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Monthly Archives: September 2014
Bai 16: Stem cells and the political left
Posted: September 24, 2014 at 3:48 am
As far as bioengineering goes, stem cells and the surrounding moral controversy have provoked a variety of particularly vehement media commentary. I suppose the conversation, thinly walking the bright line between technical scientific innovation and philosophical quandary, makes for an enigmatic hors doeuvre even more so when morality is involved. Everyone has an opinion.
There is an aphorism some philosophers toss around: You can swing your fist freely till it hits another mans nose. In less archaic terms, the truism promotes individual autonomy until this autonomy infringes upon anothers human rights. In less convoluted terms, you can do what you want as long as no one else is hurt. Regarding stem cells and those who promote research of stem cells, that nose just seems a bit further away. Or the arms are a bit shorter. Regardless, the fist has a larger diameter to swing voraciously.
While it seems obtrusive to interrupt such theoretical thoughts with empirical ones, pragmatics and research are quite the pals. That aforementioned diameter tends to be an elastic one, contingent upon the mathematics of fiscal funding and politics of a given area. As a Brown undergrad, Id like to think Rhode Islands tendency to vote socially liberally has some hopeful implications for stem cells and their potentially monumental role in future health benefits. If Rhode Island were to meet this topic at the right junctures of funding and politics, what significance would it have?
In the endeavor to answer this seemingly large, general question, we should first examine the history of stem cell research policy in America. Second, we should analyze California, a state that has gained both influence and momentum in this field of study as of late.
Stem cell research has long been a moral quandary. Controversy mostly centers on embryonic stem cells and their extraction from in vitro fertilization. While IVF is commonly known as a method to treat infertility, it is also an accessible, effective means to study the embryonic genesis of human development. Stem cell lines are created by utilizing donor embryos or embryos that would have alternatively been discarded by IVF clinics.
Without descending into an entire discussion of where life begins, its enough to know that most stem cell research dissidents first criticize the usage of embryos and hold the process in which the embryos are obtained as a secondary issue.
As research can neither start nor continue in the absence of money, this debate has become an increasingly legal one.
The federal government ended this argument with a wildly unpopular vote to allocate money, though conservatively, to stem cell research laboratories. As political compromises result in little appeasement, this funding law also proved dissatisfactory. Social conservatives protested stem cells embryonic genesis. Researchers were limited to about 20 embryonic cell lines, hardly enough to further the researchs utilitarian health goals.
While the segregation between state and federal government has sometimes provided for unsavory historical moments, a la Southern secession, it has given stem cell researchers a hope for liberty. Since states are given the power to tax their own citizens and discretion in the use of funds gained through these taxes, they can also choose to fund specific types of research.
A decade ago, a group of Californians who believed deeply in the potential health benefits of advances in stem cell research drafted a ballot initiative for the establishment of the California Institute for Regenerative Medicine. Proposition 71 ultimately passed. Since 2006, CIRM has distributed $1.3 billion to build facilities, fund laboratory research and create technology with the promise of long-term health care benefits.
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Colchester teen becomes one of the UK's youngest stem cell donors
Posted: September 24, 2014 at 3:48 am
A teenager who gave stem cells to save the life of a stranger is backing a national campaign to find more donors.
In June, Celyn Evans, 17, became one of the youngest people in the UK to donate stem cells.
The Colchester Royal Grammar School sixth-form student is supporting Anthony Nolans Save a Life at 16 campaign.
The charity wants HMRC to include details about stem cell donation when it writes to teens with their National Insurance numbers ahead of their 16th birthday.
Celyn, of West Mersea, said: You often hear that young people are self absorbed and not interested in helping others, but I think thats wrong.
People just need to be made aware of how they can help. That is why I am supporting this campaign.
Celyn joined the bone marrow donor register last September when his brothers friend developed leukaemia.
He was not able to help the family friend, but in February, Anthony Nolan contacted him to say he was a possible match for another patient in need of a potentially life-saving transplant.
Celyn agreed to donate and, after a series of check-ups, made the donation in London in June.
Like 90 per cent of donors, he gave his stem cells through a simple, outpatient process similar to giving blood.
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Colchester teen becomes one of the UK's youngest stem cell donors
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Queenstown eyed as 'medical mecca'
Posted: September 24, 2014 at 3:48 am
Queenstown could become an international mecca for regenerative medicine, with a Chinese delegation in the resort to negotiate opening a $10 million to $20m medical complex.
The delegation included businessman Xia Jie, owner of the largest chain of diagnostic and wellness clinics across China, who has been meeting the Queenstown Lakes District Council, developers, Queenstown Chamber of Commerce and Destination Queenstown as part of a four-day "fact-finding mission".
Proposed sites for the medicine and medical research centre have been investigated at Remarkables Park, Five Mile and Jack's Point.
Xia's company operates the Health 100 brand, with more than 7 million patients so far this year.
If given the green light, the centre could attract up to 10,000 international clients from China and across the globe annually.
United States-based reproductive endocrinologist, sexual and regenerative medical specialist Dr Sam Wood and stem-cell expert Professor Richard Boyd, of Melbourne's Monash University, were part of the delegation.
The proposed world-class centre could make Queenstown an important hub for regenerative medicine, Wood said.
Queenstown was being looked at because of it world-class tourism status, established "four seasons" appeal and the recreational activities on offer.
People who wanted high-end treatment wanted to go to nice places and it was common for people in the US to travel to Aspen, Colorado, Wood said.
He was hoping to introduce to Queenstown procedures he helped develop in the US, such as vampire facelifts, breast lifts and flagship "M" and "O" shots to aid male and female sexual dysfunction. As well as being a research facility, the centre would be a mecca for high-profile athletes needing rehabilitation, low-level surgeries and imaging services. It was also hoped to expand stem-cell therapy on offer in the area.
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Queenstown eyed as 'medical mecca'
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Stem cell centre proposed for resort
Posted: September 24, 2014 at 3:41 am
Xia Jie.
Medical entrepreneur Xia Jie, whose company Health 100 owns the largest chain of health clinics in China, plans to open overseas facilities to cater for wealthy clients.
That could result in an investment of about $20 million in a regenerative treatment centre in the resort, making it a Mecca for health tourism and athlete injury rehabilitation.
''We're now negotiating with the local medical teams,'' Mr Xia said yesterday through an interpreter while on a four-day fact-finding mission to Queenstown.
''Health 100 really wants to find beautiful cities around the world to take Chinese patients to and Queenstown is one of them.
''The vision is to bring the very high-end customers to have special treatment which is not carried out elsewhere in the world,'' he said.
Health 100 would invest with existing firms Queenstown Regenerative Medicine (QRM), run by Marcelle Noble, and the Queenstown Skin Institute.
Both have small premises at Remarkables Park in Frankton.
Queenstown Skin Institute director Dr Hans Raetz said Mr Xia had indicated plans for a much larger centre, with sites in Remarkables Park, Jacks Point or the Five Mile development off Frankton Ladies Mile already earmarked.
''The size depends on Mr Xia, but we've been talking between $10 million and $20 million.
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Stem cell centre proposed for resort
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Stemedix Stem Cell Therapy for ALS – Patient Experience: Dr. Robert K., MD – Video
Posted: September 24, 2014 at 3:40 am
Stemedix Stem Cell Therapy for ALS - Patient Experience: Dr. Robert K., MD
Stemeidx treats Dr. Robert K., MD. for ALS (Amyotrophic Lateral Sclerosis). Dr. Robert speaks about his patient experience with Stemedix after receiving Stemedix adipose stem cell treatment....
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Stemedix Stem Cell Therapy for ALS - Patient Experience: Dr. Robert K., MD - Video
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Autism complex treatment with stem cell therapy – Video
Posted: September 24, 2014 at 3:40 am
Autism complex treatment with stem cell therapy
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Autism complex treatment with stem cell therapy - Video
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Swastik – Stem Cell Therapy in Duchenne Muscular Dystrophy (DMD) – 23-06-2014 – Video
Posted: September 24, 2014 at 3:40 am
Swastik - Stem Cell Therapy in Duchenne Muscular Dystrophy (DMD) - 23-06-2014
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Swastik - Stem Cell Therapy in Duchenne Muscular Dystrophy (DMD) - 23-06-2014 - Video
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Gene expression patterns in pancreatic circulating tumor cells revealed
Posted: September 24, 2014 at 2:51 am
Analysis of circulating tumor cells (CTCs) in a mouse model of pancreatic cancer identified distinct patterns of gene expression in several groups of CTCs, including significant differences from the primary tumor that may contribute to the ability to generate metastases. In their study reported in the Sept. 25 issue of Cell Reports, investigators from the Massachusetts General Hospital (MGH) Cancer Center identified several different classes of pancreatic CTCs and found unexpected factors that may prove to be targets for improved treatment of the deadly tumor.
"Our ability to combine a novel microfluidic CTC isolation device, developed here at MGH, with single-cell RNA sequencing has given us new biological insights into these cells and revealed novel avenues to try and block the spread of cancer," says lead author David T. Ting, MD, MGH Cancer Center.
Pancreatic cancer is among the most deadly of tumors because it spreads rapidly via CTCs carried in the bloodstream. The earliest technologies for isolating CTCs from blood samples relied on interactions with known tumor-specific marker proteins, potentially missing cells that did not express those particular markers. The device used in the current study, called the CTC-iChip, enables the isolation of all CTCs in a blood sample, regardless of the proteins they express on their surface, by removing all other components. Since the CTCs collected are in solution, unlike with previous CTC capture devices, they are suitable for advanced RNA sequencing techniques to reveal the gene expression patterns of each individual cell.
Using a well-known mouse model of pancreatic cancer, the researchers first isolated 168 single CTCs from the bloodstreams of five individual mice. Analysis of the RNA transcripts of each CTC revealed several different subsets of CTCs, based on gene expression patterns that were different from each other and from the primary tumor. The largest subset, which the authors call 'classic CTCs,' was found to have elevated expression of a stem cell gene called Aldh1 a2, along with genes characteristic of two basic cell types -- epithelial and mesenchymal -- transition between which has been associated with tumor metastasis. Another gene expressed by almost all classic CTCs, Igfbp5, is only expressed in primary tumor at locations where epithelial cancer cells interface with the supporting stromal cells that provide a nurturing microenvironment, an observation that suggests that those regions may be the source of CTCs.
The research team was most surprised to observe that extracellular matrix (ECM) genes in general -- usually expressed primarily in stromal cells -- were highly expressed in all classic CTCs. Previous studies have suggested that the establishment of metastases depends on the appropriate cellular microenvironment -- 'soil' in which CTCs can plant themselves as 'seeds'- and that the expression of ECM genes is an important aspect of that environment. Expression of ECM genes by CTCs themselves suggests that the blood-borne cells may provide or help prepare their own 'soil.'
Analysis of CTCs from blood samples of human patients with pancreatic, breast or prostate cancer also found elevated expression of several ECM genes. One particular gene, SPARC, was highly expressed in all pancreatic CTCs as well as in 31 percent of breast CTCs. Further experiments revealed that suppressing SPARC expression in human pancreatic cancer cells reduced their ability to migrate and invade tissue, and significantly fewer metastases were generated when SPARC-suppressed pancreatic tumors were implanted into a mouse model, supporting the protein's role in a tumor's metastatic potential.
"Given our limited therapeutic options for pancreatic cancer, understanding the role of the ECM in this tumor seems to be of great importance," says Ting, who is an assistant professor of Medicine at Harvard Medical School. "Much effort has been focused on targeting the microenvironment to improve the efficacy of chemotherapy, and data indicating that environmental stromal cells can enhance a tumor's metastatic ability indicate that ECM proteins are important whether they are produced in stroma or within the tumor cells themselves. Now we need to investigate whether therapeutically targeting ECM can destroy both the tumor microenvironment and CTCs before they have a chance to metastasize."
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The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.
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Gene expression patterns in pancreatic circulating tumor cells revealed
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Cedar Rapids IA Resources – Stem Cells: Get Facts on Uses …
Posted: September 24, 2014 at 2:50 am
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Cedar Rapids IA Resources - Stem Cells: Get Facts on Uses ...
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Upper Dublin girl names semi-finalist for medical school scholarship
Posted: September 24, 2014 at 2:47 am
Jennifer Deasy has suffered from migraines since she was 11 years old more than half the 18-year-old Upper Dublin girls life. And she has an idea that just may ease the pain a bit for her and other migraine sufferers.
It also could net her a medical school scholarship.
Basically, her idea is to cure migraines with stem cell treatment.
Deasy has been named one of 12 semi-finalists for a National Academy Medical School Scholarship Challenge sponsored by the National Academy of Future Physicians and Medical Scientists.
Three of the 12 will be selected to present their research proposals at the November Congress of Future Medical Leaders in Washington, D.C., according to an academy press release. One will receive a medical school scholarship up to $185,000, with $10,000 scholarships going to the runners-up.
The winners will be determined by scholars attending the November Congress.
Deasy was one of 3,100 honor high school students who attended the February Congress, where students were challenged to identify an unsolved medical/scientific/world health problem and create an original investigation to solve that problem.
My guidance counselor nominated me to attend the February Congress, said Deasy, a 2014 Upper Dublin High School grad and current freshman at Franklin & Marshall. Attending medical school has been a dream for as long as I can remember.
I always found [medicine] cool and interesting, she said, noting her dad is an oral surgeon, three uncles are doctors and one is a nurse. She hopes to become a neurologist, both seeing patients and doing research on the brain and its workings with different hormones and how they can affect brain function, like seizures and migraines.
Pain medication or caffeine pills are currently used to treat migraine symptoms, she said. It is not known what causes the severe headaches often accompanied by nausea, and there is no cure. Continued...
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Upper Dublin girl names semi-finalist for medical school scholarship
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