Monthly Archives: June 2020

1.5 Present and future trends in biotechnology

During the twentieth century humankind has harnessed microorganisms to produce useful biochemical including antibiotics, vitamins, amino acids, flavors and colors, as well as specific proteins (Carlier 2001). Some of these proteins have important medical uses such as insulin, human growth hormone and blood factors like erythropoietin. In fact, manufacturers have developed a series of proven, safe, microbial hosts for use in the production of several enzymes (Warke and Chandratre 2003). Further, enzymes that have not been readily available in adequate quantity can be produced using technology. This in turn has opened up important applications beneficial to humankind. Additionally, modern techniques are leading to the development of tailored enzymes with optimized functional properties specific for their intended use. An example of this is the modification in specific proteases so that they work more efficiently in the alkaline environment of detergent formulations. As a result, less of the modified protease is needed to deliver equivalent cleaning power, while using fewer resources during the manufacturing process.

The microbial cell, a bacterium, yeast, or mold, is the key instrument in many enzyme production processes. To optimize the microbial strains for production of the desired enzyme, the strains genetic properties are often modified either through natural evolution or through classical breeding and selection techniques; these classical techniques have been used for decades to improve microbial production strains. The precise methods of genetic modification have been developed. The methods, sometimes termed genetic engineering, are based on processes occurring in nature - the transfer of genes between different cells.

Scientists to transfer genetic material between cells from the same or different species, microorganisms such as yeasts, molds and bacteria with new or improved properties for industrial applications can be developed. In nature, genetic modification has been occurring since life began. Such genetic changes are generally random, with a natural selection process favoring the changes best adapted for survival. Using this process, animal, plant and microbial breeders have likewise selected individuals within a species with desired characteristics for further propagation.

Using the tools of modern biotechnology, modifications can now be made more precisely and with much less chance of developing unwanted secondary changes that could potentially have undesired effects. In nature and in our production systems, microbes do not express only single enzymes. Rather, each microbial cell has the genetic nature to produce many different enzymes. Frequently, only one of these enzyme activities is needed for a specific application and the side activities are removed or substantially reduced during the recovery process. Often, these side activities are unwanted and may even be detrimental to the final use. Additionally, scientists are now able to discover and/or evolve enzymes that will catalyze pure compounds for applications including textile wet processing such as enzymatic desizing with alpha amylase, bioscouring with pectinase, protease, lipase and cellulase enzymes, binary and mixed enzymatic system, and biopolishing with cellulase enzymes, lipase enzyme for improving hydrophilic nature of polyester fibre both greatly reducing unwanted byproduct production as well as making the target product potentially safer and more effective (Buschie-Diller et al 1994).

Modern biotechnology is one tool that can help meet the challenge this growth poses and also contributed to (a) ecofriendly environment (b) safety and health, (c) reduced water demand in manufacturing processes, (e) reduced industrial waste and (f) aided in pollution remediation. Enzymes produced using modern biotechnology contributes to this effort by assuring the availability of safe, pure enzymes that replace harsh chemical processes (reducing energy consumption and environmental burden). Modern tools of biotechnology, enzymes from nature can be accessed which are sufficiently robust to be useful at extremes of pH and temperature and thus hold great promise for replacing certain chemical processes with much cleaner protein-catalyzed processes (Gubitz and Cavaco-Paulo 2001). Just as exciting, these new enzymes can make the dream of converting waste biomass to useful energy an economic reality. Overall, the use of modern biotechnology for enzyme production can have a major impact on improving the cost and quality of products at the same time working towards sustainability.

Enzymes have applications in many fields, including organic synthesis, clinical analysis, textile processes, and finishing, pharmaceuticals, detergents, food production and fermentation. The application of enzymes to organic synthesis is currently attracting more and more attention. The discovery of new microbial enzymes through extensive and persistent screening will open new, simple routes for synthetic processes and consequently, new ways to solve environmental problems (Calafell et al 2005).

Research on enzyme systems for textile processing and finishing has mainly focused on amylases and cellulases. However, recent biotechnology and genetic engineering advances have opened opportunities for successful applications of other enzyme systems, such as lipases, xylanases, laccases, proteases and pectinases (Emilla Csiszar et al 1998). Today, enzymes can be customized for specific target areas; for example, enzymatic degumming of silk, bioscouring of cotton textiles and antifelting and softening of wool. The basic mechanisms involving enzyme systems and interactions with textile substrates are likely noticed. Using several enzyme systems and application conditions, few researchers are being involved in studying the fibre/enzyme interactions and the compatibility of enzymes in combination (Gisela Buschle-Diller, and S. Haig Zeronian 1998).

Biotechnology offers an increasing potential for the production of goods to meet various human needs. In enzyme technology, a subfield of biotechnology, new processes have been and are being developed to manufacture both bulk and high value added products utilizing enzymes as biocatalysts (Tzanko et al 2002). Enzymes are also used to provide services, as in washing and environmental processes, or for analytical and diagnostic purposes. The driving force in the development of enzyme technology, both in academia and industry, has been and will continue to be:

The development of new and better products, processes and services to meet these needs; and/or

The improvement of processes to produce existing products from new raw materials as biomass.

Enzymes from nature can be accessed which are sufficiently robust to be useful at extremes of pH and temperature and thus hold great promise for replacing certain chemical processes with much cleaner protein-catalyzed processes (Csiszar et al 2001). These new enzymes can make the dream of converting waste biomass to useful energy an economic reality. Overall, the use of modern biotechnology for enzyme production can have a major impact on improving the cost and quality of products at the same time working towards sustainability.

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Biotechnology - an overview | ScienceDirect Topics

An RIT alumnus is helping to lead Bolivias response to the COVID-19 pandemic.

Mohammed Mostajo-Radji 11 (biotechnology) was appointed as Bolivias first ambassador for science, technology and innovation in February. He is typically based out of Silicon Valley, helping to encourage technology investment in Bolivia and facilitating exchanges between universities, technology companies, startups, and more.

But on March 19 he flew back home at the request of Bolivias interim president, Jeanine ez, to help coordinate his countrys efforts to combat COVID-19s spread. His country faces many challenges in fighting the virus, including one of the worlds worst healthcare systems and a unique geographic predicament.

Our countrys high altitude is by far our biggest challenge right now because most of the ventilators dont work appropriately at this level, said Mostajo-Radji. We have large populations living at altitudes above 13,000 feet and most ventilators are made and tested at sea level. In the current market its already extremely difficult to get a ventilator, but maybe only 30 percent of them actually work here.

But he is uniquely equipped to handle the rigors of the job. While at RIT, Mostajo-Radji developed an interest in science diplomacy, minoring in science, technology and society. For his senior thesis, he conducted experiments using Real-time polymerase chain reaction, the same equipment that is now commonly used to test for COVID-19. As he travels around Bolivia helping to set up testing labs, his experience with the equipment allows him to test a few samples to ensure everything is working properly.

After earning his degree at RIT, he went on to earn his Ph.D. in cellular and molecular biology at Harvard University in 2017 and is currently also a postdoctoral scholar in regeneration medicine at University of California, San Francisco.

Mostajo-Radji said he is proud to serve in this capacity and enjoys the work, but when looking back he is shocked at how quickly everything has escalated.

If you had asked me six months ago if I would have been doing this, I would have laughed, he said.

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RIT Rallies: Biotechnology alumnus helping Bolivia respond to COVID-19 pandemic | College of Science - RIT University News Services

The report presents an in-depth assessment of the Biotechnology Reagents Market including enabling technologies, key trends, market drivers, challenges, standardization, regulatory landscape, deployment models, operator case studies, opportunities, future roadmap, value chain, ecosystem player profiles and strategies. The report also presents forecasts for Biotechnology Reagents investments from 2020 till 2026.

Global biotechnology reagents market is expected to rise from its initial estimated value of USD 65.82 billion in 2018 to an estimated value of USD 118.53 billion by 2026, registering a CAGR of 7.63% in the forecast period of 2019-2026.

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The report presents the market competitive landscape and a corresponding detailed analysis of the major vendor/key players in the market. Top Companies in the Global Biotechnology Reagents Market: Agilent Technologies, Thermo Fisher Scientific, SGS, Shimadzu, Waters, Charles River Laboratories, Bioinformatics Solutions, Proteome Factory, Rapid Novor, Selvita

Biotechnology reagents are substances or compounds used to detect or synthesize another substance in order to give a reading test. These reagents are used in the field of research, genetics, molecular biology, diagnosis, immunology and bioscience. Biotechnology reagent consists of technologies such as cell culture, spectrometry, IVD, PCR, chromatography, expression and transfection, flow cytometer, and electrophoresis, and finds their application in various fields such as the immune phenotype, fluorescent microscopy, DNA analysis and cell cycle analysis.

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Life Science ReagentsAnalytical Reagents

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Protein Synthesis and PurificationGene ExpressionDNA and RNA AnalysisDrug Testing

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Biotechnology Reagents Market Analysis and Technology Advancement Outlook 2020 to 2025 - Cole of Duty

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AgeX Therapeutics, ImStem Biotechnology sign non-binding letter of intent regarding investigational MSC candidate IMS001 for Covid-19 - Pharmaceutical...

Thanks to its newly announced COVID-19 antibody therapy candidates, Vir Biotechnology's (NASDAQ:VIR) stock is still up more than 10% from the beginning of May and more than 180% from the start of the year.On top of its recent gains, there's reason to believe that Vir is positioned perfectly for continued growth.

While the company has a long way to go before it reaches profitability, between its low-risk pipeline programs for COVID-19 and a demonstrated competency for preclinical drug development for infectious disease, Vir's future seems bright.

Image source: Getty Images.

Vir's preclinical COVID-19 projects include two antibody therapies that it claims could temporary prevention and the treatment of coronavirus infections. VIR-7832 is both a prophylactic and a therapeutic, whereas VIR-7831 is only a therapeutic.

Because they are antibody therapies, Vir's candidates would be more effective at helping sick patients get better by reducing their viral load than it would be at preventing infections like a traditional vaccine might. In a nutshell, both of Vir's antibody programs could help patients to fight COVID-19 immediately by neutralizing viral particles in their bloodstream after they get a dose of the therapy. Then, once the patient's symptoms subside, the antibodies would remain in their system for several days or weeks, protecting them from re-infection. This process is key to both of Vir's COVID-19 antibody programs, but there's a bit more to the story.

Vir suspects that VIR-7832 may also function as a T-cell vaccine, training the immune system to react to future infections. This would mean that patients could be administered the antibody even if they don't expect to get sick. If Vir's hunch is correct, VIR-7832 would provide longer-lasting immunity than VIR-7831, and it might be a contender for mass production as a prophylactic.

The company's approach is uncontroversial from a scientific perspective, given that neutralizing antibodies from COVID-19 survivors have already been shown to combat the disease in vitro by numerous independent research teams and similar therapies were successfully used to treat human patients with SARS. Similarly, Vir's approach is front-run by ongoing clinical trials testing the efficacy of antibodies from recovered COVID-19 patients on improving disease outcomes in people who are currently ill.

The average vaccine in development is estimated to have only a 6% chance of proceeding all the way to approval and the market, but Vir's antibody products may fare better because they are adapted from natural antibodies known to be effective and safe. There's no guarantee of Vir's efforts ending in blockbuster revenue, but in the highly risky world of biotech, the prospects of these two COVID-19 projects are extremely favorable even from a conservative perspective.

However, given that the antibodies would be copies of naturally ocurring antibodies, it's uncertain whether intellectual property protection would be sufficient to prevent a competitor from creating very similar products. For most biotech companies, this would be a dealbreaker, as it would effectively prevent the ability to recoup development costs with a period of exclusive production rights. But not for Vir. By bucking the traditional wisdom regarding exclusivity and drug development, Vir has a real chance of entering the market sooner than competitors at a time when demand for its product would be enormously high.

That isn't to say that Vir is an unambitious company because it is moving forward with safer programs. In contrast to its two antibody therapy programs, Vir's VIR-2703 program is riskier because it uses a scientific approach which hasn't been tested in humans for the purpose of infectious disease. Rather than acting to neutralize viral particles directly like an antibody might, VIR-2703 relies on small chunks of genetic information called silencing RNAs (siRNAs) which disrupt regions of the viral genome.

Counting on this program to succeed would be a mistake. Most large pharmaceutical companies gave up trying to develop siRNA therapies in the mid-2010s after nearly a decade of failures, and the only siRNA therapy approved by the FDA isn't for an infectious disease.

On the other hand, early favorable clinical results from VIR-2703 should not be interpreted as a reason to buy the company's stock. Stumbles stemming from a lack of a proof of concept in human patients further down the pipeline could easily erase any gains. Either way, Vir's drug development pipeline looks more like a risk-balanced portfolio than a selection of technological and scientific gambles like so many other biotechs.

If Vir brings one of its COVID-19 programs to market, it'll be one more addition to the company's impressive roster of therapies and prophylactics for viral diseases. Aside from its three unique COVID-19 programs, Vir's pipeline includes a handful of other projects intended to treat or prevent illnesses caused by hepatitis B, influenza, tuberculosis, and even HIV. Importantly, all but two of these pipeline projects are in the preclinical phase, so the company's clinical acumen is far from proven.

In terms of advanced programs, the closest Vir has to offer is its VIR-2218 therapy for hepatitis B, which it suspects may be curative for most patients. If Vir brings a curative therapy to market, the company may have trouble maintaining its revenue over the long term because a cure shrinks the pool of eligible patients. As the hepatitis B therapeutics market is only worth around $2.6 billion, it's possible that Vir's hepatitis B therapy would meet the same fate as the low-earning hepatitis C therapy produced by Gilead Sciences (NASDAQ:GILD)But, with 257 million people worldwide living with hepatitis B compared to only 71 million living with hepatitis C, it's less likely that Vir will experience the same difficulties. Importantly, Vir isn't letting Gilead's experience stop them from moving forward with a curative therapy candidate. Even if the long-term profitability of VIR-2218 is in jeopardy of being a victim of its own success, Vir is willing to take a chance rather than stick to a safer opportunity.

In summary, Vir's COVID-19 pipeline has two antibody programs that have a better than average chance of passing through clinical trials.Elsewhere, the company's technology platform appears formidable, but its clinical pipeline is still in its infancy, despite a bevy of compelling seedlings.

Given the level of public need for COVID-19 treatments and vaccines, it's likely that if Vir's COVID-19 programs look promising once they hit the clinic in the summer, they'll be expedited through clinical trials. This means that the company's minimal past experience in clinical operations and clinical development will be of little use, so it's likely to need to lean heavily on larger collaborators like Biogen, GlaxoSmithKline, and Alnylam Pharmaceuticals.

It's easy to envision a future where Vir gets acquired by one of these collaborators if its trials have positive outcomes. In the meantime, progress by Vir's major competitors like Novavax and behemoth vaccine producers like Merck is unlikely to diminish the company's upward trajectory, as competing products would be targeted at preventing COVID-19 rather than both treating and preventing it.

Image Source: YCharts

As the market grows to recognize Vir as a rising contender in the COVID-19 therapeutic market, public interest in the company will explode, to the benefit of its shareholders. I'd recommend buying Vir shares now, to maximize the benefit of successive boosts to the company's stock price as its COVID-19 candidates pass through each phase of clinical trials. Holding onto Vir for a few years will maximize the gains, but don't discount the probability of near-term gains either.

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Vir Biotechnology Is Bucking The Biotech COVID-19 Trends, And Stands To Win - Motley Fool

Global Media, Sera and Reagents in Biotechnology Market: Trends Estimates High Demand by 2027

The Media, Sera and Reagents in Biotechnology Market 2020 report includes the market strategy, market orientation, expert opinion and knowledgeable information. The Media, Sera and Reagents in Biotechnology Industry Report is an in-depth study analyzing the current state of the Media, Sera and Reagents in Biotechnology Market. It provides a brief overview of the market focusing on definitions, classifications, product specifications, manufacturing processes, cost structures, market segmentation, end-use applications and industry chain analysis. The study on Media, Sera and Reagents in Biotechnology Market provides analysis of market covering the industry trends, recent developments in the market and competitive landscape.

It takes into account the CAGR, value, volume, revenue, production, consumption, sales, manufacturing cost, prices, and other key factors related to the global Media, Sera and Reagents in Biotechnology market. All findings and data on the global Media, Sera and Reagents in Biotechnology market provided in the report are calculated, gathered, and verified using advanced and reliable primary and secondary research sources. The regional analysis offered in the report will help you to identify key opportunities of the global Media, Sera and Reagents in Biotechnology market available in different regions and countries.

The final report will add the analysis of the Impact of Covid-19 in this report Media, Sera and Reagents in Biotechnology industry.

Some of The Companies Competing in The Media, Sera and Reagents in Biotechnology Market are: Athena Environmental Science, Inc., Becton, Dickinson, CellGenix, GE Healthcare, Lonza, Thermo Fisher Scientific, Inc., and

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What questions does the Media, Sera and Reagents in Biotechnology market report answer pertaining to the regional reach of the industry?

The report claims to split the regional scope of the Media, Sera and Reagents in Biotechnology market into North America, Europe, Asia-Pacific, South America & Middle East and Africa. Which among these regions has been touted to amass the largest market share over the anticipated duration

How do the sales figures look at present how does the sales scenario look for the future?

Considering the present scenario, how much revenue will each region attain by the end of the forecast period?

How much is the market share that each of these regions has accumulated presently

How much is the growth rate that each topography will depict over the predicted timeline

A short overview of the Media, Sera and Reagents in Biotechnology market scope:

Global market remuneration

Overall projected growth rate

Industry trends

Competitive scope

Product range

Application landscape

Supplier analysis

Marketing channel trends Now and later

Sales channel evaluation

Market Competition Trend

Market Concentration Rate

Reasons to Read this Report

This report provides pin-point analysis for changing competitive dynamics

It provides a forward looking perspective on different factors driving or restraining market growth

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It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors

It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments

TABLE OF CONTENT:

Chapter 1:Media, Sera and Reagents in Biotechnology Market Overview

Chapter 2: Global Economic Impact on Industry

Chapter 3:Media, Sera and Reagents in Biotechnology Market Competition by Manufacturers

Chapter 4: Global Production, Revenue (Value) by Region

Chapter 5: Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6: Global Production, Revenue (Value), Price Trend by Type

Chapter 7: Global Market Analysis by Application

Chapter 8: Manufacturing Cost Analysis

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Media, Sera and Reagents in Biotechnology Market Effect Factors Analysis

Chapter 12: GlobalMedia, Sera and Reagents in Biotechnology Market Forecast to 2027

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Research on Media, Sera and Reagents in Biotechnology Market (impact of COVID-19) with Top Players: Athena Environmental Science, Inc., Becton,...

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Top Players Listed in the Biotechnology Market Report areJohnson & Johnson, Roche, Pfizer, Merck, Sanofi, AstraZeneca, Gilead, CELGENE CORPORATION, Biogen, Amgen, Abbott, Novo Nordisk, Novartis, Lonza, .

Biotechnologymarket report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, the impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

Market Segmentations: Global Biotechnology market competition by top manufacturers, with production, price, revenue (value) and market share for each manufacturer.

Based on type, report split into DNA Sequencing, Nanobiotechnology, Tissue engineering and Regeneration, Fermentation, Cell Based Assay, PCR Technology, Chromatography Market, Others.

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In the end, Biotechnologyreport provides details of competitive developments such as expansions, agreements, new product launches, and acquisitions in the market for forecasting, regional demand, and supply factor, investment, market dynamics including technical scenario, consumer behavior, and end-use industry trends and dynamics, capacity, spending were taken into consideration.

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COVID-19 Update: Global Biotechnology Market is Expected to Grow at a Healthy CAGR with Top players: Johnson & Johnson, Roche, Pfizer, Merck,...

Here's a roundup of top developments in the biotech space over the last 24 hours:

(Biotech Stocks Hitting 52-week Highs June 1)

(Biotech Stocks Hitting 52-week Lows June 1)

Roche Holdings AG Basel ADR Common Stock (OTC: RHHBY) said the FDA approved its Tecentriq in combination with Avastin for the treatment of people with unresectable or metastatic hepatocellular carcinoma who have not received prior systemic therapy.

Allena Pharmaceuticals Inc (NASDAQ: ALNA) shares were surging ahead of the company's presentation at the Jefferies Virtual Healthcare Conference. The shares were higher in Monday's regular session, reacting to an initiation by H.C. Wainwright with a Buy rating and $10 price target.

Analyst Edward White said the biopharma is an "undervalued enzyme therapeutic company."

Following a 31.55% jump to $2.21 in Monday's regular session, Allena shares were rallying by 35.29% to $2.99 in Tuesday's premarket session.

Esperion Therapeutics Inc (NASDAQ: ESPR) shares came under pressure after a federal district court accorded class action status to a lawsuit filed on behalf of investors, alleging the company issued misleading statements about its non-statin cholesterol-lowering drug Nexletol in a bid to artificially inflate thestock price.

The stock fell after it was evident the drug did not have a clear path to regulatory approval, the lawsuit alleged.

The stock slid 3.07% to $40.77 in after-hours trading.

Related Link:The Week Ahead In Biotech: ASCO, Menlo And Merck FDA Decisions, IPOs In The Spotlight

Pfizer Inc. (NYSE: PFE) announced the establishment of the Pfizer Breakthrough Growth Initiative, through which the company said itwill invest up to $500 million in biotechnology companies to help provide funding and access to its scientific expertise to ensure continuity of the biotechnology companies' most promising clinical development programs.

Sumitovant Biopharma said its affiliate Myovant Sciences Ltd (NYSE: MYOV) has submitted an NDA for the once-daily relugolix combo tablet, comprising relugolix 40 mg, estradiol 1mg and norethindrone acetate 0.5 mg, for the treatment of women with heavy menstrual bleeding associated with uterine fibroids.

The stock was trading 0.95% higher at $17.09 in the premarket session.

Sanofi SA (NASDAQ: SNY) said the European Commission has approved its Sarclisain combination with pomalidomide and dexamethasone for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on the last therapy.

Aytu Bioscience Inc (NASDAQ: AYTU) said it has retired $15 million debt assumed in connection with its previously announced acquisition of Cerecor Inc's(NASDAQ: CERC) Commercial Portfolio.

Tetraphase Pharmaceuticals Inc (NASDAQ: TTPH) said a revised offer from Melinta received in response to another revised offer from anothersuitor,AcelRx Pharmaceuticals Inc (NASDAQ: ACRX), has been deemed a superior offer by its board.

Melinta and AcelRx have been engaged in a bidding war to lap up Tetraphase, with both companies sweetening their respective bids a few times.

The revised AcelRx offer received May 27 called for exchanging each unit ofTetraphase stock for $0.5872 in cash and 0.7409AcelRx shares, representing $1.70 in upfront per share value, and one CVR, entitling the holders to receive potential payments of up to $16 million in cash upon the achievement of certain future Xerava net sales milestones starting in 2021.

Melinta's most recent bid offered $39 million in cash,plus an additional $16 million in cash potentially payable under CVR to be issued in the proposed acquisition.

In premarket trading Tuesday, Tetraphase gained 6.9% to $2.48, while AcelRx shares were surging higher by 6.3% to $1.35.

OraSure Technologies, Inc. (NASDAQ: OSUR) said it has commenced an underwritten public offering of 8 million shares of its common stock.

The stock slipped 4.32% to $13.51 in after-hours trading.

Adaptimmune priced its underwritten public offering of 20.5 million shares of its ADSs at $11 eachfor gross proceeds of $225.5 million. The company expects the offering to close on or about June 4.

Kaleido Biosciences Inc (NASDAQ: KLDO) priced its underwritten public offering of 4.75 million shares of its common stock at $7.50 per share. The company expects to raise gross proceeds of $35.6 million from the offering. All the shares are being offered by the company. The offering is expected to close June 4.

The stock was trading 2.87% higher at $8.24 in the premarket session.

Allogene Therapeutics Inc (NASDAQ: ALLO) priced its underwritten public offering of 11.702 million shares at $47 per share for gross proceeds of $550 million.The offering is expected to close on or about June 4.

The stock fell 0.57% to $48.66 in after-hours trading.

Guardant Health Inc (NASDAQ: GH) announced the commencement of a proposed underwritten public offering of 10 million shares of its common stock, of which 3 million shares are being offered by Guardant Health and 7 million by SoftBank Investment.

The stock was up 0.1% at $48.99 premarket.

G1 Therapeutics Inc (NASDAQ: GTHX) said it has entered into a debt financing agreement with Hercules Capital, Inc. (NYSE: HTGC) for up to $100 million. The company plans to use the proceeds to fund commercialization and further development of trilaciclib, its first-in-class investigational therapy designed to improve outcomes for people with cancer treated with chemotherapy.

Intellia Therapeutics Inc (NASDAQ: NTLA) said it has commenced an underwritten public offering of $75 million of shares of its common stock. All of the shares in the proposed offering are to be sold by Intellia.

Intellia shares were trading 0.91% higher at $20.73 premarket Tuesday.

Related Link: Attention Biotech Investors: Mark Your Calendar For June PDUFA Dates

2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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The Daily Biotech Pulse: FDA Nod For Roche's Combo Therapy In Liver Cancer, Allena Rips Higher, Pfizer To Invest Up To $500M In Biotechs - Benzinga

The Biotechnology Algae Cultivation Process (Micro Algae) Market report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

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The report presents the market competitive landscape and a corresponding detailed analysis of the major vendor/key players in the market. Top Companies in the Global Biotechnology Algae Cultivation Process (Micro Algae) Market: Cellana, Ecoduna, Algenol Biofuels, Solix Biofuels, Sapphire Energy, Solazyme, Seambiotic, LGem, Cyanotech, DENSO, Mialgae and others.

Biotechnology algae cultivation process like algaculture is a form of aquaculture involving the farming of species of algae. The majority of algae that are intentionally cultivated fall into the category of microalgae (also referred to as phytoplankton, microphytes, or planktonic algae).

Global Biotechnology Algae Cultivation Process (Micro Algae) Market Split by Product Type and Applications:

This report segments the market on the basis of Types are:

Euglenophyta (Euglenoids)Chrysophyta (Golden-Brown Algae and Diatoms)Pyrrophyta (Fire Algae)Chlorophyta (Green Algae)Rhodophyta (Red Algae)Paeophyta (Brown Algae)Xanthophyta (Yellow-Green Algae)Others

On the basis of Application, the market is segmented into:

FoodFertilizer and AgarPollution ControlEnergy Production

Regional Analysis For Biotechnology Algae Cultivation Process (Micro Algae) Market:

For comprehensive understanding of market dynamics, the global Biotechnology Algae Cultivation Process (Micro Algae) market is analyzed across key geographies namely:

North America (United States, Canada and Mexico)Europe (Germany, France, UK, Russia and Italy)Asia-Pacific (China, Japan, Korea, India and Southeast Asia)South America (Brazil, Argentina, Colombia)Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Each of these regions is analyzed on basis of market findings across major countries in these regions for a macro-level understanding of the market.

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Biotechnology Algae Cultivation Process (Micro Algae) Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger and acquisitions along with trending innovation and business policies are reviewed in the report. The report contains basic, secondary and advanced information pertaining to the Market global status and trend, market size, share, growth, trends analysis, segment and forecasts from 20202026.

Following are major Table of Content of Biotechnology Algae Cultivation Process (Micro Algae) Market:

Global Market Overview, Drivers, Restraints and Opportunities, Segmentation overview

Global Market competition by top Players

Analysis by Regions

Consumption by Regions

Consumption, By Types, Revenue and Market share by Types

Consumption, By Applications, Market share (%) and Growth Rate by Applications

Complete profiling and analysis of Players

Industrial Chain, Sourcing Strategy and Downstream Buyers

Marketing Strategy Analysis, Distributors/Traders

Global Market Effect Factors Analysis

Global Market Forecast

Global Market Research Findings and Conclusion, Appendix, methodology and data source

Finally, all aspects of the Global Market are quantitatively as well qualitatively assessed to study the Global as well as regional market comparatively. This market study presents critical information and factual data about the market providing an overall statistical study of this market on the basis of market drivers, limitations and its future prospects. The report supplies the international economic competition with the assistance of Porters Five Forces Analysis and SWOT Analysis.

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How we have factored the effect of Covid-19 in our report:

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Biotechnology Algae Cultivation Process (Micro Algae) Market Global Research, Size, Share and Growth Opportunity 2020 to 2026 - Cole of Duty

SAN FRANCISCO, May 28, 2020 (GLOBE NEWSWIRE) -- UNITY Biotechnology (UNITY) [NASDAQ:UBX], a biotechnology company developing therapeutics to extend healthspan by slowing, halting or reversing diseases of aging, today announced that members of its senior management team will participate in the upcoming Goldman Sachs 41st Annual Global Healthcare Conference.

Goldman Sachs 41st Annual Global Healthcare Conference

Date: June 11, 2020Fireside Chat Time: 3:50 PM E.T. Location: Virtual

A live audio webcast of the fireside chat will be available through the Investors & Media section of UNITYs website. An archived replay will be available for 90 days following the event.

About UNITYUNITY is developing therapeutics to extend healthspan with an initial focus on cellular senescence. UNITY believes that the accumulation of senescent cells is a fundamental mechanism of aging and a driver of many common age-related diseases. Cellular senescence is a natural biological state in which a cell permanently halts division. As senescent cells accumulate with age, they begin secreting inflammatory factors, proteases, fibrotic factors, and growth factors, that disturb the tissue micro-environment. This collection of secreted proteins is referred to as the Senescence Associated Secretory Phenotype, or SASP. UNITY is developing senolytic medicines to eliminate senescent cells and thereby stop the production of the SASP, which UNITY believes addresses a root cause of age-related diseases. By stopping the production of the SASP at it source, UNITY believes senolytic medicines could slow, halt, or reverse diseases such as osteoarthritis and age-related eye diseases. More information is available atwww.unitybiotechnology.comor follow us onTwitter.

Investors Endurance AdvisorsMike Zanonimzanoni@enduranceadvisors.com

Media Canale CommunicationsJason Sparkjason@canalecomm.com

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UNITY Biotechnology to Participate in the Goldman Sachs 41st Annual Global Healthcare Conference - GlobeNewswire