Monthly Archives: June 2020

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Fears about catching coronavirus from contaminated surfaces have driven some people to become compulsive about cleaning countertops and wiping down their groceries. As the pandemic took hold, some poison centers even reported increased calls about excessive exposure to cleaning agents.

In recent weeks, the Centers for Disease Control and Prevention appeared to adjust its stance on surface transmission of the coronavirus. New language on its website was interpreted as deemphasizing concerns, creating some confusion about the risk of catching covid-19 from frequently touched objects.

Pittsburgh-based infectious disease and critical care physician Dr. Amesh Adalja said that while the contact spread of the virus can certainly occur, it is not responsible for the bulk of transmission.

Weve always known that there is a small contribution from contaminated surfaces. I think the CDC guidance reflects the fact that were trying to focus on the main route of how this virus gets from person to person. It is from another person directly, Adalja said. Our public health strategy needs to be focused on eliminating the person-to-person spread,and there can be less emphasis on contact spread.

After some news outlets ran with the idea that the CDC was no longer concerned about surface transmission, the agency issued a statement clarifying that contact with a contaminated surface is still one way to catch covid-19.

It may be possible that a person can get covid-19 by touching a surface or object that has the virus on it and then touching their own mouth, nose or possibly their eyes. But this isnt thought to be the main way the virus spreads, the statement said. The change on the website was intended to make it easier to read, and was not a result of any new science.

Dr. Arvind Venkat, an Allegheny Health Network emergency physician, observed that we live in a hyper-connected world, and social media can create controversies that arent always there. So, the combination of not having consistent communication and an environment in which everything is so fragmented is a bad combination in a public health crisis.

Venkat also past president of the Pennsylvania College of Emergency Physicians said public health authorities must communicate carefully and accurately to maintain trust with the public.

Since this is a new virus, were still learning as we go along. The fact that there is contradictory and changing data is to be expected, Venkat said. So, when something changes, we need to make sure that we convey that in a systematic way so that it doesnt get perceived as going back and forth.

So, what are the chances of catching covid-19 from an object or surface laden with germs?

I think the relative risk of picking it up from common things given the precautions that everybody is taking is much lower, said Seema Lakdawala, assistant professor of microbiology and molecular genetics at the University of Pittsburgh School of Medicine.

But if you are a health care worker and you are working in a hospital setting with patients that are symptomatic and coughing and sneezing large volumes of the virus into their environment then, yes, the risk of catching it from a surface is much higher.

The feeling among medical experts who spoke with the Tribune-Review is people are unlikely to catch the virus from doing things like grocery shopping. Lakdawala, an expert in virus transmission, said she does not wipe down her groceries.

Everyone has their own comfort level. If somebody is taking the time to wipe down every single material three times, I would say that is a waste of their time, Lakdawala said. I think its important for the general public to understand, What kind of information do I need to make a risk assessment for myself?

Adalja said that while its important for people to continue to take protective action, they can be a little less concerned about contaminated surfaces they may have touched.

I think people can be less worried about making sure they scrub their groceries. Thats less likely to be impactful than other things, like washing your hands and trying to avoid crowded spaces and other social-distancing measures.

Paul Guggenheimer is a Tribune-Review staff writer. You can contact Paul at 724-226-7706 or pguggenheimer@triblive.com.

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June 1, 2020

Germanys footballing pantheon has yet to reserve a spot for Paderborn.

The Westphalian cathedral city may date back more than 1200 years, but its achievements on the countrys soccer pitches arent quite so historic.

Though SC Paderborn 07 formed from a merger in the 1980s dines among lavish contemporaries at Germanys top table, it remains slim pickings on the global stage.

The club might not yet have made an international impression, but someone with first-hand experience of the citys footballing journey is leaving an indelible mark on the world.

Prior to co-founding Newcastle-based life science company QuantuMDx Group, Jonathan OHalloran was enmeshed within Paderborns soccer fraternity.

Taken to Germany by his fathers British Army commitments, a pre-teen Jonathan known as Jono by those closest to him supplemented kickabouts among friends with more structured matches through the club.

A left winger with a strikers instinct, he was to tweak football commentator parlance a Jono-On-The-Spot figure, always in the right place at the right time to help his sides attacks.

Like a lot of youngsters, he harboured dreams of playing professionally, but when they failed to materialise, Jonathan found a new career outlet.

Instead of being a totemic figure on the pitch, he is now at the vanguard of next generation healthcare technology, which is leading the charge to transform disease detection and treatment.

At a time when the worlds medical services are battling against the coronavirus pandemic, Jonathan is, to return to that football phrase again, Jono-On-The-Spot.

Already known for work alongside Bill and Melinda Gates foundation to improve tuberculosis detection and treatment, and the development of a panel test to prevent the spread of sexually transmitted infections, QuantuMDx recently launched a coronavirus test for laboratory use.

Working with manufacturing partner Biofortuna Limited, QuantuMDx operating out of the Lugano Building, on Newcastles Melbourne Street says the test is able to deliver results in little more than an hour.

It has scaled up production capability to an initial two million tests a week, with capacity to slide that figure up to three million.

The test, known as a SARS-CoV-2 assay, has been developed using advanced bioinformatics, with its accuracy validated by use of 90 pre-extracted residual samples from Newcastle upon Tyne Hospitals NHS Foundation Trust.

Shown to be clinically equivalent to the comparator assay presently used in NHS hospitals, QuantuMDx is now translating the test and a respiratory panel on to its landmark Q-POC platform.

A cost-effective, portable and battery-operated molecular diagnostic tool, Q-POC can analyse patient DNA samples in depending on the complexity of a test as little as ten to 30 minutes.

Such expediency and portability mean QuantuMDxs coronavirus tests could potentially be analysed in as little as 15 minutes in hospitals, pharmacies, care homes, schools or immigration zones.

For governments around the world, the development stands quite literally as a life-changing intervention in their efforts to ramp up contact tracing of COVID-19.

With potential for use in airports to quickly test travellers, it could also help the global sporting landscape emerge from its coronavirus shutdown.

With Q-POC, people doing the contact testing can put it in their backpack, go and swab people, test them and get a result immediately, says chief executive Jonathan.

That is an obvious game-changer.

In airports, if someone comes through and theyve got a fever then they can be quickly tested.

It could be used in sporting environments and by the big banks and supermarkets, which want staff back safely but quickly, continues Jonathan, who reveals the company is now looking at honing its strategy again to deliver early testing for flu and SARS.

Weve got a device the world needs; it is a silver lining to a large global cloud.

Yet it could all have been so much different.

As a youngster, it was football, rather than genetics, that piqued Brightonian Jonathans interest.

The son of a Liverpool FC- supporting mother and a father whose family followed the fortunes of Millwall, he was always destined to fall for its charms.

But when he returned to the UK from Germany, the landscape began to shift.

I was in a bit of an Army bubble in Germany; I grew up on lots of different bases and remember playing lots of football, recalls Jonathan.

We moved back when I was 13 and I began at a private school in Lewes, east Sussex.

That was a bit of a culture shock; I went from an Army school to somewhere that was very prim and proper and even made us do homework!

When I was 16 or 17, I realised my dreams of professional football were not destined to succeed and that I needed to do something else, continues Jonathan, sipping tea from a Liverpool FC mug.

I was colour-blind, dyslexic and tone deaf, so I quickly found the arts were not for me, and instead I clicked with science.

I remember a teacher showing us an experiment one day and I got it immediately I was quicker than all of the smarter kids in the class to understand genetics.

From that point on, I knew what I wanted to do.

I looked at all of the universities for a straight genetics degree, but not of them did one, so instead I studied molecular genetics with biotechnology at Sussex University.

His academic journey continued when he was accepted into the esteemed Harvard University to study how mutations in DNA sequencing cause disease.

If his school science lesson prompted an interest in genetics, Jonathans time on the other side of the Atlantic truly crystallised his career path.

I benefited from an amazing education over there, but it became pretty obvious when I started writing my thesis that the academic life wasnt for me, he says.

At that time, I was reading a lot of books on epidemiology and about how viruses and plagues can wreak havoc globally.

I realised pretty early on that we needed to improve work on human diagnostics.

So I applied for jobs in laboratories and got one at Nuffield Health, in Tunbridge Wells, continues Jonathan.

That gave me exposure to a lot of pathology disciplines, and I got to play with a lot of devices.

After about four years in, I thought, I could build one of these.

And that is exactly what he did.

QuantuMDx began life not in a high-tech, modern laboratory, but in Jonathans Sussex garage.

Now backed by medical entrepreneur Elaine Warburton, who helped Jonathan co-found the venture, he began laying the research foundations that would set the business on its trail to present-day success.

It was also around this time that the company secured a grant from the Cape Biotech Trust, which saw Jonathan relocate to the southernmost tip of Africa.

The move albeit for a transitory period would prove to be another seminal moment in Jonathans professional life and the evolution of QuantuMDx.

While I was getting the data in my makeshift laboratory, Elaine who is now a non-executive director was raising money for the business on the back of that data, he recalls.

We received funding from Cape Biotech Trust and part of the deal was that we had to move to South Africas Tygerberg Hospital for two years so I packed up the garage and went.

We were based right next to the World Health Organisations tuberculosis laboratory.

On my coffee breaks I was having discussions with its scientists about tuberculosis.

I couldnt get my head around the disease. It was killing millions of people every year, so I started learning about genetic mutations that were stopping treatments from working.

When changes to funding requirements forced Jonathan and Elaine to return to the UK earlier than planned, the duo found a home in the North East.

Eminent geneticist Professor Sir John Burn who is now QuantuMDx vice-chairman and whose CV lists time at Londons Great Ormond Street Hospital offered the fledgling business initial space at Newcastles International Centre for Life.

Providing the company with a much-needed base, the residence close to like-minded operators and an ever-flowing stream of highly- skilled university graduates provided crucial momentum, which QuantuMDx has more than maintained from its Lugano Building site.

The quality of students and the catchment area we have is quite large, says Jonathan, who now counts more than 70 staff on QuantuMDxs books.

People from the North East want to stay here; they dont want to go off to Oxford or Cambridge, and that is such a huge benefit for us.

Furthermore, every time we put a call out to the universities for support, they all say yes, we can help, weve got a group doing that.

We have really meshed ourselves into the local life sciences sector.

Speaking as a soft southerner, he laughs, Brighton is supposed to be this wonderful city, but it is nothing compared to Newcastle.

This strong ecosystem and interest in QuantuMDxs ever-evolving revolutionary technology, leaves Jonathan in no doubt where his business is headed.

I always had a vision where this company would be, he says.

If we get the execution right, we are starting the commercial growth on a path towards becoming a unicorn [the term used to describe a privately-owned start-up company valued at more than $1 billion].

We have evolved our strategy for coronavirus; we have honed it and we are now doing it.

We are poised for rapid growth; it is going to be a very exciting time for us over the next 18 months.

We are going to be a different company again.

Jonathan OHalloran@BiotechRockstar

QuantuMDxwww.quantumdx.com@QuantuMDx

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Jono-on-the-spot - North East Times

AP Photo/Crime Stoppers via Houston Chronicle, File

The case almost went cold for good.

On Jan. 15, 2012, Gelareh Bagherzadeh was sitting in the driver's seat of her silver Nissan Altima when she was shot twice in the head, point blank, from the passenger side of her car. She had been talking to a friend, who heard her scream, then silence, and called 911. Gelareh's cell phone was found at her feet. The car had smashed into the garage of a townhouse, one in a row behind The Galleria, an upscale mall in Houston, and the acrid smell of burnt tire rubber was thick in the air.

Her purse and wallet were there, seemingly intact, so it didn't appear to be a robbery. There were no signs of sexual assault.

It was a mystery, one thathad enough twists and turnsto end up the subject ofDateline and NBC News' latest true crime podcast, Motive for Murder.

"I'm no stranger to mystery, to secrets people are desperately trying to hide, and the things those people are willing to do to get what they want," Motive for Murderhost and longtimeDateline correspondent Josh Mankiewiczexplained as episode one got underway.

**This is documented real life, and Dateline covered the case in 2019,sothis isn't exactly a SPOILERalert, but there are major revelations about the case ahead.

An early theory that turned the story into national news was that perhaps Gelareh's outspoken political views had gotten her killed. Perhaps the Iranian government was involved.

The 30-year-old had moved to Houston from her native Iran for school and was studying molecular genetics at the University of Texas MD Anderson Cancer Center when she was killed. But she remained plugged in to the troubles at home andshe took part in protests in Houston supporting theIranian Green Movement, which disputed the legitimacyof then-President Mahmoud Ahmadinejad's re-election in 2009 and was demanding regime change.

Her activism certainly worried her parents, Ebrahim Bagherzadeh and Monireh Zangeneh, but they remembered their daughter being unafraid of any potential consequencesthough, according to the Houston Chronicle, she had asked that her name not be used when the paper posted a video from a 2010 protest on its website.

Friends in Gelareh's inner circle were skeptical, however, that the Iranian government would "waste their energy and time" by orchestrating the death of a student activist all the way in Texas. Though "if they had...they would take credit for it" to warn off other dissidents, observed Gelareh's close friend, Kathy Soltis.

Local police said early on that they didn't suspect either apoliticalmotive or that she was targeted because of her ethnicity.

Fingerprints found on the car, the bullets recovered at the scene, a cigarette butt on the ground outside the car doorall were sent to the lab for forensic testing.

Dead ends, the lot.

In the meantime, detectives started probing the possibility that the motive had something to do with one of three overarching motives for so many murders: love, money or pride.

Houston PD homicide investigator DetectiveRichard Bolton, now retired, recalled to Mankiewicz the inevitable part of the probe when they looked into the men in Gelareh's life, including her fairly new boyfriend, Cory Beavers, and the friend who said he heard a scream on the phone seemingly seconds before she was shot,Robeen Bandarwho also was her ex-boyfriend.

Bandar explained (to police and Mankiewicz) thatthey had had an amicable breakup and had mutually decided they would be better off just being friends.

Police asked why heheard a scream but didn't recallhearinga gun shot or screeching tires. Bandar said it was probably shock or denial of what he may indeed have heard.

Onto Gelareh's current boyfriend, Cory, the last known person to see her alive.

He told police that she had surprised him by showing up at his house, but he had a test to study for so they only hung out for awhile. When sheleft, he told her to text him when she got home to let him know she had arrived safely. He never heard from or saw her again.

Cory said he didn't know Gelareh was dead until he drove up to her house the next day and a reporter approached him and asked if he knew anything about "the girl who lived here."

He knocked on the door and Ibrahim answered, and he was the one to tell Cory that Gelareh was dead.

Police also looked intocrimes with similar M.O.s in the area, wondering if she was the victim of a carjacking gone wrong. They looked at a lawsuit her father was embroiled in at the time with a former employer.

More dead ends.

Four months after the murder, police announced that the family was offering a $200,000 reward for information that led to justice for Gelareh, the largest Crime Stoppers reward on offer in the country at the time.

The dozen or so tips that merited follow-up also led nowhere. But then there was another shooting that November.

The victim was Cory Beavers' identical twin brother, Coty. And homicide detectives don't put much stock in coincidences.

Coty Beavers' wife, Nesreen Irsan,had called 911 to report that her boyfriend had been shot. "Why did God do this to me?"she's heard wailing on the call.

She had found her husband's body in their apartment when she returned home from work. She told police she last saw Coty that morning, when he walked her down to her car to see her off, as he usually did. When police responded to her 911 call, it was apparent he had been dead for awhile. It was later determined that his wedding ring had been moved from his ring finger to the middle finger of his left hand.

Coty and Nesreen were newlyweds. According to Cory, Nesreenalso a student at MD Anderson, like Cory and Gelarehwas originally interested in him, but Cory was determined to keep his mind on his studies and introduced Nesreen to Coty. Nesreen was friends withGelareh, meanwhile, and she's the one who introduced her to Cory after he saw the two of them walking together at school. He was smitten immediatelyand after talkingto her more at a party not long after, they started dating.

By the time his newlywed brother was killed, Corystill reeling from the murder of his girlfriendwas fed up with what he felt was time wasted by the police looking at him as a suspect and any other activity that didn't get them any closer to finding Gelareh's killer.

Nesreen, meanwhile, had her own traumatic past. In the summer of 2011 she had run away from her strict Muslim household and her controlling father, whom she described as "violent and abusive," with only the clothes she was wearing. She climbed out of a window and went to a neighbor's house and asked for a rideto Coty and Cory's mom Shirley Beavers' house in Spring, Texas.

Nesreen had been dating Coty and keeping it a secret from her father, Ali Irsan, with the help of her sister Nadiawho would simultaneously cover for Nesreen but also threaten to tell on her.

When Ali Irsan found out about Nesreen and Coty, he barred his 23-year-old daughter from leaving the house.

Mayra Beltran/Houston Chronicle via AP

Police had no recourse to bring Ali's adult daughter back to their house if she didn't want to be there, so Ali showed up at Shirley's house himself (how he found out where they lived,whether the address was online or Nadia told him, or whatever, they didn't know). Ali knocked on their neighbors' doors, offering $100 for information on Coty's whereabouts. In the ensuing days, the Beavers would go outside in the morning to find that the air had been let out of their tires, so they had to start moving their cars. An order of protection Nesreen obtained against her father didn't stop himbut that at least paved the way for police to obtain a warrant to search the Irsan family's home, as well as two other properties Ali owned. They found a dismantled hand gun.

Cory recalled to Mankiewicz a fight he witnessed between Nadia and Nesreen during college, ostensibly over a petty issue,in which Nadia told her sister, "'I can't wait until my dad puts a bullet in your head.'"

"I believed her," Cory said.

Melissa Phillip/Houston Chronicle via AP, File

Going through boxes of documents they'd confiscated, police found paperwork that indicated Ali Irsan was committing multiple acts of fraud, such as falsely claiming disability benefits and opening credit cards in his kids' names.

Sothe Harris County Sheriff's Department brought in theFBI, and ultimately a task force thatcame to includethe Montgomery and Harris County sheriff offices, the FBI, the Houston Police Department, the Social Security Administration Office and Homeland Security got to work.

According to authorities, Irsan, a naturalized citizen, had first come to the U.S. from Jordan in 1978 and proceeded to marry a blind woman whom he physically and sexually abused, and had four children with. While still married, he brought a teenage bride, Shmou, over from Jordan, and they had eight more children, including Nesreen and Nadia.

In 2014, Irsan was chargedin federal court with conspiracy to defraud the United States, theft of public money and benefits fraud, and Shmou and Nadia were arrested, too. In April 2015, he pleaded guiltyto conspiracy to defraud and was sentenced to 45 months in prison; his wife and daughterwere convicted of providing false statements as part of the fraud schemeand were each sentenced to two years in prison.

But back to the double murder investigation.

Yet another thing discovered in the course of the investigation into Irsan was the revelation that he had been pulled over by a Texas State Trooper on the day of Gelareh's murder. His wife and one of his sons were also in the cara silver Toyota Camry.

Which, incidentally, matched the description given by a witness back in 2012 who told police she saw what looked to be a silver Camry speeding away from the site of the shooting. Nothing had ever come of it.

The location and timing of the traffic stop put Irsan's car exactly where it would have been had he driven away from the crime scene after the shooting. Dash-cam footage showed Ali barely able to stand, and he told the trooper hewas diabetic and suffering from low blood sugar, so he had been speeding on his way to find sugar.

There was no evidence that he was a diabetic.

It was almost a fluke that the trooper still had the dash-cam footage after two years. According to Mankiewiecz, the officer just had a funny feeling about the guy...

Furthermore, per authorities and Cory Beavers, it turned out that Gelareh and Alihad crossed pathstheir seeming lack of interaction having been a nagging issue when trying to connect Ali to both her murder and that of his son-in-law.

AfterNesreen fled her family's home in 2011, Ali started calling her classmates under the guise of simply being a concerned dad.

Gelareh wasn't having it, and told him she saw right through what he was trying to do.

Toward the end of the year, he called again. Gelareh called back and first talked to Nadia, who then passed the phone to her father, who asked (according to Cory), "Is this that Iranian bitch?" Gelareh proceeded to tell him off in Farsi. He hung up. A few weeks later she was dead.

In May 2014, Ali Irsan was charged with Gelareh's murder. That charge would be dropped for tactical reasons, because once authorities had connected him to both killings, Irsan was charged in 2015 with capital murder, for what has since been characterized as two so-called "honor killings."

Or make that three. In 1999, Irsan fatally shot his 29-year-old son-in-law Amjad Alidam. He told police Alidam had been abusing his daughter, and he killed him in self-defense. Authorities later said they couldn't build a case to prove otherwise.

In 2018, jurors spent 35 minutes deliberating before convicting him of themurders of Gelareh Bagherzadeh and Coty Beavers.

During the penalty phase of the trial, a former neighborsaidthat Ali Irsan hadbragged to him that he "got away with murder" inthe death of his other son-in-law."He said he invited his son-in-law to his house and shot him," the witness, Randy Wilkinson, testified. "He said he shot him with a 12-gauge shotgun and planted a gun on him."

His sonNasim Irsan, the one who was in the Camry with him, pleaded guilty in both murders as well and was sentenced last August to 40 years in prison. Ali Irsan iscurrently on death row in Texas.

The finale ofMotive for Murderwill be outThursday, June 4, wherever you get your podcasts.

(E! and NBC News are both members of the NBCUniversal family.)

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All About the Twisted Story Behind Motive for Murder - E! NEWS

This past semester I had the privilege of being an adjunct lecturer for a college-level general biology course. In my unit on human evolution, I taught about human diversity and skin color. At first I was intimidated; how was I going to talk about this incredibly complex topic with a class of 18- to 20-year-olds? I decided the best way to talk about race was to start with the bare facts of biology. I hope that the following (albeit reduced) explanation may help some readers understand why the ideals of white supremacy are both factually and morally wrong.

All human genes are a sequence of four different molecules. They are adenosine, thymine, cytosine and guanine. Every gene that a human being has and every living organism has, for that matter is made up of just these four molecules in different sequences. The human genome, the summation of these letter sequences, is 3 billion molecules long. If it were a book, it would have 200,000 pages in it, it would be as tall as the Washington monument (555 feet tall) and would take about 9.5 years to read aloud. Any given human is only 0.1% genetically different from another human. This means if we were to compare the 200,000-page books of sequences from two strangers, 200 pages of this book would vary (footnote 1).

In the eyes of biology, there is no such thing as race because it is a social construct. The reason we see such diversity in human skin color is because of environmental factors and slight changes in certain genes.

When the human species, Homo sapiens, first emerged in Africa 200,000 years ago, most individuals had dark skin. This was because they had a gene that resulted in their skin having lots of melanin, a pigment that helps protect skin cells from UV radiation. Living in equatorial Africa, this helped prevent skin cancer and early death. Individuals with lots of melanin could, theoretically, live longer and be able to reproduce, passing their genes onto their offspring because they were less likely to die of cancer at a young age.

As humans migrated across the planet and populations grew, individuals were born that had random small alterations, or mutations, in their melanin-producing gene. White skin, for example, is caused by having a mutation in the melanin gene which reduces its concentration in our cells. This mutation was more common in humans who had migrated away from the equator, to the north. At these higher latitudes, UV radiation is not as intense, thus the threat of skin cancer is not as great. It is also thought that having white skin in these more northern populations was advantageous because it helped individuals produce more vitamin D. Simply put, not having lots of melanin in these low-UV-radiation environments did not mean you would perish before producing offspring and actually helped you produce more vitamin D (2). This combination of random mutations and migration patterns in early humans is the basis for the modern-day concept of race.

When we look at what race is in the light of biology, the idea that one is superior to the other, that they should not mix, or that one must be conquered is meaningless. One race is not favored above the rest because there are no biologically defined races, just genetic diversity. Humans are 99.9% identical, no matter where they come from in the world, so why should 0.1% determine their worth? Why should a single change in a gene determine your socio-economic standing? Why should it mean you are more likely to be brutalized by others? Why cant that 0.1% difference be celebrated as the beauty and diversity that it really is? Its about time we start celebrating these differences in our appearances and start treating each other with the one thing we all share, our humanity.

Madeline Clark lives in Saranac Lake.

Footnotes:

1. Shuster, M., Vigna, J., Sinha, G., Tontonoz, M., and Kilburn, K.S. (2018). Biology for a changing world (3rd ed.). W.H. Freeman & Company.

2. Canfield, V.A., Berg, A., Peckins, S., Wentzel, S.M., Ang, K.C., Oppenheimer, S., and Cheng, K.C. (2013). Molecular Phylogeography of a human autosomal skin color locus under natural selection. G3: Genes|Genomes|Genetics, 3(11), 2059-2067. https://doi.org/10.1534/g3.113.007484

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SAINT-PREX, Switzerland & VALENCIA, Spain--(BUSINESS WIRE)-- Ferring Pharmaceuticals and Igenomix today announced a two-year research collaboration aimed at the discovery of novel targets and disease mechanisms in infertility and pregnancy-related conditions, including preeclampsia, with the goal of developing innovative diagnostic and therapeutic strategies in these areas of high unmet need.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200603005784/en/

A new research hub will be created in Boston, bringing together scientists and expertise from both companies. The hub will focus on investigating molecular signatures, developing novel functional genomic systems and creating translational tools to study for embryo implantation, endometrial microbiome interaction and decidualization biology to drive innovative solutions for patients.

Today, 1 in 6 couples worldwide are affected by fertility issues, with embryo implantation being a critical step to improving success rates in assisted reproduction technologies (ART) such as IVF. Furthermore, between 3 and 5% of all pregnancies are affected by preeclampsia,1 a severe complication which increases the morbidity and mortality of both mother and baby, said Joan-Carles Arce, Senior Vice President of Reproductive Medicine and Maternal Health, Ferring. Through this collaboration, we aim to advance diagnostic testing and the discovery of candidate drug targets in these areas of high unmet need and ultimately help more people build healthy families worldwide.

This new research hub will connect Igenomixs unique diagnostic capabilities with Ferrings deep therapeutic expertise, said Professor Carlos Simn, Head of Scientific Board of Igenomix Foundation and Project Lead for the new hub. We believe this collaboration will accelerate scientific findings and improve conception rates at a time when significant progress is needed in preimplantation science to help more women and families experience healthy pregnancies.

ENDS

About Fertility Issues

The World Health Organization defines infertility as a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Today, 1 in 6 couples worldwide are affected by fertility issues. Assisted Reproductive Technologies (ART) such as In Vitro Fertilisation (IVF) and Intracytoplasmic Sperm Injection (ICSI) can help couples who have problems conceiving naturally.

About Preeclampsia

Preeclampsia is a common and severe complication of pregnancy characterised by high blood pressure and multiple organ failure. It affects between 3% and 5% of all pregnancies in the US.1 There is a significant unmet need for an effective treatment for preeclampsia; currently the only treatment is delivery of the baby.

Preeclampsia is responsible for approximately 20% of all preterm births2 and increases the morbidity and mortality of both mother and baby, especially in developing countries. An effective treatment would bring significant improvements in global infant and maternal health.

About Ferring Pharmaceuticals

Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and maternal health, and in specialty areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years and has a portfolio covering treatments from conception to birth. Founded in 1950, privately-owned Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.

Learn more at http://www.ferring.com, or connect with us on Twitter, Facebook, Instagram, LinkedIn and YouTube.

About Igenomix

Igenomix is a biotech company based in Valencia, Spain, specialized in reproductive genetics. Its expertise in fertility and its advanced research capacity situates the company as a worldwide referent in this area. Igenomix has 23 laboratories across the world and employs more than 400 professionals. Since the company launch in 2010, Igenomix has published more than 450 scientific papers and its communications have taken place during high level congresses such as ESHRE (European Society of Human Reproduction) or ASRM (American Society for Reproductive Medicine). Igenomix researchers have received numerous awards recognizing research and many of them share their knowledge and knowhow in leading US universities such as Stanford or Harvard.

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WALTHAM, Mass.--(BUSINESS WIRE)--BostonGene Corporation, a biomedical software company focused on defining optimal precision medicine-based therapies for cancer patients, today announced that three abstracts were selected for poster presentations at the 2020 American Association for Cancer Research (AACR) Virtual Annual Meeting II, which will be conducted from June 22 - 24, 2020.

The presentations describe findings obtained by using BostonGenes technologies and analytical tools designed to improve diagnosis and treatment decisions for cancer patients. Results include validation of bulk RNAseq utility for accurate reconstruction of tumor microenvironment and identification of four prominent microenvironment types conserved among solid tumors. Application of BostonGene computational tools lead to better understanding of the role of microenvironment compartments in tumor pathogenesis and supporting clinical decision making for the treatment of cancer.

We are excited to present at the 2020 AACR Virtual Annual Meeting to share the clinical utility of the BostonGene solution and demonstrate how it improves diagnosis and treatment decisions for cancer patients, said Andrew Feinberg, President and CEO of BostonGene.

Details of the poster presentations are as follows:

Abstract Number: 6168 Title: Integrated whole exome and transcriptome analyses of the tumor and microenvironment provide new opportunities for rational design of cancer therapy Session: Tumor Heterogeneity and Microenvironment: Next-Generation Sequencing, Single Cell, and ImagingPoster: 4418Presenter: Alexander Bagaev, BostonGene

BostonGene developed and validated a new analytic platform for multi-parametric analyses of malignant and nonmalignant tumor compartments using genomic and transcriptomic sequencing data. Application of BostonGene platform to more than 8,500 patient data sets revealed four types of tumor microenvironment (TME) that are conserved across cancer types and demonstrate high prognostic significance and differential response to immunotherapy. This novel Molecular-Functional (MF) portrait platform, involving analytic and visualization methods, provides a robust tool for prediction of response to immunotherapy and for future tailoring of personalized therapeutic combinations.

Abstract Number: 6997 Title: Novel machine learning based deconvolution algorithm results in accurate description of tumor microenvironment from bulk RNAseq Session: Machine Learning and Artificial Intelligence for Omics, Imaging, and Diagnostics Poster: 853Presenter: Alexander Bagaev, BostonGene

BostonGene developed a novel machine learning-based algorithm for cellular deconvolution of tumor microenvironment (TME) from bulk RNAseq data. This tool accurately reconstructs proportions of major immune and stromal cell populations, as well as T cell subtypes and M1 and M2 macrophages. Validation of BostonGene algorithm performance by comparison of flow cytometry, single cell RNAseq and bulk RNAseq analysis performed on samples from different tissues will be presented. The result demonstrates utility of bulk RNAseq for accurate and robust reconstruction of TME composition and paves the road for application of the BostonGene computational tool for support of clinical decision making for the treatment of cancer.

Research conducted with Massachusetts General Hospital

Abstract Number: 7544 Title: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer Session: Predictive Biomarkers for Treatment Efficacy 1Poster: 2011Presenter: Sandipto Sarkar, Weill Cornell Medicine

In the clinical study of cabazitaxel efficacy in gastric cancer, comprehensive whole exome sequencing (WES) and RNAseq data analysis identified genetic aberrations and tumor microenvironment signatures associated with favorable response. In particular, this analysis resulted in identification of two novel biomarkers, HER2 overexpression and M2-high tumor macrophage signature, both of which associated with improved outcomes. RNAseq-based deconvolution demonstrating M2 macrophages enrichment in patients with improved PFS, was further validated by immunohistochemistry using M1 and M2 macrophage-specific markers.

Research conducted with Weill Cornell Medicine

The e-poster website will be launched June 22, 2020, the first day of the AACR Virtual Annual Meeting II. All e-posters will be made available for browsing on this date.

Additionally the abstracts will be published in an online-only Proceedings supplement to the AACR journal Cancer Research after the completion of the AACR Virtual Annual Meeting II.

About BostonGene Corporation

BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGenes unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient's individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGenes mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

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BostonGene to Present Three Abstracts at the 2020 American Association for Cancer Research (AACR) Annual Meeting - Business Wire