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Monthly Archives: September 2016
Molecular Medicine – Graduate School of Biomedical …
Posted: September 26, 2016 at 7:45 am
The Department of Molecular Medicine in the Institute of Biotechnology (IBT) was established in 1994 to administer a program to train graduate students at the interface of basic and clinical sciences with an emphasis on biomedical research focused on discovering the molecular mechanisms underlying human disease and to serve as a platform for the development of novel treatment or prevention approaches. To date, our program has awarded over 80 doctoral degrees. Our graduates are placed in top-tier research universities and pharmaceutical companies across the United States and Europe. Our faculty have been successful in securing tens of millions of dollars from private and federal agencies including the National Institutes of Health, the National Science Foundation, and the Department of Defense.
Now also located in the South Texas Research Facility (STRF), we offer a research-oriented, interdisciplinary program of study in the areas of cancer and aging and their prevention. Specific areas of study include: cell (and hormone) signaling, gene expression, epigenetics, cell cycle and checkpoint controls, DNA damage repair and associated stress responses, and regulated protein turnover. Under new leadership, Dr. Tim Huang is expanding our research to include a Systems approach to molecular medicine that offers students an integrated training program spanning molecular and cellular biology, quantitative biology, computational biology, and genomics.
Our goal is to educate and train the next generation of graduate students who will change the face of biomedical research and invent new ways to treat and prevent human diseases.
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Program in Molecular Medicine – UMass Medical School …
Posted: September 26, 2016 at 7:45 am
Recent Molecular Medicine Publications
Bowman NM, Juliano JJ, Snider CJ, Kharabora O, Meshnick SR, Vulule J, John CC, Moormann AM. Am J Trop Med Hyg. 2016 Aug 1. pii: 15-0710. [Epub ahead of print]. PMID: 27481054. (Paper)
Shin J, Salameh JS, Richter JD. Sci Rep. 2016 Jul 6;6:29395. doi: 10.1038/srep29395. PMID: 27381259. (Paper)
Tanriverdi K, Kucukural A, Mikhalev E, Tanriverdi SE, Lee R, Ambros VR, Freedman JE. Anal Biochem. 2016 May 15;501:66-74. doi: 10.1016/j.ab.2016.02.019. Epub 2016 Mar 10. PMID:26969789 [PubMed - in process]. (Paper)
Smulan LJ, Ding W, Freinkman E, Gujja S, Edwards Y J.K., Walker, AK. Cell Rep. 2016 May 16. doi.org/10.1016/j.celrep.2016.05.086. In press. (Paper)
Lee PL, Tang Y, Li H, Guertin DA. Mol Metab. 2016 Apr 11;5(6):422-32. doi: 10.1016/j.molmet.2016.04.001. eCollection 2016 Jun. PMID: 27257602. (Paper)
Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S. Dev Cell. 2016 May 23;37(4):377-86. doi: 10.1016/j.devcel.2016.04.023. PMID: 27219065. (Paper)
Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Garcia Menendez L, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP. J Biol Chem. 2016 May 20. pii: jbc.M116.718932. [Epub ahead of print]. PMID: 2722. (Paper)
Watanabe S,Tan D,Lakshminarasimhan M,Washburn MP,Hong EJ,Walz T,Peterson CL. Nat Commun.2015 May 12;6:7108. doi: 10.1038/ncomms8108. PMID: 25964121 [PubMed - indexed for MEDLINE] PMCID:PMC4431590. (Paper)
McManus M, Mick E, Hudson R, Mofenson LM, Sullivan JL, Somasundaran M, Luzuriaga K; PACTG 356 Investigators. PLoS One. 2016 Apr 22;11(4):e0154391. doi: 10.1371/journal.pone.0154391. eCollection 2016. PMID: 27104621 [PubMed - as supplied by publisher]. (Paper)
Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA. Nat Commun. 2016 Apr 21;7:11365. doi: 10.1038/ncomms11365.PMID: 27098609 [PubMed - in process]. (Paper)
Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP. Mol Cell Biol. 2016 Apr 4. pii: MCB.01121-15. [Epub ahead of print]. PMID: 27044870 [PubMed - as supplied by publisher] (Paper)
Han MS, Barrett T, Brehm MA, Davis RJ. Cell Rep. 2016 Mar 24. pii: S2211-1247(16)30249-2. doi: 10.1016/j.celrep.2016.03.008. [Epub ahead of print]. PMID: 27052181 [PubMed - as supplied by publisher]. (Paper)
San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Nat Commun. 2016 Mar 22;7:11103. doi: 10.1038/ncomms11103. PMID: 27002738. PMCID:PMC4804176 (Paper)
Hung HF, Hehnly H, Doxsey S. Curr Biol. 2016 Mar 2. pii: S0960-9822(16)00075-0. doi: 10.1016/j.cub.2016.01.025. [Epub ahead of print]. PMID: 26948879 [PubMed - as supplied by publisher] (Paper)
Vernia S, Cavanagh-Kyros J, Barrett T, Tournier C, Davis RJ. Cell Rep. 2016 Mar 2. pii: S2211-1247(16)30129-2. doi: 10.1016/j.celrep.2016.02.026. [Epub ahead of print]. PMID: 26947074 [PubMed - as supplied by publisher]. (Paper)
Tang W, Tu S, Lee HC, Weng Z, Mello CC. Cell. 2016 Feb 25;164(5):974-84. doi: 10.1016/j.cell.2016.02.008. PMID: 26919432 [PubMed - in process] (Paper)
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Program in Molecular Medicine - UMass Medical School ...
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What Is Integrative Medicine? – WebMD
Posted: September 26, 2016 at 7:45 am
Experts explore new ways to treat the mind, body, and spirit -- all at the same time.
At age 68, Martha McInnis has had her share of health woes: breast cancer, high cholesterol, clogged arteries, osteoporosis, and scoliosis -- curvature of the spine. Once a year she journeys from her home in Alabama to the Duke University Medical Center in North Carolina where an internist, endocrinologist, and other specialists monitor her with blood tests, X-rays, bone scans, and other tests.
But McInnis knows that she's more than the sum of her illnesses. When her checkup ends, she heads for the Duke Center for Integrative Medicine, where she has learned about nutrition, fitness, yoga, tai chi, meditation, and other practices she says have helped her to live better. "I became an avid tai chi person," she says. "I'm a type A personality. I knew I had to do something about my lifestyle. I had to bring myself down to a type B."
Many Americans have never heard of integrative medicine, but this holistic movement has left its imprint on many of the nation's hospitals, universities, and medical schools.
Both doctors and patients alike are bonding with the philosophy of integrative medicine and its whole-person approach -- designed to treat the person, not just the disease.
IM, as it's often called, depends on a partnership between the patient and the doctor, where the goal is to treat the mind, body, and spirit, all at the same time.
While some of the therapies used may be nonconventional, a guiding principle within integrative medicine is to use therapies that have some high-quality evidence to support them.
The Duke Center for Integrative Medicine is a classic model of integrative care. It combines conventional Western medicine with alternative or complementary treatments, such as herbal medicine, acupuncture, massage, biofeedback, yoga, and stress reduction techniques -- all in the effort to treat the whole person. Proponents prefer the term "complementary" to emphasize that such treatments are used with mainstream medicine, not as replacements or alternatives.
Integrative medicine got a boost of greater public awareness -- and funding -- after a landmark 1993 study. That study showed that one in three Americans had used an alternative therapy, often under the medical radar.
In the past decade, integrative medicine centers have opened across the country. According to the American Hospital Association, the percentage of U.S. hospitals that offer complementary therapies has more than doubled in less than a decade, from 8.6% in 1998 to almost 20% in 2004. Another 24% of hospitals said they planned to add complementary therapies in the future. Patients usually pay out of pocket, although some services -- such as nutritional counseling, chiropractic treatments, and biofeedback -- are more likely to be reimbursed by insurance.
What makes integrative medicine appealing? Advocates point to deep dissatisfaction with a health care system that often leaves doctors feeling rushed and overwhelmed and patients feeling as if they're nothing more than diseased livers or damaged joints. Integrative medicine seems to promise more time, more attention, and a broader approach to healing -- one that is not based solely on the Western biomedical model, but also draws from other cultures.
"Patients want to be considered whole human beings in the context of their world," says Esther Sternberg, MD, a National Institutes of Health senior scientist and author of The Balance Within: The Science Connecting Health and Emotions.
Sternberg, a researcher who has done groundbreaking work on interactions between the brain and the immune system, says technological breakthroughs in science during the past decade have convinced even skeptics that the mind-body connection is real.
"Physicians and academic researchers finally have the science to understand the connection between the brain and the immune system, emotions and disease," she says. "All of that we can now finally understand in terms of sophisticated biology."
That newfound knowledge may help doctors to see why an integrative approach is important, she says.
"It's no longer considered fringe," Sternberg says. "Medical students are being taught to think in an integrated way about the patient, and ultimately, that will improve the management of illness at all levels."
The Osher Center for Integrative Medicine at the University of California, San Francisco, takes a similarly broad view of health and disease. The center, which includes a patient clinic, says on its web site: "Integrative medicine seeks to incorporate treatment options from conventional and alternative approaches, taking into account not only physical symptoms, but also psychological, social and spiritual aspects of health and illness."
To promote integrative medicine at the national level, the Osher Center and Duke have joined with 42 other academic medical centers -- including those at Harvard, Columbia, Georgetown, and the University of Pennsylvania -- to form the Consortium of Academic Health Centers for Integrative Medicine.
Even medical schools have added courses on nontraditional therapies, although doing so can sometimes be a point of contention among faculty.
At the University of California, San Francisco, medical students can augment their coursework in infectious disease and immunology with electives, such as "Herbs and Dietary Supplements" or "Massage and Meditation." They can even opt to study as exchange students at the American College of Traditional Chinese Medicine. In the world of integrative medicine, it's not unusual to see a Western-trained MD who also has credentials in acupuncture or hypnosis, or a registered nurse who is also a yoga teacher and massage therapist.
Not all doctors are jumping onboard, though. Some critics have charged that integrative medicine is driven largely by market forces, as well as public fascination and demand for alternative treatments.
"This is a very faddish country," says Tom Delbanco, MD, a Harvard Medical School professor and doctor at Beth Israel Deaconess Medical Center in Boston. In one national survey of hospitals that offer complementary therapies, 44% listed "physician resistance" as one of the top three hurdles in implementing programs, along with "budgetary constraints" (65%) and "lack of evidence-based research" (39%).
Delbanco says he's concerned that there's not enough scientific evidence to justify the amount of resources spent on integrative medicine and complementary therapies. "I worry that people are making claims in the context of scientific medicine that they cannot really justify. I think there have been few rigorously controlled, scientifically sound studies in the area, and when they have been done, the vast majority have shown these medicines to be no different from placebo."
"I have no trouble with offering hope," he adds. "I think people need hope and optimism. Where I have trouble is when we promise things to people that aren't real."
The search for solid evidence is key: which therapies help and which don't? "There's a clamoring for understanding the biology of this," Sternberg says. Many proponents of integrative care say that it's crucial to hold alternative therapies up to scientific scrutiny, rather than dismissing them outright, because doctors and patients alike need answers. For example, a patient may be taking an herb that is harmful or may interfere with prescription drugs.
As a result, researchers across the country are studying complementary and alternative therapies for safety and effectiveness. Duke is studying whether stress-reduction techniques, such as meditation and writing in a journal, can help prevent preterm labor, which can be precipitated by stress-related hormones. In other clinical trials, researchers are trying to determine, among other things, how acupuncture affects brain activity, how biofeedback can better treat incontinence, and whether the medicinal herb valerian improves sleep in patients with Parkinson's disease.
With the large numbers of people using nontraditional therapies, even finding out what doesn't work can be valuable. For example, researchers affiliated with the Osher Center at the University of California, San Francisco, completed a study that showed that saw palmetto did not improve benign prostate hyperplasia, a noncancerous enlargement of the prostate gland. More than 2 million men in the U.S. take saw palmetto as an alternative to drugs. The results were published in The New England Journal of Medicine.
Tracy Gaudet, MD, director of the Duke Center for Integrative Medicine, says she encounters little resistance once fellow doctors understand that integrative medicine doesn't entail "blindly advocating for alternative approaches and rejecting conventional ones."
"That's not what we're about," she says. "There's a lot of quackery out there and a lot of dangerous therapies. Our first priority is to guide people away from them."
"We all want the same thing: the best care for patients," Gaudet says.
SOURCES: Esther Sternberg, MD, director, Integrative Neural Immune Program; chief of section on neuroendocrine immunology and behavior, National Institute of Mental Health and National Institutes of Health. Tracy Gaudet, MD, director, Duke Center for Integrative Medicine, Duke University. Susan Folkman, PhD, director, Osher Center for Integrative Medicine, University of California, San Francisco; chairwoman, Consortium of Academic Health Centers for Integrative Medicine. Tom Delbanco, MD, professor of general medicine and primary care, Harvard Medical School. Eisenberg, D.M. The New England Journal of Medicine, Jan. 28, 1993; vol 328: pp 246-252. Bent, S. The New England Journal of Medicine, Feb. 9, 2006; vol 354: pp 557-566. American Hospital Association statistics book, 2004. Osher Center for Integrative Medicine web site. ClinicalTrials.gov web site: "Effect of Acupuncture on Human Brain Activity;" "Enhancing Non-Pharmacologic Therapy for Incontinence;" Valerian to Improve Sleep in Patients With Parkinson's Disease."
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Integrative Medicine at Beaumont
Posted: September 26, 2016 at 7:45 am
Integrative medicine, sometimes referred to as holistic medicine or complementary medicine, combines conventional and alternative approaches to address the biological, psychological, social and spiritual aspects of health and illness. Our services are available for both adults and children.
Beaumont's Integrative Medicine Program focuses on healing the whole person, with the goal of improving quality of life for patients, their families and others close to them.
We offer clinical massage, acupuncture, naturopathy, guided imagery, reflexology, energy balancing with Reiki, scar therapy, lymphatic wellness massage, Indian Head Massage, hydrotherapy, Cranial Sacral Therapy, neuromuscular therapy, meditation and yoga which combine the best of Eastern traditions while complimenting traditional Western medical practice.
The goal of any successful integrative medicine program is to truly "integrate" allopathic medicine with mind-body-spirit modalities with the ultimate goal of helping patients adapt to traditional medical treatments. Our modalities directly affect the body's physiological healing process while gently awakening the mind-body-spirit connection needed to enhance the healing process.
Beaumont is also one of only a few centers in the United States who offers oncology/hospital massage training. This graduate program, overseen by Beaumont's integrative medicine department is offered through Beaumont's School of Allied Health.
Patients, their caregivers and the hospital staff need both private and group programs therefore we have structured our offerings around their stated needs. Individual treatments (regardless of hospital affiliation) include:
Our Medical Director, Maureen Anderson M.D., is board certified by the American Board of Integrative and Holistic Medicine, with additional education in the functional medicine approach. Her primary training and board certifications are in emergency medicine and general pediatrics. Over the years, Dr. Anderson has cared for patients of every age, presenting with a whole constellation of symptoms and diseases.
The wisdom and experience gained during years as an emergency physician have afforded her a unique and broad perspective, which nicely complements her integrative medicine skills and expertise. Dr. Anderson brings all of this, along with a passion for wellness, and a genuine interest in the total well-being of others to her integrative medicine practice
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About – Duke Integrative Medicine
Posted: September 26, 2016 at 7:45 am
Integrative medicine avoids the false dichotomy between conventional and complementary medicine. New therapies are selected on the basis of their scientifically proven safety and effectiveness, regardless of their origin. The result is an array of services intended to tackle the complex dynamics contributing to your health. Often, the physical state is symptomatic of mental, emotional, social, spiritual, or environmental factors that only a comprehensive, personalized health plan can resolve.
At the core of integrative medicine is the concept of the partnership between patient and healthcare practitioner. With a preference for the least invasive and most natural therapies, the full range of the healing sciences is brought to bear on strengthening your innate healing response by physicians and providers trained in both conventional and integrative medicine. When you have recovered your health and vitality, we will help you maintain your wellness and prevent the onset or recurrence of disease.
To learn more, see our Patient Bill of Rights.
At Duke Integrative Medicine, we operate our practice at the highest possible standards of excellence in a world-class facility Duke Universitys Center for Living Campus. Nestled in the woodlands of Duke Forest, and surrounded by serene meditation gardens, we offer quiet, soothing, contemplative spaces designed to calm and focus your senses and rejuvenate your spirit. Find your answers in our library under a cathedral ceiling, surrounded by walls of glass and views of nature, or visit with like-minded souls in our Integrative Caf. Every feature of the environment is designed to nourish the wellness within.
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About - Duke Integrative Medicine
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Pediatric Integrative Medicine | Cleveland Clinic Children’s
Posted: September 26, 2016 at 7:45 am
Cleveland Clinic Childrens Center for Pediatric Integrative Medicine is dedicated to addressing the increasing demand for integrative healthcare by researching and providing access to practices that address the physical as well as lifestyle, emotional, and spiritual needs of children.
As the body of evidence for integrative medicine grows, we remain at the forefront of providing the most updated education and practices to our patients. We are able to care for children through their mid-20s, then provide seamless transition to adult providers.
Integrative Medicine services have become very popular in the United States, with more than 70 percent of Americans using them in some form.
Your child may benefit from integrative medicine as a complement to the care they are already receiving to treat chronic illness. Integrative medicine may help to reduce the severity or frequency of disease episodes, decrease stress related to chronic disease, and enjoy a better quality of life.
Our team members can coordinate appointments together to provide the patient with the best care.
Our team of dedicated pediatric physicians and therapists are certified to perform a number of complementary therapies, including:
Conditions that are commonly treated with integrative medicine include:
Increasingly, research shows that how we live, what we think, and how we feel affect our health. While conventional medicine can help diminish the consequences of unhealthy lifestyles, integrative medicine can reverse those consequences, prevent illness and reduce symptoms, resulting in:
Our team of dedicated pediatric physicians and therapists are certified to perform a number of complementary therapies, including:
The Center for Pediatric Integrative Medicine looks into the role of mind, body, spirit and lifestyle changes and how they can affect chronic disease. Studies yield evidence-based results that continue to encourage medical schools, hospitals and physicians to accept and incorporate these methods.
For example, research at Cleveland Clinic has shown that integrative medicine, including guided imagery, massage or Reiki, can help patients reduce their anxiety before surgery, to cope better with postoperative pain and to maximize their recovery.
To learn more, we invite you to explore research from the:
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Pediatric Integrative Medicine | Cleveland Clinic Children's
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Basic Genetics
Posted: September 26, 2016 at 7:45 am
Tour of Basic Genetics
What are Traits?
Explore traits, the characteristics that make us unique.
What are DNA & Genes?
Get to know the molecule that holds the instructions for building every living thing.
What is Inheritance?
Learn how traits pass from parents to offspring.
What is Mutation?
Take a look at how variation occurs.
We are pleased to offer you a partial preview of our new Tour of Basic Genetics.
More chapters will be available soon. But we wanted to make the new chapters available as soon as possible, especially for those who are using mobile devices or the most-recent version of web browsers that no longer support Adobe Flash content.
Our flash-based old tour is still available.
How do Scientists Read Chromosomes?
To read a set of chromosomes, scientists look for key features to identify their similarities and differences.
Make a Karyotype
Try your hand at organizing a profile of human chromosomes.
Using Karyotypes To Diagnose Genetic Disorders
Certain genetic disorders can be diagnosed by looking at a person's chromosomes.
Are Telomeres The Key To Aging And Cancer?
Protective tips at the end of our chromosomes get shorter as we age.
Related content from Pigeon Breeding: Genetic Linkage Sex Linkage
What are dominant and recessive?
The terms dominant and recessive describe the inheritance patterns of certain traits. But what do they really mean?
Sexual vs. Asexual Reproduction
Compare the two ways for organisms to pass genetic information to their offspring.
The 4 Types of DNA and Molecular Genealogy
DNA analysis can help build the family tree. Find out about autosomal, x chromosome, y chromosome, and mitochondrial DNA.
Types of Proteins
Explore the types of proteins and learn about their varied functions.
Transcribe and Translate a Gene
See how cells "read" the information in a DNA sequence to build a protein, then build one yourself!
What makes a firefly glow?
Walk through protein synthesis with this animated example.
Prions
Mad Cow and Creutzfeldt-Jakob are examples of prion diseases. What makes them unusual, and why are they controversial?
Observable Human Characteristics
Take a look at several inherited human characteristics and learn more about them. Which variations do you have?
Traits Activities
Do these fun activities about inherited traits and disease risk with your family or at public gatherings.
Build a DNA Molecule
Find out how the DNA code letters A, C, G, and T make a DNA molecule by building one yourself.
Anatomy of a Gene
Introns, exons, and regulatory sequences: Examine the parts of a gene from "start" to "stop."
Things You May Not KNow About DNA
Put an end to these common misconceptions about DNA and Heredity.
How do Cells Read Genes?
See how cells interpret DNA sentences.
PTC: The Genetics of Bitter Taste
An accidental discovery leads to important clues about human evolution.
Genes and Blood Type
Take a look at the inheritance of the ABO blood typing system and the genes behind it.
The Time of Our Lives
Learn about the genetic underpinnings of biological clocks.
DNA Day is April 25th. Check out the NHGRI DNA Day website.
RNA: The Versatile Molecule
RNA's chemical structure gives it the flexibility to take on a variety of shapes and functions.
RNA's Role In The Central Dogma
Learn the essential roles of the three most plentiful types of RNA messenger, transfer, and ribosomal in the processes of transcription and translation.
Beyond the Central Dogma
Learn about some of the less-known roles of RNA.
The Outcome of Mutation
Small changes to DNA can lead to big variations in traits.
Homeotic Genes and Body Patterns
Bizarre mutations in fruit flies led to the discovery of genes that guide development.
Test Neurofibromin Activity In A Cell
See how a mutated protein can affect normal cell division.
Mutation and Haplotypes
Genetic variations can provide clues about common ancestry.
APA format:
Genetic Science Learning Center. (2016, March 1) Basic Genetics. Retrieved September 23, 2016, from http://learn.genetics.utah.edu/content/basics/
CSE format:
Basic Genetics [Internet]. Salt Lake City (UT): Genetic Science Learning Center; 2016 [cited 2016 Sep 23] Available from http://learn.genetics.utah.edu/content/basics/
Chicago format:
Genetic Science Learning Center. "Basic Genetics." Learn.Genetics.March 1, 2016. Accessed September 23, 2016. http://learn.genetics.utah.edu/content/basics/.
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Stem-cell-based therapy promising for treatment of breast …
Posted: September 26, 2016 at 7:42 am
Friday, April 24, 2015
New animal model of breast-to-brain cancer spread allows testing of therapeutic stem cell approach
Investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study published online in the journal Brain also describes a strategy of preventing the potential negative consequences of stem cell therapy.
Metastatic brain tumors often from lung, breast or skin cancers are the most commonly observed tumors within the brain and account for about 30 percent of advanced breast cancer metastases, says Khalid Shah, MS, PhD, director of the Molecular Neurotherapy and Imaging Laboratory in the MGH Departments of Radiology and Neurology, who led the study. Our results are the first to provide insight into ways of targeting brain metastases with stem-cell-directed molecules that specifically induce the death of tumor cells and then eliminating the therapeutic stem cells.
Tagged therapeutic stem cells (green) targeting breast cancer metastases (red) in the brain of a mouse model. (Khalid Shah, MS, PhD, Massachusetts General Hospital)
In their search for novel, tumor-specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed a mouse model that more closely mimics what is seen in patients. They found that injecting into the carotid artery breast cancer cells that express markers allowing them to enter the brain cells labelled with bioluminescent and fluorescent markers to enable tracking by imaging technologies resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced breast cancer patients. Current therapeutic options for such patients are limited, particularly when there are many metastases.
To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell-death-inducing receptors found only on the surface of cancer cells. Previous research by Shah and his colleagues had shown that two types of stem cells are naturally attracted toward tumors in the brain. After first verifying in their model that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor-free areas, the team implanted TRAIL-expressing stem cells into the brains of metastasis-bearing mice, which reduced the growth of tumors. Injecting the TRAIL-expressing stem cells into the carotid artery, a likely strategy for clinical application, led to significantly slower tumor growth and increased survival, compared with animals receiving unaltered stem cells or control injections.
The safe use of a stem-cell-based therapy against brain metastasis would require preventing the engineered cells from persisting within the brain, where they could affect normal tissue and possibly give rise to new tumors. To facilitate removal of the therapeutic stem cells from the brain at the conclusion of therapy, the researchers created cells that, in addition to TRAIL, express a viral gene called HSV-TK, which renders them susceptible to the effects of the antiviral drug ganciclovir. Several tests in cultured cells indicated that ganciclovir would cause the death of HSV-TK-expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV-TK.
Shah and his team are currently developing similar animal models of brain metastasis from lung cancers and from melanoma. They also are working to improve understanding of the therapeutic efficacy of simultaneously targeting multiple tumor-specific molecules on the surface of metastatic cells within the brain and anticipate that their findings will make a major contribution towards developing novel targeted therapies for metastatic tumors in the brain. In addition to Shah, who is an associate professor at Harvard Medical School and a principal faculty member at Harvard Stem Cell Institute, the authors of the Brain report are co-lead authors Wanlu Du, PhD, and Tugba Bagci-Onder, PhD, along with Jose-Luiz Figueiredo, MD, and Jordi Martinez-Quintanilla, PhD all of the MGH Molecular Neurotherapy and Imaging Laboratory. The study was supported by National Institutes of Health grants CA138922 and NS071197 and a grant from the James McDonald Foundation.
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $760 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
Katie Marquedant, kmarquedant@partners.org, 617 726-0337
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Wake Forest Institute for Regenerative Medicine (WFIRM …
Posted: September 24, 2016 at 9:46 pm
New Video Series - Watch Now
Scroll down to get an inside look into the lab and hear directly from our scientists about their projects aimed at helping patients with conditions such as diabetes, lung disease, hemophilia A and gastrointestinal disorders.
An International Leader in Regenerative Medicine
The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies. Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies - all with the goal to cure, rather than merely treat, disease.
The Next Evolution of Medical Treatments
Regenerative medicine has been called the "next evolution of medical treatments," by the U.S. Department of Health and Human Services. With its potential to heal, this new field of science is expected to revolutionize health care. It is our mission at WFIRM to improve patients' lives by developing regenerative medicine therapies and support technologies.
"We have many challenges to meet, but are optimistic about the ability of the field to have a significant impact on human health. We believe regenerative medicine promises to be one of the most pervasive influences on public health in the modern era."-Anthony Atala, MD, Director
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What is Integrative Medicine? – Duke Integrative Medicine
Posted: September 24, 2016 at 9:45 pm
Integrative medicine is an approach to care that puts the patient at the center and addresses the full range of physical, emotional, mental, social, spiritual and environmental influences that affect a persons health. Employing a personalized strategy that considers the patients unique conditions, needs and circumstances, it uses the most appropriate interventions from an array of scientific disciplines to heal illness and disease and help people regain and maintain optimum health.
Integrative medicine is grounded in the definition of health. The World Health Organization (WHO) defines health as a state of complete physical, mental and social wellbeing and not merely the absence of disease or infirmity.
Integrative medicine seeks to restore and maintain health and wellness across a persons lifespan by understanding the patients unique set of circumstances and addressing the full range of physical, emotional, mental, social, spiritual and environmental influences that affect health. Through personalizing care, integrative medicine goes beyond the treatment of symptoms to address all the causes of an illness. In doing so, the patients immediate health needs as well as the effects of the long-term and complex interplay between biological, behavioral, psychosocial and environmental influences are taken into account.
Integrative medicine is not the same as alternative medicine, which refers to an approach to healing that is utilized in place of conventional therapies, or complementary medicine, which refers to healing modalities that are used to complement allopathic approaches. If the defining principles are applied, care can be integrative regardless of which modalities are utilized.
The defining principles of integrative medicine are:
In addition to addressing and handling the immediate health problem(s) as well as the deeper causes of the disease or illness, integrative medicine strategies also focus on prevention and foster the development of healthy behaviors and skills for effective self-care that patients can use throughout their lives.
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What is Integrative Medicine? - Duke Integrative Medicine
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