Monthly Archives: September 2016

Molecular genetics is the field of biology and genetics that studies the structure and function of genes at a molecular level. The study of chromosomes and gene expression of an organism can give insight into heredity, genetic variation, and mutations. This is useful in the study of developmental biology and in understanding and treating genetic diseases.

Gene amplification is a procedure in which a certain gene or DNA sequence is replicated many times in a process called DNA replication.

The recombinant DNA molecules are then put into a bacterial strain (usually E. coli) which produces several identical copies by transformation. Transformation is the DNA uptake mechanism possessed by bacteria. However, only one recombinant DNA molecule can be cloned within a single bacteria cell, so each clone is of just one DNA insert.

In separation and detection DNA and mRNA are isolated from cells and then detected simply by the isolation. Cell cultures are also grown to provide a constant supply of cells ready for isolation.

First, laboratories use a normal cellular modification of mRNA that adds up to 200 adenine nucleotides to the end of the molecule (poly(A) tail). Once this has been added, the cell is ruptured and its cell contents are exposed to synthetic beads that are coated with thymine string nucleotides. Because Adenine and Thymine pair together in DNA, the poly(A) tail and synthetic beads are attracted to one another, and once they bind in this process the cell components can be washed away without removing the mRNA. Once the mRNA has been isolated, reverse transcriptase is employed to convert it to single-stranded DNA, from which a stable double-stranded DNA is produced using DNA polymerase. Complementary DNA (cDNA) is much more stable than mRNA and so, once the double-stranded DNA has been produced it represents the expressed DNA sequence scientists look for.[4]

This technique is used to identify which genes or genetic mutations produce a certain phenotype. A mutagen is very often used to accelerate this process. Once mutants have been isolated, the mutated genes can be molecularly identified.

Forward saturation genetics is a method for treating organisms with a mutagen, then screens the organism's offspring for particular phenotypes. This type of genetic screening is used to find and identify all the genes involved in a trait.[5]

A mutation in a gene can cause encoded proteins and the cells that rely on those proteins to malfunction. Conditions related to gene mutations are called genetic disorders. However, altering a patient's genes can sometimes be used to treat or cure a disease as well. Gene therapy can be used to replace a mutated gene with the correct copy of the gene, to inactivate or knockout the expression of a malfunctioning gene, or to introduce a foreign gene to the body to help fight disease.[6] Major diseases that can be treated with gene therapy include viral infections, cancers, and inherited disorders, including immune system disorders.[7]

Gene therapy delivers a copy of the missing, mutated, or desired gene via a modified virus or vector to the patient's target cells so that a functional form of the protein can then be produced and incorporated into the body.[8] These vectors are often siRNA.[9] Treatment can be either in vivo or ex vivo. The therapy has to be repeated several times for the infected patient to continually be relieved, as repeated cell division and cell death slowly randomizes the body's ratio of functional-to-mutant genes. Gene therapy is an appealing alternative to some drug-based approaches, because gene therapy repairs the underlying genetic defect using the patients own cells with minimal side effects.[10] Gene therapies are still in development and mostly used in research settings. All experiments and products are controlled by the U.S. FDA and the NIH. [11][12]

Classical gene therapies usually require efficient transfer of cloned genes into the disease cells so that the introduced genes are expressed at sufficiently high levels to change the patient's physiology. There are several different physicochemical and biological methods that can be used to transfer genes into human cells. The size of the DNA fragments that can be transferred is very limited, and often the transferred gene is not a conventional gene. Horizontal gene transfer is the transfer of genetic material from one cell to another that is not its offspring. Artificial horizontal gene transfer is a form of genetic engineering.[13]

The Human Genome Project is a molecular genetics project that began in the 1990s and was projected to take fifteen years to complete. However, because of technological advances the progress of the project was advanced and the project finished in 2003, taking only thirteen years. The project was started by the U.S. Department of Energy and the National Institutes of Health in an effort to reach six set goals. These goals included:

The project was worked on by eighteen different countries including the United States, Japan, France, Germany, and the United Kingdom. The collaborative effort resulted in the discovery of the many benefits of molecular genetics. Discoveries such as molecular medicine, new energy sources and environmental applications, DNA forensics, and livestock breeding, are only a few of the benefits that molecular genetics can provide.[14]

NCBI: http://www.ncbi.nlm.nih.gov/About/primer/genetics_molecular.html

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Molecular genetics - Wikipedia, the free encyclopedia

OMICS International welcomes all the attendees, speakers, sponsors and other research expertise from all over the world to theInternational conferenceon Clinical and Medical Genetics(Clinical Genetics 2016)which is going to be held duringNovember 28-29,2016inAtlanata, USA.We are very much honored to invite you all to exchange and share your views and experience on theCurrent Advancements and Novel Research on Clinical and Medical Genetics.

Clinical and medical geneticsare involved in the diagnosis and management ofhereditary disorderswhich determines the safety and effectiveness ofmedications,devices,diagnostic productsandtreatment regimenswhich are intended for human use and also be used for prevention, treatment, diagnosis or for relieving symptoms of a disease. There is a rapid growth in the field of Clinical and Molecular Genetics because of the increased prevalence ofinfectious diseases, causative mutating organisms which led to the discovery of novel clinical and genetic testing methods. TheGenetic testingmarket sale is estimated to reach $25 billion annually by 2021 with a growth rate of 10% in the United States. The genetic testing market is believed to reach approximately $60 billion by 2020 globally. US represent the largest market for genetic testing worldwide.

Track -1: Clinical Genetics:

Clinical Genetics is the medical specialty which provides adiagnostic serviceand"genetic counselling"for individuals or families with, or at risk of, conditions which may have a genetic basis. Genetic disorders can affect any body system and any age group. The aim of Genetic Services is tohelp those affected by, or at risk of, a genetic disorder to live and reproduce as normally as possible. Genetic disorders include :

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on Histocompatibility andImmunogenetics, November 28-30, 2016 San Antonio, USA; Conference on Genomics and Pharmacogenomics, September 12-14, 2016, Berlin, Germany; Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;Geneticsand Genomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage, Mutation and Cancer, March 13-18, 2016, Ventura, USA; Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA; Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track -2:Medical Genetics:

Medical geneticsis the branch ofmedicinethat involves the diagnosis and management ofhereditary disorders. Medical genetics differs fromhuman geneticsin that human genetics is a field of scientific research that may or may not apply to medicine, while medical genetics refers to the application of genetics to medical care. For example, research on the causes and inheritance ofgenetic disorderswould be considered within both human genetics and medical genetics, while the diagnosis, management, and counselling people with genetic disorders would be considered part of medical genetics.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on Histocompatibility andImmunogenetics, November 28-30, 2016 San Antonio, USA; Conference on Genomics and Pharmacogenomics, September 12-14, 2016, Berlin, Germany; Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;Geneticsand Genomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage, Mutation and Cancer, March 13-18, 2016, Ventura, USA; Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA; Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track -3:Mendelian Genetics: Past and the future

For thousands of years there were lot of questions aboutgeneticsand people followed different processes to produce hybrids of different plants and animals. But most of their trails failed as the actual mechanism behind it was unknown. ThereafterMendelwas the first to explain the concept of heredity after experimenting on pea plant (Pisum sativum)through his laws. He proposed Law of Segregation where only one allele pass from parent to offspring as the allele of parents gets separated ,Law of independent Assortment where different pairs of allele passes from parents independently, Law of Dominance where some alleles are dominant the remaining are recessive. Based on this, several hypotheses were proposed later.

Currently there are vast advancements in the field of genetics where researches are focusing on the different diseases caused by variations ingenesand many institutions are investing in the research. For example, US government, along with NIH funded Human Genome project based onDNA sequencingtechnologies. Due to the development of new techniques in Bioinformatics there is a huge decrease in the price of genome sequencing, from $100 million to $1000.

The involvement of genetics in heart diseases, cancer and other implications remained far from clear. There are possibilities of practicing human cloning, eugenics apart from these genetic advancements.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on Histocompatibility andImmunogenetics, November 28-30, 2016 San Antonio, USA; Conference on Genomics and Pharmacogenomics, September 12-14, 2016, Berlin, Germany; Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;Geneticsand Genomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage, Mutation and Cancer, March 13-18, 2016, Ventura, USA; Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA; Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-4:Clinical Genomics

Clinical genomics is the use ofgenomic sequencingin clinical basis like for diagnosis, treatment of disease caused in patients. It is a new and rapidly changing field. The diseases like cystic fibrosis and sickle cell anaemia, which are caused by a single base pair change to DNA sequencing, these mutations can be corrected by CRISPR/ Cas technology.

Cas technologyis based ongenomeediting which is proposed by Editas Medicine with an investment of about $43million. Researchers adopted this technique as most of the microbes useproteinand RNAs against invading viruses. The technique involves the editing of stretches in DNA and also to edit single base pairs of the human genome. It was also believed to cure untreatable diseases possibly.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-5:Oncogenomics and Therapeutics

Oncogenomics is the study of the relationship between cancer and the genome of an individual. Its goal is to identifyoncogenesfor the diagnosis and treatment of cancer.Canceris a genetic disease as it is caused by genetic variation in DNA.NIH offers about $7.4 billion on research related to genetics and about $5.8 on cancer related research. The various techniques used are DNA sequencing,microarray, digital karyotyping, bacterial artificial chromosome.

The American Cancer Society reported that among 1.5 million cases half a million die from the disease mostly of breast cancer, lung cancer, bladder cancer, leukemia. The expenditure on cancer care in 2010 was $125 billion and is estimated to reach $156 billion by 2020 in US.US occupies seventh place inbreast cancerworldwide.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track- 6:Clinical Epigenetics

Clinical epigeneticsuses the techniques involved in molecular biology to detect the alterations in DNA methylation or histone modification to diagnose disorders produced by heritable defects in thegene expression. DNA methylation involves in the addition of methyl groups to adenine and guanine bases. DNA is useful for cell development and when methylation occurs on CpG dinucleotide where cytosine precedes guanine suppresses the gene regulation. The nucleosome consists of historians where the tails of histone protrude from nucleosome and therefore they can be modified. The chemical groups attract activating or suppressing complexes to chromatin, which affects its shape, making it more or less available for gene expression. Epigenetic enzyme marketing consists of DNA-modifying, RNA-modifying, Protein is modifying Enzymes which is expected to reach a high rate by 2019. Bisulfite conversion kits; ChIP- seq kits; RNA sequencing kits; whole genome amplification kits are some of the epigenetic kits among which ChIP-seq kits segment had the biggest share in 2014.The market value ofepigeneticswas $413.24 million in 2014, it is expected to reach a CAGR of 13.64% from 2014 to 2019 and it is estimated to grow $783.17 million by 2019 globally.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain;Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK;conference on Histocompatibility andImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomics and Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;Geneticsand Genomics Conference,June 1-3, 2016, Nanjing, China;DNA Damage, Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulationin Development and Disease Conference,29 March 2016, Austin, USA;Maintenance ofGenome Stability2016,March 7-10, 2016, Panama, Central America.

Track-7:Regenerative Biology and Stem Cell Research

Regenerative biology involves the restoration or renewal of damaged genes, cells, tissues, organisms orecosystemthat is produced by some natural fluctuations.Regenerationis mediated by gene regulation and it may be complete (same as old tissue) or incomplete (fibrosis). The market value for tissue engineering and regeneration products was $55.9 billion in 2010 and $59.8 billion in 2011, and is expected to reach $89.7 billion by 2016 at a CAGR of 8.4% globally. According to the reports, the market value of regenerative medicine was about $2.5 billion in the US.

Stem cells are undifferentiated biological cells that undergo mitosis to produce more cells, which are found in multicellular organisms. They are of two types, embryonic and adult stem cells. The stem cell treatment was found to be a lifesaving treatment for the patients with solid tumors and blood disorders.Stem cellscan be obtained from the umbilical cord after babys birth. Possibly they can also be obtained from peripheral blood and bone marrow. According to the reports, in US the availability of stem cell therapy was $15.2 million in 2007 and $16.5 million in 2008 and it is estimated to reach $11 billion by 2020.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-8:Microbial and Human Genetics

There are millions ofmicroorganismsthat have a rapid impact on our health. They play a vital role in maintaining the health as well as in the onset of diseases.

Genomics applies DNA sequencing methods andBioinformaticsto analyze the structure and function of genomes. It started from bacteriophage but was overtaken by bacterial genomics. Its applications were included in the fields of medicine, biotechnology and social sciences.

Proteomics is the study of the structure and functions of proteins as they are the essential components of the various metabolic pathways of cells. It is more complicated when compared to genomic studies as it varies from cell to cell.Mass spectroscopyand microarray techniques are mostly used to study proteins presently.

The global market for DNA sequencing products and services in 2012 was $3.5 billion and $4.5 billion in 2013. It is expected to reach $11.7 billion by 2018 with a CAGR of 21.2%.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-9:Next Generation Sequencing

Next Generation Sequencingis a novel method for sequencing DNA and RNA more rapidly, which has made the study of genomics easy. It is the most versatile tool for medical and biological research. The techniques involved are Illumina sequencing, Roche 454 sequencing, Ion torrent: proton sequencing,Solid sequencing. Illumina sequencing is based on DNA colonies or clusters that involves in the clonal amplification of DNA on a surface.454 pyro sequencing amplifies DNA in side water droplets in an oily solution. Ion torrent sequencing is based on using sequencing chemistry with semiconductor based detection system. It is based on detection of hydrogen ions used during polymerisation of DNA whereas solid sequencing involves sequencing by ligation. The NGS market reached $231.7 million in 2012 and $510.7 million in 2013 and is expected to reach $7.6 billion by 2018 with a CAGR of 71.6% globally.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America..

Track-10:Clinical Metabolics and Lipidomics

Lipids are the major components of biological membranes as well as the metabolites of organisms. Lipids play crucial role in biology. Imbalance in the lipid molecules leads to numerous diseases like atherosclerosis, obesity, diabetes, andAlzheimer's disease. Lipidomics is a system-based study of all lipids, which aims at the analysis of lipids in the biological system. Lipidomics is the main tool for potential biomarker discovery, diagnosis the disease and to understand disease pathology mainly in the fields of neurodegeneration, psychiatry, oncology, metabolic diseases, and infectious diseases. The global biomarkers market was $29.3 billion in 2013 and is expected to grow $53.6 billion in 2018 at a CAGR of 12.8%.

Clinical metabolomics is the major and the most powerful tool to screen metabolites in the biological samples. These provide predictive and prognostic biomarkers which are useful to monitor disease states and to improve therapeutic levels. Discovery of biomarkers to differentiate diseases at molecular levels is a difficult task as the metabolite profile is related to the phenotype of an organism;metabolomicsprovide a better understanding of systemic diseases. Metabolomics is also practiced in crop breeding, toxicology, plant biotechnology. The market value formetabolomicswas $712 million in 2012 and is expected to reach nearly $1.4 billion in 2017 at a CAGR of 14.2% globally.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain;Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK;conference on Histocompatibility andImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomics and Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;Geneticsand Genomics Conference,June 1-3, 2016, Nanjing, China;DNA Damage, Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulationin Development and Disease Conference,29 March 2016, Austin, USA;Maintenance ofGenome Stability2016,March 7-10, 2016, Panama, Central America.

Track-11:Medical and Developmental Genetics

Right from the zygote to a developed individual every process is regulated by genes.Developmental geneticsis concerned with the process in which genes regulate the development. It is the study of cell fate, cell determination and embryonic development. There are many theories proposed and among them differential gene expression is the most accepted one. The ability to produce an organism from cells is called totipotent, unipotent stem cells produce a family of related cells. Pluripotent and multipoint produce only few organs or tissues, but all these cells forms, acell lineagewhose differentiation can be done by a master control gene. Likewise immune cells are produced from bone marrow; B-cells are responsible for antibody production. By Invivo production of B-cells, antibody diversity can be achieved as process follows differential gene expression. The prenatal and newborngenetic testingmarket were $1.12 billionin 2012 and expected to grow $8.37 billionin 2019 at a CAGR of 26.9% from 2013 to 2019 globally.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-12: Genetic Medicine

Genetic medicineis the integration and application of genomic technologies allows biomedical researchers and clinicians to collect data from large study population and to understand disease and genetic bases of drug response. It includes genome structure, functional genomics,epigenomics,genome scale population genomics, systems analysis, pharmacogenomics and proteomics. The Division of Genetic Medicine provides an academic environment enabling researchers to explore new relationships between disease susceptibility and human genetics. The Division of Genetic Medicine was established to host both research and clinical research programs focused on the genetic basis of health and disease. Equipped with state-of-the-art research tools and facilities, our faculty members are advancing knowledge of the common genetic determinants of cancer, congenital neuropathies, and heart disease.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-13:GeneticProbe

A section ofDNAof known structure or function which is marked with aradioactive isotope, dye or enzyme so that it can be used to detect the presence of specific sequences of bases in another DNA or RNA molecule.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-14:Genetic Linkage Analysis

Geneticlinkage analysis is a statistical method that is used to associate functionality of genes to their location onchromosomes. Neighboring genes on the chromosome have a tendency to stick together when passed on to offsprings. Therefore, if some disease is often passed to offsprings along with specific marker-genes , then it can be concluded that the gene(s) which are responsible for the disease are located close on the chromosome to these markers.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-15:Genetic Testing for Diseases

This is the analysis of chromosomes, proteins, and metabolites.Genetic testing for diseasescan provide important information for diagnosing, treating and preventing illness. Genetic testing identifies the changes in chromosomes, genes, or proteins. These are performed on a sample of blood, hair, skin, amniotic fluid, or other tissue.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-16:Genetic Syndromes and Related Disorders

Genetic disorder is a genetic problem which is associated with the abnormalities in the genome, it may or may not be heritable. For example, cancer can be caused by some inherited genes or by newmutationsor it may be environmental cause in some patients. There are many genetic disorders among them Single-gene disorder is the one which is the resultant of a single mutated gene. It includes diseases like Cystic fibrosis,Sickle-cell-anemia, Polycystic kidney disease, Hemophilia-A, Albinism. Multifactorial diseases include diabetes and heart diseases. Most of the genetic disorders can be identified at birth or in childhood like Huntingtons disease. Treatment for these genetic disorders is still a battle where around 1800 clinical trials have been completed. Presently Gene therapy is followed in which a new gene is introduced to a patient which is very complicated. The market value of products to treatgenetic disorderswas $12.8 billion in 2009 and $17.3 in 2014 globally.

The market value for cancer treatment was about $51.2 billion in 2014 and is expected to reach $66.4 billion by 2019, with a CAGR of 5.4% from 2014 to 2019 globally.The autism spectrum disorders(ASD) market was about $346.2 million in 2013 and $360.9 million in 2014. The market value is expected to grow to $412.7 million by 2019, with a CAGR of 2.7 %.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-17:Genetics Market:

While the evidence base is still growing, genetic services industry leaders strongly believe that emerging testing capabilities will have significant clinical impact in the future. Many expressed opinions that genetic services will make significant contributions to prediction, detection, and care selection, leading to better quality care and increased affordability. Available genetic tests and genomic applications, can be categorized according to their clinical method of use across prediction, detection, and care selection. The prenatal and newborngenetic testingmarket were $1.12 billionin 2012 and expected to grow $8.37 billionin 2019 at a CAGR of 26.9% from 2013 to 2019 globally.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Track-18: Genetic Testing for Inherited Cardiac Disease

Over the past 2 decades, investigators in the field of cardiac genetics have evolved a complex understanding of the pathophysiological basis of inherited cardiac diseases, which predispose individuals to sudden cardiac death. In this Review, we describe the current status of gene discovery and the associations between phenotype and genotype in the cardiac channelopathies and cardiomyopathies. The various indications for genetic testing and its utility in the clinic are assessed in relation to diagnosis, cascade testing, guiding management, and prognosis. Some common problems exist across all phenotypes: the variable penetrance and expressivity of genetic disease, and the difficulty of assessing the functional and clinical effects of novel mutations. These issues will be of particular importance as the next-generation sequencing technologies are used by genetics laboratories to provide results from large panels of genes. The accurate interpretation of these results will be the main challenge for the future.

Related Conferences:

World congress onHuman Genetics, October 31 - November 02, 2016 Valencia, Spain; Conference on Genetics Counseling andGenomicsMedicine, Aug 11-12, 2016 Birmingham, UK; Conference on HistocompatibilityandImmunogenetics, November 28-30, 2016 San Antonio, USA;Conference on Genomicsand Pharmacogenomics, September 12-14, 2016, Berlin, Germany;Conference onCancer Genomics, Aug 8-9, 2016 Las Vegas, USA;GeneticsandGenomics Conference, June 1-3, 2016, Nanjing, China;DNA Damage,Mutation and Cancer,March 13-18, 2016, Ventura, USA;Chromatin andEpigenetics, 20 March 2016, Dubrovnik, Croatia; Chromatin,Non-coding RNAsand RNAP II Regulation in Development and Disease Conference, 29 March 2016, Austin, USA;Maintenance ofGenome Stability2016, March 7-10, 2016, Panama, Central America.

Cell Therapy-2015

OMICS International Conferencessuccessfully hosted its premier4thInternational Conference and Exhibition on Cell & Gene Therapyduring August 10-12, 2015 at Crowne Plaza London-Heathrow, London, United Kingdom.

The conference brought together a comprehensive range of the cell and gene therapy researchers, educators from research universities as well as representatives from industry and professional cell and gene therapy societies.

Cell Therapy-2015is known for uplifting the future of cell and gene therapy and its allied areas by encouraging students and fellow researchers to present their work through poster presentations and young research forum. Students participated with great zeal and the best posters were awarded for their efforts and outstanding contribution to the cell and gene therapy research.

OMICS InternationalConferenceswishes to acknowledge with its deep sincere gratitude to all the supporters from the Editorial Board Members of our Open Access Journals, Keynote speakers, Honorable guests, valuable speakers, poster presenters, students, delegates and special thanks to the media partnersfor their promotion to make this event a huge success.

This4thInternational Conference and Exhibition on Cell & Gene Therapybased on the themeGenomic therapies from base pairs to bedsidewhich covered the below scientific sessions like Cell and Gene Therapy: Potential Applications, Plant Stem Cell Rejuvenation, Plant Stem Cells: Human Therapeutics, Stem Cell Therapies, Cellular Therapies, Advanced Gene Therapeutics, Molecular basis of epigenetics, Cancer Therapies, Nano-Therapy, Bioengineering Therapeutics, Clinical Trials and Research in Cell and Gene Therapies, Regulatory and Ethical Issues of Therapies.

The conference was greeted by the conference Moderator:Dr. Andrei Laikhter,Chemgenes Corporation, USA. The support was extended by the Keynote Speaker:Dr. James Koropatnic,Lawson Health Research Institute and Western University;Dr. Anelia Atanassova,BioGlobaX Inc., Canada;Dr. Noriyuki Kasahara,University of Miami, USA;Dr. Robert Hawkins,The Christie Hospital and University of Manchester, UK andDr. Paul L. Hermonat, Central Arkansas Veterans Healthcare System, USA

OMICSInternationalacknowledges the support of below Chairs and Co-chairs with whom we were able to run the scientific sessions smoothly it included:Dr. Ajan Reginald,Cell Therapy Limited, UK;Dr. Andrei Laikhter,Chemgenes Corporation, USA;Dr. Vasiliki Kalodimou,IASO Maternity Hospital, Greece;Dr. Geeta Shroff,Nutech Medicworld, India;Dr. Nady Golestaneh,Georgetown University School of Medicine, USA;Dr. James Koropatnick,Lawson Health Research Institute and Western University, Canada;Dr. Robert Hawkins,Christie Hospital and University of Manchester, UK.

This4thInternational Conference and Exhibition on Cell & Gene Therapywas uplifted with more than 32 oral presentations by researchers, scientists, professors, industry delegates and more than 15 poster participants around the globe. OMICS International has taken the privilege of felicitating Cell Therapy-2015 Organizing Committee Members, Editorial Board Members of the supported Journals and Keynote Speakers who supported for the success of this event.

With the enormous feedback from the participants and supporters 4thInternational Conference and Exhibition on Cell & Gene Therapy,OMICS International Conferencesis glad to announce its5thInternational Conference and Exhibition on Cell & Gene Therapy(Cell Therapy-2016) event from May 19-21, 2016 at San Antonio, USA

- See more at: http://cellgenetherapy.conferenceseries.com/#sthash.npJGo7Qv.dpuf

OMICS International Conferencessuccessfully hosted its premier4thInternational Conference and Exhibition on Cell & Gene Therapyduring August 10-12, 2015 at Crowne Plaza London-Heathrow, London, United Kingdom.

The conference brought together a comprehensive range of the cell and gene therapy researchers, educators from research universities as well as representatives from industry and professional cell and gene therapy societies.

Cell Therapy-2015is known for uplifting the future of cell and gene therapy and its allied areas by encouraging students and fellow researchers to present their work through poster presentations and young research forum. Students participated with great zeal and the best posters were awarded for their efforts and outstanding contribution to the cell and gene therapy research.

OMICS InternationalConferenceswishes to acknowledge with its deep sincere gratitude to all the supporters from the Editorial Board Members of our Open Access Journals, Keynote speakers, Honorable guests, valuable speakers, poster presenters, students, delegates and special thanks to the media partnersfor their promotion to make this event a huge success.

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Clinical Genetics Congress | Clinical Genetics 2016 ...