Monthly Archives: December 2012

Adult Stem Cell Therapy Breakthrough Leads to Crowd Funding Campaign on Indiegogo.com for Centagen, Inc.

Posted: December 31, 2012 at 7:44 pm

Centagen has developed a breakthrough stem cell therapy that rejuvenates a patient's own adult stem cells. The Company has found a way to expand a patients own stem cells in the lab millions of times while rejuvenating the cells. For example, a patients blood pleuropotent stem cells could be rejuvenated and expanded in the lab and then re-injected to repair and rejuvenate organs and tissues damaged by aging or disease. Centagen has announced a funding campaign at http://www.indiegogo.com/centagen for additonal research and development.

Boulder, Colorado (PRWEB) December 31, 2012

Each of us has a limited supply of the kind of stem cells needed to rebuild, repair, and rejuvenate any part of our body. As we age, the supply and healing power of our stem cells diminishes. By providing a practically unlimited supply of one's own rejuvenated stem cells, we may keep people young and healthy for well over a century. In particular, regenerating tissues and organs prepared by expanding ones own stem cells could help with Alzheimers disease, diabetes, immune senescence, damaged heart tissue, arteriosclerosis, failing kidneys, failing hearing or eyesight, osteoporosis, weak muscles, and aged skin.

The technology requires no genetic engineering of the stem cells, so the procedure is much safer than the current procedures requiring genetic tampering. Only a patients adult stem cells are used, so there are no ethical issues common with embryonic stem cell use or side effects due to tissue rejection by your immune system.

Centagen has recently opened a crowd funding bid at http://www.indiegogo.com/centagen in concert with Maximum Life foundation, whose mission is to make 100 years old the new 50.

Forward-Looking Statements for Centagen, Inc.

This press release contains several forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements reflect management's current expectations, as of the date of this press release, and involve certain risks and uncertainties. Forward-looking statements include statements herein with respect to the successful execution of the Company's business strategy of stem cell therapeutics. The Company's actual results could differ materially from those anticipated in these forward- looking statements as a result of various factors and the Company's further development is highly dependent on future medical and research developments and market acceptance, which is outside of its control. The Company may not update these forward-looking statements in a timely manner as conditions change.

Bryant Villeponteau, Ph.D. Centagen (877) 757-1923 Email Information

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Adult Stem Cell Therapy Breakthrough Leads to Crowd Funding Campaign on Indiegogo.com for Centagen, Inc.

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The Latest With Bob Harman, DVM

Posted: December 31, 2012 at 6:49 pm


The Latest With Bob Harman, DVM Julie Johnson, DVM - VetStem
The Latest With Bob Harman, DVM: discusses animal stem cell treatment with Julie Ryan Johnson, DVM - Vet-Stem provides stem cells from a small sample of fat for the treatment of arthritis and tendon and ligament injuries in dogs, horses, and cats.

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The Latest With Bob Harman, DVM

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Dr.Geetha Iyer talks about regeneration techniques at Cornea – Video

Posted: December 31, 2012 at 6:49 pm


Dr.Geetha Iyer talks about regeneration techniques at Cornea
In the 29th episode, Dr.Geetha Iyer, Senior Consultant, Cornea and Ocular surface talks about Stem Cells, regeneration, artificial cornea through latest MOOKP procedures

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Dr.Geetha Iyer talks about regeneration techniques at Cornea - Video

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The Latest With Stem Cells Show Thomas Ichim, CEO of MediStem and Dr. Bob Harman, DVM – Video

Posted: December 31, 2012 at 6:49 pm


The Latest With Stem Cells Show Thomas Ichim, CEO of MediStem and Dr. Bob Harman, DVM
The Latest With Thomas Ichim, CEO of Medistem talks to Dr. Bob Harman, DVM about animal stem cell treatment - Vet-Stem provides stem cells from a small sample of fat for the treatment of arthritis and tendon and ligament injuries in dogs, horses, and cats.

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The Latest With Stem Cells Show Thomas Ichim, CEO of MediStem and Dr. Bob Harman, DVM - Video

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Work From Home Business Opportunity Stemenhance Stemtech – Video

Posted: December 31, 2012 at 6:49 pm


Work From Home Business Opportunity Stemenhance Stemtech
http://www.workfrom-homebusiness.com video explains about a work from home business which might be an opportunity that you #39;ve been looking for to finally earn enough money on a part time basis that you can quit your full time job while working with a truly unique and revolutionary company that #39;s helping thousands of people reach optimum health. Check out video at http The company I #39;m referring to is called Stemtech and with their patented stem cell technology stemenhance they #39;re able to turbo change the healing process of any injury by literally creating new healthy cells to repair the injured area. What this means is that were finally able to attack the problem at the root cause at a cellular level. The result has been nothing less than phenomenal. Opportunities like this one doesn #39;t come around very often. Adult stem cell nutrition does not have anything to do with stem cells or embryonic stem cells. It is about the concept of consuming nutritional substances that will automatically support the release of a stem cell from the bone marrow and also your body #39;s own natural health renewal system. So if your looking for work form home business ideas and to be involved with a totally unique cutting edge stem cell nutrition company which has chosen network marketing platform to deliver the information of stemtech health sciences to the public like yourself which you have the chance to earn all the money you #39;d ever need I strongly urge you to take a close look at Stem Tech home based ...

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Work From Home Business Opportunity Stemenhance Stemtech - Video

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Two kinds of stem cells.mp4 – Video

Posted: December 31, 2012 at 6:49 pm


Two kinds of stem cells.mp4
In the beginning... there were two kinds of stem cells, embryonic and non-embryonic. A third, induced pluripotential stem cells, were developed in the 19080 #39;s. Each type of stem cell has its pluses and its minuses when it comes to use in regenerative medicine. The field is exploding with promise, particularly for diseases associated with aging such as osteoarthritis.

By: Nathan Wei

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Scientists use urine to make stem cells – Video

Posted: December 31, 2012 at 6:48 pm


Scientists use urine to make stem cells
Chinese scientists from the Guangzhou Institutes of Biomedicine and Health have converted cells found in urine into pluripotent stem cells that can be used to create neurons and brain cells. The researchers say the find holds huge potential for the rapid testing and development of new treatments for neuro-degenerative disorders. Ben Gruber reports.

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Scientists use urine to make stem cells - Video

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Illinois Nano-Bio Node – BioE Seminar Series Oct. 11, 2012 – The role of cell geometry in stem cells – Video

Posted: December 31, 2012 at 6:48 pm


Illinois Nano-Bio Node - BioE Seminar Series Oct. 11, 2012 - The role of cell geometry in stem cells
"The role of cell geometry and adhesion ligand presentation in guiding stem cell differentiation" Kris Kilian, PhD Materials Science and Engineering, University of Illinois at Urbana-Champaign October 11, 2012 "Substrates that are designed to mimic the extracellular matrix are useful tools for studying cellular processes. Recently, we showed how micropatterning single mesenchymal stem cells can be used to reveal geometric cues that guide lineage specification. Shapes that promote a contractile cytoskeleton promote osteogenesis while shapes that promote a less organized cytoskeleton promote adipogenesis. In a separate study we found that the density and affinity of an immobilized cell adhesion ligand influences lineage specification. Surfaces presenting the high affinity cyclic-RGD peptide guide MSCs to express elevated levels of osteogenic markers. In contrast, surfaces presenting the lower affinity linear-RGD peptide promote expression of markers associated with myogenesis at high density and neurogenesis at low density of ligand. In both of these studies, the control of integrin-mediated adhesion and actomyosin contractility were found to guide specific differentiation programs. In this talk, I will present our efforts in the design of model systems that vary physical and biochemical cues independently and together. These studies reveal a picture of the microenvironment where cell geometry, matrix mechanics, adhesion ligand presentation and paracrine signaling play a ...

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Illinois Nano-Bio Node - BioE Seminar Series Oct. 11, 2012 - The role of cell geometry in stem cells - Video

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Kathleen Dardis Singleton on Stem Cell Research – Video

Posted: December 31, 2012 at 6:48 pm


Kathleen Dardis Singleton on Stem Cell Research
Written and performed by Kathleen Dardis Singleton. Directed and produced by Matthew J. Singleton.

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Kathleen Dardis Singleton on Stem Cell Research - Video

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Investigators’ Study Hints That Stem Cells Prepare for Maturity Much Earlier Than Anticipated

Posted: December 30, 2012 at 12:45 pm

Newswise KANSAS CITY, MOUnlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility pluripotency, meaning that as an organism develops, stem cells must be ready at a moments notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells.

Scientists from the lab of Stowers Investigator Ali Shilatifard, Ph.D., report in the December 27, 2012 online issue of Cell that one way cells stay so plastic is by stationing a protein called Ell3 at stretches of DNA known as enhancers required to activate a neighboring gene. Their findings suggest that Ell3 parked at the enhancer of a developmentally regulated gene, even one that is silent, primes it for future expression. This finding is significant as many of these same genes are abnormally switched on in cancer.

We now know that some enhancer misregulation is involved in the pathogenesis of solid and hematological malignances, says Shilatifard. But a problem in the field has been how to identify inactive or poised enhancer elements. Our discovery that Ell3 interacts with enhancers in ES cells gives us a hand-hold to identify and to study them.

In 2000, Shilatifard identified Ell3 as the third member of the Ell (for Eleven-nineteen lysine-rich leukemia gene) family of elongation factors, proteins that increase the rate at which genes are expressed. At the time, we didnt think much of Ell3 because it was highly expressed in testes, says Shilatifard, noting that then people thought that sperm were merely vessels used to carry paternal DNA to an egg and that associated factors would have little relevance to the regulation of future gene expression in the resulting embryo.

But a few years back, a curious Open University graduate student working in the Shilatifard lab, Chengqi Lin, started exploring a potential function for the neglected gene by initiating a global search for regions occupied by Ell3 in the genome of mouse embryonic stem cells. His search in collaboration with a bioinformatician in the Shilatifard lab, Alexander S. Garruss, revealed that Ell3 sits on more than 5,000 enhancers, including many that regulate genes governing stem cell maturation into spinal cord, kidney, and blood cells.

What was interesting was that Ell3 marked enhancers that are active and inactive, as well as enhancers that are known as poised, says Lin, referring to a transition state from inactive to active. That indicated that Ell3s major function might be to prime activation of genes that are just about to be expressed during development.

The fact that silent genes can be primed for expression was no surprise: researchers knew that the enzymatic machine that copies DNA into the RNA blueprint for proteinsa protein called Pol IIoften pauses at the start of a gene, presumably revving its engine in preparation to jump across the genetic start gate in response to a developmental signal. However, Shilatifard and colleagues showed several years ago that paused Pol II is not a prerequisite for rapid transcriptional induction.

The surprise came when researchers used a molecular trick to deplete mouse ES cells of Ell3 and then did a genomic survey. They found that paused Pol II vanished from the start sites of many genes in Ell3-deficient cells. This means that not only does Ell3 preferentially mark stem enhancers, but also that its presence there is necessary to keep an idling Pol II ready for action.

Most of the current study defines how, when the developmental time is right, enhancer-bound Ell3 cooperates with components of a big-boss elongation factor called the Super Elongation Complex to release Pol II from the start gate, allowing the expression of genes required for stem cell differentiation. Critical among those findings is their observation that mouse stem cells depleted of Ell3 failed to activate genes expressed in mature cell types.

These results alone are cause for any lab to start chilling the champagne, yet a surprising coda to the study, leaves readers with yet another revelation. Collaborating with Fengli Guo, Ph.D., head of the Stowers electron microscopy core, the team prepared highly magnified images of mouse sperm and observed that both Ell3 and Pol II were present, in sperm nuclei.

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Investigators' Study Hints That Stem Cells Prepare for Maturity Much Earlier Than Anticipated

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