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Monthly Archives: September 2018
Detroit Michigan Stem Cell Therapy – americanregen.com
Posted: September 28, 2018 at 9:41 am
Detroit Michigan Stem Cell Therapy
Stem Cell Therapy in Detroit Michigan is a process whereby stem cells from one area ofthe body are relocated to an area of injury or disease. In Stem Cell Therapy, therelocated stem cells form into the type of cell that the body needs to heal the injury.Stem Cell Therapy has the potential to not only heal the injury or disease, but alsoreverse the effect of diseases.
A variety of diseases are being treated by Stem Cell Therapy in Detroit Michigan. Diseasesand injuries range from COPD, arthritis, sports related injuries, Crohns Disease,neurological disorders and many more. The process by which Stem Cell Therapy takesplace in Detroit Michigan takes just a few hours. The cells are pulled through fat tissue orbone marrow in one area of the body, typically the pelvic area, and are immediatelydisposed into the area of the injury
If you would like to learn more about regenerative medicine or how it can help you, please call us at (248) 876-4242.
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Global catastrophic risk – Wikipedia
Posted: September 27, 2018 at 3:47 pm
Hypothetical future event that has the potential to damage human well-being on a global scale
A global catastrophic risk is a hypothetical future event which could damage human well-being on a global scale,[2] even crippling or destroying modern civilization.[3] An event that could cause human extinction or permanently and drastically curtail humanity's potential is known as an existential risk.[4]
Potential global catastrophic risks include anthropogenic risks, caused by humans (technology, governance, climate change), and natural or external risks.[3] Examples of technology risks are hostile artificial intelligence and destructive biotechnology or nanotechnology. Insufficient or malign global governance creates risks in the social and political domain, such as a global war, including nuclear holocaust, bioterrorism using genetically modified organisms, cyberterrorism destroying critical infrastructure like the electrical grid; or the failure to manage a natural pandemic. Problems and risks in the domain of earth system governance include global warming, environmental degradation, including extinction of species, famine as a result of non-equitable resource distribution, human overpopulation, crop failures and non-sustainable agriculture. Examples of non-anthropogenic risks are an asteroid impact event, a supervolcanic eruption, a lethal gamma-ray burst, a geomagnetic storm destroying electronic equipment, natural long-term climate change, or hostile extraterrestrial life.
Philosopher Nick Bostrom classifies risks according to their scope and intensity.[5] A "global catastrophic risk" is any risk that is at least "global" in scope, and is not subjectively "imperceptible" in intensity. Those that are at least "trans-generational" (affecting all future generations) in scope and "terminal"[clarification needed] in intensity are classified as existential risks. While a global catastrophic risk may kill the vast majority of life on earth, humanity could still potentially recover. An existential risk, on the other hand, is one that either destroys humanity (and, presumably, all but the most rudimentary species of non-human lifeforms and/or plant life) entirely or at least prevents any chance of civilization recovering. Bostrom considers existential risks to be far more significant.[6]
Similarly, in Catastrophe: Risk and Response, Richard Posner singles out and groups together events that bring about "utter overthrow or ruin" on a global, rather than a "local or regional" scale. Posner singles out such events as worthy of special attention on cost-benefit grounds because they could directly or indirectly jeopardize the survival of the human race as a whole.[7] Posner's events include meteor impacts, runaway global warming, grey goo, bioterrorism, and particle accelerator accidents.
Researchers experience difficulty in studying near human extinction directly, since humanity has never been destroyed before.[8] While this does not mean that it will not be in the future, it does make modelling existential risks difficult, due in part to survivorship bias.
Bostrom identifies four types of existential risk. "Bangs" are sudden catastrophes, which may be accidental or deliberate. He thinks the most likely sources of bangs are malicious use of nanotechnology, nuclear war, and the possibility that the universe is a simulation that will end. "Crunches" are scenarios in which humanity survives but civilization is slowly destroyed. The most likely causes of this, he believes, are exhaustion of natural resources, a stable global government that prevents technological progress, or dysgenic pressures that lower average intelligence. "Shrieks" are undesirable futures. For example, if a single mind enhances its powers by merging with a computer, it could dominate human civilization. Bostrom believes that this scenario is most likely, followed by flawed superintelligence and a repressive totalitarian regime. "Whimpers" are the gradual decline of human civilization or current values. He thinks the most likely cause would be evolution changing moral preference, followed by extraterrestrial invasion.[4]
Some risks, such as that from asteroid impact, with a one-in-a-million chance of causing humanity's extinction in the next century,[9] have had their probabilities predicted using straightforward, well-understood, and (in principle) precise methods (although even in cases like these, the exact rate of large impacts is contested).[10] Similarly, the frequency of volcanic eruptions of sufficient magnitude to cause catastrophic climate change, similar to the Toba Eruption, which may have almost caused the extinction of the human race,[11] has been estimated at about 1 in every 50,000 years.[12]
The relative danger posed by other threats is much more difficult to calculate. Given the limitations of ordinary calculation and modeling, expert elicitation is frequently used instead to obtain probability estimates.[13] In 2008, an informal survey of experts on different global catastrophic risks at the Global Catastrophic Risk Conference at the University of Oxford suggested a 19% chance of human extinction by the year 2100. The conference report cautions that the results should be taken "with a grain of salt".[14]
The 2016 annual report by the Global Challenges Foundation estimates that an average American is more than five times more likely to die during a human-extinction event than in a car crash.[15][16]
There are significant methodological challenges in estimating these risks with precision. Most attention has been given to risks to human civilization over the next 100 years, but forecasting for this length of time is difficult. The types of threats posed by nature may prove relatively constant, though new risks could be discovered. Anthropogenic threats, however, are likely to change dramatically with the development of new technology; while volcanoes have been a threat throughout history, nuclear weapons have only been an issue since the 20th century. Historically, the ability of experts to predict the future over these timescales has proved very limited. Man-made threats such as nuclear war or nanotechnology are harder to predict than natural threats, due to the inherent methodological difficulties in the social sciences. In general, it is hard to estimate the magnitude of the risk from this or other dangers, especially as both international relations and technology can change rapidly.
Existential risks pose unique challenges to prediction, even more than other long-term events, because of observation selection effects. Unlike with most events, the failure of a complete extinction event to occur in the past is not evidence against their likelihood in the future, because every world that has experienced such an extinction event has no observers, so regardless of their frequency, no civilization observes existential risks in its history.[8] These anthropic issues can be avoided by looking at evidence that does not have such selection effects, such as asteroid impact craters on the Moon, or directly evaluating the likely impact of new technology.[5]
In addition to known and tangible risks, unforeseeable black swan extinction events may occur, presenting an additional methodological problem.[17]
Some scholars have strongly favored reducing existential risk on the grounds that it greatly benefits future generations. Derek Parfit argues that extinction would be a great loss because our descendants could potentially survive for four billion years before the expansion of the Sun makes the Earth uninhabitable.[18][19] Nick Bostrom argues that there is even greater potential in colonizing space. If future humans colonize space, they may be able to support a very large number of people on other planets, potentially lasting for trillions of years.[6] Therefore, reducing existential risk by even a small amount would have a very significant impact on the expected number of people who will exist in the future.
Exponential discounting might make these future benefits much less significant. However, Jason Matheny has argued that such discounting is inappropriate when assessing the value of existential risk reduction.[9]
Some economists have discussed the importance of global catastrophic risks, though not existential risks. Martin Weitzman argues that most of the expected economic damage from climate change may come from the small chance that warming greatly exceeds the mid-range expectations, resulting in catastrophic damage.[20] Richard Posner has argued that we are doing far too little, in general, about small, hard-to-estimate risks of large-scale catastrophes.[21]
Numerous cognitive biases can influence people's judgment of the importance of existential risks, including scope insensitivity, hyperbolic discounting, availability heuristic, the conjunction fallacy, the affect heuristic, and the overconfidence effect.[22]
Scope insensitivity influences how bad people consider the extinction of the human race to be. For example, when people are motivated to donate money to altruistic causes, the quantity they are willing to give does not increase linearly with the magnitude of the issue: people are roughly as concerned about 200,000 birds getting stuck in oil as they are about 2,000.[23] Similarly, people are often more concerned about threats to individuals than to larger groups.[22]
There are economic reasons that can explain why so little effort is going into existential risk reduction. It is a global good, so even if a large nation decreases it, that nation will only enjoy a small fraction of the benefit of doing so. Furthermore, the vast majority of the benefits may be enjoyed by far future generations, and though these quadrillions of future people would in theory perhaps be willing to pay massive sums for existential risk reduction, no mechanism for such a transaction exists.[5]
Some sources of catastrophic risk are natural, such as meteor impacts or supervolcanoes. Some of these have caused mass extinctions in the past. On the other hand, some risks are man-made, such as global warming,[24] environmental degradation, engineered pandemics and nuclear war.
The Cambridge Project at Cambridge University states that the "greatest threats" to the human species are man-made; they are artificial intelligence, global warming, nuclear war, and rogue biotechnology.[25] The Future of Humanity Institute also states that human extinction is more likely to result from anthropogenic causes than natural causes.[5][26]
It has been suggested that learning computers that rapidly become superintelligent may take unforeseen actions, or that robots would out-compete humanity (one technological singularity scenario).[27] Because of its exceptional scheduling and organizational capability and the range of novel technologies it could develop, it is possible that the first Earth superintelligence to emerge could rapidly become matchless and unrivaled: conceivably it would be able to bring about almost any possible outcome, and be able to foil virtually any attempt that threatened to prevent it achieving its objectives.[28] It could eliminate, wiping out if it chose, any other challenging rival intellects; alternatively it might manipulate or persuade them to change their behavior towards its own interests, or it may merely obstruct their attempts at interference.[28] In Bostrom's book, Superintelligence: Paths, Dangers, Strategies, he defines this as the control problem.[29] Physicist Stephen Hawking, Microsoft founder Bill Gates and SpaceX founder Elon Musk have echoed these concerns, with Hawking theorizing that this could "spell the end of the human race".[30]
In 2009, the Association for the Advancement of Artificial Intelligence (AAAI) hosted a conference to discuss whether computers and robots might be able to acquire any sort of autonomy, and how much these abilities might pose a threat or hazard. They noted that some robots have acquired various forms of semi-autonomy, including being able to find power sources on their own and being able to independently choose targets to attack with weapons. They also noted that some computer viruses can evade elimination and have achieved "cockroach intelligence." They noted that self-awareness as depicted in science-fiction is probably unlikely, but that there were other potential hazards and pitfalls.[31] Various media sources and scientific groups have noted separate trends in differing areas which might together result in greater robotic functionalities and autonomy, and which pose some inherent concerns.[32][33]
A survey of AI experts estimated that the chance of human-level machine learning having an "extremely bad (e.g., human extinction)" long-term effect on humanity is 5%.[34] A survey by the Future of Humanity Institute estimated a 5% probability of extinction by superintelligence by 2100.[14] Eliezer Yudkowsky believes that risks from artificial intelligence are harder to predict than any other known risks due to bias from anthropomorphism. Since people base their judgments of artificial intelligence on their own experience, he claims that they underestimate the potential power of AI.[35]
Biotechnology can pose a global catastrophic risk in the form of bioengineered organisms (viruses, bacteria, fungi, plants or animals). In many cases the organism will be a pathogen of humans, livestock, crops or other organisms we depend upon (e.g. pollinators or gut bacteria). However, any organism able to catastrophically disrupt ecosystem functions, e.g. highly competitive weeds, outcompeting essential crops, poses a biotechnology risk.
A biotechnology catastrophe may be caused by accidentally releasing a genetically engineered organism escaping from controlled environments, by the planned release of such an organism which then turns out to have unforeseen and catastrophic interactions with essential natural or agro-ecosystems, or by intentional usage of biological agents in biological warfare, bioterrorism attacks.[36] Pathogens may be intentionally or unintentionally genetically modified to change virulence and other characteristics.[36] For example, a group of Australian researchers unintentionally changed characteristics of the mousepox virus while trying to develop a virus to sterilize rodents.[36] The modified virus became highly lethal even in vaccinated and naturally resistant mice.[37][38] The technological means to genetically modify virus characteristics are likely to become more widely available in the future if not properly regulated.[36]
Terrorist applications of biotechnology have historically been infrequent. To what extent this is due to a lack of capabilities or motivation is not resolved.[36] However, given current development, more risk from novel, engineered pathogens is to be expected in the future.[36] Exponential growth has been observed in the biotechnology sector, and Noun and Chyba predict that this will lead to major increases in biotechnological capabilities in the coming decades.[36] They argue that risks from biological warfare and bioterrorism are distinct from nuclear and chemical threats because biological pathogens are easier to mass-produce and their production is hard to control (especially as the technological capabilities are becoming available even to individual users).[36] A survey by the Future of Humanity Institute estimated a 2% probability of extinction from engineered pandemics by 2100.[14]
Noun and Chyba propose three categories of measures to reduce risks from biotechnology and natural pandemics: Regulation or prevention of potentially dangerous research, improved recognition of outbreaks and developing facilities to mitigate disease outbreaks (e.g. better and/or more widely distributed vaccines).[36]
Cyberattacks have the potential to destroy everything from personal data to electric grids. Christine Peterson, co-founder and past president of the Foresight Institute, believes a cyberattack on electric grids has the potential to be a catastrophic risk.[39]
Global warming refers to the warming caused by human technology since the 19th century or earlier. Projections of future climate change suggest further global warming, sea level rise, and an increase in the frequency and severity of some extreme weather events and weather-related disasters. Effects of global warming include loss of biodiversity, stresses to existing food-producing systems, increased spread of known infectious diseases such as malaria, and rapid mutation of microorganisms. In November 2017, a statement by 15,364 scientists from 184 countries indicated that increasing levels of greenhouse gases from use of fossil fuels, human population growth, deforestation, and overuse of land for agricultural production, particularly by farming ruminants for meat consumption, are trending in ways that forecast an increase in human misery over coming decades.[3]
An environmental or ecological disaster, such as world crop failure and collapse of ecosystem services, could be induced by the present trends of overpopulation, economic development,[40] and non-sustainable agriculture. Most environmental scenarios involve one or more of the following: Holocene extinction event,[41] scarcity of water that could lead to approximately one half of the Earth's population being without safe drinking water, pollinator decline, overfishing, massive deforestation, desertification, climate change, or massive water pollution episodes. Detected in the early 21st century, a threat in this direction is colony collapse disorder,[42] a phenomenon that might foreshadow the imminent extinction[43] of the Western honeybee. As the bee plays a vital role in pollination, its extinction would severely disrupt the food chain.
An October 2017 report published in The Lancet stated that toxic air, water, soils, and workplaces were collectively responsible for 9 million deaths worldwide in 2015, particularly from air pollution which was linked to deaths by increasing susceptibility to non-infectious diseases, such as heart disease, stroke, and lung cancer.[44] The report warned that the pollution crisis was exceeding "the envelope on the amount of pollution the Earth can carry" and threatens the continuing survival of human societies.[44]
Romanian American economist Nicholas Georgescu-Roegen, a progenitor in economics and the paradigm founder of ecological economics, has argued that the carrying capacity of Earth that is, Earth's capacity to sustain human populations and consumption levels is bound to decrease sometime in the future as Earth's finite stock of mineral resources is presently being extracted and put to use; and consequently, that the world economy as a whole is heading towards an inevitable future collapse, leading to the demise of human civilization itself.[45]:303f Ecological economist and steady-state theorist Herman Daly, a student of Georgescu-Roegen, has propounded the same argument by asserting that "... all we can do is to avoid wasting the limited capacity of creation to support present and future life [on Earth]."[46]:370
Ever since Georgescu-Roegen and Daly published these views, various scholars in the field have been discussing the existential impossibility of allocating earth's finite stock of mineral resources evenly among an unknown number of present and future generations. This number of generations is likely to remain unknown to us, as there is no way or only little way of knowing in advance if or when mankind will ultimately face extinction. In effect, any conceivable intertemporal allocation of the stock will inevitably end up with universal economic decline at some future point.[47]:253256 [48]:165 [49]:168171 [50]:150153 [51]:106109 [52]:546549 [53]:142145
Nick Bostrom suggested that in the pursuit of knowledge, humanity might inadvertently create a device that could destroy Earth and the Solar System.[54] Investigations in nuclear and high-energy physics could create unusual conditions with catastrophic consequences. For example, scientists worried that the first nuclear test might ignite the atmosphere.[55][56] More recently, others worried that the RHIC[57] or the Large Hadron Collider might start a chain-reaction global disaster involving black holes, strangelets, or false vacuum states. These particular concerns have been refuted,[58][59][60][61] but the general concern remains.
Biotechnology could lead to the creation of a pandemic, chemical warfare could be taken to an extreme, nanotechnology could lead to grey goo in which out-of-control self-replicating robots consume all living matter on earth while building more of themselvesin both cases, either deliberately or by accident.[62]
Many nanoscale technologies are in development or currently in use.[63] The only one that appears to pose a significant global catastrophic risk is molecular manufacturing, a technique that would make it possible to build complex structures at atomic precision.[64] Molecular manufacturing requires significant advances in nanotechnology, but once achieved could produce highly advanced products at low costs and in large quantities in nanofactories of desktop proportions.[63][64] When nanofactories gain the ability to produce other nanofactories, production may only be limited by relatively abundant factors such as input materials, energy and software.[63]
Molecular manufacturing could be used to cheaply produce, among many other products, highly advanced, durable weapons.[63] Being equipped with compact computers and motors these could be increasingly autonomous and have a large range of capabilities.[63]
Chris Phoenix and Treder classify catastrophic risks posed by nanotechnology into three categories:
Several researchers state that the bulk of risk from nanotechnology comes from the potential to lead to war, arms races and destructive global government.[37][63][65] Several reasons have been suggested why the availability of nanotech weaponry may with significant likelihood lead to unstable arms races (compared to e.g. nuclear arms races):
Since self-regulation by all state and non-state actors seems hard to achieve,[67] measures to mitigate war-related risks have mainly been proposed in the area of international cooperation.[63][68] International infrastructure may be expanded giving more sovereignty to the international level. This could help coordinate efforts for arms control. International institutions dedicated specifically to nanotechnology (perhaps analogously to the International Atomic Energy Agency IAEA) or general arms control may also be designed.[68] One may also jointly make differential technological progress on defensive technologies, a policy that players should usually favour.[63] The Center for Responsible Nanotechnology also suggests some technical restrictions.[69] Improved transparency regarding technological capabilities may be another important facilitator for arms-control.
Grey goo is another catastrophic scenario, which was proposed by Eric Drexler in his 1986 book Engines of Creation[70] and has been a theme in mainstream media and fiction.[71][72] This scenario involves tiny self-replicating robots that consume the entire biosphere using it as a source of energy and building blocks. Nowadays, however, nanotech expertsincluding Drexlerdiscredit the scenario. According to Phoenix, a "so-called grey goo could only be the product of a deliberate and difficult engineering process, not an accident".[73]
The scenarios that have been explored most frequently are nuclear warfare and doomsday devices. Although the probability of a nuclear war per year is slim, Professor Martin Hellman has described it as inevitable in the long run; unless the probability approaches zero, inevitably there will come a day when civilization's luck runs out.[74] During the Cuban missile crisis, U.S. president John F. Kennedy estimated the odds of nuclear war at "somewhere between one out of three and even".[75] The United States and Russia have a combined arsenal of 14,700 nuclear weapons,[76] and there is an estimated total of 15,700 nuclear weapons in existence worldwide.[76] Beyond nuclear, other military threats to humanity include biological warfare (BW). By contrast, chemical warfare, while able to create multiple local catastrophes, is unlikely to create a global one.
Nuclear war could yield unprecedented human death tolls and habitat destruction. Detonating large numbers of nuclear weapons would have an immediate, short term and long-term effects on the climate, causing cold weather and reduced sunlight and photosynthesis[77] that may generate significant upheaval in advanced civilizations.[78] However, while popular perception sometimes takes nuclear war as "the end of the world", experts assign low probability to human extinction from nuclear war.[79][80] In 1982, Brian Martin estimated that a USSoviet nuclear exchange might kill 400450 million directly, mostly in the United States, Europe and Russia, and maybe several hundred million more through follow-up consequences in those same areas.[79] A survey by the Future of Humanity Institute estimated a 4% probability of extinction from warfare by 2100, with a 1% chance of extinction from nuclear warfare.[14]
The 20th century saw a rapid increase in human population due to medical developments and massive increases in agricultural productivity[81] such as the Green Revolution.[82] Between 1950 and 1984, as the Green Revolution transformed agriculture around the globe, world grain production increased by 250%. The Green Revolution in agriculture helped food production to keep pace with worldwide population growth or actually enabled population growth. The energy for the Green Revolution was provided by fossil fuels in the form of fertilizers (natural gas), pesticides (oil), and hydrocarbon-fueled irrigation.[83] David Pimentel, professor of ecology and agriculture at Cornell University, and Mario Giampietro, senior researcher at the National Research Institute on Food and Nutrition (INRAN), place in their 1994 study Food, Land, Population and the U.S. Economy the maximum U.S. population for a sustainable economy at 200 million. To achieve a sustainable economy and avert disaster, the United States must reduce its population by at least one-third, and world population will have to be reduced by two-thirds, says the study.[84]
The authors of this study believe that the mentioned agricultural crisis will begin to have an effect on the world after 2020, and will become critical after 2050. Geologist Dale Allen Pfeiffer claims that coming decades could see spiraling food prices without relief and massive starvation on a global level such as never experienced before.[85][86]
Wheat is humanity's third-most-produced cereal. Extant fungal infections such as Ug99[87] (a kind of stem rust) can cause 100% crop losses in most modern varieties. Little or no treatment is possible and infection spreads on the wind. Should the world's large grain-producing areas become infected, the ensuing crisis in wheat availability would lead to price spikes and shortages in other food products.[88]
Several asteroids have collided with earth in recent geological history. The Chicxulub asteroid, for example, is theorized to have caused the extinction of the non-avian dinosaurs 66 million years ago at the end of the Cretaceous. No sufficiently large asteroid currently exists in an Earth-crossing orbit; however, a comet of sufficient size to cause human extinction could impact the Earth, though the annual probability may be less than 108.[89] Geoscientist Brian Toon estimates that a 60-mile meteorite would be large enough to "incinerate everybody".[90] Asteroids with around a 1km diameter have impacted the Earth on average once every 500,000 years; these are probably too small to pose an extinction risk, but might kill billions of people.[89][91] Larger asteroids are less common. Small near-Earth asteroids are regularly observed and can impact anywhere on the Earth injuring local populations [92]. As of 2013, Spaceguard estimates it has identified 95% of all NEOs over 1km in size.[93]
In April 2018, the B612 Foundation reported "It's a 100 per cent certain we'll be hit [by a devastating asteroid], but we're not 100 per cent sure when."[94][95] In June 2018, the US National Science and Technology Council warned that America is unprepared for an asteroid impact event, and has developed and released the "National Near-Earth Object Preparedness Strategy Action Plan" to better prepare.[96][97][98][99][100]
Extraterrestrial life could invade Earth[101] either to exterminate and supplant human life, enslave it under a colonial system, steal the planet's resources, or destroy the planet altogether.
Although evidence of alien life has never been documented, scientists such as Carl Sagan have postulated that the existence of extraterrestrial life is very likely. In 1969, the "Extra-Terrestrial Exposure Law" was added to the United States Code of Federal Regulations (Title 14, Section 1211) in response to the possibility of biological contamination resulting from the U.S. Apollo Space Program. It was removed in 1991.[102] Scientists consider such a scenario technically possible, but unlikely.[103]
An article in The New York Times discussed the possible threats for humanity of intentionally sending messages aimed at extraterrestrial life into the cosmos in the context of the SETI efforts. Several renowned public figures such as Stephen Hawking and Elon Musk have argued against sending such messages on the grounds that extraterrestrial civilizations with technology are probably far more advanced than humanity and could pose an existential threat to humanity.[104]
Climate change refers to a lasting change in the Earth's climate. The climate has ranged from ice ages to warmer periods when palm trees grew in Antarctica. It has been hypothesized that there was also a period called "snowball Earth" when all the oceans were covered in a layer of ice. These global climatic changes occurred slowly, prior to the rise of human civilization about 10 thousand years ago near the end of the last Major Ice Age when the climate became more stable. However, abrupt climate change on the decade time scale has occurred regionally. Since civilization originated during a period of stable climate, a natural variation into a new climate regime (colder or hotter) could pose a threat to civilization.
In the history of the Earth, many ice ages are known to have occurred. More ice ages will be possible at an interval of 40,000100,000 years. An ice age would have a serious impact on civilization because vast areas of land (mainly in North America, Europe, and Asia) could become uninhabitable. It would still be possible to live in the tropical regions, but with possible loss of humidity and water. Currently, the world is in an interglacial period within a much older glacial event. The last glacial expansion ended about 10,000 years ago, and all civilizations evolved later than this. Scientists do not predict that a natural ice age will occur anytime soon. This may be due to manmade emissions potentially delaying the possible onset or another ice age for at least another 50,000 years.
A number of astronomical threats have been identified. Massive objects, e.g. a star, large planet or black hole, could be catastrophic if a close encounter occurred in the Solar System. In April 2008, it was announced that two simulations of long-term planetary movement, one at the Paris Observatory and the other at the University of California, Santa Cruz, indicate a 1% chance that Mercury's orbit could be made unstable by Jupiter's gravitational pull sometime during the lifespan of the Sun. Were this to happen, the simulations suggest a collision with Earth could be one of four possible outcomes (the others being Mercury colliding with the Sun, colliding with Venus, or being ejected from the Solar System altogether). If Mercury were to collide with Earth, all life on Earth could be obliterated entirely: an asteroid 15km wide is believed to have caused the extinction of the non-avian dinosaurs, whereas Mercury is 4,879km in diameter.[105]
Another cosmic threat is a gamma-ray burst, typically produced by a supernova when a star collapses inward on itself and then "bounces" outward in a massive explosion. Under certain circumstances, these events are thought to produce massive bursts of gamma radiation emanating outward from the axis of rotation of the star. If such an event were to occur oriented towards the Earth, the massive amounts of gamma radiation could significantly affect the Earth's atmosphere and pose an existential threat to all life. Such a gamma-ray burst may have been the cause of the OrdovicianSilurian extinction events. Neither this scenario nor the destabilization of Mercury's orbit are likely in the foreseeable future.[106]
If the Solar System were to pass through a dark nebula, a cloud of cosmic dust, severe global climate change would occur.[107]
A powerful solar flare or solar superstorm, which is a drastic and unusual decrease or increase in the Sun's power output, could have severe consequences for life on Earth.[citation needed]
If our universe lies within a false vacuum, a bubble of lower-energy vacuum could come to exist by chance or otherwise in our universe, and catalyze the conversion of our universe to a lower energy state in a volume expanding at nearly the speed of light, destroying all that we know without forewarning.[108][further explanation needed] Such an occurrence is called vacuum decay.
The magnetic poles of the Earth shifted many times in geologic history. The duration of such a shift is still debated. Theories exist that during such times, the Earth's magnetic field would be substantially weakened, threatening civilization by allowing radiation from the Sun, especially solar wind, solar flares or cosmic radiation, to reach the surface. These theories have been somewhat discredited, as statistical analysis shows no evidence for a correlation between past reversals and past extinctions.[109][110]
Numerous historical examples of pandemics[111] had a devastating effect on a large number of people. The present, unprecedented scale and speed of human movement make it more difficult than ever to contain an epidemic through local quarantines. A global pandemic has become a realistic threat to human civilization.
Naturally evolving pathogens will ultimately develop an upper limit to their virulence.[112] Pathogens with the highest virulence, quickly killing their hosts reduce their chances of spread the infection to new hosts or carriers.[113] This simple model predicts that - if virulence and transmission are not genetically linked - pathogens will evolve towards low virulence and rapid transmission. However, this is not necessarily a safeguard against a global catastrophe, for the following reasons:
1. The fitness advantage of limited virulence is primarily a function of a limited number of hosts. Any pathogen with a high virulence, high transmission rate and long incubation time may have already caused a catastrophic pandemic before ultimately virulence is limited through natural selection.2. In models where virulence level and rate of transmission are related, high levels of virulence can evolve.[114] Virulence is instead limited by the existence of complex populations of hosts with different susceptibilities to infection, or by some hosts being geographically isolated.[112] The size of the host population and competition between different strains of pathogens can also alter virulence.[115] 3. A pathogen that infects humans as a secondary host and primarily infects another species (a zoonosis) has no constraints on its virulence in people, since the accidental secondary infections do not affect its evolution.[116]
A geological event such as massive flood basalt, volcanism, or the eruption of a supervolcano[117] could lead to a so-called volcanic winter, similar to a nuclear winter. One such event, the Toba eruption,[118] occurred in Indonesia about 71,500 years ago. According to the Toba catastrophe theory,[119] the event may have reduced human populations to only a few tens of thousands of individuals. Yellowstone Caldera is another such supervolcano, having undergone 142 or more caldera-forming eruptions in the past 17 million years.[120]A massive volcano eruption would eject extraordinary volumes of volcanic dust, toxic and greenhouse gases into the atmosphere with serious effects on global climate (towards extreme global cooling: volcanic winter if short-term, and ice age if long-term) or global warming (if greenhouse gases were to prevail).
When the supervolcano at Yellowstone last erupted 640,000 years ago, the thinnest layers of the ash ejected from the caldera spread over most of the United States west of the Mississippi River and part of northeastern Mexico. The magma covered much of what is now Yellowstone National Park and extended beyond, covering much of the ground from Yellowstone River in the east to the Idaho falls in the west, with some of the flows extending north beyond Mammoth Springs.[121]
According to a recent study, if the Yellowstone caldera erupted again as a supervolcano, an ash layer one to three millimeters thick could be deposited as far away as New York, enough to "reduce traction on roads and runways, short out electrical transformers and cause respiratory problems". There would be centimeters of thickness over much of the U.S. Midwest, enough to disrupt crops and livestock, especially if it happened at a critical time in the growing season. The worst-affected city would likely be Billings, Montana, population 109,000, which the model predicted would be covered with ash estimated as 1.03 to 1.8 meters thick.[122]
The main long-term effect is through global climate change, which reduces the temperature globally by about 515 degrees C for a decade, together with the direct effects of the deposits of ash on their crops. A large supervolcano like Toba would deposit one or two meters thickness of ash over an area of several million square kilometers.(1000 cubic kilometers is equivalent to a one-meter thickness of ash spread over a million square kilometers). If that happened in some densely populated agricultural area, such as India, it could destroy one or two seasons of crops for two billion people.[123]
However, Yellowstone shows no signs of a supereruption at present, and it is not certain that a future supereruption will occur there.[124][125]
Research published in 2011 finds evidence that massive volcanic eruptions caused massive coal combustion, supporting models for significant generation of greenhouse gases. Researchers have suggested that massive volcanic eruptions through coal beds in Siberia would generate significant greenhouse gases and cause a runaway greenhouse effect.[126] Massive eruptions can also throw enough pyroclastic debris and other material into the atmosphere to partially block out the sun and cause a volcanic winter, as happened on a smaller scale in 1816 following the eruption of Mount Tambora, the so-called Year Without a Summer. Such an eruption might cause the immediate deaths of millions of people several hundred miles from the eruption, and perhaps billions of deaths[127] worldwide, due to the failure of the monsoon[citation needed], resulting in major crop failures causing starvation on a profound scale.[127]
A much more speculative concept is the verneshot: a hypothetical volcanic eruption caused by the buildup of gas deep underneath a craton. Such an event may be forceful enough to launch an extreme amount of material from the crust and mantle into a sub-orbital trajectory.
Planetary management and respecting planetary boundaries have been proposed as approaches to preventing ecological catastrophes. Within the scope of these approaches, the field of geoengineering encompasses the deliberate large-scale engineering and manipulation of the planetary environment to combat or counteract anthropogenic changes in atmospheric chemistry. Space colonization is a proposed alternative to improve the odds of surviving an extinction scenario.[128] Solutions of this scope may require megascale engineering.Food storage has been proposed globally, but the monetary cost would be high. Furthermore, it would likely contribute to the current millions of deaths per year due to malnutrition.[citation needed]
Some survivalists stock survival retreats with multiple-year food supplies.
The Svalbard Global Seed Vault is buried 400 feet (120m) inside a mountain on an island in the Arctic. It is designed to hold 2.5 billion seeds from more than 100 countries as a precaution to preserve the world's crops. The surrounding rock is 6C (21F) (as of 2015) but the vault is kept at 18C (0F) by refrigerators powered by locally sourced coal.[129][130]
More speculatively, if society continues to function and if the biosphere remains habitable, calorie needs for the present human population might in theory be met during an extended absence of sunlight, given sufficient advance planning. Conjectured solutions include growing mushrooms on the dead plant biomass left in the wake of the catastrophe, converting cellulose to sugar, or feeding natural gas to methane-digesting bacteria.[131][132]
Insufficient global governance creates risks in the social and political domain, but the governance mechanisms develop more slowly than technological and social change. There are concerns from governments, the private sector, as well as the general public about the lack of governance mechanisms to efficiently deal with risks, negotiate and adjudicate between diverse and conflicting interests. This is further underlined by an understanding of the interconnectedness of global systemic risks.[133]
The Bulletin of the Atomic Scientists (est. 1945) is one of the oldest global risk organizations, founded after the public became alarmed by the potential of atomic warfare in the aftermath of WWII. It studies risks associated with nuclear war and energy and famously maintains the Doomsday Clock established in 1947. The Foresight Institute (est. 1986) examines the risks of nanotechnology and its benefits. It was one of the earliest organizations to study the unintended consequences of otherwise harmless technology gone haywire at a global scale. It was founded by K. Eric Drexler who postulated "grey goo".[134][135]
Beginning after 2000, a growing number of scientists, philosophers and tech billionaires created organizations devoted to studying global risks both inside and outside of academia.[136]
Independent non-governmental organizations (NGOs) include the Machine Intelligence Research Institute, which aims to reduce the risk of a catastrophe caused by artificial intelligence,[137] with donors including Peter Thiel and Jed McCaleb.[138] The Lifeboat Foundation (est. 2009) funds research into preventing a technological catastrophe.[139] Most of the research money funds projects at universities.[140] The Global Catastrophic Risk Institute (est. 2011) is a think tank for catastrophic risk. It is funded by the NGO Social and Environmental Entrepreneurs. The Global Challenges Foundation (est. 2012), based in Stockholm and founded by Laszlo Szombatfalvy, releases a yearly report on the state of global risks.[15][16] The Future of Life Institute (est. 2014) aims to support research and initiatives for safeguarding life considering new technologies and challenges facing humanity.[141] Elon Musk is one of its biggest donors.[142] The Nuclear Threat Initiative seeks to reduce global threats from nuclear, biological and chemical threats, and containment of damage after an event.[143] It maintains a nuclear material security index.[144]
University-based organizations include the Future of Humanity Institute (est. 2005) which researches the questions of humanity's long-term future, particularly existential risk. It was founded by Nick Bostrom and is based at Oxford University. The Centre for the Study of Existential Risk (est. 2012) is a Cambridge-based organization which studies four major technological risks: artificial intelligence, biotechnology, global warming and warfare. All are man-made risks, as Huw Price explained to the AFP news agency, "It seems a reasonable prediction that some time in this or the next century intelligence will escape from the constraints of biology". He added that when this happens "we're no longer the smartest things around," and will risk being at the mercy of "machines that are not malicious, but machines whose interests don't include us."[145] Stephen Hawking was an acting adviser. The Millennium Alliance for Humanity and the Biosphere is a Stanford University-based organization focusing on many issues related to global catastrophe by bringing together members of academic in the humanities.[146][147] It was founded by Paul Ehrlich among others.[148] Stanford University also has the Center for International Security and Cooperation focusing on political cooperation to reduce global catastrophic risk.[149]
Other risk assessment groups are based in or are part of governmental organizations. The World Health Organization (WHO) includes a division called the Global Alert and Response (GAR) which monitors and responds to global epidemic crisis.[150] GAR helps member states with training and coordination of response to epidemics.[151] The United States Agency for International Development (USAID) has its Emerging Pandemic Threats Program which aims to prevent and contain naturally generated pandemics at their source.[152] The Lawrence Livermore National Laboratory has a division called the Global Security Principal Directorate which researches on behalf of the government issues such as bio-security and counter-terrorism.[153]
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Stem Cell Treatment/Therapy COST in India| DheerajBojwani.Com
Posted: September 26, 2018 at 2:46 pm
Get your Stem Cell Treatment in India with Dheeraj Bojwani Consultants
Stem Cell treatment is an intricate process. Stem Cell transplant patients need utmost care with respect to both emotionally and physically. Dheeraj Bojwani Consultants is a prominent medical tourism company in India making world-class medical facilities from best surgeons and hospitals accessible for international patients looking for budget-friendly treatment abroad.
Mrs. Marilyn Obiora - Nigeria Stem Cell Therapy For her Daughter in India
Hi, my name is Mrs. Marilyn Obiora, and I am from Nigeria. I came to India for my daughter's Stem Cell Therapy in India. My daughter had her first stroke in 2011. She couldn't sit, talk and had lost control of her neck. We could not find suitable help for her condition and searched for treatment in India.
We sent a query to the dheerajbojwani.com and received fast reply. Within no time we were in India for my daughter's treatment. We are very pleased with the treatment offered and there has been serious improvement in her condition in just two weeks. Thanks to the Dheeraj Bojwani Consultants, my daughter is regaining proper body functions and recuperating well.
Medical science has come a long way since its practice began thousands of years ago. Scientists are finding superior and more resourceful ways to cure diseases of different organs. Stem cells are undifferentiated parent cells that can transform into specialized cell types, divide further and produce more stem cells of the same group. Stem Cell therapy is performed to prevent or treat a health condition. Stem Cell Treatment is a reproductive therapy where nourishing tissues reinstate damaged tissues for relief from incurable diseases. Stem cell treatment is one of the approaches with a potential to heal a wide range of diseases in the near future. Science has always provided ground-breaking answers to obdurate health conditions, but the latest medical miracle that the medical fraternity has gifted to mankind is the Stem Cell Therapy.
Stem cell therapy is an array of techniques intended to replace cells damaged or destroyed by disease with healthy functioning ones. Even though the techniques are relatively new, their applications and advantages are broad and surprising the medical world with every new research. Stem cells are obtained from bone marrow or human umbilical cord. They are also known as the fundamental cells of our body and have the power to develop into any type of tissue cell in the body. Stem cell treatment is based on the principle that the cells move to the site of injury and transform themselves to form new tissue cells to replace the damaged ones. They have the capacity to proliferate and renew themselves indefinitely and can form mature muscle cells, nerve cells, and blood cells. In this type of therapy, they are derived from the body, kept under artificial conditions where they mature into the type of cells that are required to heal a certain part of the body or disease.
Stem cells are being studied and used to treat different types of cancers, disorders related to the blood, immune disorders, and metabolic disorders. Some other diseases and health conditions that may be healed using stem cell treatment are,
Recently, a team of researchers successfully secured the peripheral nerves in the upper arms of a patient suffering peripheral nerve damage, by using skin-derived stem cells (SDSCs) and a previously developed collagen tube, premeditated to successfully bridge gaps in injured nerves.
A research has found potential in bone marrow stem cell therapy to treat TB. Patients injected with new mesenchymal stromal cells derived from their own bone marrow showed positive response against the TB bacteria. The therapy also didnt show any serious adverse effects.
Stem cells are also used to treat hair loss. A small amount of fat is taken from the waist area of the patient by a mini-liposuction process. This fat contains dormant stem cells, and is then spun to separate the stem cells from the fat. An activation solution is added to the cells, and may be multiplied in number, depending on the size of the bald area. Once activated, the solution is washed off so that only cells remain. Now, the stem cells are injected into the scalp. One can find some hair growth in about two to four weeks.
Damaged cones in retinas can be regenerated and eyesight restored through stem cell. Stem cell therapy could regenerate damaged cones in people, especially in the cone-rich regions of the retina that provide daytime/color vision.
Kidney transplants have become more common and easier thanks stem cell therapy. Normally patients who undergo organ transplants need a lifetime of costly anti-rejection drugs but the new procedure may negate this need, with organ donors stem cells. Unless there is a perfect match donor, patients have to wait long for an organ transplant. Though still in early stages, the stem cell research is being considered as a potential player in the field of transplantation.
Transplanted stem cells serve as migratory signals for the brain's own neurogenic cells, guiding the new host cells towards the injured brain tissue. Stem cells have the potential to give rise to many different cell types that carry out different functions. While the stem cells in adult bone marrow tend to develop into the cells that make up the organ system from which they originated. These multipotent stem cells can be manipulated to take up the characteristics of neural cells.
Experts are using Stem cell Transplant to treat the symptoms of spinal cord injury by transplantation of cells directly into the gray matter of the patients spinal cord. Expectedly, the cells will integrate into the patients own neural tissue and create new circuitry to help transmit nerve signals to muscles. The transplanted cells may also promote reorganization of the spinal cord segmental circuitry, possibly leading to improved motor function.
Stem cells are capable of differentiating into a variety of different cell types, and if the architecture of damaged tendon is restored, it would improve the management of patients with these injuries significantly.
A promising benefit of stem cell therapy is its potential for cardiac tissue regeneration to reverse tissue loss underlying the development of heart failure after cardiac injury. Possible mechanisms of recovery include generation of heart muscle cells, stimulation of new blood vessels growth, secretion of growth factors.
It is a complex and multifarious procedure, with several risks and complications involved and is thus recommended to a few patients when other treatments have failed. Stem Cell therapy is recommended when other treatments fail to give positive results. The best candidates for Stem cell Treatment are those in good health and have stem cells available from a sibling, or any other family member.
India has been recognized as the new medical destination for Stem Cell therapies. Hundreds of international patients from around the world visit to India for high quality medical care at par with developed nations like the US, UK, at the most affordable costs.
The Hospitals in India have the most extensive diagnostic and imaging facilities including Asias most advanced MRI and CT technology. India provides services of the most leading doctors and Stem Cell Therapy professionals at reasonable cost budget in the following cities :
Ms. Olu Adegbenro from Nigeria
Thanks to Dheeraj Bojwani Group for today I can live a happy life. Three years ago, I was diagnosed with optical atrophy due to advanced staged of Glaucoma. Eventually it turned up to as stage where my vision was completely impaired. Then, when I connected with the Dheeraj Bojwani Group after lots of research, evaluation, judgments and discussion, a specialist from the group suggested stem cell therapy. Today its been five years after the Therapy and I am extremely happy with the results of my stem cell treatment in India as my vision has improved a lot post treatment.
India offers outstanding Stem Cell Treatment at cost far below that prevailing in USA or other Western countries. Even with travel expenses taken into account, the comprehensive medical tourism packages still provide a savings measured in the thousands of dollars for major procedures. A cost comparison can give you the exact idea about the difference which shows the low cost stem cell treatment in India :
There are many reasons for India becoming a popular medical tourism spot is the low cost stem cell treatment in the area. When in contrast to the first world countries like, US and UK, medical care in India costs as much as 60-90% lesser, that makes it a great option for the citizens of those countries to opt for stem cell treatment in India because of availability of top stem cell treatment clinics in India, affordable prices strategic connectivity, food, zero language barrier and many other reasons.
The maximum number of patients for Stem Cell Treatment comes from Nigeria, Kenya, Ethiopia, USA, UK, Australia, Saudi Arabia, UAE, Uzbekistan, Bangladesh
Below are the downloadable links that will help you to plan your medical trip to India in a more organized and better way. Attached word and pdf files gives information that will help you to know India more and make your trip to India easy and memorable one.
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Stem Cell Treatment/Therapy COST in India| DheerajBojwani.Com
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Stem Cell Ruidoso New Mexico 88345
Posted: September 26, 2018 at 2:44 pm
Stem cell therapy has ended up being a popular argument in the international medical scene. This highly controversial therapy has actually received combined opinions from numerous stakeholders in the health care industry and has actually also attracted the interest of political leaders, spiritual leaders and the basic population at large. Stem cell treatment is thought about an advanced treatment for people suffering from a large range of degenerative conditions. Some typical concerns regarding this treatment are addressed below.
Are you a stem cell therapy provider close to Ruidoso NM 88345? Contact us for more information about joining our website.
Stem cells can be referred to as blank state or non-specialized cells that have the ability to become specialized cells in the body such as bone, muscle, nerve or organ cells. This indicates that these unique cells can be used to regrow or develop a wide variety of damaged cells and tissues in the body. Stem cell therapy is for that reason a treatment that focuses on attaining tissue regrowth and can be utilized to treat health conditions and illnesses such as osteoarthritis, degenerative disc disease, spine injury, muscular degeneration, motor neuron illness, ALS, Parkinsons, cardiovascular disease and much more.
Being a treatment that is still under research, stem cell therapy has not been totally accepted as a practical treatment option for the above pointed out health conditions and illnesses. A lot of research study is currently being carried out by scientists and medical professionals in different parts of the world to make this treatment practical and efficient. There are nevertheless numerous limitations imposed by governments on research study involving embryonic stem cells.
Currently, there have not been numerous case studies carried out for this form of treatment. Nevertheless, with the few case studies that have actually been conducted, among the significant issues that has been raised is the increase in a clients danger of establishing cancer. Cancer is triggered by the quick multiplication of cells that tend not to die so quickly. Stem cells have been connected with comparable growth aspects that may cause formation of growths and other cancerous cells in clients.
Contact us for more information about stem cell therapy in Ruidoso NM 88345
Stem cells can be drawn out from a young embryo after conception. These stem cells are typically referred to as embryonic stem cells. After the stem cells are extracted from the embryo, the embryo is terminated. This is essentially one of the major reasons for debate in the field of stem cell studio. Lots of people say that termination of an embryo is unethical and undesirable.
Stem cells can still be acquired through other means as they can be discovered in the blood, bone marrow and umbilical cables of adult humans. Regular body cells can also be reverse-engineered to become stem cells that have restricted capabilities.
New studio has nevertheless shown promise as scientists target at developing stem cells that do not form into growths in later treatment phases. These stem cells can for that reason effectively transform into other kinds of specialized cells. This treatment is for that reason worth researching into as numerous clients can gain from this innovative treatment.
Find a stem cell provider close to Ruidoso NM 88345
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Stem Cell Ruidoso New Mexico 88345
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Maternalfetal medicine – Wikipedia
Posted: September 25, 2018 at 10:46 pm
Maternalfetal medicine (MFM) (also known as perinatology) is a branch of medicine that focuses on managing health concerns of the mother and fetus prior to, during, and shortly after pregnancy.
Maternalfetal medicine specialists are physicians who subspecialize within the field of obstetrics.[1] Their training typically includes a four-year residency in obstetrics and gynecology followed by a three-year fellowship. They may perform prenatal tests, provide treatments, and perform surgeries. They act both as a consultant during lower-risk pregnancies and as the primary obstetrician in especially high-risk pregnancies. After birth, they may work closely with pediatricians or neonatologists. For the mother, perinatologists assist with pre-existing health concerns, as well as complications caused by pregnancy.
Maternalfetal medicine began to emerge as a discipline in the 1960s. Advances in research and technology allowed physicians to diagnose and treat fetal complications in utero, whereas previously, obstetricians could only rely on heart rate monitoring and maternal reports of fetal movement. The development of amniocentesis in 1952, fetal blood sampling during labor in the early 1960s, more precise fetal heart monitoring in 1968, and real-time ultrasound in 1971 resulted in early intervention and lower mortality rates.[2] In 1963, Albert William Liley developed a course of intrauterine transfusions for Rh incompatibility at the National Women's Hospital in Australia, regarded as the first fetal treatment.[3] Other antenatal treatments, such as the administration of glucocorticoids to speed lung maturation in neonates at risk for respiratory distress syndrome, led to improved outcomes for premature infants.
Consequently, organizations were developed to focus on these emerging medical practices, and in 1991, the First International Congress of Perinatal Medicine was held, at which the World Association of Perinatal Medicine was founded.[2]
Today, maternal-fetal medicine specialists can be found in major hospitals internationally. They may work in privately owned clinics, or in larger, government-funded institutions.[4][5]
The field of maternal-fetal medicine is one of the most rapidly evolving fields in medicine, especially with respect to the fetus. Research is being carried on in the field of fetal gene and stem cell therapy in hope to provide early treatment for genetic disorders,[6] open fetal surgery for the correction of birth defects like congenital heart disease,[7] and the prevention of preeclampsia.
Maternalfetal medicine specialists attend to patients who fall within certain levels of maternal care. These levels correspond to health risks for the baby, mother, or both, during pregnancy.[8]
They take care of pregnant women who have chronic conditions (e.g. heart or kidney disease, hypertension, diabetes, and thrombophilia), pregnant women who are at risk for pregnancy-related complications (e.g. preterm labor, pre-eclampsia, and twin or triplet pregnancies), and pregnant women with fetuses at risk. Fetuses may be at risk due to chromosomal or congenital abnormalities, maternal disease, infections, genetic diseases and growth restriction.[9]
Expecting mothers with chronic conditions, such as high blood pressure, drug use during or before pregnancy, or a diagnosed medical condition may require a consult with a maternal-fetal specialist. In addition, women who experience difficulty conceiving may be referred to a maternal-fetal specialist for assistance.
During pregnancy, a variety of complications of pregnancy can arise. Depending on the severity of the complication, a maternal-fetal specialist may meet with the patient intermittently, or become the primary obstetrician for the length of the pregnancy. Post-partum, maternal-fetal specialists may follow up with a patient and monitor any medical complications that may arise.
The rates of maternal and infant mortality due to complications of pregnancy have decreased by over 23% since 1990, from 377,000 deaths to 293,000 deaths. Most deaths can be attributed to infection, maternal bleeding, and obstructed labor, and their incidence of mortality vary widely internationally.[10] The Society for Maternal-fetal Medicine (SMFM) strives to improve maternal and child outcomes by standards of prevention, diagnosis and treatment through research, education and training.[11]
Maternalfetal medicine specialists are obstetrician-gynecologists who undergo an additional 3 years of specialized training in the assessment and management of high-risk pregnancies. In the United States, such obstetrician-gynecologists are certified by the American Board of Obstetrician Gynecologists (ABOG) or the American Osteopathic Board of Obstetrics and Gynecology.
Maternalfetal medicine specialists have training in obstetric ultrasound, invasive prenatal diagnosis using amniocentesis and chorionic villus sampling, and the management of high-risk pregnancies. Some are further trained in the field of fetal diagnosis and prenatal therapy where they become competent in advanced procedures such as targeted fetal assessment using ultrasound and Doppler, fetal blood sampling and transfusion, fetoscopy, and open fetal surgery.[12][13]
For the ABOG, MFM subspecialists are required to do a minimum of 12 months in clinical rotation and 18-months in research activities. They are encouraged to use simulation and case-based learning incorporated in their training, a certification in advanced cardiac life support (ACLS) is required, they are required to develop in-service examination and expand leadership training. Obstetrical care and service has been improved to provide academic advancement for MFM in-patient directorships, improve skills in coding and reimbursement for maternal care, establish national, stratified system for levels of maternal care, develop specific, proscriptive guidelines on complications with highest maternal morbidity and mortality, and finally, increase departmental and divisional support for MFM subspecialists with maternal focus. As Maternalfetal medicine subspecialists improve their work ethics and knowledge of this advancing field, they are capable of reducing the rate of maternal mortality and maternal morbidity.[14]
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Stem Cell Seneca South Carolina 29678
Posted: September 25, 2018 at 10:44 pm
Stem cell treatment has actually become a popular debate in the worldwide medical scene. This highly questionable treatment has gotten combined opinions from numerous stakeholders in the health care industry and has also attracted the attention of politicians, religious leaders and the general population at large. Stem cell treatment is thought about an advanced treatment for individuals struggling with a vast array of degenerative conditions. Some common concerns regarding this treatment are answered listed below.
Stem cells can be referred to as blank state or non-specialized cells that have the ability to become specialized cells in the body such as bone, muscle, nerve or organ cells. This indicates that these unique cells can be used to restore or develop a wide variety of damaged cells and tissues in the body. Stem cell therapy is therefore a treatment that targets at attaining tissue regrowth and can be used to cure health conditions and illnesses such as osteoarthritis, degenerative disc illness, spine injury, muscular degeneration, motor nerve cell disease, ALS, Parkinsons, heart disease and a lot more.
Stem cells can be drawn out from a young embryo after conception. These stem cells are commonly referred to as embryonic stem cells. After the stem cells are drawn out from the embryo, the embryo is ended. This is basically among the major causes of debate in the field of stem cell research. Many individuals say that termination of an embryo is dishonest and undesirable.
Stem cells can still be obtained through other methods as they can be found in the blood, bone marrow and umbilical cords of adult people. Typical body cells can likewise be reverse-engineered to become stem cells that have limited abilities.
Being a treatment that is still under studio, stem cell treatment has actually not been completely accepted as a sensible treatment option for the above pointed out health conditions and illnesses. A great deal of research study is currently being performed by scientists and medical experts in various parts of the world to make this treatment viable and effective. There are nevertheless numerous restrictions imposed by federal governments on studio involving embryonic stem cells.
Currently, there have not been lots of case studies carried out for this form of treatment. Nevertheless, with the few case studies that have actually been performed, among the major issues that has been raised is the boost in a patients danger of developing cancer. Cancer is triggered by the rapid multiplication of cells that tend not to pass away so quickly. Stem cells have actually been connected with comparable development elements that might lead to formation of tumors and other malignant cells in patients.
New studio has actually however revealed pledge as researchers target at developing stem cells that do not form into growths in later treatment phases. These stem cells can therefore successfully transform into other types of specialized cells. This treatment is for that reason worth researching into as many patients can benefit from this advanced treatment.
stem cell provider near Seneca SC 29678
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The Ethics Of Transhumanism And The Cult Of Futurist Biotech
Posted: September 25, 2018 at 10:43 pm
Cryogenic pods. Computer illustration of people in cryogenic pods. Their bodies are being preserved by storing them at very low temperatures. They will remain frozen until a time when the technology might exist to resurrect the dead, a technique known as cryonics. Alternatively a new body may be cloned from their tissue. Some companies offer to store dead peoples bodies.
Transhumanism (also abbreviated as H+) is a philosophical movement which advocates for technology not only enhancing human life, but to take over human life by merging human and machine. The idea is that in one future day, humans will be vastly more intelligent, healthy, and physically powerful. In fact, much of this movement is based upon the notion that death is not an option with a focus to improve the somatic body and make humans immortal.
Certainly, there are those in the movement who espouse the most extreme virtues of transhumanism such as replacing perfectly healthy body parts with artificial limbs. But medical ethicists raise this and other issues as the reason why transhumanism is so dangerous to humans when what is considered acceptable life-enhancement has virtually no checks and balances over who gets a say when we go too far. For instance, Kevin Warwick of Coventry University, a cybernetics expert, asked the Guardian, What is wrong with replacing imperfect bits of your body with artificial parts that will allow you to perform better or which might allow you to live longer? while another doctor stated that he would have no part in such surgeries. There is, after all, a difference between placing a pacemaker or performing laser eye surgery on the body to prolong human life and lend a greater degree of quality to human life, and that of treating the human body as a tabula rasa upon which to rewrite what is, effectively, the natural course of human life.
A largely intellectual movement whose aim is to transform humanity through the development of a panoply of technologies which ostensibly enhance human intellect, physiology, and the very legal status of what being human means, transhumanism is a social project whose inspiration can be dated back to 19th century continental European philosophy and later through the writings of J. B. S. Haldane, a British scientist and Marxist, who in 1923 delivered a speech at the Heretics Society, an intellectual club at Cambridge University, entitled Daedalus or, Science and the Future which foretold the future of the end of ofcoalfor power generation in Britain while proposing a network of windmills which would be used for the electrolytic decomposition of water into oxygen and hydrogen (they would generate hydrogen). According to many transhumanists, this is one of the founding projects of the movement. To read this one might think this was a precursor to the contemporary ecological movement.
The philosophical tenets, academic theories, and institutional practices of transhumanism are well-known.Max More, a British philosopher and leader of the extropian movement claims that transhumanism is the continuation and acceleration of the evolution of intelligent life beyond its currently human form and human limitations by means of science and technology, guided by life-promoting principles and values. This very definition, however, is a paradox since the ethos of this movement is to promote life through that which is not life, even by removing pieces of life, to create something billed as meta-life. Indeed, it is clear that transhumanism banks on its own contradiction: that life is deficient as is, yet can be bettered by prolonging life even to the detriment of life.
Stefan Lorenz Sorgneris a German philosopher and bioethicist who has written widely on the ethical implications of transhumanism to include writings on cryonics and longevity of human life, all of which which go against most ecological principles given the amount of resources needed to keep a body in suspended animation post-death. At the heart of Sorgners writings, like those of Kyle Munkittrick, invoke an almost nave rejection of death, noting that death is neither natural nor a part of human evolution. In fact, much of the writings on transhumanism take a radical approach to technology: anyone who dare question that cutting off healthy limbs to make make way for a super-Olympian sportsperson would be called a Luddite, anti-technology. But that is a false dichotomy since most critics of transhumanism are not against all technology, but question the ethics of any technology that interferes with the human rights of humans.
Take for instance the recent push by many on the ostensible Left who favor surrogacy as a step on the transhumanist ladder, with many publications on this subject, none so far which address the human rights of women who are not only part of this equation, but whose bodies are being used in the this faux-futurist vision of life without the mention of female bodies. Versos publication of a troubling piece by Sophie Lewis earlier this year, aptly titled Gestators of All Genders Unite speaks to the lack of ethics in a field that seems to be grasping at straws in removing the very mention of the bodies which reproduce and give birth to human life: females. In eliminating the specificity of the female body, Lewis attempts to stitch together a utopian future where genders are having children, even though the reality of reproduction across the Mammalia class demonstrates that sex, not gender, determines where life is gestated and birthed. What Lewis attempts in fictionalizing a world of dreamy hopefulness actually resembles more an episode of The Handmaids Tale where this writer has lost sense of any irony. Of course pregnancy is not about gender. It is uniquely about sex and the class of gestators are females under erasure by this dystopian movement anxious to pursue a vision of a world without women.
While many transhumanist ideals remain purely theoretical in scope, what is clear is that females are the class of humans who are being theorised out of social and political discourse. Indeed, much of the social philosophy surrounding transhumanist projects sets out to eliminate genderin the human species through the application of advanced biotechnology andassisted reproductive technologies, ultimately inspired by Shulamith Firestone'sThe Dialectic of Sex and much of Donna Haraways writing on cyborgs. From parthenogenesisto the creation ofartificial wombs, this movement seeks to remove the specificity of not gender, but sex, through the elision of medical terminology and procedures which portend to advance a technological human-cyborg built on the ideals of a post-sex model.
The problem, however, is that women are quite aware that sex-based inequality has zilch to do with anything other than their somatic sex. And nothing transhumanist theories can propose will wash away the reality of the sexed human body upon which social stereotypes are plied.
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The Ethics Of Transhumanism And The Cult Of Futurist Biotech
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What is Diabetes?
Posted: September 25, 2018 at 7:41 am
Diabetes can strike anyone, from any walk of life.
And it does in numbers that are dramatically increasing. In the last decade, the cases of people living with diabetes jumped almost 50 percent to more than 30 million Americans. Worldwide, it afflicts more than 422 million people.
Diabetes is a leading cause of blindness, kidney failure, amputations, heart failure and stroke.
Living with diabetes places an enormous emotional, physical and financial burden on the entire family. Annually, diabetes costs the American public more than $245 billion.
Just what is diabetes?
To answer that, you first need to understand the role of insulin in your body. When you eat, your body turns food into sugars, or glucose. At that point, your pancreas is supposed to release insulin. Insulin serves as a key to open your cells, to allow the glucose to enter -- and allow you to use the glucose for energy.
But with diabetes, this system does not work.
Several major things can go wrong causing the onset of diabetes. Type 1 and type 2 diabetes are the most common forms of the disease, but there are also other kinds, such as gestational diabetes, which occurs during pregnancy, as well as other forms.
Do you want to learn more about the basics of diabetes?Read our brochure: "What is Diabetes?" in Englishor"Que es La Diabetes?" in Spanish.
The more severe form of diabetes is type 1, or insulin-dependent diabetes. Its sometimes called juvenile diabetes, because type 1 diabetes usually develops in children and teenagers, though it can develop at any age.
With type 1 diabetes, the bodys immune system attacks part of its own pancreas. Scientists are not sure why. But the immune system mistakenly sees the insulin-producing cells in the pancreas as foreign, and destroys them. This attack is known as "autoimmune" disease.
These cells called islets (pronounced EYE-lets) are the ones that sense glucose in the blood and, in response, produce the necessary amount of insulin to normalize blood sugars.
Insulin serves as a key to open your cells, to allow the glucose to enter -- and allow you to use the glucose for energy. Without insulin, there is no key. So, the sugar stays -- and builds up-- in the blood. The result: the bodys cells starve from the lack of glucose. And, if left untreated, the high level of blood sugar can damage eyes, kidneys, nerves, and the heart, and can also lead to coma and death.
So, a person with type 1 treats the disease by taking insulin injections. This outside source of insulin now serves as the key -- bringing glucose to the bodys cells.
The challenge with this treatment is that its often not possible to know precisely how much insulin to take. The amount is based on many factors, including:
Food
Exercise
Stress
Emotions and general health
These factors fluctuate greatly throughout every day. So, deciding on what dose of insulin to take is a complicated balancing act.
If you take too much, then your body burns too much glucose -- and your blood sugar can drop to a dangerously low level. This is a condition called hypoglycemia, which, if untreated, can be potentially life-threatening.
If you take too little insulin, your body can again be starved of the energy it needs, and your blood sugar can rise to a dangerously high level -- a condition called hyperglycemia. This also increases the chance of long-term complications.
The most common form of diabetes is called type 2, or non-insulin dependent diabetes.
This is also called adult onset diabetes, since it typically develops after age 35. However, a growing number of younger people are now developing type 2 diabetes.
People with type 2 are able to produce some of their own insulin. Often, its not enough. And sometimes, the insulin will try to serve as the key to open the bodys cells, to allow the glucose to enter. But the key wont work. The cells wont open. This is called insulin resistance.
Often, type 2 is tied to people who are overweight, with a sedentary lifestyle.
Treatment focuses on diet and exercise. If blood sugar levels are still high, oral medications are used to help the body use its own insulin more efficiently. In some cases, insulin injections are necessary.
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What is Diabetes?
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Jim DeMint – Wikipedia
Posted: September 25, 2018 at 7:41 am
Jim DeMintPresident of the Heritage FoundationIn officeApril 4, 2013 May 2, 2017Preceded byEdwin FeulnerSucceeded byEdwin Feulner (Acting)United States Senatorfrom South CarolinaIn officeJanuary 3, 2005 January 2, 2013Preceded byErnest HollingsSucceeded byTim ScottMember of the U.S. House of Representativesfrom South Carolina's 4th districtIn officeJanuary 3, 1999 January 3, 2005Preceded byBob InglisSucceeded byBob InglisPersonal detailsBornJames Warren DeMint (1951-09-02) September 2, 1951 (age67)Greenville, South Carolina, U.S.Political partyRepublicanSpouse(s)Debbie HendersonChildren4EducationUniversity of Tennessee, Knoxville (BA)Clemson University (MBA)
James Warren DeMint (born September 2, 1951) is an American writer and retired politician who served as a United States Senator from South Carolina from 2005 to 2013. He is a member of the Republican Party and a leading figure in the Tea Party movement.[1][2][3] He previously served as the United States Representative for South Carolina's 4th congressional district from 1999 to 2005. DeMint resigned from the Senate on January 1, 2013 to become president of The Heritage Foundation, a conservative think tank.[4] On May 2, 2017, the board of trustees at Heritage removed DeMint as president of the organization.[5][6]
In June 2017, DeMint became a senior advisor to Citizens for Self-Governance, an organization that supports a convention to propose amendments to the United States Constitution for the purpose of reducing federal government spending and power.[7] Also in 2017, DeMint became the founding chairman of the Conservative Partnership Institute, which focuses on the professional development of conservative staffers and elected officials.
DeMint was born in Greenville, South Carolina, one of four children. His parents, Betty W. (ne Rawlings) and Thomas Eugene DeMint,[8] divorced when he was five years old. Following the divorce, Betty DeMint operated a dance studio out of the family's home.[9][10]
DeMint was educated at Christ Church Episcopal School and Wade Hampton High School in Greenville. DeMint played drums for a cover band called Salt & Pepper.[11] He received a bachelor's degree in 1973 from the University of Tennessee,[12] where he was a part of the Sigma Alpha Epsilon Fraternity, and received an MBA in 1981 from Clemson University.[12] DeMint's wife, Debbie, is one of three children of the late Greenville advertising entrepreneur and South Carolina Republican figure James Marvin Henderson, Sr.[13]
DeMint joined his father-in-laws advertising firm in Greenville in 1981, working in the field of market research.[12][14] In 1983, he founded The DeMint Group, a research firm with businesses, schools, colleges, and hospitals as clients.[14] DeMints first involvement in politics began in 1992, when he was hired by Republican Representative Bob Inglis in his campaign for South Carolinas Fourth Congressional District. Inglis defeated three-term incumbent Democrat Liz J. Patterson, and DeMint performed message-testing and marketing for Inglis through two more successful elections.[15] In 1998, Inglis ran for the U.S. Senate, and DeMint left his firm to run for Inglis old seat.[12][15]
DeMint was elected to the U.S. House of Representatives in 1999 and served South Carolinas Fourth Congressional District until 2005, when he was elected to the U.S. Senate.[16] His peers elected him to be president of his GOP freshman class.[17][18] DeMint pledged to serve only three terms in the House, and in 2003 he announced his run for the Senate seat of outgoing Democrat Ernest Hollings in the 2004 election cycle.[14]
The Washington Post and The Christian Post have described DeMint as a "staunch conservative", based on his actions during his time in the House.[19][20] He broke rank with his party and powerful state interests several times: DeMint was one of 34 Republicans to oppose President Bushs No Child Left Behind program and one of 25 to oppose Medicare Part D.[17] He sought to replace No Child Left Behind with a state-based block-grant program for schools.[14] DeMint also worked to privatize Social Security by allowing the creation of individual investment accounts in the federal program. In 2003, DeMint sponsored legislation to allow people under the age of 55 to set aside 3 percent to 8 percent of their Social Security withholding income in personal investment accounts.[14] DeMint was also the only South Carolina House member to vote for normalizing trade relations with China, arguing in favor of free trade between the countries. He also provided a crucial swing vote on a free trade bill regarding Caribbean countries. His votes led South Carolinas influential textile industry to heavily oppose him in his subsequent House and Senate races.[21][22]
In November 2004, DeMint defeated Inez Tenenbaum, South Carolina's education superintendent, to fill Ernest Hollings' vacated seat in the 109th United States Congress.[23] For his first term, he was appointed to the Commerce, Science and Transportation Committee, the Environment and Public Works Committee, the Joint Economic Committee, and the Special Committee on Aging.[24] In 2006, DeMint began leading the Senate Steering Committee.[25] DeMint also served as a member of the Committee on Foreign Relations and the Committee on Commerce, Science, and Transportation.[26][27] In 2008, DeMint formed the Senate Conservatives Fund, a political action committee with the intention of supporting conservative candidates that may have otherwise been overlooked by the national party.[28]
As a member of the 111th United States Congress, DeMint joined the United States Senate Committee on Banking, Housing, and Urban Affairs.[29] In 2009, DeMint was one of two Senators who voted against Hillary Clinton's appointment to Secretary of State, and the next year he introduced legislation to completely repeal the Patient Protection and Affordable Care Act, commonly referred to as Obamacare.[30][31] Later in 2010, he introduced another piece of legislation titled the Regulations from the Executive in Need of Scrutiny, which aimed to require congressional approval of any major regulation change made by a federal agency.[32] At the end of his first term, DeMint was appointed to the Senate Impeachment Trial Committee regarding the impeachment of federal judge Thomas Porteous.[33]
DeMint was reelected in 2010, at which time he became the highest-ranking elected official associated with the Tea Party.[34] During the first year of his second term, DeMint released a letter signed by over 30 other Senate Republicans asking the supercommittee tasked with balancing the federal budget to do so within the next ten years, and without creating any net tax increases.[35] In 2012, DeMint resigned his seat in order to become president of the Heritage Foundation.[36]
Jim DeMint is a member of the Republican Party[37] and is aligned with the Tea Party movement.[38] In 2011, DeMint was identified by Salon as one of the most conservative members of the Senate.[37][38][39] He founded the Senate Conservatives Fund, a political action committee (PAC), which supports conservative, small government, Tea Partyallied Republican politicians in primary challenges and general elections.[40][41] In 2013, the PAC endorsed a strategy to defund the Affordable Care Act that culminated in the 2013 shutdown of the federal government.[42]
Throughout his political career, DeMint has favored a type of tax reform that would replace the federal income tax with a national sales tax and, in addition, abolish the Internal Revenue Service.[43] He has supported many changes to federal spending, such as prioritizing a balanced budget amendment instead of increasing the national debt limit.[44] As a senator, DeMint proposed a two-year earmark ban to prevent members of Congress from spending federal money on projects in their home states.[41] In 2008, presidential candidates John McCain, Hillary Clinton, and Barack Obama co-sponsored DeMint's earmark reform proposal, although it ultimately failed to pass in the Senate.[45] In March 2010, DeMint's earmark reform plans were again defeated.[46] In November of the same year, DeMint, along with nine other senators including Rand Paul and Marco Rubio, proposed another moratorium on earmarks which was adopted by Senate Republicans.[47][48]
DeMint has also been a proponent of free trade agreements, advocated for the privatization of Social Security benefits, and in 2009 authored the "Health Care Freedom Plan", which proposed giving tax credits to those who are unable to afford health insurance.[43][49][50]
DeMint was opposed to the Emergency Economic Stabilization Act of 2008 and the bailouts during the automotive industry crisis of 20082010. He also led a group of Senators in opposing government loans to corporations.[51][52] He supports a high level of government accountability through the auditing federal agencies.[51]
In October 2009, after the Honduran Army, on orders from the Honduran Supreme Court, removed Manuel Zelaya as President, DeMint visited the country to gather information.[53] The trip was approved by Senate Minority Leader Mitch McConnell but opposed by Foreign Relations Committee Chairman John Kerry. DeMint supported the new government, while the Obama administration favored Zelaya's return to the presidency.[53]
In late 2009, DeMint criticized Barack Obama for waiting eight months into his first term as president before nominating a new head of the Transportation Security Administration.[54] After the attempted bombing of Northwest Flight 253 in December 2009, DeMint stated that President Obama had not put enough focus on terrorism while in office.[54]
In 1999, DeMint voted against the NATO intervention during the Kosovo war.[51] DeMint voted to authorize military force in Iraq in 2002.[51] In 2011, DeMint voted in favor of Rand Paul's resolution opposing military involvement in Libya.[38][51] He favored preventing Iran from developing nuclear weapons over a policy of containment after their development.[55]
DeMint has also expressed concern about various United Nations treaties, such as the Convention on the Rights of Persons with Disabilities and the Law of the Sea Treaty.[56][57] DeMint favors legal immigration and opposes granting amnesty to illegal immigrants.[58] He has expressed opposition to the Border Security, Economic Opportunity, and Immigration Modernization Act of 2013 on the basis that granting amnesty to illegal immigrants may cost American taxpayers trillions of dollars.[59][60][61]
DeMint identifies as pro-life, opposing abortion except when the mother's life is in danger[62][63] and opposing research from stem cells derived from human embryos.[64][65] He supports school prayer and introduced legislation to allow schools to display banners including references to God.[62]
DeMint is firmly opposed to same-sex marriage. In his book Now or Never: Saving America from Economic Collapse, DeMint states:
Does government have the right to reshape cultural mores by redefining religious institutions to sanction behavior that is considered immoral by all the world's religions? In America, people should have a right to live with whomever they want, but redefining marriage to promote behavior that is deemed costly and destructive is not the proper role of government.[66]
DeMint also argues that same-sex marriage infringes upon religious liberty:
We just cannot have, particularly the federal government, redefining marriage or telling us what is right or wrong. And if we help America understand that, folks, we're not trying to get the government to do it our way or your way; what we're asking for is the freedom to allow people to live out their faith and values and their lives the way they want. And we believe that our side will win because I'm convinced that most Americans want to have decent moral lives and share our same values. But if the government continues to press in the wrong direction, it begins to change our culture.[67]
DeMint has repeatedly voted for a constitutional amendment banning same-sex marriage.[68] He has also voted to ban same-sex adoption in Washington, D.C.[68] DeMint drew considerable criticism by saying that openly gay teachers should be banned from teaching in public schools.[69]
The Human Rights Campaign gives DeMint a score of 0% on gay rights.[70]
DeMint voted against the Patient Protection and Affordable Care Act, also known as Obamacare, in December 2009,[71] and he voted against the Health Care and Education Reconciliation Act of 2010.[72]
He voted in favor of declaring English the official language of the US government.[58]
DeMint served as an informal advisor to Fourth District congressman Bob Inglis from 1993 to 1999.[73] When Inglis kept his promise to serve only three terms and gave up his seat to run for the Senate against Fritz Hollings, DeMint entered the Republican primary for the district, which includes Greenville and Spartanburg. The district is considered the most Republican in the state, and it was understood that whoever won the primary would be heavily favored to be the district's next congressman.
DeMint finished second in the primary behind State Senator and fellow Greenville resident Michael Fair, even though he didn't carry a single county in the district.[74] In the runoff, DeMint defeated Fair by only 2,030 votes.[75] He then defeated Democratic State Senator Glenn Reese with 57 percent of the vote to Reese's 40 percentto date, the only time since 1992 that a Democrat has crossed the 40 percent mark in this district since Inglis recaptured it for the Republicans in 1992.[76] DeMint faced no major-party opposition in 2000, and defeated an underfunded Democrat in 2002.
DeMint declared his candidacy for the Senate on December 12, 2002, after Hollings announced that he would retire after the 2004 elections. DeMint was supposedly the White House's preferred candidate in the Republican primary.
In the Republican primary on June 8, 2004, DeMint placed a distant second, 18 percentage points behind former governor David Beasley and just barely ahead of Thomas Ravenel. Ravenel endorsed DeMint in the following runoff. DeMint won the runoff handily, however.
DeMint then faced Democratic state education superintendent Inez Tenenbaum in the November general election. DeMint led Tenenbaum through much of the campaign and ultimately defeated her by 9.6 percentage points. DeMint's win meant that South Carolina was represented by two Republican Senators for the first time since Reconstruction, when Thomas J. Robertson and John J. Patterson served together as Senators.
DeMint stirred controversy during debates with Tenenbaum when he stated his belief that openly gay people should not be allowed to teach in public schools. When questioned by reporters, DeMint also stated that single mothers who live with their boyfriends should similarly be excluded from being educators.[77][78] He later apologized for making the remarks, saying they were "distracting from the main issues of the debate." He also noted that these were opinions based on his personal values, not issues he would or could deal with as a member of Congress.[79] In a 2008 interview, he said that while government does not have the right to restrict homosexuality, it also should not encourage it through legalizing same-sex marriage, due to the "costly secondhand consequences" to society from the prevalence of certain diseases among homosexuals.[80]
DeMint won re-nomination in the Republican Party primary. Democratic Party opponent Alvin Greene won an upset primary victory over Vic Rawl, who was heavily favored. Due to various electoral discrepancies, Greene received scrutiny from Democratic Party officials, with some calling for Greene to withdraw or be replaced.[81] DeMint consistently led Greene by more than 30 points throughout the campaign and won reelection by a landslide.
Prior to the 2010 elections, DeMint founded the Senate Conservatives Fund (SCF), a political action committee that is "dedicated to electing strong conservatives to the United States Senate" and that is associated with the Tea Party movement.[82][83][84] As of February 2011, DeMint continued to serve as Chair of SCF, which states that it raised $9.1 million toward the 2010 U.S. Senate elections and which endorsed successful first-time Senate candidates Pat Toomey, Rand Paul, Mike Lee, Ron Johnson, Marco Rubio .[85] DeMint also supported Joe Miller of Alaska through the SCF. Miller was an attorney and former federal magistrate and the Tea Party's candidate opposing Lisa Murkowski the incumbent senator in the Alaska primary. Miller won in a close election, however Murkowski ran as a write in candidate and won the election by 39.1% to Miller's 35.1% and by a popular vote of 101,091 to 90,839 respectively.
On October 1, 2010, DeMint, in comments that echoed what he had said in 2004, told a rally of his supporters that openly homosexual and unmarried sexually active people should not be teachers.[86] In response, the National Organization for Women, the National Education Association, the gay rights group Human Rights Campaign, GOProud (a GOP group), and the National Gay and Lesbian Task Force asked for Demints apology.[77][87]
On December 6, 2012, DeMint announced he would resign from the Senate before the 113th Congress convened in January 2013 to become president of The Heritage Foundation.[4][88]
On December 17, 2012, South Carolina governor Nikki Haley announced that she would name Congressman Tim Scott to fill the vacated seat.[89] A special election was held on November 4, 2014, to fill the remainder of the term. On April 4, 2013, DeMint started his first full day as president of the Heritage Foundation.[90] The Washington Post reported that DeMint's predecessor at the Heritage Foundation, Ed Feulner, was paid a base salary of $477,097 in 2010 (compared to a senator's salary of $174,000) and that year DeMint was one of the poorest members of the Senate, with an estimated wealth of $40,501.[91]
On May 2, 2017, DeMint submitted his resignation after a unanimous vote by the Foundation's board of trustees.[6]
In June 2017, DeMint became a senior advisor to Citizens for Self-Governance, a group which is seeking to call a convention to propose amendments to the United States Constitution in order to reduce federal government spending and power. According to DeMint, "The Tea Party needs a new mission. They realize that all the work they did in 2010 has not resulted in all the things they hoped for. Many of them are turning to Article V." The proposed constitutional convention would impose fiscal restraint on Washington D.C., reduce the federal government's authority over states, and impose term limits on federal officials.[7]
In 2017, DeMint founded the Conservative Partnership Institute, of which he serves as chairman.[92][93] The stated purpose of the CPI is the professional development of conservative staffers and elected officials.[92]
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Jim DeMint - Wikipedia
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Gene & Cell Therapy Defined | ASGCT – American Society of …
Posted: September 24, 2018 at 1:44 pm
Gene therapy is a field of biomedical research with the goal of influencing the course of various genetic and acquired (so-called multi factorial) diseases at the DNA/RNA level. Cell therapy aims at targeting various diseases at the cellular level, i.e. by restoring a certain cell population or using cells as carriers of therapeutic cargo. For many diseases, gene and cell therapy are applied in combination. In addition, these two fields have helped provide reagents, concepts, and techniques that are illuminating the finer points of gene regulation, stem cell lineage, cell-cell interactions, feedback loops, amplification loops, regenerative capacity, and remodeling.
Gene therapy is defined as a set of strategies that modify the expression of an individuals genes or repair abnormal genes. Each strategy involves the administration of a specific nucleic acid (DNA or RNA). Nucleic acids are normally not taken up by cells, thus special carriers, so-called 'vectors' are required. Vectors can be of either viral or non-viral nature.
Cell therapy is defined as the administration of living whole cells for the patient for the treatment of a disease. The origin of the cells can be from the same individual (autologous source) or from another individual (allogeneic source). Cells can be derived from stem cells, such as bone marrow or induced pluripotent stem cells (iPSCs), reprogrammed from skin fibroblasts or adipocytes. Stem cells are applied in the context of bone marrow transplantation directly. Other strategies involve the application of more or less mature cells, differentiated in vitro (in a dish) from stem cells.
Historically, the discovery of recombinant DNA technology in the 1970s provided the tools to efficiently develop gene therapy. Scientists used these techniques to readily manipulate bacterial and viral genomes, isolate genes, identify mutations involved in human diseases, characterize and regulate gene expression and produce human proteins from genes (e.g. production of insulin in bacteria revolutionized medicine). Later, various viral and non-viral vectors were developed along with the development of regulatory elements (e.g. promoters that regulate gene expression), which are necessary to induce and control gene expression. Gene transfer in animal models of disease have been attempted and led to early success. Various routes of administrations have been explored (injection into the bloodstream, into the ventricles of the brain, into muscle etc).
The development of suitable gene therapy treatments for many genetic diseases and some acquired diseases has encountered many challenges, such as immune response against the vector or the inserted gene. Current vectors are considered very safe and recent gene therapy trials documented excellent safety profile of modern gene therapy products. Further development involves uncovering basic scientific knowledge of the affected tissues, cells, and genes, as well as redesigning vectors, formulations, and regulatory cassettes for the genes. While effective long-term treatments for many genetic and inherited diseases are elusive today, some success is being observed in the treatment of several types of immunodeficiency diseases, cancers, and eye disorders.
Historically, blood transfusions were the first type of cell therapy and are now considered routine. Bone marrow transplantation has also become a well-established medical treatment for many diseases, including cancer, immune deficiency and others. Cell therapy is expanding its repertoire of cell types for administration. Cell therapy treatment strategies include: isolation and transfer of specific stem cell populations, induction of mature cells to become pluripotent cells, administration of effector cells and reprogramming of mature cells into iPSCs. Administration of large numbers of effector cells has benefited cancer patients, transplant patients with unresolved infections, and patients with vision problems.
Several diseases benefit most from treatments that combine the technologies of gene and cell therapy. For example, some patients have a severe combined immunodeficiency disease (SCID) but unfortunately, do not have a suitable donor of bone marrow. Scientists have identified that patients with SCID are deficient in adenosine deaminase gene (ADA-SCID), or the common gamma chain located on the X chromosome (X-linked SCID). Several dozen patients have been treated with a combined gene and cell therapy approach. Each individuals hematopoietic stem cells were treated with a viral vector that expressed a copy of the relevant normal gene. After selection and expansion, these corrected stem cells were returned to the patients. Many patients improved and required less exogenous enzymes. However, some serious adverse events did occur and their incidence is prompting development of theoretically safer vectors and protocols. The combined approach also is pursued in several cancer therapies.
Genome editing (gene editing) has recently gained significant attention, due to the discovery and application of the clustered regularly interspaced short palindromic repeats (CRISPR) system. Actually, genome editing dates back several years and earlier generation genome editing systems are currently tested in clinical trials (such as zinc-finger nucleases). The aim of genome editing is to disrupt a disease-causing mutation or correct faulty genes at the chromosomal DNA. Genome editing can be performed in the patients own cells in vitro and edited cells can be administered to the patient (thus genome editing can be combined with cell therapy). However, it is also possible to perform genome editing in vivo by administering the genome editing agent packaged in viral and non-viral vectors.
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