able to find him and help him as part of the WDN, Peyton said via email. He was an example of why this network is so important and the vital need to include our wildlife in disaster planning to ensure they do not suffer.

The Wildlife Disaster Network is focused on expanding and growing so that they can serve as a resource for all wildlife in need, especially in disaster areas. The program is largely funded through donations from the public as it continues education and training programs across the state and works to develop treatment for the animals.

The assistance of UC Davis staff Dr. Jamie Peyton and her team, in particular has been, and continues to be, key in making the Wildlife Disaster Network work, Macintyre said via email. Neither CDFW nor UC Davis has the staff or resources to provide treatment to these animals alone, but combined, this team of professionals is phenomenal.

Written by: Simran Kalkat science@theaggie.org

Original post:
UC Davis partners with government agency to treat animals injured by wildfires - The Aggie

While a cup of coffee is not as hydrating as a glass of water, it can count toward your daily liquid intake. "Because it acts as a diuretic, I would count coffee as about half as much liquid as it really is," physician Catherine Waldrop, M.D., tells mbg. "Forinstance, one cup of coffee would count as half a cup of water," she explains.

That said, drinking multiple cups of coffee or tea without also drinking water could end in dehydration. "A cup of coffee is not going to dehydrate you that much," integrative medicine doctor Bindiya Gandhi, M.D., says, "but many cups of coffee without water intake will."

Dry, chapped lips could be a sign you've gone overboard, gastroenterologist Will Bulsiewicz, M.D., MSCI, previously explained. Other signs of dehydration include dark yellow urine and not feeling an urge to pee often enough.

Summary: One cup of coffee would count as about half a glass of water.

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Do Coffee & Tea Count As Water? MDs Spill The (Surprising) Answer - mindbodygreen.com

Hailing the role of Ayurveda, a top executive of an international forum has urged Indian companies to invest and forge partnerships in Qatars nascent alternative medical branch that recently received licence for operations.Speaking at an online event held to celebrate the 5th World Ayurveda Day, Yousif al-Jaber, International Business Delegation Summit chairman, said: Qatar has recently opened doors for the ancient Indian medical science of Ayurveda. On behalf of IBD members, I encourage investors from India to forge partnerships with Qatari companies. Indias Ministry of Ayush launched World Ayurveda Day in 2016.Anchor Anu Sharma conducted Qatars first global healthcare webinar titled, Ayurvedhodhayam - the Rise of Ayurveda organised by Qatarstories. In her opening address, Angeline Premalatha, Indian embassy counsellor, spoke on the efficacy of Ayurveda and thanked the Qatar government for granting license for Ayurvedic doctors to practice in Doha.Ayurvedic and allopathic doctors from Qatar and India spoke on the scope and benefits of the old Indian medical science at the webinar. Representatives from Ayurvedic pharma and a wellness expert shared their experiences and the way forward for this branch of healthcare in India and Qatar.During his presentation on Global Investments in Health Sector, al-Jaber said: Qatari companies may think of investing in Ayurvedic companies in India if there is good business model. Qatar spent QR22bn, around 11% of its budget, for healthcare in 2020, he said while highlighting Qatars healthcare initiatives like announcing health insurance for all government employees.Speaking on the Ayurveda Day theme Ayurveda and Covid-19 Dr P M Varier, Kottakkal Arya Vidya Sala chairman, highlighted prevention, control and management of the pandemic. He lauded Qatar for being highly vigilant and said: Hardcore measures are good for the society. He mentioned Indias programmes and control measures to check the spread of Covid-19.Longtime Qatar resident Dr Mohan Thomas, chairman of Cochi Medicity and Tourism, spoke on the rising prospects of medical tourism business in India that has grown from $3bn in 2003 to $8bn in 2019. India offers great medical tourism options in all medical branches, not just Ayurveda, he said.Dr Rashmi M L, the first Indian Ayurvedic doctor to receive licence to practise in Qatar, hailed the Qatar government for introducing new complementary medical practice like Ayurveda in Qatar. We need to spread awareness about the benefits of Ayurveda in Qatar, especially its preventive aspects because Ayurveda can make an impact on Qatars healthcare, she said.Dr G C Gangadharan, director of Ramayya Ayurvedic Hospital, spoke on the importance of integrative medicine (IM) and stressed its need because of Covid-19. All modern medical sciences understand the IM language. There are individual efforts, but IM needs institutional support in India, he said and suggested Ayurveda has to change its form to address the changing dynamics of health issues.Dr Rajiv Vasudevan, managing director of Ayurvvaid Hospital, gave an outline of Qatars population and health data. He said Qatars current population is around 2.6mn and it grows at 1.7% and 88% of its population comprises expatriates, where 75% are males and 25% are females. Life expectancy is 80 years and 80% of the population is under universal health cover. On death data, he said, Cardiac issues caused 24% deaths, diabetes (17%) and an alarming 28% because of road accident injuries. He hoped for regulatory support from Qatar government for importing Ayurvedic medicines from India.Ritika Patni, Singapore-based Ayurveda founder and CEO, spoke on the topic Future and Mental Health Wellbeing. She highlighted wellness and lifestyle benefits of adapting to Ayurveda as well as yoga, a complementary branch.Dr Ram N Kumar, managing director of Nirogstreet, spoke on using the digital medium to spread awareness and to expand market of Ayurvedic products while speaking on the topic Ayurveda Web Marketing.Dr D Ramanathan, managing director of Sitaram Ayurveda Speciality Thrissur, gave an overview of the Ayurveda industry while Dr Suresh Kumar of Triveni Nursing Home Trivandrum spoke on entrepreneurship and business development in Ayurveda.Balaji, Qatarstories director, concluded the webinar by thanking participants and the Indian embassy in Qatar.

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Experts highlight efficacy of Ayurveda at webinar READ MORE - Gulf Times

COVID-19 Coronavirus molecule, March 24, 2020.

CDC | API | Gamma-Rapho via Getty Images

A team of CRISPR scientists at the New York Genome Center, New York University and Icahn School of Medicine at Mount Sinai said they have identified the genes that can protect human cells against Covid-19, a disease that has infected over 40 million and led to 1 million deaths worldwide.

The discovery comes after an eight-month screen of all 20,000 genes in the human genome led by Dr. Neville Sanjana at the New York Genome Center. Leading virologist at Mount Sinai, Dr. Benjamin tenOever, developed a series of human lung cell models for the coronavirus screening to better understand immune responses to the disease and co-authored the study.

Their study, published online last month by Cell, will appear in the scientific peer-reviewed journal's Jan. 7 print issue.

The goal was two-fold: to identify the genes that make human cells more resistant to SARS-CoV-2 virus; and test existing drugs on the market that may help stop the spread of the disease.

The breakthrough comes at a time when drug makers such as Pfizer, Oxford-AstraZeneca and Moderna are fast-forwarding vaccine and therapeutics to treat Covid-19. On Friday, Pfizer and BioNTech requested emergency authorization from the FDA for their Covid vaccine that contains genetic material called messenger RNA, which scientists expect provokes the immune system to fight the virus.

In order to better understand the complex relationships between host and virus genetic dependencies, the team used a broad range of analytical and experimental methods to validate their results. This integrative approach included genome editing, single-cell sequencing, confocal imaging and computational analyses of gene expression and proteomic datasets.

After intensive research, the scientists and doctors claim they have found 30 genes that block the virus from infecting human cells including RAB7A, a gene that seems to regulate the ACE-2 receptor that the virus binds to and uses to enter the cell. The spike protein's first contact with a human cell is through ACE-2 receptor.

"Our findings confirmed what scientists believe to be true about ACE-2 receptor's role in infection; it holds the key to unlocking the virus," said Dr. tenOever. "It also revealed the virus needs a toolbox of components to infect human cells. Everything must be in alignment for the virus to enter human cells."

The team discovered that the top-ranked genes those whose loss reduces viral infection substantially clustered into a handful of protein complexes, including vacuolar ATPases, Retromer, Commander, Arp2/3, and PI3K. Many of these protein complexes are involved in trafficking proteins to and from the cell membrane.

"We were very pleased to see multiple genes within the same family as top-ranked hits in our genome-wide screen. This gave us a high degree of confidence that these protein families were crucial to the virus lifecycle, either for getting into human cells or successful viral replication," said Dr. Zharko Daniloski, a postdoctoral fellow in the Sanjana Lab and co-first author of the study.

Using proteomic data, they found that several of the top-ranked host genes directly interact with the virus's own proteins, highlighting their central role in the viral lifecycle. The team also analyzed common host genes required for other viral pathogens, such as Zika or H1N1 pandemic influenza.

The research team also identified drugs that are currently on the market for different diseases that they claim block the entry of Covid-19 into human cells by increasing cellular cholesterol. In particular, they found three drugs currently on the market were more than 100-fold more effective in stopping viral entry in human lung cells:

The other five drugs that were tested called PIK-111, Compound 19, SAR 405, Autophinib, ALLN -- are used in research but are not yet branded and used in clinical trials for existing diseases.

Our findings confirmed what scientists believe to be true about ACE-2 receptor's role in infection; it holds the key to unlocking the virus.

Their findings offer insight into novel therapies that may be effective in treating Covid-19 and reveal the underlying molecular targets of those therapies.

The bioengineers in New York were working on other projects with gene-editing technology from CRISPR but quickly pivoted to studying the coronavirus when it swept through the metropolitan area last March. "Seeing the tragic impact of Covid-19 here in New York and across the world, we felt that we could use the high-throughput CRISPR gene editing tools that we have applied to other diseases to understand what are the key human genes required by the SARS-CoV-2 virus," said Dr. Sanjana.

Dr. Neville Sanjana and his team at the New York Genome Center used CRISPR to identify the genes that can protect human cells against Covid-19.

New York Genome Center

As he explained, "current treatments for SARS-CoV-2 infection currently go after the virus itself, but this study offers a better understanding of how host genes influence viral entry and will enable new avenues for therapeutic discovery."

Previously, Dr. Sanjana has applied genome-wide CRISPR screens to identify the genetic drivers of diverse diseases, including drug resistance in melanoma, immunotherapy failure, lung cancer metastasis, innate immunity, inborn metabolic disorders and muscular dystrophy.

"The hope is that the data from this study which pinpoints required genes for SARS-CoV-2 infection could in the future work be combined with human genome sequencing data to identify individuals that might be either more susceptible or more resistant to Covid-19," Dr. Sanjana said.

The New York team is not the first to use CRISPR gene editing techniques to fight Covid-19. Other bioengineering groups at MIT and Stanford have been using CRISPR to develop ways to fight the SARS-CoV-2 and develop diagnostic tools for Covid-19.

The potential for using CRISPR to eliminate viruses has already generated some enthusiasm in the research community. Last year, for example, Excision BioTherapeuticslicenseda technology from Temple University that uses CRISPR, combined with antiretroviral therapy, to eliminate HIV, the virus that causes AIDS.

Continue reading here:
Gene experts claim they identified human genes that can protect against Covid-19 - CNBC

According to Reportsweb Health Coaching Market report 2026, discusses various factors driving or restraining the market, which will help the future market to grow with promising CAGR. The Health Coaching Market Research Reports offers an extensive collection of reports on different markets covering crucial details.

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Health Coaching Market Research Report 2020-2026

Chapter 1: Industry Overview

Chapter 2: Health Coaching Market International and Market Analysis

Chapter 3: Environment Analysis of Health Coaching

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Chapter 7: Analysis of Health Coaching Market Key Manufacturers

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Health Coaching Market has Huge Growth by Industry| Aetna, National Consortium for Credentialing of Health & Wellness Coaches, Wellcoaches School...