Monthly Archives: March 2017

Top 6 Everyday Products Using Biotechnology – The Merkle

Posted: March 25, 2017 at 7:42 pm

Biotechnology is a popular trend that can be found in various aspects of our everyday lives. While it is true biotechnology is a very complicated concept to grasp, it is also one of the most promising technologies to be found today. Biotechnology will help our society address some of its greatest challenges moving forward. Below are some very common use cases for biotechnology most people will have come in contact with already.

It is anything but surprising to learn biotechnology has made a big impact on the medical sector over the past few years. Biotechnology, or more specifically, bio-processing, is used to develop new pharmaceuticals which are often difficult to produce due to purity quality control requirements. Some of the more popular biotech pharmaceuticals include Remicade, Rituxan, Prevarn, and Avastin.

Very few consumers give fabrics a second thought, other than to determine whether the material would rub against the skin. Interestingly enough, most fabrics are dyed through a fermentation vat process. Biochemicals are very common in the production of dyes, polyester, and nylon. It is evident there is some form of biotechnology involved in every piece of synthetic clothing we wear today.

Even though biofuel is not as popular as it could be, the concept holds a lot of merit for the future. Biodiesel helps reduce the carbon impact, which is of great importance to the future of our species. To produce biofuel, one needs specific plant-derived sugars which are then fermented using biotechnology to create ethanol. Further advances in the development of biofuel will see the introducing of alternative compoundsto jet fuel.

It may come as a surprise to find out Goodyear Tire is actively exploring the boundaries of biotechnology. Through a partnership with Genencor, the company is researching synthetic rubber created out of mostly renewable raw materials. In doing so, the company hopes to replace the crude oil requirements necessary to produce a single passenger tie.

As unusual as it may sound, some of the foods we consume on a regular basis are a direct result of biotechnology. Most of the products usedin food and [soft] drinks are processed using biochemicals. Sweeteners, flavors and acidity regulators found in nearly every product are just a few examples of how biotechnology is affecting our daily lives. Even the packaging used by supermarkets is made of biochemicals.

It appears very few people are aware of what can be found in alcoholic beverages these days. The production process of alcohol is a clear example of industrial biotechnology. This process involves converting starch to sugar and fermenting the yeast. Both parts are biotechnology in its simplest form. There is a lot more to the beer in a bottle than meets the eye, that much is certain.

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PUMA BIOTECHNOLOGY, INC. (NASDAQ:PBYI) Files An 8-K Changes in Registrant’s Certifying Accountant – Market Exclusive

Posted: March 25, 2017 at 7:42 pm

PUMA BIOTECHNOLOGY, INC. (NASDAQ:PBYI) Files An 8-K Changes in Registrant's Certifying Accountant
Market Exclusive
Puma Biotechnology, Inc. is a biopharmaceutical company that focuses on the development and commercialization of products for the treatment of cancer. The Company focuses on in-licensing the global development and commercialization rights to over ...

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PUMA BIOTECHNOLOGY, INC. (NASDAQ:PBYI) Files An 8-K Changes in Registrant's Certifying Accountant - Market Exclusive

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Symposium discusses latest and future of stem cell therapy – The Pasadena Star-News

Posted: March 25, 2017 at 7:41 pm

DUARTE>> Dozens of doctors, scientists, businesses and others gathered at City of Hope Thursday for the second California Institute for Regenerative Medicine (CIRM), Alpha Stem Cell Clinics symposium.

CIRM, the states stem cell agency, has developed a network of Alpha Stem Cell Clinics that focus on innovative stem cell-based therapies. The network of three clinics are located at City of Hope, University of California, San Diego, and UCLA/UC Irvine campuses.

The event served as a way for clinics to share their most recent advancements and successes in stem cell therapy clinical trials, and even hear directly from patients who benefited from some of the trials.

We want to review the trials, but we also want to see what other questions we should be asking, said Dr. John Zaia, the Aaron Miller and Edith Miller Chair in Gene Therapy, and director of the Center for Gene Therapy and principal investigator of City of Hopes Alpha Stem Cell Clinic. How will insurance companies charge or pay for these treatments? How do companies plan to develop these treatments? The symposium provides an opportunity to think about these other aspects.

There were also panel speakers who offered more of a motivational talk, such as Pat Furlong, founding president of Parent Project Muscular Dystrophy, discussing how to remove stakeholder barriers to stem cell therapy treatment.

Furlong had to become her and her sons own advocate when they were diagnosed with Duchenne Muscular Dystrophy at a young age. She found there was no standard of care for the disease and no studies or trials in progress to find a treatment, let alone a cure.

Families just didnt know the questions to ask, she said. At the time, few people cared about rare diseases.

After years of no real hope and losing her sons at 15 and 17 years old, with her and her groups persistence, Furlong said there are now 40 companies researching the disease and millions of dollars have gone into research specifically for Duchenne.

City of Hopes Dr. Behnam Badie, chief of neurosurgery and director of the Brain Tumor Program, and Christine Brown, Ph.D., Heritage Provider Network Professor in Immunotherapy and associate director of the T Cell Therapeutics Research Laboratory, discussed their recent successful treatment of a patient with recurrent multifocal glioblastoma using CAR-T cell therapy.

The case study for this unique type of immunotherapy on the most aggressive form of brain cancer was published in the Dec. 29 edition of the New England Journal of Medicine.

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In the Phase I clinical trial, the patient, who did not respond to other types of therapy including radiation and even developed tumors in his brain and spinal cord, was treated with his own genetically modified chimeric antigen receptor (CAR) T cells, injected directly into the tumor and through the ventricular system. The patient experienced remission over 8 months.

City of Hope is one of a few cancer centers in the nation offering studies in CAR-T cell therapy, and is the only cancer center investigating CAR-T cells targeting the specific receptors more common in a majority of glioblastomas.

Dr. Badie and Brown noted that working with CIRM has been instrumental in helping them along with their trial, and not just the funding.

You cant create a good trial without studying the product, said Brown. These are expensive trials. We have to treat these patients and understand what is going on.

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Symposium discusses latest and future of stem cell therapy - The Pasadena Star-News

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Erectile dysfunction: Stem cell therapy restores sexual function in phase I trial – Medical News Today

Posted: March 25, 2017 at 7:41 pm

Early results of a clinical trial suggest that stem cell therapy may be a promising treatment for erectile dysfunction, after the procedure was found to restore sexual function in men with the condition.

The stem cell therapy involves injecting the patients' own stem cells - derived from abdominal fat cells - into the erectile tissue of the penis.

Lead researcher Dr. Martha Haahr, of Odense University Hospital in Denmark, and colleagues found that within 6 months of the procedure, 8 of the 21 men treated were able to engage in spontaneous sexual intercourse.

The researchers recently presented their findings at EAU17 - the European Association of Urology's annual conference - held in London in the United Kingdom.

Erectile dysfunction (ED) is a condition whereby a man has difficulties getting or maintaining an erection in order to engage in sexual intercourse.

According to the National Institute of Diabetes and Digestive Kidney Diseases, around 12 percent of men under the age of 60, and 22 percent of men aged between 60 and 69, have ED.

High blood pressure, diabetes, heart disease, chronic kidney disease, and prostate surgery are some of the physical conditions that can cause ED. Psychological issues - such as anxiety, stress, depression, and low self-esteem - can also contribute to ED.

Current treatments for ED include PDE5 inhibitors (such as Viagra), penile implants, and injections. However, Dr. Haahr and team note that all of these therapies can have significant side effects.

As a result, researchers are on the hunt for alternative treatments for ED, and stem cell therapy has emerged as a promising candidate in animal trials.

In their phase I trial, Dr. Haahr and colleagues tested stem cell therapy on 21 men who had ED as a result of undergoing radical prostatectomy for prostate cancer. None of the men had responded to standard medical treatment for ED.

For the stem cell procedure, abdominal fat cells were extracted from each man through liposuction. Stem cells were then isolated from the fat cells and injected into the corpus cavernosum of the penis - the spongy tissue that normally becomes filled with blood during an erection.

Before the stem cell procedure and 6 and 12 months after, the participants' erectile function was assessed using the International Index of Erectile Function (IIEF) questionnaire. An IIEF score of 5-7 represents severe erectile dysfunction, 12-16 is mild to moderate erectile dysfunction, and 22-25 is no erectile dysfunction.

All 21 men saw their erectile function improve with stem cell therapy: their IIEF score increased from 6 prior to treatment to 12 at 6 months after treatment.

Eight of the men reported that they had been able to engage in spontaneous sexual activity 6 months after stem cell therapy, and this outcome remained evident at 12 months after treatment. These men saw their IIEF score rise from 7 to 14 with stem cell therapy.

"What we have done establishes that this technique can lead to men recovering a spontaneous erection - in other words, without the use of other medicines, injections, or implants," says Dr. Haahr.

Although the study findings are preliminary, the team says that they show promise for stem cell therapy as an effective treatment strategy for ED.

"We are the first to use a man's own fat stem cells as a treatment for erectile dysfunction in a clinical trial. The technique has been trialed in animal work, but this is the first time stem cell therapy has allowed patients to recover sufficient erectile function to enable intercourse," says Dr. Haahr.

"We are pleased with the preliminary outcomes, especially as these men had previously seen no effect from traditional medical treatment and continue to have good erectile function after 12 months follow-up, indicating that this might be a long-term solution.

This suggests the possibility of therapeutic options for patients suffering from erectile dysfunction from other causes. But we need to remember that this is a small trial, with no control group. We're still some time away from a clinically available solution."

Dr. Martha Haahr

The researchers are now in the process of initiating a phase II trial to further investigate the safety and efficacy of stem cell therapy for ED.

Learn how eating more fruits could help to lower the risk of ED.

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Study shows potential of stem cell therapy to repair lung damage – Hindustan Times

Posted: March 25, 2017 at 7:41 pm

Researchers found that along with reducing inflammation in the lung, Mesenchymal stem cell therapy also resulted in significant improvements in lung structure, suggesting that this form of treatment has the potential to repair the damaged lung.

Stem cell therapy may potentially reduce lung inflammation in patients suffering from chronic obstructive pulmonary disease (COPD) and cystic fibrosis, a new study conducted on mice suggests.

Researchers from Queens University Belfast in the UK investigated the effectiveness of Mesenchymal stem cell (MSC) therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

They delivered stem cells intravenously to mice at four and six weeks of age, before collecting sample tissue and cells from the lungs at about eight weeks.

These findings were compared to a control group that did not receive the MSC therapy. The results showed that inflammation was significantly reduced in the group receiving MSC therapy.

Cell count for both monocytic cells and neutrophils - signs of inflammation - were significantly reduced after MSC therapy, researchers said.

Analysis of lung tissue revealed a reduction in the mean linear intercept and other measures of lung destruction in MSC treated mice.

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Researchers found that along with reducing inflammation in the lung, MSC therapy also resulted in significant improvements in lung structure, suggesting that this form of treatment has the potential to repair the damaged lung.

These preliminary findings demonstrate the potential effectiveness of MSC treatment as a means of repairing the damage caused by chronic lung diseases such as COPD, said Declan Doherty of Queens University Belfast.

The ability to counteract inflammation in the lungs by utilising the combined anti-inflammatory and reparative properties of MSCs could potentially reduce the inflammatory response in individuals with chronic lung disease whilst also restoring lung function in these patients, Doherty added.

Lung damage caused by chronic inflammation in conditions such as COPD and cystic fibrosis leads to reduced lung function and eventually respiratory failure.

MSC therapy is currently being investigated as a promising therapeutic approach for a number of incurable, degenerative lung diseases.

Follow @htlifeandstyle for more

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Got a Minute?: What is your diabetes risk – The Livingston County News

Posted: March 25, 2017 at 7:40 pm

Got a Minute?: What is your diabetes risk
The Livingston County News
The theme is Take it, the ADA diabetes or pre-diabetes risk test; Share it, share this test with those you care about; and Learn it, find out if you are at risk for pre-diabetes or diabetes and if so, start learning and take charge. According to ...

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Got a Minute?: What is your diabetes risk - The Livingston County News

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Diabetes group tours stores – Valdosta Daily Times

Posted: March 25, 2017 at 7:40 pm

VALDOSTA Approximately 1.1 million people in Georgia, or 14.2 percent of the adult population, have diabetes, according to the American Diabetes Association.

Each year, an estimated 60,000 people in Georgia are diagnosed with diabetes.

The South Georgia Medical Center Diabetes Management Center seeks to help those diagnosed live a healthier lifestyle, according to a hospital press release.

"Because diabetes increases a persons risk for other serious medical conditions, such as heart disease, stroke, blindness, kidney disease and lower extremity amputations, its critical that diabetes be managed carefully," said Dawn Taylor, DMC director.

She said staying healthy means more than just following a doctors plan and taking medication. The DMC offers various education and tools to help.

One important opportunity open to anyone with diabetes is the centers Diabetes Support Group which meets monthly.

On Monday, nearly 50 people gathered at Winn-Dixie to participate in a grocery store tour led by DMC team members, according to SGMC.

The tour focused on accurately reading food labels, calculating carbohydrate servings, and making overall healthier meal choices.

"As you learn healthier ways to eat, snack, and cook for your diabetes, youll also learn how to make healthier choices for your family members, Taylor said.

More information on the DMC, visit sgmc.org/diabetes or call (229) 433-7200.

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The dangers of diabetes – Carlsbad Current-Argus

Posted: March 25, 2017 at 7:40 pm

Julio Munoz, M.D., FACP 1:04 a.m. MT March 25, 2017

Julio Munoz MD(Photo: Courtesy Photo)

Diabetes affects nearly 30 million people in the United States a stunning 10 percent of the overall population. And recent research reveals that diabetes is now the third leading cause of death, not the seventh, as was previously thought. Perhaps the most concerning statistic is that one in four persons living with diabetes is unaware that they have the disease.

The American Diabetes Association sponsors Diabetes Alert Day to serve as an annual wake-up call. The organization wants to remind Americans about the seriousness and prevalence of diabetes, particularly when the disease is left un-diagnosed or untreated. This year, Diabetes Alert Day is Tuesday, March 28.

The incidence of type 2 diabetes in this country has tripled in the last twenty years. The adoption of sugary diets and sedentary lifestyles has caused the disease to reach epidemic proportions. On the positive side, this condition doesnt have to be a death sentence. Its almost always avoidable, and even reversible, with serious lifestyle changes.

Researchers estimate that, if current trends continue, one in three Americans will have diabetes by the year 2050. Left untreated, diabetes can lead to kidney failure, limb amputations, blindness, and even death. Early diagnosis and treatment is critical to preventing irreversible damage to your health and longevity, so awareness and access to care are the key areas of focus.

Here are the top five ways to keep blood sugar at healthy levels, and to keep type 2 diabetes from impacting you and your loved ones:

If you have a family history of diabetes, you are at increased risk for developing type 2 diabetes yourself. Also, the condition is more common in African Americans, Hispanics, Native Americans, Asians and Pacific Islanders. Above-average body weight increases diabetes risk for people of all backgrounds.

Only your doctor can tell for sure if you are diabetic or pre-diabetic. As part of your annual health physical, be sure to talk to your doctor about the results of your fasting blood sugar and A1C tests. If your numbers are heading in the wrong direction, you can act quickly to get back on the right track.

If you need assistance in diagnosing or managing your metabolic health, or you just need to be connected with a primary care physician, contact Pecos Valley Internal Medicine at 575-234-9692 or visit http://www.PecosValleyDocs.com.

I would also like to take this opportunity to invite the public to a free Diabetes seminar on Thursday, March 30, at 3p.m. at Carlsbad Medical Center in the private dining room. The seminar will be presented by Susan Dade, RD, LD, CDE and Danielle Weathers, RD, LD, and will include information on healthy diets and eating habits for those living with Diabetes. For more information on the seminar, please call 575-628-5069.

Dr. Julio Munoz is a board certified internal medicine physician with over 30 years of experience.He received his medical degree from Autonomous University of Santo Domingo, Dominican Republic, and completed his residency at Bronx-Lebanon Hospital Center in Bronx, NY. In addition to being certified by the American Board of Internal Medicine, Dr. Munoz is also a Fellow of the American College of Physicians (FACP). He is a member of the medical staff at Carlsbad Medical Center.

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Is Diabetes the Disease or the Symptom – Huffington Post

Posted: March 25, 2017 at 7:40 pm

Earlier this week I was told I was diabetic. When sharing it with people, some felt maybe this was not the type of news the founder of Less Cancer should broadcast.

I am sure that it is exactly the kind of thing to share. Since founding the organization in 2004, I have always been open about some of the lifestyle challenges and risks I have engaged in; from being a chain smoker as a child to having a diet so poor that as a college student at 661/2 and 168 lbs, I was diagnosed with malnutrition.

Since that time I have been far from saved. I did quit smoking twenty-one years ago when my son was born, as he had a respiratory issue that would have prevented me from ever holding him. Fortunately, the doctor that was treating him at the time used his agency to say that I would have to leave my clothes outdoors and take a shower before picking him up. With the help of the patch, I quit right away.

Pancreatic cancer and diabetes have been linked in patients who have had diabetes for less than five years, yet it is unclear if diabetes contributed to the cancer or if the pre-cancerous cells caused the diabetes. Also, research suggests that new-onset diabetes in people over 50 may be an early symptom of pancreatic cancer. (Pancan.org) My sister died of pancreatic cancer at a young age.

Type 2 diabetes has a stronger link to family history and lineage than type 1, although it too depends on environmental factors. If there is a family history of type 2 diabetes, it may be difficult to figure out whether it is due to lifestyle factors or genetic susceptibility. I only know of a few family members with type 2 diabetes, and they were all at an enviably healthy weight.(Diabetes.org)

However, for over twenty years I have been vigilant about eating and serving certified organic foods to my family. For me, sugar is the head-spinning devil. And no matter how healthily I eat around it, its just too tough to burn off a slice of cake. I walk at least a few times a week, and I have started running on the treadmill with a trainer when I am back home in Virginia.

When I heard the news of my diagnosis, I felt ashamed as to how I could not know better. Certainly, I had been warned. I was most angry with myself because, with my very non-profit salary, I understood that I would never really be able to afford the meds for a diabetic. My doctor has given me three months to turn things around.

However there is something even more insidious, and that is isolation.

In my work, without intention or awareness, I seem to have systematically built a wall around myself to the outside world and my own personal needs.

I am immensely grateful for the handful of amazing friends and my immediate family, with whom I am in touch daily. But something strange began happening as I heard from more and more people that I did not know and started connecting with on social media, and then through blogs. In the course of the day, I often speak to more strangers than people I know. I am on the road so much that I often eat alone and have little social contact.

After the United States Congressional Caucus and the Cancer Prevention Workshop this past February, on the only free day I had I met with a few of the cyclists for the bike ride to raise money for Less Cancer. The day of my birthday in Detroitmy big nightwas spent on my laptop, in my hotel. I took a moment to check Facebook and email only to notice an embarrassing amount of birthday wishesbetween social media and email it was well into the hundreds.

As I drove out of town the next day, hurrying to my next stop, I could not help but think how strange it felt to look at all these communications from so many people I did not know-despite being very appreciated. I meet kind and wonderful people each day and I am one of those people that love others more than myself.

As more people get to know me and the work of Less Cancer, I receive accolades but not always from people I know. I feel a need to protect myself by establishing boundaries, thus creating even greater distance between me and the world.

Somehow the more I connect and work with the masses my wall, unseen by the outside seemingly inches higher, insidiously moving further away from filling my metaphoric bucket or addressing some very basic needs.

With a focus outwards on the rest of the world, I move further and further away from my needs.

In trying to understand my diabetes diagnosis, I find myself asking what isolation means to human healthworking alone, traveling alone, and frequently not having any connections beyond people who want to talk to me about my work.

In a report by Soledad OBrien, Surgeon General Dr. Vivek Murthy said the greatest public health crisis (according to the surgeon general) isnt cancer or heart disease. Its isolationisolation and the affects of being socially disconnected.

I may never know if my diagnosis is hereditary or lifestyle, stress or isolation. You can count on me turning my sights inward as a matter of health. Watching diet and exercise, connecting with friends and asking for help with the work for Less Cancer.

I will be exploring more about isolation as it impacts human health, including diabetes. Diabetes can, in fact, be a cancer risk. Now more than ever, we need to get a handle on these preventable diseases, and it needs to start with me.

Is this my legacy to my children? Is this what I leave thema future knowing that the idea of Less Cancer will be a missed opportunity to turn the steadily increasing incidences of cancer around. A future with a cancer economy?

I am not giving up-if you want to help, please help the work of Less Cancer not because of me but rather because we are doing life-saving work that is making change.

First published in Thrive Global

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Is Diabetes the Disease or the Symptom - Huffington Post

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Discovery School walks the walk in Type 1 diabetes awareness … – Richland Source

Posted: March 25, 2017 at 7:40 pm

MANSFIELD -- Students at Discovery School are learning about Type 1 diabetes and the differences it has with Type 2.

Not only are the students talking the talk -- they are walking the walk. Discovery School's student body will hold a Kids Walk for Type 1 Diabetes March 29 at 11:40 a.m.

The event was sparked when student Jager Thornton, 4, was diagnosed with the disease.

Jarger's mother, Ashley Thornton said she wants to make sure people are aware of the differences between the two types, not "lumped together as one disease."

Type 1, or insulin-dependent diabetes is a chronic condition in which the body no longer creates its own insulin. Insulin is a hormone necessary for blood cells to create energy from consumed sugar.

Type 2 diabetes, a much more commonly-known version of diabetes, occurs when the body becomes resistant to insulin or doesn't make enough insulin, according to the Mayo Clinic.

"We've adjusted pretty well," Thornton said of her son's condition. "It's a lot of routine, finger pokes, loss of sleep. It was life altering. My son's life is now in the hands of his caretakers. If he get's too little insulin he could die."

Third grade teacher, Lindsay Wicker said allowing students to have an opportunity to take action is a emphasized mantra for students at Discovery School.

"I tell my students that all the time," Wicker said. "And when (Ashley) said she was wanting help raising awareness, I thought this would be a great opportunity to have my third-grade students to be able to take action for something important."

Wicker's students are reading facts about the disease during morning announcements, stuffed information about the disease into envelopes to spread to their peers and are helped organize the walk.

"It's a great opportunity to make a difference even though they are only in third grade," she said.

Discovery School has raised $500 for the JDRF, the leading global organization for Type 1 diabetes research, in the first week.

Students also were given three paper shoes to sell for any amount of money. The money will be donated to the JDRF Organization.

"It's impressive. They don't have to sell the shoes," Thornton said. "They have one more week (to raise money); they are on Spring Break right now."

Thornton said she is gratefulto Discovery School for its cooperation and willingness to teach students about the disease. She hopes the education will provide her son with the ability to fit in and feel like his classmates.

"One thing I want for Jager is more people to be aware of Type 1 of this disease," Thornton said. "I just wish people would learn there is more than (the Type 2 version), that it's not the same."

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Discovery School walks the walk in Type 1 diabetes awareness ... - Richland Source

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